Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACBD7 Gene

Aliases for ACBD7 Gene

  • Acyl-CoA Binding Domain Containing 7 2 3 5
  • Acyl-Coenzyme A Binding Domain Containing 7 2 3
  • Acyl-CoA-Binding Domain-Containing Protein 7 3
  • BA455B2.2 3

External Ids for ACBD7 Gene

Previous GeneCards Identifiers for ACBD7 Gene

  • GC10U900450
  • GC10M015157
  • GC10M015117
  • GC10M015031

Summaries for ACBD7 Gene

GeneCards Summary for ACBD7 Gene

ACBD7 (Acyl-CoA Binding Domain Containing 7) is a Protein Coding gene. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include lipid binding and fatty-acyl-CoA binding. An important paralog of this gene is DBI.

UniProtKB/Swiss-Prot for ACBD7 Gene

  • Binds medium- and long-chain acyl-CoA esters.

Additional gene information for ACBD7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACBD7 Gene

Genomics for ACBD7 Gene

GeneHancer (GH) Regulatory Elements for ACBD7 Gene

Promoters and enhancers for ACBD7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J015088 Promoter/Enhancer 1.5 Ensembl ENCODE 659.7 0.0 -40 1.2 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2 ZNF213 ZNF143 ACBD7 RPP38 C10orf111 DCLRE1C MINDY3 GAPDHP45
GH10J015096 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.9 -9.2 -9185 3.1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF213 RPP38 C10orf111 HSPA14 ACBD7 LOC105376431
GH10J015122 Enhancer 1 FANTOM5 ENCODE 19.1 -35.0 -35011 1.7 HDGF PKNOX1 EBF1 BATF KLF5 RELA GATA3 POLR2A ZNF143 ATF7 GC10P015124 ACBD7 C10orf111 RPP38 GAPDHP45 DCLRE1CP1 OLAH LOC105376431 GC10P015108 NMT2
GH10J014530 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.2 +556.3 556286 3.5 ELF3 FOXA2 MLX ARID4B SIN3A RAD21 DNMT3B THRB RARA YY1 CDNF HSPA14 SUV39H2 DCLRE1CP1 ACBD7 GAPDHP45 FAM107B GC10M014524 LOC105376429
GH10J015043 Promoter 0.8 EPDnew 11 +44.8 44845 0.1 SOX13 ATF4 CEBPA CEBPG TRIM24 GABPA OLAH DCLRE1CP1 ACBD7 GAPDHP45 C10orf111 RPP38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACBD7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACBD7 gene promoter:
  • LyF-1
  • Evi-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • C/EBPbeta
  • CUTL1
  • NRF-2

Genomic Locations for ACBD7 Gene

Genomic Locations for ACBD7 Gene
chr10:15,075,475-15,088,776
(GRCh38/hg38)
Size:
13,302 bases
Orientation:
Minus strand
chr10:15,117,474-15,130,775
(GRCh37/hg19)
Size:
13,302 bases
Orientation:
Minus strand

Genomic View for ACBD7 Gene

Genes around ACBD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACBD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACBD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACBD7 Gene

Proteins for ACBD7 Gene

  • Protein details for ACBD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6N7-ACBD7_HUMAN
    Recommended name:
    Acyl-CoA-binding domain-containing protein 7
    Protein Accession:
    Q8N6N7
    Secondary Accessions:
    • A6NCI2
    • B3KTG8

    Protein attributes for ACBD7 Gene

    Size:
    88 amino acids
    Molecular mass:
    9790 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACBD7 Gene

neXtProt entry for ACBD7 Gene

Post-translational modifications for ACBD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACBD7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACBD7 Gene

Domains & Families for ACBD7 Gene

Gene Families for ACBD7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ACBD7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6N7

UniProtKB/Swiss-Prot:

ACBD7_HUMAN :
  • Belongs to the ACBD7 family.
Family:
  • Belongs to the ACBD7 family.
genes like me logo Genes that share domains with ACBD7: view

Function for ACBD7 Gene

Molecular function for ACBD7 Gene

UniProtKB/Swiss-Prot Function:
Binds medium- and long-chain acyl-CoA esters.

Phenotypes From GWAS Catalog for ACBD7 Gene

Gene Ontology (GO) - Molecular Function for ACBD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding IEA --
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with ACBD7: view

Phenotypes for ACBD7 Gene

genes like me logo Genes that share phenotypes with ACBD7: view

Animal Model Products

miRNA for ACBD7 Gene

miRTarBase miRNAs that target ACBD7

Clone Products

  • Addgene plasmids for ACBD7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACBD7 Gene

Localization for ACBD7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACBD7 gene
Compartment Confidence
cytosol 3
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ACBD7 Gene

Pathways & Interactions for ACBD7 Gene

genes like me logo Genes that share pathways with ACBD7: view

Interacting Proteins for ACBD7 Gene

Gene Ontology (GO) - Biological Process for ACBD7 Gene

None

No data available for SIGNOR curated interactions for ACBD7 Gene

Drugs & Compounds for ACBD7 Gene

(2) Drugs for ACBD7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(30) Additional Compounds for ACBD7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with ACBD7: view

Transcripts for ACBD7 Gene

mRNA/cDNA for ACBD7 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACBD7 Gene

Acyl-CoA binding domain containing 7:
Representative Sequences:

Clone Products

  • Addgene plasmids for ACBD7

Alternative Splicing Database (ASD) splice patterns (SP) for ACBD7 Gene

No ASD Table

Relevant External Links for ACBD7 Gene

GeneLoc Exon Structure for
ACBD7
ECgene alternative splicing isoforms for
ACBD7

Expression for ACBD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACBD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACBD7 Gene

This gene is overexpressed in Brain - Amygdala (x7.4), Brain - Caudate (basal ganglia) (x6.7), Brain - Nucleus accumbens (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x5.1), Brain - Frontal Cortex (BA9) (x4.6), Brain - Hippocampus (x4.1), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for ACBD7 Gene

This gene is overexpressed in Fetal Brain (24.5), Brain (16.2), and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACBD7 Gene



Protein tissue co-expression partners for ACBD7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACBD7 Gene:

ACBD7

SOURCE GeneReport for Unigene cluster for ACBD7 Gene:

Hs.644598

Evidence on tissue expression from TISSUES for ACBD7 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ACBD7: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACBD7 Gene

Orthologs for ACBD7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACBD7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACBD7 34 33
  • 98.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ACBD7 33
  • 91.29 (n)
-- 34
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia ACBD7 34
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Acbd7 16 34 33
  • 82.95 (n)
rat
(Rattus norvegicus)
Mammalia Acbd7 33
  • 82.95 (n)
cow
(Bos Taurus)
Mammalia ACBD7 34 33
  • 82.58 (n)
OneToOne
chicken
(Gallus gallus)
Aves ACBD7 34 33
  • 82.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACBD7 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acbd7 33
  • 76.14 (n)
zebrafish
(Danio rerio)
Actinopterygii acbd7 34 33
  • 66.67 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000546 33
  • 61.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8498 33
  • 56.82 (n)
CG8628 34
  • 48 (a)
ManyToMany
CG8629 34
  • 48 (a)
ManyToMany
CG5804 34
  • 41 (a)
ManyToMany
CG15829 34
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acbp-1 34
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACB1 34
  • 44 (a)
OneToMany
Species where no ortholog for ACBD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACBD7 Gene

ENSEMBL:
Gene Tree for ACBD7 (if available)
TreeFam:
Gene Tree for ACBD7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACBD7: view image

Paralogs for ACBD7 Gene

Paralogs for ACBD7 Gene

(7) SIMAP similar genes for ACBD7 Gene using alignment to 1 proteins:

  • ACBD7_HUMAN

Pseudogenes.org Pseudogenes for ACBD7 Gene

genes like me logo Genes that share paralogs with ACBD7: view

Variants for ACBD7 Gene

Sequence variations from dbSNP and Humsavar for ACBD7 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000098112 -- 15,075,989(-) A/G 3_prime_UTR_variant
rs1000310335 -- 15,080,938(-) G/T intron_variant
rs1000514913 -- 15,086,819(-) C/A intron_variant
rs1000530287 -- 15,079,426(-) C/G intron_variant
rs1000598676 -- 15,080,578(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACBD7 Gene

Variant ID Type Subtype PubMed ID
nsv831794 CNV loss 17160897

Variation tolerance for ACBD7 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACBD7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACBD7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACBD7 Gene

Disorders for ACBD7 Gene

Additional Disease Information for ACBD7

No disorders were found for ACBD7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACBD7 Gene

Publications for ACBD7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58

Products for ACBD7 Gene

Sources for ACBD7 Gene

Content
Loading form....