Aliases for ACBD3 Gene
External Ids for ACBD3 Gene
Previous HGNC Symbols for ACBD3 Gene
Previous GeneCards Identifiers for ACBD3 Gene
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACBD3 Gene
ACBD3 (Acyl-CoA Binding Domain Containing 3) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include fatty-acyl-CoA binding. An important paralog of this gene is TMED8.
UniProtKB/Swiss-Prot Summary for ACBD3 Gene
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356).
(Microbial infection) Sensitizes PI4KB activation by Kobuviral (Aichi) 3A protein.