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Aliases for ACAD11 Gene

Aliases for ACAD11 Gene

  • Acyl-CoA Dehydrogenase Family Member 11 2 3 3 5
  • Acyl-Coenzyme A Dehydrogenase Family, Member 11 2 3
  • ACAD-11 3 4
  • Acyl-CoA Dehydrogenase Family, Member 11 2
  • EC 1.3.99.- 4

External Ids for ACAD11 Gene

Previous GeneCards Identifiers for ACAD11 Gene

  • GC03M133761
  • GC03M132276
  • GC03M129656

Summaries for ACAD11 Gene

Entrez Gene Summary for ACAD11 Gene

  • This gene encodes an acyl-CoA dehydrogenase enzyme with a preference for carbon chain lengths between 20 and 26. Naturally occurring read-through transcription occurs between the upstream gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene. [provided by RefSeq, Aug 2015]

GeneCards Summary for ACAD11 Gene

ACAD11 (Acyl-CoA Dehydrogenase Family Member 11) is a Protein Coding gene. Diseases associated with ACAD11 include Nephronophthisis 3. Among its related pathways are Mitochondrial Fatty Acid Beta-Oxidation and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is ACAD10.

UniProtKB/Swiss-Prot for ACAD11 Gene

  • Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.

Additional gene information for ACAD11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACAD11 Gene

Genomics for ACAD11 Gene

GeneHancer (GH) Regulatory Elements for ACAD11 Gene

Promoters and enhancers for ACAD11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J132657 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 667.6 +0.8 797 4.5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ACAD11 UBA5 NPHP3 DNAJC13 NPHP3-ACAD11
GH03J132605 Promoter/Enhancer 0.7 EPDnew ENCODE 650.2 +54.7 54689 1.9 ACAD11 UBA5 ACKR4 HSPA8P19 NPHP3-ACAD11
GH03J132662 Enhancer 0.6 ENCODE 650.7 -1.6 -1629 0.2 SOX5 SOX13 CLOCK FOXA2 FOXA3 GATAD2B DPF2 ZBTB40 FOXA1 ZNF217 ACAD11 UBA5 NPHP3-AS1 NPHP3-ACAD11
GH03J132627 Promoter 0.5 EPDnew 661.1 +33.6 33596 0.1 ACAD11 UBA5 HSPA8P19 ACKR4 NPHP3-ACAD11
GH03J132579 Promoter 0.5 EPDnew 650.2 +81.1 81146 0.1 ACAD11 ACKR4 NPHP3-ACAD11 DNAJC13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACAD11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACAD11 gene promoter:
  • STAT3
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • ISGF-3
  • AREB6
  • POU2F1a
  • POU2F1
  • CUTL1
  • C/EBPalpha

Genomic Locations for ACAD11 Gene

Genomic Locations for ACAD11 Gene
chr3:132,558,138-132,660,723
(GRCh38/hg38)
Size:
102,586 bases
Orientation:
Minus strand
chr3:132,276,982-132,379,567
(GRCh37/hg19)
Size:
102,586 bases
Orientation:
Minus strand

Genomic View for ACAD11 Gene

Genes around ACAD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACAD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACAD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAD11 Gene

Proteins for ACAD11 Gene

  • Protein details for ACAD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q709F0-ACD11_HUMAN
    Recommended name:
    Acyl-CoA dehydrogenase family member 11
    Protein Accession:
    Q709F0
    Secondary Accessions:
    • Q08AF0
    • Q658N9
    • Q658Y2
    • Q6ZND2
    • Q8WUT6
    • Q9H9R3

    Protein attributes for ACAD11 Gene

    Size:
    780 amino acids
    Molecular mass:
    87283 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=BAB14158.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACAD11 Gene

    Alternative splice isoforms for ACAD11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACAD11 Gene

Post-translational modifications for ACAD11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACAD11 Gene

No data available for DME Specific Peptides for ACAD11 Gene

Domains & Families for ACAD11 Gene

Gene Families for ACAD11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ACAD11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q709F0

UniProtKB/Swiss-Prot:

ACD11_HUMAN :
  • Belongs to the acyl-CoA dehydrogenase family.
Family:
  • Belongs to the acyl-CoA dehydrogenase family.
genes like me logo Genes that share domains with ACAD11: view

Function for ACAD11 Gene

Molecular function for ACAD11 Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Enzyme Numbers (IUBMB) for ACAD11 Gene

Phenotypes From GWAS Catalog for ACAD11 Gene

Gene Ontology (GO) - Molecular Function for ACAD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003995 acyl-CoA dehydrogenase activity TAS --
GO:0004466 long-chain-acyl-CoA dehydrogenase activity IDA 21237683
GO:0016491 oxidoreductase activity IEA --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA --
GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity IDA 21237683
genes like me logo Genes that share ontologies with ACAD11: view
genes like me logo Genes that share phenotypes with ACAD11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACAD11

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACAD11 Gene

Localization for ACAD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACAD11 Gene

Peroxisome. Mitochondrion. Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316. {ECO:0000269 PubMed:21237683}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACAD11 gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 4
cytosol 2

Gene Ontology (GO) - Cellular Components for ACAD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21237683
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005777 peroxisome ISS --
GO:0031966 mitochondrial membrane IDA 21237683
genes like me logo Genes that share ontologies with ACAD11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACAD11 Gene

Pathways & Interactions for ACAD11 Gene

genes like me logo Genes that share pathways with ACAD11: view

Gene Ontology (GO) - Biological Process for ACAD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006635 fatty acid beta-oxidation TAS --
GO:0008152 metabolic process IEA --
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IDA 21237683
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ACAD11: view

No data available for SIGNOR curated interactions for ACAD11 Gene

Drugs & Compounds for ACAD11 Gene

(2) Drugs for ACAD11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(30) Additional Compounds for ACAD11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with ACAD11: view

Transcripts for ACAD11 Gene

mRNA/cDNA for ACAD11 Gene

Unigene Clusters for ACAD11 Gene

Acyl-CoA dehydrogenase family, member 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACAD11 Gene

No ASD Table

Relevant External Links for ACAD11 Gene

GeneLoc Exon Structure for
ACAD11
ECgene alternative splicing isoforms for
ACAD11

Expression for ACAD11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACAD11 Gene

Protein differential expression in normal tissues from HIPED for ACAD11 Gene

This gene is overexpressed in Gallbladder (41.0) and Liver (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACAD11 Gene



Protein tissue co-expression partners for ACAD11 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACAD11 Gene:

ACAD11

SOURCE GeneReport for Unigene cluster for ACAD11 Gene:

Hs.441378

mRNA Expression by UniProt/SwissProt for ACAD11 Gene:

Q709F0-ACD11_HUMAN
Tissue specificity: Widely expressed with highest levels in brain followed by liver, heart and kidney.

Evidence on tissue expression from TISSUES for ACAD11 Gene

  • Liver(4.3)
  • Lymph node(4.2)
  • Stomach(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with ACAD11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACAD11 Gene

Orthologs for ACAD11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACAD11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACAD11 34 33
  • 99.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACAD11 34 33
  • 88.33 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ACAD11 34 33
  • 88.25 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 82 (a)
OneToMany
-- 34
  • 76 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Acad11 16 34 33
  • 81.17 (n)
rat
(Rattus norvegicus)
Mammalia Acad11 33
  • 81.02 (n)
oppossum
(Monodelphis domestica)
Mammalia ACAD11 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACAD11 34 33
  • 71.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACAD11 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acad11 33
  • 65.68 (n)
zebrafish
(Danio rerio)
Actinopterygii acad11 34 33
  • 63.55 (n)
OneToOne
zgc55835 33
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15181g 33
  • 45.99 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL213W 33
  • 41.95 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.25699 33
bread mold
(Neurospora crassa)
Ascomycetes NCU01181 33
  • 53.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Cin.11416 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11416 33
Species where no ortholog for ACAD11 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for ACAD11 Gene

ENSEMBL:
Gene Tree for ACAD11 (if available)
TreeFam:
Gene Tree for ACAD11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACAD11: view image

Paralogs for ACAD11 Gene

Paralogs for ACAD11 Gene

(3) SIMAP similar genes for ACAD11 Gene using alignment to 5 proteins:

  • ACD11_HUMAN
  • D6RDI8_HUMAN
  • F8WEV0_HUMAN
  • H0Y9C6_HUMAN
  • Q08AE9_HUMAN
genes like me logo Genes that share paralogs with ACAD11: view

Variants for ACAD11 Gene

Sequence variations from dbSNP and Humsavar for ACAD11 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs139371109 uncertain-significance, not provided 132,605,177(-) C/A/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs727503787 uncertain-significance, not provided 132,659,702(-) T/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs141257781 not-provided, not provided 132,618,721(-) C/T coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000006782 -- 132,660,511(-) G/A upstream_transcript_variant
rs1000006957 -- 132,598,059(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACAD11 Gene

Variant ID Type Subtype PubMed ID
nsv998211 CNV loss 25217958
nsv979879 CNV duplication 23825009
nsv965409 CNV deletion 23825009
nsv829728 CNV gain 17160897
nsv591798 CNV loss 21841781
nsv591797 CNV loss 21841781
nsv591796 CNV loss 21841781
nsv1150596 CNV duplication 26484159
nsv1110768 CNV insertion 24896259
nsv1109545 CNV deletion 24896259
esv3597828 CNV loss 21293372
esv3597827 CNV loss 21293372
esv3569006 CNV loss 25503493
esv2675190 CNV deletion 23128226
esv2669271 CNV deletion 23128226

Variation tolerance for ACAD11 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACAD11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACAD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAD11 Gene

Disorders for ACAD11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACAD11 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nephronophthisis 3
  • nphp3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ACAD11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ACAD11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACAD11 Gene

Publications for ACAD11 Gene

  1. Identification and characterization of new long chain acyl-CoA dehydrogenases. (PMID: 21237683) He M … Vockley J (Molecular genetics and metabolism 2011) 3 4 58
  2. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for ACAD11 Gene

Sources for ACAD11 Gene

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