This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced ... See more...

Aliases for ACAD10 Gene

Aliases for ACAD10 Gene

  • Acyl-CoA Dehydrogenase Family Member 10 2 3 4 5
  • Acyl-Coenzyme A Dehydrogenase Family, Member 10 2 3
  • ACAD-10 3 4
  • Acyl-CoA Dehydrogenase Family, Member 10 2
  • EC 1.3.99.- 4
  • MGC5601 2
  • ACAD10 5

External Ids for ACAD10 Gene

Previous GeneCards Identifiers for ACAD10 Gene

  • GC00U909456
  • GC12P110586
  • GC12P112123
  • GC12P109137

Summaries for ACAD10 Gene

Entrez Gene Summary for ACAD10 Gene

  • This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Nov 2008]

GeneCards Summary for ACAD10 Gene

ACAD10 (Acyl-CoA Dehydrogenase Family Member 10) is a Protein Coding gene. Diseases associated with ACAD10 include Mitochondrial Trifunctional Protein Deficiency. Among its related pathways are Metabolism and Mitochondrial Fatty Acid Beta-Oxidation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and flavin adenine dinucleotide binding. An important paralog of this gene is ACAD11.

UniProtKB/Swiss-Prot Summary for ACAD10 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACAD10 Gene

Genomics for ACAD10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ACAD10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACAD10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACAD10

Top Transcription factor binding sites by QIAGEN in the ACAD10 gene promoter:
  • aMEF-2
  • AREB6
  • FOXI1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • HFH-3
  • MEF-2A
  • Nkx6-1

Genomic Locations for ACAD10 Gene

Genomic Locations for ACAD10 Gene
chr12:111,686,053-111,757,107
(GRCh38/hg38)
Size:
71,055 bases
Orientation:
Plus strand
chr12:112,123,857-112,194,911
(GRCh37/hg19)
Size:
71,055 bases
Orientation:
Plus strand

Genomic View for ACAD10 Gene

Genes around ACAD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACAD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACAD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACAD10 Gene

Proteins for ACAD10 Gene

  • Protein details for ACAD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6JQN1-ACD10_HUMAN
    Recommended name:
    Acyl-CoA dehydrogenase family member 10
    Protein Accession:
    Q6JQN1
    Secondary Accessions:
    • G3XAJ0
    • Q8N828
    • Q8NAP2
    • Q96BX5

    Protein attributes for ACAD10 Gene

    Size:
    1059 amino acids
    Molecular mass:
    118834 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15056.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for ACAD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACAD10 Gene

Post-translational modifications for ACAD10 Gene

  • Ubiquitination at Lys787
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACAD10 Gene

Domains & Families for ACAD10 Gene

Gene Families for ACAD10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ACAD10 Gene

GenScript: Design optimal peptide antigens:
  • Acyl-CoA dehydrogenase family member 10 (ACD10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6JQN1

UniProtKB/Swiss-Prot:

ACD10_HUMAN :
  • Belongs to the acyl-CoA dehydrogenase family.
Family:
  • Belongs to the acyl-CoA dehydrogenase family.
genes like me logo Genes that share domains with ACAD10: view

Function for ACAD10 Gene

Molecular function for ACAD10 Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA dehydrogenase only active with R- and S-2-methyl-C15-CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=A + a 2,3-saturated acyl-CoA = a 2,3-dehydroacyl-CoA + AH2; Xref=Rhea:RHEA:48608, ChEBI:CHEBI:13193, ChEBI:CHEBI:17499, ChEBI:CHEBI:60015, ChEBI:CHEBI:65111;.

Enzyme Numbers (IUBMB) for ACAD10 Gene

Phenotypes From GWAS Catalog for ACAD10 Gene

Gene Ontology (GO) - Molecular Function for ACAD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003995 acyl-CoA dehydrogenase activity TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA --
GO:0016787 hydrolase activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with ACAD10: view
genes like me logo Genes that share phenotypes with ACAD10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACAD10

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACAD10 Gene

Localization for ACAD10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACAD10 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ACAD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion NAS 21237683
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ACAD10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ACAD10 Gene

Pathways & Interactions for ACAD10 Gene

genes like me logo Genes that share pathways with ACAD10: view

Gene Ontology (GO) - Biological Process for ACAD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006635 fatty acid beta-oxidation TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ACAD10: view

No data available for SIGNOR curated interactions for ACAD10 Gene

Drugs & Compounds for ACAD10 Gene

(2) Drugs for ACAD10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(30) Additional Compounds for ACAD10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with ACAD10: view

Transcripts for ACAD10 Gene

mRNA/cDNA for ACAD10 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACAD10

Alternative Splicing Database (ASD) splice patterns (SP) for ACAD10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - -
SP8: - -
SP9: - -
SP10: - -
SP11: - - - - - - - - - - - - - - - - - - - - - -
SP12:
SP13:
SP14:

ExUns: 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b
SP1: - - -
SP2: -
SP3: - - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:

Relevant External Links for ACAD10 Gene

GeneLoc Exon Structure for
ACAD10

Expression for ACAD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACAD10 Gene

Protein differential expression in normal tissues from HIPED for ACAD10 Gene

This gene is overexpressed in Breast (14.6), Bone (13.1), and Pancreas (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACAD10 Gene



Protein tissue co-expression partners for ACAD10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACAD10

SOURCE GeneReport for Unigene cluster for ACAD10 Gene:

Hs.331141

mRNA Expression by UniProt/SwissProt for ACAD10 Gene:

Q6JQN1-ACD10_HUMAN
Tissue specificity: Widely expressed with highest expression in fetal brain, followed by heart, muscle, kidney and adult brain. Expression levels varying from isoform to isoform.

Evidence on tissue expression from TISSUES for ACAD10 Gene

  • Nervous system(4.6)
  • Liver(4.4)
  • Skin(4.4)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with ACAD10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACAD10 Gene

Orthologs for ACAD10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACAD10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ACAD10 30 31
  • 99.3 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ACAD10 30 31
  • 86.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ACAD10 30 31
  • 83.55 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Acad10 30 17 31
  • 80.69 (n)
OneToMany
Acad12 31
  • 73 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia ACAD10 31
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ACAD10 31
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ACAD10 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia acad10 30
  • 64.56 (n)
Worm
(Caenorhabditis elegans)
Secernentea CELE_K09H11.1 30
  • 50.64 (n)
K09H11.1 31
  • 45 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons IBR3 30
  • 54.42 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0675000 30
  • 54.27 (n)
Os.27104 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4955 31
  • 55 (a)
OneToOne
Species where no ortholog for ACAD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ACAD10 Gene

ENSEMBL:
Gene Tree for ACAD10 (if available)
TreeFam:
Gene Tree for ACAD10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACAD10: view image

Paralogs for ACAD10 Gene

(1) SIMAP similar genes for ACAD10 Gene using alignment to 7 proteins:

  • ACD10_HUMAN
  • D6RFF6_HUMAN
  • F8VXK4_HUMAN
  • F8W0Q4_HUMAN
  • F8W179_HUMAN
  • F8W1A9_HUMAN
  • F8W1I9_HUMAN
genes like me logo Genes that share paralogs with ACAD10: view

Variants for ACAD10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACAD10 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs34245489 - p.Ala880Val
rs35276160 - p.Gln200Arg
rs35753710 - p.Thr216Pro
rs36046440 - p.Asp463Asn

Additional dbSNP identifiers (rs#s) for ACAD10 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACAD10 Gene

Variant ID Type Subtype PubMed ID
dgv1556n100 CNV gain 25217958
dgv2874n54 CNV gain 21841781
dgv304e214 CNV gain 21293372
dgv514e212 CNV gain 25503493
esv2760710 CNV gain 21179565
esv3581893 CNV gain 25503493
esv3630762 CNV gain 21293372
esv3630763 CNV gain 21293372
nsv1119985 CNV deletion 24896259

Variation tolerance for ACAD10 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACAD10 Gene

Human Gene Mutation Database (HGMD)
ACAD10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACAD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACAD10 Gene

Disorders for ACAD10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACAD10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mitochondrial trifunctional protein deficiency
  • abetalipoproteinemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ACAD10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ACAD10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACAD10 Gene

Publications for ACAD10 Gene

  1. Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians. (PMID: 20390405) Bian L … Baier LJ (Diabetologia 2010) 3 23 41
  2. Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1. (PMID: 15560374) Ye X … Mao Y (Molecular biology reports 2004) 2 3 4
  3. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. (PMID: 22423221) Qayyum R … Reiner AP (PLoS genetics 2012) 3 41
  4. Identification and characterization of new long chain acyl-CoA dehydrogenases. (PMID: 21237683) He M … Vockley J (Molecular genetics and metabolism 2011) 3 4
  5. Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. (PMID: 21642993) Wu C … Lin D (Nature genetics 2011) 3 41

Products for ACAD10 Gene

  • Signalway Proteins for ACAD10

Sources for ACAD10 Gene