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Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008]
ABT1 (Activator Of Basal Transcription 1) is a Protein Coding gene. Diseases associated with ABT1 include Neuronal Intranuclear Inclusion Disease and Spinocerebellar Ataxia 17. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003713 | transcription coactivator activity | TAS | 10648625 |
GO:0003723 | RNA binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 19299493 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS | 10648625 |
GO:0005667 | transcription factor complex | IEA | -- |
GO:0005730 | nucleolus | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | 21873635 |
GO:0000472 | endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | 21873635 |
GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | IBA | 21873635 |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006366 | transcription by RNA polymerase II | TAS | 10648625 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ABT1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ABT1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ABT1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Abt1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Abt1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ABT1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ABT1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ABT1 31 |
|
OneToOne | |
African clawed frog (Xenopus laevis) |
Amphibia | MGC52939 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | abt1 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG32708 31 |
|
OneToMany | |
CG41562 31 |
|
OneToMany | |||
CG40813 31 |
|
OneToMany | |||
CG10993 31 |
|
OneToMany | |||
CG32706 31 |
|
OneToMany | |||
CG6999 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | F57B10.8 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ESF2 31 33 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4929 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
neuronal intranuclear inclusion disease |
|
|
spinocerebellar ataxia 17 |
|
|
spinal muscular atrophy, distal, autosomal recessive, 1 |
|
|
autosomal dominant non-syndromic intellectual disability 1 |
|
|
autosomal recessive distal hereditary motor neuronopathy |
|
|