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Aliases for ABLIM3 Gene

Aliases for ABLIM3 Gene

  • Actin Binding LIM Protein Family Member 3 2 3 5
  • AbLIM-3 3 4
  • Actin Binding LIM Protein Family, Member 3 2
  • Actin-Binding LIM Protein Family Member 3 4
  • Actin-Binding LIM Protein 3 3
  • HMFN1661 3
  • KIAA0843 4

External Ids for ABLIM3 Gene

Previous GeneCards Identifiers for ABLIM3 Gene

  • GC05P148549
  • GC05P148501
  • GC05P143667

Summaries for ABLIM3 Gene

Entrez Gene Summary for ABLIM3 Gene

  • This gene encodes a member of the actin-binding LIM (abLIM) family of proteins. These proteins are characterized by an N-terminal LIM domain and a C-terminal dematin-like domain. The encoded protein interacts with actin filaments and may be a component of adherens junctions in several cell types. A variant of this gene may be associated with pain sensitivity in male human patients. [provided by RefSeq, Sep 2016]

GeneCards Summary for ABLIM3 Gene

ABLIM3 (Actin Binding LIM Protein Family Member 3) is a Protein Coding gene. Among its related pathways are Developmental Biology and Netrin Signaling. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is ABLIM1.

UniProtKB/Swiss-Prot for ABLIM3 Gene

  • May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

Gene Wiki entry for ABLIM3 Gene

Additional gene information for ABLIM3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABLIM3 Gene

Genomics for ABLIM3 Gene

GeneHancer (GH) Regulatory Elements for ABLIM3 Gene

Promoters and enhancers for ABLIM3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J149140 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 675.4 +1.0 1045 4.5 FOXA2 ARID4B SIN3A ZNF48 YY1 GLIS2 ZNF143 ATF7 KLF13 SP3 ABLIM3 HMGXB3 FBXO38 ENSG00000251330 SH3TC2 ADRB2 GC05M149047
GH05J149243 Promoter 0.5 EPDnew 650.1 +102.5 102501 0.1 ABLIM3 AFAP1L1 ENSG00000248647 ENSG00000253406 GC05M149047
GH05J149060 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 12.4 -79.1 -79136 4.6 ATF1 PKNOX1 NFIB ARID4B SIN3A RCOR1 FOS SP5 CEBPB MIER2 SH3TC2 SH3TC2-DT MIR584 ABLIM3 GC05M149060 RNU6-732P GC05M149047
GH05J149162 Enhancer 0.9 ENCODE dbSUPER 15.4 +21.0 20973 1.5 ELF3 MEIS2 TAF1 CEBPG BATF IRF4 RARA FOSL1 EED FOSL2 ABLIM3 AFAP1L1 ENSG00000248647 ENSG00000253406 IL17B CARMN SH3TC2 GC05M149047
GH05J149209 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.2 +72.4 72357 8.5 ZNF493 ZFP64 BMI1 KLF14 RCOR1 FOS ZNF680 ZNF654 ZBTB11 ZC3H11A HMGXB3 FBXO38 ENSG00000251330 AFAP1L1 TIGD6 LOC102546294 RPL7P1 ENSG00000248647 ENSG00000253406 RPS20P4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABLIM3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ABLIM3 gene promoter:
  • LCR-F1
  • Sox5
  • Hand1
  • E47
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • AML1a
  • RFX1

Genomic Locations for ABLIM3 Gene

Genomic Locations for ABLIM3 Gene
119,060 bases
Plus strand
119,060 bases
Plus strand

Genomic View for ABLIM3 Gene

Genes around ABLIM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABLIM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABLIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABLIM3 Gene

Proteins for ABLIM3 Gene

  • Protein details for ABLIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-binding LIM protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K121
    • Q19VH3
    • Q658S1
    • Q68CI5
    • Q9BV32

    Protein attributes for ABLIM3 Gene

    683 amino acids
    Molecular mass:
    77802 Da
    Quaternary structure:
    • Directly interacts with F-actin and ABRA.
    • Sequence=BAA74866.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABLIM3 Gene

    Alternative splice isoforms for ABLIM3 Gene


neXtProt entry for ABLIM3 Gene

Post-translational modifications for ABLIM3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABLIM3 Gene

Domains & Families for ABLIM3 Gene

Gene Families for ABLIM3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ABLIM3 Gene

Suggested Antigen Peptide Sequences for ABLIM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ABLIM3: view

No data available for UniProtKB/Swiss-Prot for ABLIM3 Gene

Function for ABLIM3 Gene

Molecular function for ABLIM3 Gene

UniProtKB/Swiss-Prot Function:
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.

Phenotypes From GWAS Catalog for ABLIM3 Gene

Gene Ontology (GO) - Molecular Function for ABLIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with ABLIM3: view
genes like me logo Genes that share phenotypes with ABLIM3: view

Animal Model Products

miRNA for ABLIM3 Gene

miRTarBase miRNAs that target ABLIM3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABLIM3 Gene

Localization for ABLIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABLIM3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABLIM3 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ABLIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 22684256
GO:0005737 cytoplasm IEA --
GO:0015629 actin cytoskeleton IBA --
GO:0030027 lamellipodium IDA 22684256
genes like me logo Genes that share ontologies with ABLIM3: view

Pathways & Interactions for ABLIM3 Gene

genes like me logo Genes that share pathways with ABLIM3: view

Pathways by source for ABLIM3 Gene

1 KEGG pathway for ABLIM3 Gene
1 Qiagen pathway for ABLIM3 Gene

Gene Ontology (GO) - Biological Process for ABLIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0030032 lamellipodium assembly IMP 22684256
GO:0030036 actin cytoskeleton organization IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ABLIM3: view

No data available for SIGNOR curated interactions for ABLIM3 Gene

Drugs & Compounds for ABLIM3 Gene

No Compound Related Data Available

Transcripts for ABLIM3 Gene

Unigene Clusters for ABLIM3 Gene

Actin binding LIM protein family, member 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABLIM3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP5: - - -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP2: -

Relevant External Links for ABLIM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABLIM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABLIM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABLIM3 Gene

This gene is overexpressed in Liver (x4.9).

Protein differential expression in normal tissues from HIPED for ABLIM3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.8), Liver (10.3), and Heart (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABLIM3 Gene

Protein tissue co-expression partners for ABLIM3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABLIM3 Gene:


SOURCE GeneReport for Unigene cluster for ABLIM3 Gene:


mRNA Expression by UniProt/SwissProt for ABLIM3 Gene:

Tissue specificity: Expressed predominantly in heart and brain.

Evidence on tissue expression from TISSUES for ABLIM3 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Heart(4.3)
  • Blood(4.2)
  • Intestine(4.2)
  • Stomach(4.2)
genes like me logo Genes that share expression patterns with ABLIM3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ABLIM3 Gene

Orthologs for ABLIM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABLIM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABLIM3 34 33
  • 99.76 (n)
(Canis familiaris)
Mammalia ABLIM3 34 33
  • 94.19 (n)
(Bos Taurus)
Mammalia ABLIM3 34 33
  • 93.41 (n)
(Monodelphis domestica)
Mammalia ABLIM3 34
  • 92 (a)
(Rattus norvegicus)
Mammalia Ablim3 33
  • 92 (n)
(Mus musculus)
Mammalia Ablim3 16 34 33
  • 91.84 (n)
(Ornithorhynchus anatinus)
Mammalia ABLIM3 34
  • 81 (a)
(Gallus gallus)
Aves ABLIM3 34 33
  • 82 (n)
(Anolis carolinensis)
Reptilia ABLIM3 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ablim3 33
  • 76.1 (n)
(Danio rerio)
Actinopterygii ablim3 34 34
  • 75 (a)
ABLIM3 (2 of 3) 34
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005425 33
  • 52.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta Unc-115a 33
  • 49.17 (n)
Species where no ortholog for ABLIM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABLIM3 Gene

Gene Tree for ABLIM3 (if available)
Gene Tree for ABLIM3 (if available)
Evolutionary constrained regions (ECRs) for ABLIM3: view image

Paralogs for ABLIM3 Gene

Paralogs for ABLIM3 Gene

(6) SIMAP similar genes for ABLIM3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ABLIM3: view

Variants for ABLIM3 Gene

Sequence variations from dbSNP and Humsavar for ABLIM3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs386352274 uncertain-significance, not provided 149,247,895(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs386352275 uncertain-significance, not provided 149,247,814(+) G/A coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant
rs1000155921 -- 149,155,399(+) T/C intron_variant
rs1000155922 -- 149,240,841(+) C/T intron_variant
rs1000176739 -- 149,143,547(+) AAAAAAAAAA/AAAAAAAAA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABLIM3 Gene

Variant ID Type Subtype PubMed ID
dgv3190n106 CNV deletion 24896259
dgv3404e59 CNV duplication 20981092
esv1009293 CNV deletion 20482838
esv1067040 CNV insertion 17803354
esv1591742 CNV deletion 17803354
esv1941617 CNV deletion 18987734
esv2159994 CNV deletion 18987734
esv2319677 CNV deletion 18987734
esv2479942 CNV deletion 19546169
esv2599932 CNV deletion 19546169
esv2730903 CNV deletion 23290073
esv2730904 CNV deletion 23290073
esv2742645 CNV deletion 23290073
esv3566798 CNV deletion 23714750
esv3566799 CNV deletion 23714750
esv3570490 CNV loss 25503493
esv3575887 CNV gain 25503493
esv3607137 CNV gain 21293372
esv3607138 CNV gain 21293372
nsv328915 CNV deletion 16902084
nsv329799 CNV deletion 16902084
nsv517567 CNV gain 19592680
nsv830517 CNV gain 17160897

Variation tolerance for ABLIM3 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABLIM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABLIM3 Gene

Disorders for ABLIM3 Gene

Additional Disease Information for ABLIM3

No disorders were found for ABLIM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABLIM3 Gene

Publications for ABLIM3 Gene

  1. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. (PMID: 17194709) Barrientos T … Frey N (The Journal of biological chemistry 2007) 3 4 58
  2. Actin binding LIM protein 3 (abLIM3). (PMID: 16328021) Krupp M … Teufel A (International journal of molecular medicine 2006) 3 22 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S … Nakagawara A (Oncogene 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ABLIM3 Gene

Sources for ABLIM3 Gene

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