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Aliases for ABLIM1 Gene

Aliases for ABLIM1 Gene

  • Actin Binding LIM Protein 1 2 3 5
  • Actin-Binding LIM Protein Family Member 1 3 4
  • AbLIM-1 3 4
  • LIMAB1 3 4
  • ABLIM 3 4
  • Actin-Binding Double-Zinc-Finger Protein 3
  • Actin-Binding Double Zinc Finger Protein 4
  • Actin-Binding LIM Protein 1 3
  • KIAA0059 4
  • Limatin 4

External Ids for ABLIM1 Gene

Previous HGNC Symbols for ABLIM1 Gene

  • LIMAB1

Previous GeneCards Identifiers for ABLIM1 Gene

  • GC10M115109
  • GC10M115434
  • GC10M116322
  • GC10M115855
  • GC10M116180
  • GC10M116190
  • GC10M109817

Summaries for ABLIM1 Gene

Entrez Gene Summary for ABLIM1 Gene

  • This gene encodes a LIM zinc-binding domain-containing protein that binds to actin filaments and mediates interactions between actin and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2017]

GeneCards Summary for ABLIM1 Gene

ABLIM1 (Actin Binding LIM Protein 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and Netrin Signaling. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is ABLIM3.

UniProtKB/Swiss-Prot for ABLIM1 Gene

  • May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.

Gene Wiki entry for ABLIM1 Gene

Additional gene information for ABLIM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABLIM1 Gene

Genomics for ABLIM1 Gene

GeneHancer (GH) Regulatory Elements for ABLIM1 Gene

Promoters and enhancers for ABLIM1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J114537 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 23.9 +279.9 279918 7.7 PKNOX1 ZNF366 POLR2A SCRT2 EED BCLAF1 IKZF2 RUNX3 SRF CBFB ABLIM1 CCDC186 FAM160B1 ENSG00000229668 PPIAP19
GH10J114630 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +188.2 188173 5 PKNOX1 ZFP64 SIN3A ZNF2 ZNF48 YY1 KLF7 FOS RXRA JUNB ABLIM1 PPIAP19 ENSG00000229668
GH10J114496 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 19.9 +322.6 322623 4.9 BACH1 STAT5A EBF1 ZNF316 POLR2A NFATC1 NFE2 BCLAF1 MAFK RUNX3 ABLIM1 FAM160B1 CCDC186 ENSG00000229668 GC10M114474
GH10J114486 Enhancer 1.3 Ensembl ENCODE dbSUPER 14.3 +332.9 332855 3.8 FOXA2 MLX ARID4B DMAP1 ETS1 TCF12 FOS MIER2 REST PPARG ABLIM1 GC10M114474 ENSG00000229668
GH10J114765 Enhancer 1.2 Ensembl ENCODE dbSUPER 15.2 +54.2 54190 3.5 KLF17 ZNF2 RAD21 RARA YY1 ZNF335 GLIS2 ZNF366 REST ZEB2 ABLIM1 LOC101927692 ATRNL1 TAF9BP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ABLIM1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ABLIM1 gene promoter:
  • SRF
  • SRF (504 AA)
  • Arnt
  • IRF-7A
  • AREB6
  • LCR-F1
  • Lmo2
  • AhR
  • YY1
  • C/EBPalpha

Genomic Locations for ABLIM1 Gene

Genomic Locations for ABLIM1 Gene
390,534 bases
Minus strand
253,894 bases
Minus strand

Genomic View for ABLIM1 Gene

Genes around ABLIM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABLIM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABLIM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABLIM1 Gene

Proteins for ABLIM1 Gene

  • Protein details for ABLIM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-binding LIM protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NI16
    • A6NJ06
    • A8MXA9
    • B3KVH2
    • Q15039
    • Q5JVV1
    • Q5JVV2
    • Q5T6N2
    • Q5T6N3
    • Q5T6N5
    • Q68CQ9
    • Q9BUP1

    Protein attributes for ABLIM1 Gene

    778 amino acids
    Molecular mass:
    87688 Da
    Quaternary structure:
    • Binds F-actin. Interacts with ABRA.
    • Sequence=BAA06681.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABLIM1 Gene

neXtProt entry for ABLIM1 Gene

Post-translational modifications for ABLIM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABLIM1 Gene

Domains & Families for ABLIM1 Gene

Gene Families for ABLIM1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ABLIM1: view

No data available for UniProtKB/Swiss-Prot for ABLIM1 Gene

Function for ABLIM1 Gene

Molecular function for ABLIM1 Gene

UniProtKB/Swiss-Prot Function:
May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.

Phenotypes From GWAS Catalog for ABLIM1 Gene

Gene Ontology (GO) - Molecular Function for ABLIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with ABLIM1: view
genes like me logo Genes that share phenotypes with ABLIM1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABLIM1

CRISPR Products

miRNA for ABLIM1 Gene

miRTarBase miRNAs that target ABLIM1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABLIM1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABLIM1 Gene

Localization for ABLIM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABLIM1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABLIM1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ABLIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 22684256
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton TAS 9245787
GO:0030027 lamellipodium IDA 22684256
genes like me logo Genes that share ontologies with ABLIM1: view

Pathways & Interactions for ABLIM1 Gene

genes like me logo Genes that share pathways with ABLIM1: view

Pathways by source for ABLIM1 Gene

1 KEGG pathway for ABLIM1 Gene
1 Qiagen pathway for ABLIM1 Gene

Gene Ontology (GO) - Biological Process for ABLIM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007601 visual perception TAS 9245787
GO:0009887 animal organ morphogenesis TAS 9245787
GO:0030032 lamellipodium assembly IMP 22684256
GO:0060271 cilium assembly IMP 22684256
genes like me logo Genes that share ontologies with ABLIM1: view

No data available for SIGNOR curated interactions for ABLIM1 Gene

Drugs & Compounds for ABLIM1 Gene

No Compound Related Data Available

Transcripts for ABLIM1 Gene

mRNA/cDNA for ABLIM1 Gene

(55) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABLIM1 Gene

Actin binding LIM protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABLIM1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABLIM1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: -
SP8: -

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25

Relevant External Links for ABLIM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABLIM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABLIM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABLIM1 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.8), Brain - Cerebellar Hemisphere (x5.0), and Brain - Cerebellum (x4.1).

Protein differential expression in normal tissues from HIPED for ABLIM1 Gene

This gene is overexpressed in Cervix (17.7) and Heart (17.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABLIM1 Gene

Protein tissue co-expression partners for ABLIM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABLIM1 Gene:


SOURCE GeneReport for Unigene cluster for ABLIM1 Gene:


mRNA Expression by UniProt/SwissProt for ABLIM1 Gene:

Tissue specificity: Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.

Evidence on tissue expression from TISSUES for ABLIM1 Gene

  • Nervous system(4.7)
  • Eye(4.4)
  • Kidney(4.3)
  • Liver(4.3)
  • Blood(4.2)
  • Bone marrow(4.1)
  • Lung(2.5)
  • Muscle(2.4)
  • Heart(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with ABLIM1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ABLIM1 Gene

Orthologs for ABLIM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABLIM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABLIM1 34 33
  • 99.57 (n)
(Canis familiaris)
Mammalia ABLIM1 34 33
  • 90.87 (n)
(Bos Taurus)
Mammalia ABLIM1 34 33
  • 90.27 (n)
(Mus musculus)
Mammalia Ablim1 16 34 33
  • 87.8 (n)
(Ornithorhynchus anatinus)
Mammalia ABLIM1 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Ablim1 33
  • 86.28 (n)
(Monodelphis domestica)
Mammalia ABLIM1 34
  • 83 (a)
(Gallus gallus)
Aves ABLIM1 34 33
  • 84.3 (n)
(Anolis carolinensis)
Reptilia ABLIM1 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100170541 33
  • 77.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28513 33
(Danio rerio)
Actinopterygii ablim1a 34 33
  • 73.39 (n)
ablim1b 34
  • 65 (a)
Species where no ortholog for ABLIM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABLIM1 Gene

Gene Tree for ABLIM1 (if available)
Gene Tree for ABLIM1 (if available)
Evolutionary constrained regions (ECRs) for ABLIM1: view image

Paralogs for ABLIM1 Gene

Paralogs for ABLIM1 Gene

(19) SIMAP similar genes for ABLIM1 Gene using alignment to 9 proteins:

  • F8W8M4_HUMAN
  • H0Y3K7_HUMAN
  • H0Y7N6_HUMAN
  • Q5T6N2_HUMAN
  • Q5T6N4_HUMAN
genes like me logo Genes that share paralogs with ABLIM1: view

Variants for ABLIM1 Gene

Sequence variations from dbSNP and Humsavar for ABLIM1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000002460 -- 114,459,382(-) A/G intron_variant
rs1000013098 -- 114,499,582(-) G/A intron_variant
rs1000026487 -- 114,432,022(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000038982 -- 114,606,622(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000062320 -- 114,719,588(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABLIM1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER inversion 18451855
nsv528140 CNV loss 19592680
nsv472340 CNV novel sequence insertion 20440878
nsv1134057 CNV deletion 24896259
nsv1127143 CNV deletion 24896259
nsv1038050 CNV gain 25217958
esv3624617 CNV loss 21293372
esv3624615 CNV loss 21293372
esv3546884 CNV deletion 23714750
esv3546882 CNV deletion 23714750
esv2741184 CNV deletion 23290073
esv26785 CNV loss 19812545
esv2676795 CNV deletion 23128226

Variation tolerance for ABLIM1 Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABLIM1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABLIM1 Gene

Disorders for ABLIM1 Gene

Additional Disease Information for ABLIM1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ABLIM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABLIM1 Gene

Publications for ABLIM1 Gene

  1. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. (PMID: 9245787) Roof DJ … Li T (The Journal of cell biology 1997) 2 3 4 22 58
  2. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 44 58
  3. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 44 58
  4. Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. (PMID: 17194709) Barrientos T … Frey N (The Journal of biological chemistry 2007) 3 4 58
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58

Products for ABLIM1 Gene

Sources for ABLIM1 Gene

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