Aliases for ABI3BP Gene

Aliases for ABI3BP Gene

  • ABI Family Member 3 Binding Protein 2 3 5
  • Target Of Nesh-SH3 2 3 4
  • ABI Family, Member 3 (NESH) Binding Protein 2 3
  • ABI Gene Family Member 3-Binding Protein 3 4
  • Nesh-Binding Protein 3 4
  • NESHBP 3 4
  • TARSH 3 4
  • ABI Gene Family, Member 3 (NESH) Binding Protein 3
  • NeshBP 4
  • Tarsh 4

External Ids for ABI3BP Gene

Previous GeneCards Identifiers for ABI3BP Gene

  • GC03M101951
  • GC03M100468
  • GC03M097836

Summaries for ABI3BP Gene

GeneCards Summary for ABI3BP Gene

ABI3BP (ABI Family Member 3 Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include heparin binding and glycosaminoglycan binding. An important paralog of this gene is FNDC1.

Additional gene information for ABI3BP Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABI3BP Gene

Genomics for ABI3BP Gene

GeneHancer (GH) Regulatory Elements for ABI3BP Gene

Promoters and enhancers for ABI3BP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J100991 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 756 +0.9 919 3.2 ZNF362 ZNF384 MAFK PRDM10 ZSCAN4 ZNF629 SCRT2 JUND ZBTB17 ATF3 ABI3BP PDCL3P4 NXPE3 RF00026-724 RNU6-865P
GH03J101643 Enhancer 1.1 Ensembl ENCODE dbSUPER 20.2 -650.8 -650816 2.9 SMARCE1 ZKSCAN8 ZNF148 BACH1 ZNF687 ZNF639 GMEB1 CAVIN1 RFX1 GTF2E2 RPL24 SENP7 ZBTB11-AS1 ABI3BP NXPE3 TFG PDCL3P4 ENSG00000201511 piR-43651-006
GH03J101529 Enhancer 1.2 Ensembl ENCODE dbSUPER 17.7 -538.1 -538143 4.7 SMARCE1 RUNX1 CC2D1A L3MBTL2 DACH1 TEAD4 SP1 ZKSCAN8 ZNF148 GTF2F1 ABI3BP NFKBIZ SENP7 ENSG00000242299 TRMT10C TFG ZBTB11-AS1 RPL24 IMPG2 PDCL3P4
GH03J101641 Enhancer 1 ENCODE dbSUPER 17.7 -648.2 -648237 0.2 SMARCE1 CC2D1A ELF1 TEAD4 ZKSCAN8 GTF2F1 MLLT1 BACH1 CBFA2T2 SMARCA4 RPL24 SENP7 NXPE3 ABI3BP ZBTB11 ENSG00000201511 piR-43651-006
GH03J100968 Enhancer 0.8 Ensembl ENCODE dbSUPER 16.8 +21.9 21862 5.5 CEBPB OSR2 CREB1 WT1 PRDM6 GLIS1 ABI3BP ZBTB11 RF00026-724 RNU6-865P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABI3BP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ABI3BP gene promoter:
  • aMEF-2
  • AML1a
  • C/EBPalpha
  • Evi-1
  • FOXF2
  • HFH-3
  • MEF-2A
  • POU3F2
  • POU6F1 (c2)
  • STAT1

Genomic Locations for ABI3BP Gene

Genomic Locations for ABI3BP Gene
244,360 bases
Minus strand
244,360 bases
Minus strand

Genomic View for ABI3BP Gene

Genes around ABI3BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABI3BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABI3BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABI3BP Gene

Proteins for ABI3BP Gene

  • Protein details for ABI3BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Target of Nesh-SH3
    Protein Accession:
    Secondary Accessions:
    • B3KSL4
    • Q6ZW20
    • Q6ZW22
    • Q9C082
    • Q9UFI6

    Protein attributes for ABI3BP Gene

    1075 amino acids
    Molecular mass:
    118642 Da
    Quaternary structure:
    • Probably interacts with ABI3.
    • Sequence=CAB56034.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ABI3BP Gene


neXtProt entry for ABI3BP Gene

Post-translational modifications for ABI3BP Gene

  • Glycosylation at Asn44, Asn690, Asn259, Asn288, Asn878, and Asn313
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • TARSH_HUMAN (1785)

No data available for DME Specific Peptides for ABI3BP Gene

Domains & Families for ABI3BP Gene

Gene Families for ABI3BP Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ABI3BP Gene


Suggested Antigen Peptide Sequences for ABI3BP Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ56632, moderately similar to Target of Nesh-SH3 (B4DSV9_HUMAN)
  • Nesh-binding protein (TARSH_HUMAN)
genes like me logo Genes that share domains with ABI3BP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ABI3BP Gene

Function for ABI3BP Gene

Phenotypes From GWAS Catalog for ABI3BP Gene

Gene Ontology (GO) - Molecular Function for ABI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent RCA 20551380
GO:0005515 protein binding IEA --
GO:0005518 collagen binding IEA --
GO:0005539 glycosaminoglycan binding IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with ABI3BP: view

Phenotypes for ABI3BP Gene

genes like me logo Genes that share phenotypes with ABI3BP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABI3BP

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ABI3BP Gene

Localization for ABI3BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABI3BP Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABI3BP gene
Compartment Confidence
extracellular 3
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for ABI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region HDA 27068509
GO:0005614 interstitial matrix IEA --
GO:0005615 extracellular space HDA 20551380
GO:0031012 extracellular matrix IEA --
GO:0062023 colocalizes_with collagen-containing extracellular matrix HDA 20551380
genes like me logo Genes that share ontologies with ABI3BP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABI3BP Gene

Pathways & Interactions for ABI3BP Gene

PathCards logo

SuperPathways for ABI3BP Gene

No Data Available

Interacting Proteins for ABI3BP Gene

Gene Ontology (GO) - Biological Process for ABI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with ABI3BP: view

No data available for Pathways by source and SIGNOR curated interactions for ABI3BP Gene

Drugs & Compounds for ABI3BP Gene

No Compound Related Data Available

Transcripts for ABI3BP Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABI3BP Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2: -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33 ^ 34 ^ 35 ^ 36 ^ 37a · 37b
SP1: -

Relevant External Links for ABI3BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABI3BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABI3BP Gene

mRNA differential expression in normal tissues according to GTEx for ABI3BP Gene

This gene is overexpressed in Artery - Tibial (x4.2).

Protein differential expression in normal tissues from HIPED for ABI3BP Gene

This gene is overexpressed in Serum (21.9), Vitreous humor (11.9), and Skin (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ABI3BP Gene

Protein tissue co-expression partners for ABI3BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABI3BP Gene:


SOURCE GeneReport for Unigene cluster for ABI3BP Gene:


mRNA Expression by UniProt/SwissProt for ABI3BP Gene:

Tissue specificity: Expressed in brain, heart, lung, liver, pancreas kidney and placenta.

Evidence on tissue expression from TISSUES for ABI3BP Gene

  • Lung(4.5)
  • Liver(4.1)
  • Thyroid gland(2.5)
genes like me logo Genes that share expression patterns with ABI3BP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ABI3BP Gene

Orthologs for ABI3BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABI3BP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABI3BP 33
  • 98 (a)
(Bos Taurus)
Mammalia ABI3BP 33 32
  • 87.53 (n)
(Canis familiaris)
Mammalia ABI3BP 33
  • 76 (a)
(Mus musculus)
Mammalia Abi3bp 33
  • 68 (a)
(Monodelphis domestica)
Mammalia ABI3BP 33
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia ABI3BP 33
  • 57 (a)
(Gallus gallus)
Aves ABI3BP 33 32
  • 63.37 (n)
(Anolis carolinensis)
Reptilia ABI3BP 33
  • 52 (a)
(Danio rerio)
Actinopterygii abi3bp 33
  • 43 (a)
ABI3BP (1 of 2) 33
  • 32 (a)
-- 32
Species where no ortholog for ABI3BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABI3BP Gene

Gene Tree for ABI3BP (if available)
Gene Tree for ABI3BP (if available)
Evolutionary constrained regions (ECRs) for ABI3BP: view image

Paralogs for ABI3BP Gene

Paralogs for ABI3BP Gene

(1) SIMAP similar genes for ABI3BP Gene using alignment to 23 proteins:

  • H0Y897_HUMAN
  • H0YF18_HUMAN
  • H0YF57_HUMAN
  • H7C4H3_HUMAN
  • H7C4N5_HUMAN
  • H7C4S3_HUMAN
  • H7C4T1_HUMAN
  • H7C4X4_HUMAN
  • H7C524_HUMAN
  • H7C556_HUMAN
  • H7C5S3_HUMAN
genes like me logo Genes that share paralogs with ABI3BP: view

Variants for ABI3BP Gene

Sequence variations from dbSNP and Humsavar for ABI3BP Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000001664 -- 100,881,765(-) CACA/CA intron_variant
rs1000018951 -- 100,841,622(-) T/C intron_variant
rs1000038255 -- 100,888,529(-) G/T intron_variant
rs1000048953 -- 100,771,395(-) A/T genic_downstream_transcript_variant, intron_variant
rs1000073738 -- 100,935,122(-) A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABI3BP Gene

Variant ID Type Subtype PubMed ID
dgv182e55 CNV gain 17911159
dgv183e55 CNV gain 17911159
dgv819n67 CNV loss 20364138
dgv8480n54 CNV loss 21841781
dgv8481n54 CNV loss 21841781
esv21526 CNV loss 19812545
esv2308387 CNV deletion 18987734
esv2422136 CNV deletion 20811451
esv2534604 CNV deletion 19546169
esv2659333 CNV deletion 23128226
esv2668933 CNV deletion 23128226
esv2725700 CNV deletion 23290073
esv2759163 CNV loss 17122850
esv28693 CNV loss 19812545
esv3393889 CNV insertion 20981092
esv3562288 CNV deletion 23714750
esv3597180 CNV loss 21293372
esv3597183 CNV loss 21293372
esv5408 CNV loss 18987735
nsv10294 CNV loss 18304495
nsv3922 CNV deletion 18451855
nsv441834 CNV loss 18776908
nsv514163 CNV loss 21397061
nsv525082 CNV loss 19592680
nsv822202 CNV loss 20364138
nsv954333 CNV deletion 24416366

Variation tolerance for ABI3BP Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.16; 95.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABI3BP Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABI3BP Gene

Disorders for ABI3BP Gene


  • Note=Defects in ABI3BP has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea. {ECO:0000269 PubMed:28493397}.

Additional Disease Information for ABI3BP

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ABI3BP Gene.

No data available for MalaCards and Genatlas for ABI3BP Gene

Publications for ABI3BP Gene

  1. Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3. (PMID: 11501947) Matsuda S … Hamaguchi M (Journal of human genetics 2001) 2 3 4 56
  2. Genome-wide association study of suicide attempts in mood disorder patients. (PMID: 21041247) Perlis RH … Smoller JW (The American journal of psychiatry 2010) 3 43 56
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 43 56
  4. Cancer-associated loss of TARSH gene expression in human primary lung cancer. (PMID: 16205947) Terauchi K … Fushiki S (Journal of cancer research and clinical oncology 2006) 3 23 56
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56

Products for ABI3BP Gene

Sources for ABI3BP Gene