Aliases for ABI3 Gene
External Ids for ABI3 Gene
Previous GeneCards Identifiers for ABI3 Gene
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for ABI3 Gene
ABI3 (ABI Family Member 3) is a Protein Coding gene. Diseases associated with ABI3 include Mucocutaneous Leishmaniasis and Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1. An important paralog of this gene is ABI1.
UniProtKB/Swiss-Prot Summary for ABI3 Gene
May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.