Aliases for ABI2 Gene
External Ids for ABI2 Gene
Previous GeneCards Identifiers for ABI2 Gene
GeneCards Summary for ABI2 Gene
ABI2 (Abl Interactor 2) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and Regulation of actin dynamics for phagocytic cup formation. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding and SH3 domain binding. An important paralog of this gene is ABI1.
UniProtKB/Swiss-Prot for ABI2 Gene
May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).