Aliases for ABHD8 Gene
Aliases for ABHD8 Gene
External Ids for ABHD8 Gene
- HGNC: 23759
- Entrez Gene: 79575
- Ensembl: ENSG00000127220
- UniProtKB: Q96I13
Previous GeneCards Identifiers for ABHD8 Gene
- GC19M017402
- GC19M016969
Summaries for ABHD8 Gene
-
This gene is upstream of, and in a head-to-head orientation with the gene for the mitochondrial ribosomal protein L34. The predicted protein contains alpha/beta hydrolase fold and secretory lipase domains. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABHD8 Gene
ABHD8 (Abhydrolase Domain Containing 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD8 Gene
Genomics for ABHD8 Gene
GeneHancer (GH) Regulatory Elements for ABHD8 Gene
Promoters and enhancers for ABHD8 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ABHD8 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ABHD8 Gene
Genomic Locations for ABHD8 Gene
- chr19:17,292,131-17,310,236
- (GRCh38/hg38)
- Size:
- 18,106 bases
- Orientation:
- Minus strand
- chr19:17,402,940-17,421,045
- (GRCh37/hg19)
Genomic View for ABHD8 Gene
Genes around ABHD8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by Entrez Gene
- 19p13.11 by HGNC
- 19p13.11 by Ensembl
ABHD8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ABHD8 Gene
Proteins for ABHD8 Gene
-
Protein details for ABHD8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96I13-ABHD8_HUMAN
- Recommended name:
- Protein ABHD8
- Protein Accession:
- Q96I13
- Q9HAE9
Protein attributes for ABHD8 Gene
- Size:
- 439 amino acids
- Molecular mass:
- 47331 Da
- Quaternary structure:
- No Data Available
Protein Expression for ABHD8 Gene
Post-translational modifications for ABHD8 Gene
Other Protein References for ABHD8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ABHD8
- Novus Biologicals Antibodies for ABHD8
- Invitrogen Antibodies for ABHD8
- GeneTex ABHD8 Antibody for ABHD8
-
Boster Bio Antibodies for ABHD8
Protein Products
-
OriGene Purified Proteins for ABHD8
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- Origene Custom Protein Services for ABHD8
- antibodies-online: Search results for 6 available ABHD8 Proteins ranked by validation data
- Compare Top ABHD8 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ABHD8
Assay Products
No data available for DME Specific Peptides for ABHD8 Gene
Domains & Families for ABHD8 Gene
Gene Families for ABHD8 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ABHD8 Gene
Suggested Antigen Peptide Sequences for ABHD8 Gene
Graphical View of Domain Structure for InterPro Entry
Q96I13- Family:
-
- Belongs to the AB hydrolase superfamily.
Function for ABHD8 Gene
Enzyme Numbers (IUBMB) for ABHD8 Gene
Phenotypes From GWAS Catalog for ABHD8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for ABHD8 Gene
- MGI mutant phenotypes for ABHD8:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ABHD8:
-
- Multipolar spindles
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for ABHD8 Gene
- MGI Knock Outs for ABHD8:
-
- Abhd8 Abhd8<tm1b(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ABHD8
-
CRISPR Products
-
OriGene CRISPR knockouts for ABHD8
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- genomics-online: gRNA clones - Search results for 109 available ABHD8 gene related products
- Overview of 109 available ABHD8 gene related products
- Applied Biological Materials CRISPR for ABHD8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABHD8
- GenScript: Design CRISPR guide RNA sequences for ABHD8
miRNA for ABHD8 Gene
- miRTarBase miRNAs that target ABHD8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABHD8
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- genomics-online: shRNA clones - Search results for 109 available ABHD8 gene related products
- Overview of 109 available ABHD8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ABHD8
- VectorBuilder custom plasmid, inducible vectors for ABHD8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABHD8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABHD8
- Applied Biological Materials Clones for ABHD8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ABHD8
No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABHD8 Gene
Localization for ABHD8 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
- Nuclear bodies (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0070062 | extracellular exosome | HDA | 18570454 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for ABHD8 Gene
Transcripts for ABHD8 Gene
mRNA/cDNA for ABHD8 Gene
- (96) Selected AceView cDNA sequences:
- (10) Additional mRNA sequences :
- (1) REFSEQ mRNAs :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000247706 2090 bps (uc002ngb.4)
- ENST00000593489 555 bps (uc060vgr.1)
- ENST00000594194 570 bps (uc060vgs.1)
Unigene Clusters for ABHD8 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ABHD8
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABHD8
- genomics-online: gRNA clones - Search results for 109 available ABHD8 gene related products
- Overview of 109 available ABHD8 gene related products
- Applied Biological Materials CRISPR for ABHD8
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABHD8
- GenScript: Design CRISPR guide RNA sequences for ABHD8
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABHD8
- Browse OriGene Inhibitory RNA Products For ABHD8
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABHD8
- genomics-online: shRNA clones - Search results for 109 available ABHD8 gene related products
- Overview of 109 available ABHD8 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ABHD8
- VectorBuilder custom plasmid, inducible vectors for ABHD8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABHD8
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABHD8
- Applied Biological Materials Clones for ABHD8
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||
| SP2: | |||||||||||||||||
| SP3: | - |
Expression for ABHD8 Gene
mRNA differential expression in normal tissues according to GTEx for ABHD8 Gene
This gene is overexpressed in Brain - Cortex (x4.3).
This gene is overexpressed in Breast (50.8), Neutrophil (9.4), and Pancreatic juice (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ABHD8 Gene
NURSA nuclear receptor signaling pathways regulating expression of ABHD8 Gene:
ABHD8SOURCE GeneReport for Unigene cluster for ABHD8 Gene:
Hs.515664Evidence on tissue expression from TISSUES for ABHD8 Gene
- Nervous system(4.8)
- Muscle(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for ABHD8
-
OriGene qPCR primer pairs for ABHD8
- genomics-online: primer clones - Search results for 109 available ABHD8 gene related products
- Overview of 109 available ABHD8 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD8 Gene
Orthologs for ABHD8 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ABHD8 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ABHD8 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ABHD8 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Abhd8 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Abhd8 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ABHD8 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ABHD8 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ABHD8 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | abhd8 33 |
|
||
| Str.5563 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | abhd8a 34 33 |
|
OneToMany | |
| BX255969.1 34 |
|
OneToMany |
- Species where no ortholog for ABHD8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ABHD8 Gene
- ENSEMBL:
- Gene Tree for ABHD8 (if available)
- TreeFam:
- Gene Tree for ABHD8 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ABHD8: view image
Paralogs for ABHD8 Gene
No data available for Paralogs for ABHD8 Gene
Variants for ABHD8 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000101771 | -- | 17,303,356(-) | C/T | 5_prime_UTR_variant | |
| rs1000392743 | -- | 17,291,692(-) | T/C | downstream_transcript_variant | |
| rs1000605234 | -- | 17,297,394(-) | C/T | intron_variant | |
| rs1001048620 | -- | 17,301,212(-) | G/A/C/T | coding_sequence_variant, missense_variant, synonymous_variant | |
| rs1001053746 | -- | 17,292,194(-) | C/T | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
20.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.73;
73.25% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ABHD8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ABHD8
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD8 Gene
Disorders for ABHD8 Gene
Additional Disease Information for ABHD8
No disorders were found for ABHD8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD8 Gene
Publications for ABHD8 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. (PMID: 20852631) Antoniou AC … Couch FJ (Nature genetics 2010) 3 58
Products for ABHD8 Gene
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- Custom Antibody ServicesOriGene Antibodies for ABHD8
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- OriGene qPCR primer pairs and template standards for ABHD8
- OriGene qPCR primer pairs for ABHD8
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- VectorBuilder custom plasmid, inducible vectors for ABHD8
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ABHD8
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 36 available ABHD8 Antibodies ranked by validation data
- Compare Top ABHD8 Antibodies
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- Quality Products:
- GeneTex ABHD8 Antibody for ABHD8
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- genomics-online: cdna clones - Search results for 109 available ABHD8 gene related products
- Overview of 109 available ABHD8 gene related products
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- genomics-online: gRNA clones - Search results for 109 available ABHD8 gene related products
- Overview of 109 available ABHD8 gene related products
- genomics-online: primer clones - Search results for 109 available ABHD8 gene related products
- Overview of 109 available ABHD8 gene related products
- genomics-online: shRNA clones - Search results for 109 available ABHD8 gene related products
- Overview of 109 available ABHD8 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABHD8
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Sources for ABHD8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio