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Aliases for ABHD17C Gene

Aliases for ABHD17C Gene

  • Abhydrolase Domain Containing 17C 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 17C 3 4
  • Family With Sequence Similarity 108, Member C1 2 3
  • Abhydrolase Domain-Containing Protein 17C 3 4
  • FAM108C1 3 4
  • Abhydrolase Domain-Containing Protein FAM108C1 3
  • Protein ABHD17C 3
  • EC 3.-.-.- 4

External Ids for ABHD17C Gene

Previous HGNC Symbols for ABHD17C Gene

  • FAM108C1

Previous GeneCards Identifiers for ABHD17C Gene

  • GC15P080972

Summaries for ABHD17C Gene

GeneCards Summary for ABHD17C Gene

ABHD17C (Abhydrolase Domain Containing 17C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and serine-type peptidase activity. An important paralog of this gene is ABHD17A.

Additional gene information for ABHD17C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD17C Gene

Genomics for ABHD17C Gene

GeneHancer (GH) Regulatory Elements for ABHD17C Gene

Promoters and enhancers for ABHD17C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I080693 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.4 +16.7 16667 5 ARID4B SIN3A ZNF121 GLIS2 SMARCB1 GLIS1 CTCF HIC1 CTBP1 VEZF1 PIR33016 ABHD17C CEMIP RNU6-380P ENSG00000271983 GC15P080692
GH15I080776 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 6.5 +98.3 98271 3.3 PKNOX1 ARID4B SIN3A ZBTB7B ZNF48 GLIS2 ELK1 ZNF143 FOS SP3 CEMIP TLNRD1 ABHD17C PIR33016
GH15I080701 Enhancer 0.8 ENCODE dbSUPER 11 +22.5 22527 0.8 ELF1 OSR2 ZNF121 ZSCAN21 PRDM6 SCRT2 ZSCAN5C ZNF629 RCOR1 ABHD17C PIR33016 CEMIP
GH15I080704 Enhancer 0.7 dbSUPER 10.1 +25.2 25154 1.6 HDGF ATF1 ZBTB21 ZSCAN4 FEZF1 HIC1 ZNF335 GLIS2 ZNF366 PRDM10 RNU6-380P CEMIP ABHD17C PIR33016
GH15I080620 Enhancer 0.5 ENCODE dbSUPER 12 -58.9 -58860 0.9 JUN ABHD17C RNU6-380P CEMIP ARNT2 MIR5572 GC15P080662
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ABHD17C on UCSC Golden Path with GeneCards custom track

Genomic Locations for ABHD17C Gene

Genomic Locations for ABHD17C Gene
chr15:80,679,684-80,755,621
(GRCh38/hg38)
Size:
75,938 bases
Orientation:
Plus strand
chr15:80,972,025-81,047,962
(GRCh37/hg19)

Genomic View for ABHD17C Gene

Genes around ABHD17C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD17C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD17C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD17C Gene

Proteins for ABHD17C Gene

  • Protein details for ABHD17C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PCB6-AB17C_HUMAN
    Recommended name:
    Protein ABHD17C
    Protein Accession:
    Q6PCB6
    Secondary Accessions:
    • Q1RMD6
    • Q9NPM1

    Protein attributes for ABHD17C Gene

    Size:
    329 amino acids
    Molecular mass:
    35831 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD17C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD17C Gene

Post-translational modifications for ABHD17C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD17C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD17C Gene

Domains & Families for ABHD17C Gene

Gene Families for ABHD17C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ABHD17C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ABHD17C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PCB6

UniProtKB/Swiss-Prot:

AB17C_HUMAN :
  • Belongs to the AB hydrolase superfamily. ABHD17 family.
Family:
  • Belongs to the AB hydrolase superfamily. ABHD17 family.
genes like me logo Genes that share domains with ABHD17C: view

Function for ABHD17C Gene

Enzyme Numbers (IUBMB) for ABHD17C Gene

Phenotypes From GWAS Catalog for ABHD17C Gene

Gene Ontology (GO) - Molecular Function for ABHD17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008474 palmitoyl-(protein) hydrolase activity IMP 26701913
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD17C: view

Phenotypes for ABHD17C Gene

genes like me logo Genes that share phenotypes with ABHD17C: view

Animal Model Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD17C Gene

Localization for ABHD17C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD17C gene
Compartment Confidence
extracellular 2
nucleus 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ABHD17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with ABHD17C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ABHD17C Gene

Pathways & Interactions for ABHD17C Gene

SuperPathways for ABHD17C Gene

No Data Available

Interacting Proteins for ABHD17C Gene

Gene Ontology (GO) - Biological Process for ABHD17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002084 protein depalmitoylation IEA --
GO:0018345 protein palmitoylation IMP 26701913
GO:1902817 negative regulation of protein localization to microtubule IEA --
GO:1905668 positive regulation of protein localization to endosome IEA --
genes like me logo Genes that share ontologies with ABHD17C: view

No data available for Pathways by source and SIGNOR curated interactions for ABHD17C Gene

Drugs & Compounds for ABHD17C Gene

No Compound Related Data Available

Transcripts for ABHD17C Gene

Unigene Clusters for ABHD17C Gene

Abhydrolase domain containing 17C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD17C Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1:
SP2: - -
SP3: - - -
SP4: - - -

Relevant External Links for ABHD17C Gene

GeneLoc Exon Structure for
ABHD17C
ECgene alternative splicing isoforms for
ABHD17C

Expression for ABHD17C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD17C Gene

mRNA differential expression in normal tissues according to GTEx for ABHD17C Gene

This gene is overexpressed in Colon - Transverse (x4.4) and Esophagus - Mucosa (x4.3).

Protein differential expression in normal tissues from HIPED for ABHD17C Gene

This gene is overexpressed in Bone (24.5), Peripheral blood mononuclear cells (13.0), and Heart (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD17C Gene



Protein tissue co-expression partners for ABHD17C Gene

NURSA nuclear receptor signaling pathways regulating expression of ABHD17C Gene:

ABHD17C

SOURCE GeneReport for Unigene cluster for ABHD17C Gene:

Hs.459072
genes like me logo Genes that share expression patterns with ABHD17C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD17C Gene

Orthologs for ABHD17C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABHD17C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ABHD17C 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ABHD17C 33 34
  • 92.2 (n)
mouse
(Mus musculus)
Mammalia Abhd17c 33 16 34
  • 90.52 (n)
chimpanzee
(Pan troglodytes)
Mammalia FAM108C1 33
  • 90.15 (n)
ABHD17C 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd17c 33
  • 89.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD17C 34
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ABHD17C 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABHD17C 34 33
  • 85.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD17C 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd17c 33
  • 78.71 (n)
Str.1269 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6584 33
zebrafish
(Danio rerio)
Actinopterygii abhd17c 33 34
  • 79.93 (n)
zgc55468 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10703 33
fruit fly
(Drosophila melanogaster)
Insecta CG33096 33 34
  • 67.96 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010402 33
  • 65.86 (n)
worm
(Caenorhabditis elegans)
Secernentea aho-3 33
  • 57.98 (n)
Y41E3.18 34
  • 22 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31020 33
  • 52.62 (n)
rice
(Oryza sativa)
Liliopsida Os02g0796600 33
  • 57.1 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.30013 33
corn
(Zea mays)
Liliopsida Zm.1574 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8399 34
  • 73 (a)
OneToMany
Species where no ortholog for ABHD17C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABHD17C Gene

ENSEMBL:
Gene Tree for ABHD17C (if available)
TreeFam:
Gene Tree for ABHD17C (if available)

Paralogs for ABHD17C Gene

Paralogs for ABHD17C Gene

(2) SIMAP similar genes for ABHD17C Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ABHD17C Gene

genes like me logo Genes that share paralogs with ABHD17C: view

Variants for ABHD17C Gene

Sequence variations from dbSNP and Humsavar for ABHD17C Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000018984 -- 80,712,527(+) A/G/T intron_variant
rs1000034123 -- 80,709,965(+) A/C intron_variant
rs1000160901 -- 80,712,684(+) C/T intron_variant
rs1000296313 -- 80,712,509(+) G/A intron_variant
rs1000297012 -- 80,727,725(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD17C Gene

Variant ID Type Subtype PubMed ID
esv3569764 CNV gain 25503493
nsv1070286 CNV deletion 25765185
nsv1118325 CNV deletion 24896259
nsv471685 CNV gain 15918152
nsv952008 CNV duplication 24416366

Variation tolerance for ABHD17C Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABHD17C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD17C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD17C Gene

Disorders for ABHD17C Gene

Additional Disease Information for ABHD17C

No disorders were found for ABHD17C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD17C Gene

Publications for ABHD17C Gene

  1. ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. (PMID: 26701913) Lin DT … Conibear E (eLife 2015) 3 58
  2. Genome-wide association study of antibody response to smallpox vaccine. (PMID: 22542470) Ovsyannikova IG … Poland GA (Vaccine 2012) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ABHD17C Gene

Sources for ABHD17C Gene

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