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Aliases for ABHD16B Gene

Aliases for ABHD16B Gene

  • Abhydrolase Domain Containing 16B 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 16B 3 4
  • Abhydrolase Domain-Containing Protein 16B 3 4
  • C20orf135 3 4
  • Chromosome 20 Open Reading Frame 135 2
  • Protein ABHD16B 3
  • DJ591C20.1 3
  • EC 3.-.-.- 4

External Ids for ABHD16B Gene

Previous HGNC Symbols for ABHD16B Gene

  • C20orf135

Previous GeneCards Identifiers for ABHD16B Gene

  • GC20P062493

Summaries for ABHD16B Gene

GeneCards Summary for ABHD16B Gene

ABHD16B (Abhydrolase Domain Containing 16B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD16A.

Additional gene information for ABHD16B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD16B Gene

Genomics for ABHD16B Gene

GeneHancer (GH) Regulatory Elements for ABHD16B Gene

Promoters and enhancers for ABHD16B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J063857 Enhancer 1.3 Ensembl ENCODE dbSUPER 660.2 -1.8 -1807 4.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 SLC30A9 GLIS2 PAF1 ABHD16B GMEB2 SAMD10 ENSG00000268858 GC20M063809
GH20J063863 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.4 +3.7 3659 3.6 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 DNAJC5 ENSG00000268858 TPD52L2 DIDO1 GMEB2 PRPF6 CICP4 RTEL1 MIR647 ARFRP1
GH20J063893 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 +35.5 35478 5.4 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 DNAJC5 RGS19 OPRL1 ZBTB46 C20orf181 FNDC11 SRMS ZBTB46-AS1 ENSG00000229299 LKAAEAR1
GH20J063884 Enhancer 0.9 ENCODE dbSUPER 9.1 +23.8 23797 1.7 GTF2F1 SIN3A EBF1 RFX5 HIC1 SCRT2 ATF7 RUNX3 ZNF687 RXRA MIR941-2 MIR941-4 RNU1-134P ZNF512B PRPF6 SAMD10 ENSG00000229299 ZBTB46 LIME1 SLC2A4RG
GH20J063853 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.3 -6.0 -6031 3.5 HDGF ELF3 NFIB RB1 DMAP1 DNMT3B THRB ZSCAN9 ZNF614 ZNF207 ZBTB46 ZBTB46-AS1 DNAJC5 UCKL1 ABHD16B HELZ2 GC20M063809
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ABHD16B on UCSC Golden Path with GeneCards custom track

Genomic Locations for ABHD16B Gene

Genomic Locations for ABHD16B Gene
1,776 bases
Plus strand

Genomic View for ABHD16B Gene

Genes around ABHD16B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD16B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD16B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD16B Gene

Proteins for ABHD16B Gene

  • Protein details for ABHD16B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ABHD16B
    Protein Accession:

    Protein attributes for ABHD16B Gene

    469 amino acids
    Molecular mass:
    52555 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD16B Gene

Post-translational modifications for ABHD16B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD16B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD16B Gene

Domains & Families for ABHD16B Gene

Gene Families for ABHD16B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ABHD16B Gene


Suggested Antigen Peptide Sequences for ABHD16B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. ABHD16 family.
  • Belongs to the AB hydrolase superfamily. ABHD16 family.
genes like me logo Genes that share domains with ABHD16B: view

Function for ABHD16B Gene

Enzyme Numbers (IUBMB) for ABHD16B Gene

Gene Ontology (GO) - Molecular Function for ABHD16B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ABHD16B: view
genes like me logo Genes that share phenotypes with ABHD16B: view

Animal Model Products

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ABHD16B Gene

Localization for ABHD16B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD16B gene
Compartment Confidence
golgi apparatus 3
extracellular 2
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ABHD16B Gene

Pathways & Interactions for ABHD16B Gene

SuperPathways for ABHD16B Gene

No Data Available

Interacting Proteins for ABHD16B Gene

Gene Ontology (GO) - Biological Process for ABHD16B Gene


No data available for Pathways by source and SIGNOR curated interactions for ABHD16B Gene

Drugs & Compounds for ABHD16B Gene

No Compound Related Data Available

Transcripts for ABHD16B Gene

mRNA/cDNA for ABHD16B Gene

(23) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ABHD16B Gene

Abhydrolase domain containing 16B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD16B Gene

No ASD Table

Relevant External Links for ABHD16B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABHD16B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD16B Gene

Protein differential expression in normal tissues from HIPED for ABHD16B Gene

This gene is overexpressed in Pancreas (45.9) and Adipocyte (21.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ABHD16B Gene

Protein tissue co-expression partners for ABHD16B Gene

NURSA nuclear receptor signaling pathways regulating expression of ABHD16B Gene:


SOURCE GeneReport for Unigene cluster for ABHD16B Gene:

genes like me logo Genes that share expression patterns with ABHD16B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD16B Gene

Orthologs for ABHD16B Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD16B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABHD16B 34 33
  • 99.29 (n)
(Bos Taurus)
Mammalia C13H20ORF135 34
  • 87 (a)
ABHD16B 33
  • 86.99 (n)
(Canis familiaris)
Mammalia ABHD16B 34 33
  • 82.27 (n)
(Rattus norvegicus)
Mammalia Abhd16b 33
  • 78.82 (n)
(Mus musculus)
Mammalia Abhd16b 16 34 33
  • 78.56 (n)
(Monodelphis domestica)
Mammalia ABHD16B 34
  • 57 (a)
(Danio rerio)
Actinopterygii abhd16a 34
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1309 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea F37A4.1 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9728 34
  • 35 (a)
-- 34
  • 20 (a)
Species where no ortholog for ABHD16B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABHD16B Gene

Gene Tree for ABHD16B (if available)
Gene Tree for ABHD16B (if available)
Evolutionary constrained regions (ECRs) for ABHD16B: view image

Paralogs for ABHD16B Gene

Paralogs for ABHD16B Gene

(1) SIMAP similar genes for ABHD16B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ABHD16B: view

Variants for ABHD16B Gene

Sequence variations from dbSNP and Humsavar for ABHD16B Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000397742 -- 63,862,719(+) G/C coding_sequence_variant, missense_variant
rs1000755296 -- 63,861,254(+) A/G 5_prime_UTR_variant
rs1001026041 -- 63,860,737(+) C/G upstream_transcript_variant
rs1001167842 -- 63,862,023(+) C/G coding_sequence_variant, synonymous_variant
rs1001359164 -- 63,863,067(+) C/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD16B Gene

Variant ID Type Subtype PubMed ID
nsv428381 CNV gain+loss 18775914
nsv469773 CNV gain 16826518
nsv509784 CNV insertion 20534489
nsv828804 CNV loss 20364138

Variation tolerance for ABHD16B Gene

Gene Damage Index Score: 5.43; 71.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABHD16B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD16B Gene

Disorders for ABHD16B Gene

Additional Disease Information for ABHD16B

No disorders were found for ABHD16B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD16B Gene

Publications for ABHD16B Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  2. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3 58
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ABHD16B Gene

Sources for ABHD16B Gene

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