A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described... See more...

Aliases for ABHD16A Gene

Aliases for ABHD16A Gene

  • Abhydrolase Domain Containing 16A 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 16A 3 4
  • Abhydrolase Domain-Containing Protein 16A 3 4
  • Phosphatidylserine Lipase ABHD16A 3 4
  • Monoacylglycerol Lipase ABHD16A 3 4
  • HLA-B Associated Transcript 5 2 3
  • Protein G5 3 4
  • HBAT5 3 4
  • BAT5 3 4
  • NG26 3 4
  • HLA-B-Associated Transcript 5 4
  • Protein ABHD16A 3
  • EC 3.1.1.23 4
  • EC 3.1.-.- 4
  • D6S82E 3
  • PP199 3
  • G5 4

External Ids for ABHD16A Gene

Previous HGNC Symbols for ABHD16A Gene

  • BAT5

Previous GeneCards Identifiers for ABHD16A Gene

  • GC06M031440
  • GC06M031657
  • GC06M031661
  • GC06M031665
  • GC06M031696
  • GC06M031704
  • GC06M032071
  • GC06M032140
  • GC06M031710
  • GC06M031773
  • GC06M031824
  • GC06M031858
  • GC06M031893
  • GC06M031944
  • GC06M031987
  • GC06M032022

Summaries for ABHD16A Gene

Entrez Gene Summary for ABHD16A Gene

  • A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for ABHD16A Gene

ABHD16A (Abhydrolase Domain Containing 16A) is a Protein Coding gene. Diseases associated with ABHD16A include Coronary Artery Aneurysm and Lynch Syndrome. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD16B.

UniProtKB/Swiss-Prot Summary for ABHD16A Gene

  • Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914).

Gene Wiki entry for ABHD16A Gene

Additional gene information for ABHD16A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABHD16A Gene

Genomics for ABHD16A Gene

GeneHancer (GH) Regulatory Elements for ABHD16A Gene

Promoters and enhancers for ABHD16A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J031700 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.7 726 3.3 SIN3A SP1 ZBTB40 SREBF1 SIX5 FOXA1 RBPJ SMARCE1 POLR2A ATF1 ABHD16A MIR4646 DDX39B LY6G5B SKIV2L ATF6B MDC1 LSM2 MICA PBX2
GH06J031691 Promoter/Enhancer 0.8 EPDnew dbSUPER 750.4 +11.8 11763 0.1 GTF2E2 ZBTB11 VEZF1 TEAD2 LOC105375018 ABHD16A MIR4646 ENSG00000204422 lnc-LY6G6E-1 MG828730-062 RF00017-5414
GH06J031693 Promoter 0.6 EPDnew 750.4 +10.3 10315 0.1 ZNF148 IKZF1 PKNOX1 ABHD16A LOC105375018 MIR4646 ENSG00000204422 lnc-LY6G6E-1 MG828730-062 RF00017-5414
GH06J031688 Promoter/Enhancer 0.5 EPDnew dbSUPER 750.4 +15.2 15215 0.1 LOC105375018 ABHD16A LY6G5C lnc-LY6G5C-1 ENSG00000204422 lnc-LY6G6E-1 MG828730-062 RF00017-5414
GH06J031733 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 31.2 -34.1 -34095 8.5 E2F8 ZNF785 ZNF24 SP1 ZBTB40 CTCF SIX5 ZBTB6 LCORL FOXA1 MSH5 CLIC1 MSH5-SAPCD1 LY6G5B DDX39B ATF6B LSM2 GPANK1 NFKBIL1 SKIV2L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABHD16A on UCSC Golden Path with GeneCards custom track

Genomic Locations for ABHD16A Gene

Genomic Locations for ABHD16A Gene
chr6:31,686,949-31,703,360
(GRCh38/hg38)
Size:
16,412 bases
Orientation:
Minus strand
chr6:31,654,726-31,671,221
(GRCh37/hg19)
Size:
16,496 bases
Orientation:
Minus strand

Genomic View for ABHD16A Gene

Genes around ABHD16A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD16A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD16A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ABHD16A Gene

  • Protein details for ABHD16A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95870-ABHGA_HUMAN
    Recommended name:
    Phosphatidylserine lipase ABHD16A
    Protein Accession:
    O95870
    Secondary Accessions:
    • A2BEY3
    • B7Z4R6
    • Q5SRR1
    • Q5SRR2
    • Q8WYH0
    • Q9NW33

    Protein attributes for ABHD16A Gene

    Size:
    558 amino acids
    Molecular mass:
    63243 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD16A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD16A Gene

Post-translational modifications for ABHD16A Gene

  • Ubiquitination at Lys452
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABHD16A Gene

Domains & Families for ABHD16A Gene

Gene Families for ABHD16A Gene

Protein Domains for ABHD16A Gene

Suggested Antigen Peptide Sequences for ABHD16A Gene

GenScript: Design optimal peptide antigens:
  • HLA-B associated transcript 5 (A2ABS2_HUMAN)
  • HLA-B associated transcript 5 (A2ADL2_HUMAN)
  • HLA-B associated transcript 5 (A2BEY2_HUMAN)
  • HLA-B associated transcript 5 (A6PWU5_HUMAN)
  • Protein G5 (ABHGA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95870

UniProtKB/Swiss-Prot:

ABHGA_HUMAN :
  • Belongs to the AB hydrolase superfamily. ABHD16 family.
Family:
  • Belongs to the AB hydrolase superfamily. ABHD16 family.
genes like me logo Genes that share domains with ABHD16A: view

Function for ABHD16A Gene

Molecular function for ABHD16A Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoserine + H(+); Xref=Rhea:RHEA:44500, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:84461, ChEBI:CHEBI:84462; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + H(+); Xref=Rhea:RHEA:41752, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:75020, ChEBI:CHEBI:75029; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoserine + H2O = (9Z,12Z)-octadecadienoate + 1-octadecanoyl-sn-glycero-3-phosphoserine + H(+); Xref=Rhea:RHEA:44516, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:84466, ChEBI:CHEBI:84467; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphocholine + H(+); Xref=Rhea:RHEA:44520, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:74340, ChEBI:CHEBI:84470; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-glycerol + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-glycerol + H(+); Xref=Rhea:RHEA:44524, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:84472, ChEBI:CHEBI:84475; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H(+); Xref=Rhea:RHEA:44528, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72833, ChEBI:CHEBI:72837; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + H(+); Xref=Rhea:RHEA:44540, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:84489, ChEBI:CHEBI:84490; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H(+); Xref=Rhea:RHEA:40919, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:72841, ChEBI:CHEBI:75158; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.; EC=3.1.1.23; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate; Xref=Rhea:RHEA:44312, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30807, ChEBI:CHEBI:75562; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44313; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39963, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:75455; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39964; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38488; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:38492; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:44732, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75457; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44733; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:44728, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:75612; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44729; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:26133; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2; Xref=Rhea:RHEA:45412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57406, ChEBI:CHEBI:85232; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45413; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+); Xref=Rhea:RHEA:45416, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:85236, ChEBI:CHEBI:85238; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45417; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:48428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75568; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:48429; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by beta-lactone-based lipid inhibitors, such as beta-lactone palmostatin-B.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.9 uM for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) (in absence of BSA) {ECO:0000269 PubMed:25290914}; KM=137.8 uM for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) (in presence of BSA) {ECO:0000269 PubMed:25290914}; KM=20.9 uM for 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (in presence of BSA) {ECO:0000269 PubMed:25290914}; Vmax=7.3 nmol/min/mg enzyme with 1-(9Z,12Z-octadecadienoyl)- glycerol (1-LG) as substrate (in absence of BSA) {ECO:0000269 PubMed:25290914}; Vmax=13.2 nmol/min/mg enzyme with 1-(9Z,12Z-octadecadienoyl)- glycerol (1-LG) as substrate (in presence of BSA) {ECO:0000269 PubMed:25290914}; pH dependence: Optimum pH is 7.2-8.0. {ECO:0000269 PubMed:25290914};

Enzyme Numbers (IUBMB) for ABHD16A Gene

Phenotypes From GWAS Catalog for ABHD16A Gene

Gene Ontology (GO) - Molecular Function for ABHD16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity ISS --
GO:0004622 NOT lysophospholipase activity IDA 25290914
GO:0005515 protein binding IPI 14667819
GO:0016787 hydrolase activity IEA --
GO:0047372 acylglycerol lipase activity IDA,IEA 25290914
genes like me logo Genes that share ontologies with ABHD16A: view
genes like me logo Genes that share phenotypes with ABHD16A: view

Animal Models for ABHD16A Gene

MGI Knock Outs for ABHD16A:
  • Abhd16a Abhd16a<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ABHD16A Gene

miRTarBase miRNAs that target ABHD16A

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABHD16A Gene

Localization for ABHD16A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD16A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD16A gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
nucleus 1
peroxisome 0
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for ABHD16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABHD16A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABHD16A Gene

Pathways & Interactions for ABHD16A Gene

PathCards logo

SuperPathways for ABHD16A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABHD16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006660 phosphatidylserine catabolic process ISS --
GO:0052651 monoacylglycerol catabolic process IDA 25290914
GO:1905344 prostaglandin catabolic process IDA 25290914
genes like me logo Genes that share ontologies with ABHD16A: view

No data available for Pathways by source and SIGNOR curated interactions for ABHD16A Gene

Drugs & Compounds for ABHD16A Gene

(1) Drugs for ABHD16A Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KC01 Pharma A selective inhibitor of ABHD16A 0

(1) ApexBio Compounds for ABHD16A Gene

Compound Action Cas Number
KC01 A selective inhibitor of ABHD16A
genes like me logo Genes that share compounds with ABHD16A: view

Transcripts for ABHD16A Gene

mRNA/cDNA for ABHD16A Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD16A Gene

No ASD Table

Relevant External Links for ABHD16A Gene

GeneLoc Exon Structure for
ABHD16A
ECgene alternative splicing isoforms for
ABHD16A

Expression for ABHD16A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD16A Gene

Protein differential expression in normal tissues from HIPED for ABHD16A Gene

This gene is overexpressed in Nasal epithelium (23.7) and Peripheral blood mononuclear cells (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD16A Gene



Protein tissue co-expression partners for ABHD16A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABHD16A Gene:

ABHD16A

SOURCE GeneReport for Unigene cluster for ABHD16A Gene:

Hs.388188

Evidence on tissue expression from TISSUES for ABHD16A Gene

  • Blood(4.4)
  • Liver(4.3)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ABHD16A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD16A Gene

Orthologs for ABHD16A Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD16A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD16A 33 32
  • 99.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ABHD16A 33 32
  • 93.85 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ABHD16A 33 32
  • 93.13 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abhd16a 32
  • 90.8 (n)
mouse
(Mus musculus)
Mammalia Abhd16a 17 33 32
  • 90.62 (n)
oppossum
(Monodelphis domestica)
Mammalia ABHD16A 33
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD16A 33
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD16A 33
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd16a 32
  • 68.61 (n)
Str.10410 32
African clawed frog
(Xenopus laevis)
Amphibia bat5-prov 32
zebrafish
(Danio rerio)
Actinopterygii abhd16a 33 32
  • 68.09 (n)
OneToMany
wufb55e01 32
fruit fly
(Drosophila melanogaster)
Insecta CG1309 33 32
  • 52.93 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005364 32
  • 52.74 (n)
worm
(Caenorhabditis elegans)
Secernentea F37A4.1 33 32
  • 47.76 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9728 33
  • 40 (a)
ManyToMany
-- 33
  • 33 (a)
ManyToMany
Species where no ortholog for ABHD16A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD16A Gene

ENSEMBL:
Gene Tree for ABHD16A (if available)
TreeFam:
Gene Tree for ABHD16A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ABHD16A: view image

Paralogs for ABHD16A Gene

Paralogs for ABHD16A Gene

(1) SIMAP similar genes for ABHD16A Gene using alignment to 7 proteins:

  • ABHGA_HUMAN
  • B0UXB6_HUMAN
  • B3KNX9_HUMAN
  • B7Z8I9_HUMAN
  • F2Z3G6_HUMAN
  • F2Z3H2_HUMAN
  • F2Z3Q3_HUMAN
genes like me logo Genes that share paralogs with ABHD16A: view

Variants for ABHD16A Gene

Sequence variations from dbSNP and Humsavar for ABHD16A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000470101 -- 31,688,011(-) C/A intron_variant
rs1000958518 -- 31,693,656(-) C/G intron_variant
rs1001055964 -- 31,701,842(-) T/A intron_variant
rs1001121901 -- 31,700,214(-) C/T intron_variant
rs1001266566 -- 31,700,673(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD16A Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv1161370 CNV deletion 26073780
nsv830627 CNV loss 17160897

Variation tolerance for ABHD16A Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 59.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABHD16A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD16A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD16A Gene

Disorders for ABHD16A Gene

MalaCards: The human disease database

(2) MalaCards diseases for ABHD16A Gene - From: GeneCards

Disorder Aliases PubMed IDs
coronary artery aneurysm
  • coronary aneurysm
lynch syndrome
  • colorectal cancer, hereditary nonpolyposis, type 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ABHD16A

genes like me logo Genes that share disorders with ABHD16A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABHD16A Gene

Publications for ABHD16A Gene

  1. Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A). (PMID: 25290914) Savinainen JR … Laitinen JT (PloS one 2014) 3 4 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 56
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56

Products for ABHD16A Gene

Sources for ABHD16A Gene