Aliases for ABHD16A Gene
External Ids for ABHD16A Gene
Previous HGNC Symbols for ABHD16A Gene
Previous GeneCards Identifiers for ABHD16A Gene
A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for ABHD16A Gene
ABHD16A (Abhydrolase Domain Containing 16A) is a Protein Coding gene. Diseases associated with ABHD16A include Coronary Artery Aneurysm and Lynch Syndrome. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD16B.
UniProtKB/Swiss-Prot Summary for ABHD16A Gene
Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (PubMed:25290914). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (PubMed:25290914).