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Aliases for ABHD16A Gene

Aliases for ABHD16A Gene

  • Abhydrolase Domain Containing 16A 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 16A 3 4
  • Abhydrolase Domain-Containing Protein 16A 3 4
  • HLA-B Associated Transcript 5 2 3
  • Protein G5 3 4
  • BAT5 3 4
  • NG26 3 4
  • HLA-B-Associated Transcript 5 4
  • Protein ABHD16A 3
  • EC 3.-.-.- 4
  • D6S82E 3
  • PP199 3
  • G5 4

External Ids for ABHD16A Gene

Previous HGNC Symbols for ABHD16A Gene

  • BAT5

Previous GeneCards Identifiers for ABHD16A Gene

  • GC06M031440
  • GC06M031657
  • GC06M031661
  • GC06M031665
  • GC06M031696
  • GC06M031704
  • GC06M031710
  • GC06M031773
  • GC06M031824
  • GC06M031858
  • GC06M031893

Summaries for ABHD16A Gene

Entrez Gene Summary for ABHD16A Gene

  • A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for ABHD16A Gene

ABHD16A (Abhydrolase Domain Containing 16A) is a Protein Coding gene. Diseases associated with ABHD16A include Coronary Artery Aneurysm. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD16B.

Gene Wiki entry for ABHD16A Gene

Additional gene information for ABHD16A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD16A Gene

Genomics for ABHD16A Gene

GeneHancer (GH) Regulatory Elements for ABHD16A Gene

Promoters and enhancers for ABHD16A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031700 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.8 810 3.3 CLOCK MLX YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF263 SP3 ABHD16A MIR4646 DDX39B ATF6B SKIV2L LY6G5B LSM2 PBX2 MDC1 RPL3P2
GH06I031733 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.2 -34.0 -34011 8.5 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 MSH5 CLIC1 DDX39B LY6G5B ATF6B LSM2 CSNK2B SKIV2L GPANK1 BAG6
GH06I031725 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10 -25.1 -25137 5.6 HDGF HNRNPUL1 PKNOX1 CLOCK ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 DDAH2 DDX39B LY6G5B ATF6B LSM2 SKIV2L PBX2 NFKBIL1 CSNK2B MSH5
GH06I031269 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.3 +432.0 431983 4.4 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A GLI4 ZNF2 IRF4 YY1 HLA-C PIR41455 PSORS1C3 PPT2 TNXB LSM2 PSORS1C2 HCG18 HCG27 ENSG00000229836
GH06I031706 Promoter 0.9 EPDnew 0.8 -3.4 -3420 0.1 PKNOX1 L3MBTL2 CBFA2T3 EP300 RELA ZNF592 MEF2D SMARCA4 IKZF1 ID3 LY6G6F LY6G6F-LY6G6D ABHD16A ENSG00000204422
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ABHD16A on UCSC Golden Path with GeneCards custom track

Genomic Locations for ABHD16A Gene

Genomic Locations for ABHD16A Gene
chr6:31,686,949-31,703,444
(GRCh38/hg38)
Size:
16,496 bases
Orientation:
Minus strand
chr6:31,654,726-31,671,221
(GRCh37/hg19)

Genomic View for ABHD16A Gene

Genes around ABHD16A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD16A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD16A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for ABHD16A Gene

  • Protein details for ABHD16A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95870-ABHGA_HUMAN
    Recommended name:
    Protein ABHD16A
    Protein Accession:
    O95870
    Secondary Accessions:
    • A2BEY3
    • B7Z4R6
    • Q5SRR1
    • Q5SRR2
    • Q8WYH0
    • Q9NW33

    Protein attributes for ABHD16A Gene

    Size:
    558 amino acids
    Molecular mass:
    63243 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI17808.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI18401.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAM26084.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAM45793.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABHD16A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD16A Gene

Post-translational modifications for ABHD16A Gene

  • Ubiquitination at posLast=452452
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABHD16A Gene

Domains & Families for ABHD16A Gene

Gene Families for ABHD16A Gene

Protein Domains for ABHD16A Gene

Graphical View of Domain Structure for InterPro Entry

O95870

UniProtKB/Swiss-Prot:

ABHGA_HUMAN :
  • Belongs to the AB hydrolase superfamily. ABHD16 family.
Family:
  • Belongs to the AB hydrolase superfamily. ABHD16 family.
genes like me logo Genes that share domains with ABHD16A: view

Function for ABHD16A Gene

Enzyme Numbers (IUBMB) for ABHD16A Gene

Phenotypes From GWAS Catalog for ABHD16A Gene

Gene Ontology (GO) - Molecular Function for ABHD16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 NOT lysophospholipase activity IDA 25290914
GO:0005515 protein binding IPI 14667819
GO:0016787 hydrolase activity IEA --
GO:0047372 acylglycerol lipase activity IDA 25290914
genes like me logo Genes that share ontologies with ABHD16A: view
genes like me logo Genes that share phenotypes with ABHD16A: view

Animal Models for ABHD16A Gene

MGI Knock Outs for ABHD16A:

Animal Model Products

miRNA for ABHD16A Gene

miRTarBase miRNAs that target ABHD16A

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABHD16A Gene

Localization for ABHD16A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD16A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD16A gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ABHD16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABHD16A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABHD16A Gene

Pathways & Interactions for ABHD16A Gene

SuperPathways for ABHD16A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABHD16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052651 monoacylglycerol catabolic process IDA 25290914
GO:1905344 prostaglandin catabolic process IDA 25290914
genes like me logo Genes that share ontologies with ABHD16A: view

No data available for Pathways by source and SIGNOR curated interactions for ABHD16A Gene

Drugs & Compounds for ABHD16A Gene

(1) Drugs for ABHD16A Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
KC01 Pharma A selective inhibitor of ABHD16A 0

(1) ApexBio Compounds for ABHD16A Gene

Compound Action Cas Number
KC01 A selective inhibitor of ABHD16A
genes like me logo Genes that share compounds with ABHD16A: view

Drug Products

Transcripts for ABHD16A Gene

Unigene Clusters for ABHD16A Gene

Abhydrolase domain containing 16A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD16A Gene

No ASD Table

Relevant External Links for ABHD16A Gene

GeneLoc Exon Structure for
ABHD16A
ECgene alternative splicing isoforms for
ABHD16A

Expression for ABHD16A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD16A Gene

Protein differential expression in normal tissues from HIPED for ABHD16A Gene

This gene is overexpressed in Nasal epithelium (23.7) and Peripheral blood mononuclear cells (15.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD16A Gene



Protein tissue co-expression partners for ABHD16A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABHD16A Gene:

ABHD16A

SOURCE GeneReport for Unigene cluster for ABHD16A Gene:

Hs.388188

Evidence on tissue expression from TISSUES for ABHD16A Gene

  • Blood(4.4)
  • Liver(4.4)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ABHD16A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD16A Gene

Orthologs for ABHD16A Gene

This gene was present in the common ancestor of animals.

Orthologs for ABHD16A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD16A 34 33
  • 99.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ABHD16A 33 34
  • 93.85 (n)
dog
(Canis familiaris)
Mammalia ABHD16A 33 34
  • 93.13 (n)
rat
(Rattus norvegicus)
Mammalia Abhd16a 33
  • 90.8 (n)
mouse
(Mus musculus)
Mammalia Abhd16a 16 34 33
  • 90.62 (n)
oppossum
(Monodelphis domestica)
Mammalia ABHD16A 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD16A 34
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABHD16A 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd16a 33
  • 68.61 (n)
Str.10410 33
African clawed frog
(Xenopus laevis)
Amphibia bat5-prov 33
zebrafish
(Danio rerio)
Actinopterygii abhd16a 34 33
  • 68.09 (n)
OneToMany
wufb55e01 33
fruit fly
(Drosophila melanogaster)
Insecta CG1309 33 34
  • 52.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005364 33
  • 52.74 (n)
worm
(Caenorhabditis elegans)
Secernentea F37A4.1 33 34
  • 47.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9728 34
  • 40 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
Species where no ortholog for ABHD16A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABHD16A Gene

ENSEMBL:
Gene Tree for ABHD16A (if available)
TreeFam:
Gene Tree for ABHD16A (if available)

Paralogs for ABHD16A Gene

Paralogs for ABHD16A Gene

(1) SIMAP similar genes for ABHD16A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ABHD16A: view

Variants for ABHD16A Gene

Sequence variations from dbSNP and Humsavar for ABHD16A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000470101 -- 31,688,011(-) C/A intron_variant
rs1000958518 -- 31,693,656(-) C/G intron_variant
rs1001055964 -- 31,701,842(-) T/A intron_variant
rs1001121901 -- 31,700,214(-) C/T intron_variant
rs1001266566 -- 31,700,673(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABHD16A Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv1161370 CNV deletion 26073780
nsv830627 CNV loss 17160897

Variation tolerance for ABHD16A Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 59.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABHD16A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD16A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD16A Gene

Disorders for ABHD16A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ABHD16A Gene - From: GeneCards

Disorder Aliases PubMed IDs
coronary artery aneurysm
  • coronary aneurysm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ABHD16A

genes like me logo Genes that share disorders with ABHD16A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABHD16A Gene

Publications for ABHD16A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58

Products for ABHD16A Gene

Sources for ABHD16A Gene

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