Aliases for ABHD15 Gene

Aliases for ABHD15 Gene

  • Abhydrolase Domain Containing 15 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 15 3 4
  • Abhydrolase Domain-Containing Protein 15 3 4
  • Protein ABHD15 3 4
  • EC 3.1.1.- 4
  • ABHD15 5

External Ids for ABHD15 Gene

Previous GeneCards Identifiers for ABHD15 Gene

  • GC17M024912
  • GC17M027887
  • GC17M024097

Summaries for ABHD15 Gene

GeneCards Summary for ABHD15 Gene

ABHD15 (Abhydrolase Domain Containing 15) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is ABHD1.

Additional gene information for ABHD15 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABHD15 Gene

Genomics for ABHD15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ABHD15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J029565 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 605.9 -0.6 -609 5.1 GATAD2A CTCF PRDM10 ZNF629 ZNF692 POLR2A ZNF7 TARDBP FOXA1 LARP7 TP53I13 ABHD15 ENSG00000264290 lnc-ABHD15-2 lnc-TAOK1-8 CORO6 ANKRD13B ABHD15-AS1
GH17J030404 Enhancer 0.9 Ensembl ENCODE 5 -837.9 -837864 1.8 ZNF692 PRDM1 ZIC2 SOX6 SOX13 TCF7 TCF7L2 HMBOX1 NFE2 ZNF316 ENSG00000264456 SUZ12P1 SH3GL1P2 RNF135 ENSG00000264290 DPRXP4 CORO6 GOSR1 ABHD15 piR-40110-269
GH17J029505 Enhancer 0.3 Ensembl 11.5 +60.7 60736 1 SPI1 ZNF146 TP53I13 RNU4-34P TAOK1 ABHD15 piR-50444-171 lnc-TP53I13-5 RF00017-2331
GH17J028777 Enhancer 0.7 FANTOM5 Ensembl 4.7 +789.0 789036 2.8 SCRT2 NFE2 ZNF316 SCRT1 ARNT ZNF18 ZNF362 EMSY PROCA1 TRAF4 ABHD15 SEBOX piR-60051-041 RPL31P58 RF00017-2319 ERAL1 FAM222B
GH17J029563 Enhancer 0.5 FANTOM5 ENCODE 5.8 +3.0 3028 0.4 PKNOX1 CTCF ABHD15 SSH2 ABHD15-AS1 TP53I13 TAOK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABHD15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ABHD15

Top Transcription factor binding sites by QIAGEN in the ABHD15 gene promoter:
  • c-Ets-1
  • MRF-2
  • Nkx6-1
  • NRSF form 1
  • NRSF form 2
  • p53
  • Roaz

Genomic Locations for ABHD15 Gene

Genomic Locations for ABHD15 Gene
6,491 bases
Minus strand
6,591 bases
Minus strand

Genomic View for ABHD15 Gene

Genes around ABHD15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD15 Gene

Proteins for ABHD15 Gene

  • Protein details for ABHD15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein ABHD15
    Protein Accession:
    Secondary Accessions:
    • Q96EC5

    Protein attributes for ABHD15 Gene

    468 amino acids
    Molecular mass:
    51771 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ABHD15 Gene

Post-translational modifications for ABHD15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ABHD15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ABHD15 Gene

Domains & Families for ABHD15 Gene

Gene Families for ABHD15 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ABHD15 Gene


Suggested Antigen Peptide Sequences for ABHD15 Gene

GenScript: Design optimal peptide antigens:
  • Abhydrolase domain-containing protein 15 (ABH15_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
  • Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
genes like me logo Genes that share domains with ABHD15: view

Function for ABHD15 Gene

Enzyme Numbers (IUBMB) for ABHD15 Gene

Phenotypes From GWAS Catalog for ABHD15 Gene

Gene Ontology (GO) - Molecular Function for ABHD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0016788 hydrolase activity, acting on ester bonds IBA --
GO:0034338 short-chain carboxylesterase activity IBA 21873635
GO:0047372 acylglycerol lipase activity IBA 21873635
genes like me logo Genes that share ontologies with ABHD15: view
genes like me logo Genes that share phenotypes with ABHD15: view

Animal Models for ABHD15 Gene

MGI Knock Outs for ABHD15:
  • Abhd15 Abhd15<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ABHD15 Gene

miRTarBase miRNAs that target ABHD15

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABHD15

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABHD15 Gene

Localization for ABHD15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD15 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD15 gene
Compartment Confidence
extracellular 3
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ABHD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with ABHD15: view

Pathways & Interactions for ABHD15 Gene

PathCards logo

SuperPathways for ABHD15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABHD15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044255 cellular lipid metabolic process IBA 21873635
genes like me logo Genes that share ontologies with ABHD15: view

No data available for Pathways by source and SIGNOR curated interactions for ABHD15 Gene

Drugs & Compounds for ABHD15 Gene

No Compound Related Data Available

Transcripts for ABHD15 Gene

mRNA/cDNA for ABHD15 Gene

4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABHD15

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD15 Gene

No ASD Table

Relevant External Links for ABHD15 Gene

GeneLoc Exon Structure for

Expression for ABHD15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABHD15 Gene

Protein differential expression in normal tissues from HIPED for ABHD15 Gene

This gene is overexpressed in Kidney (23.4), Spleen (23.3), and Heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ABHD15

SOURCE GeneReport for Unigene cluster for ABHD15 Gene:


Evidence on tissue expression from TISSUES for ABHD15 Gene

  • Liver(2.2)
genes like me logo Genes that share expression patterns with ABHD15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD15 Gene

Orthologs for ABHD15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ABHD15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABHD15 30 31
  • 99 (n)
(Bos Taurus)
Mammalia ABHD15 30 31
  • 88.68 (n)
(Canis familiaris)
Mammalia ABHD15 30 31
  • 88.2 (n)
(Mus musculus)
Mammalia Abhd15 30 17 31
  • 85.01 (n)
(Rattus norvegicus)
Mammalia Abhd15 30
  • 84.09 (n)
(Monodelphis domestica)
Mammalia ABHD15 31
  • 76 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia abhd15 30
  • 57.96 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8045 30
(Danio rerio)
Actinopterygii ABHD15 31
  • 46 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EHT1 31
  • 16 (a)
EEB1 31
  • 14 (a)
-- 31
  • 14 (a)
Species where no ortholog for ABHD15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ABHD15 Gene

Gene Tree for ABHD15 (if available)
Gene Tree for ABHD15 (if available)
Evolutionary constrained regions (ECRs) for ABHD15: view image

Paralogs for ABHD15 Gene

Paralogs for ABHD15 Gene Pseudogenes for ABHD15 Gene

genes like me logo Genes that share paralogs with ABHD15: view

Variants for ABHD15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ABHD15 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs542939 - p.Thr334Ala

Additional dbSNP identifiers (rs#s) for ABHD15 Gene

Structural Variations from Database of Genomic Variants (DGV) for ABHD15 Gene

Variant ID Type Subtype PubMed ID
esv22811 CNV loss 19812545
nsv521557 CNV loss 19592680
nsv833409 CNV gain 17160897

Variation tolerance for ABHD15 Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABHD15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABHD15 Gene

Disorders for ABHD15 Gene

No disorders were found for ABHD15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD15 Gene

Publications for ABHD15 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance. (PMID: 29768196) Xia W … Bogner-Strauss JG (Cell reports 2018) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for ABHD15 Gene

Sources for ABHD15 Gene