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Aliases for ABHD10 Gene

Aliases for ABHD10 Gene

  • Abhydrolase Domain Containing 10 2 3 5
  • Alpha/Beta Hydrolase Domain-Containing Protein 10 4
  • Abhydrolase Domain-Containing Protein 10 4
  • EC 3.1.1.93 4

External Ids for ABHD10 Gene

Previous GeneCards Identifiers for ABHD10 Gene

  • GC03P113181
  • GC03P111697
  • GC03P109073

Summaries for ABHD10 Gene

Entrez Gene Summary for ABHD10 Gene

  • This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

GeneCards Summary for ABHD10 Gene

ABHD10 (Abhydrolase Domain Containing 10) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include serine-type peptidase activity and hydrolase activity, hydrolyzing O-glycosyl compounds.

UniProtKB/Swiss-Prot for ABHD10 Gene

  • Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.

Additional gene information for ABHD10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABHD10 Gene

Genomics for ABHD10 Gene

GeneHancer (GH) Regulatory Elements for ABHD10 Gene

Promoters and enhancers for ABHD10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I111978 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 559.5 +0.4 402 2.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF207 ABHD10 PLCXD2 PLCXD2-AS1 TAGLN3
GH03I111858 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -116.3 -116266 8.6 SIN3A FEZF1 ZNF2 BRCA1 ZNF48 YY1 GLIS2 ATF7 RUNX3 SP3 PHLDB2 LOC105374040 ABHD10 PLCXD2 TAGLN3 PLCXD2-AS1 SLC9C1 GC03P111896
GH03I111931 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 16.6 -44.1 -44109 7.2 FOXA2 JUN MZF1 FEZF1 HIC1 ZNF664 POLR2A FOSL2 FOS TCF7L2 ABHD10 PLCXD2 PLCXD2-AS1 SLC35A5 PHLDB2 GC03P111896
GH03I112083 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.4 +107.2 107187 4.5 HDGF PKNOX1 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ZNF121 C3orf52 SLC9C1 ENSG00000261488 MIR567 ABHD10 GCSAM TMPRSS7
GH03I111922 Enhancer 1.2 Ensembl ENCODE dbSUPER 15.2 -54.1 -54105 5.2 PKNOX1 FOXA2 MZF1 FEZF1 RAD21 RFX5 YY1 SCRT2 RCOR1 RXRA ABHD10 PLCXD2-AS1 CD200 SLC35A5 GC03P111896 PHLDB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ABHD10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ABHD10 gene promoter:

Genomic Locations for ABHD10 Gene

Genomic Locations for ABHD10 Gene
chr3:111,978,876-111,993,368
(GRCh38/hg38)
Size:
14,493 bases
Orientation:
Plus strand
chr3:111,697,828-111,712,210
(GRCh37/hg19)

Genomic View for ABHD10 Gene

Genes around ABHD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABHD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABHD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABHD10 Gene

Proteins for ABHD10 Gene

  • Protein details for ABHD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUJ1-ABHDA_HUMAN
    Recommended name:
    Mycophenolic acid acyl-glucuronide esterase, mitochondrial
    Protein Accession:
    Q9NUJ1
    Secondary Accessions:
    • B7Z6A8
    • C9IZX5
    • D3DN63
    • Q8TCF9

    Protein attributes for ABHD10 Gene

    Size:
    306 amino acids
    Molecular mass:
    33933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABHD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABHD10 Gene

Post-translational modifications for ABHD10 Gene

  • Ubiquitination at Lys200
  • Modification sites at PhosphoSitePlus

Other Protein References for ABHD10 Gene

No data available for DME Specific Peptides for ABHD10 Gene

Domains & Families for ABHD10 Gene

Gene Families for ABHD10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for ABHD10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUJ1

UniProtKB/Swiss-Prot:

ABHDA_HUMAN :
  • Belongs to the AB hydrolase superfamily.
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with ABHD10: view

Function for ABHD10 Gene

Molecular function for ABHD10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Mycophenolic acid O-acyl-glucuronide + H(2)O = mycophenolate + D-glucuronate.
UniProtKB/Swiss-Prot Function:
Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.

Enzyme Numbers (IUBMB) for ABHD10 Gene

Phenotypes From GWAS Catalog for ABHD10 Gene

Gene Ontology (GO) - Molecular Function for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds TAS --
GO:0016787 hydrolase activity IEA --
GO:0102390 mycophenolic acid acyl-glucuronide esterase activity IEA --
genes like me logo Genes that share ontologies with ABHD10: view
genes like me logo Genes that share phenotypes with ABHD10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABHD10

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABHD10 Gene

Localization for ABHD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABHD10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABHD10 gene
Compartment Confidence
mitochondrion 5
cytosol 5
peroxisome 2
nucleus 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol IDA 22294686
genes like me logo Genes that share ontologies with ABHD10: view

Pathways & Interactions for ABHD10 Gene

genes like me logo Genes that share pathways with ABHD10: view

Pathways by source for ABHD10 Gene

Gene Ontology (GO) - Biological Process for ABHD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019391 glucuronoside catabolic process IDA 22294686
GO:0052695 cellular glucuronidation TAS --
genes like me logo Genes that share ontologies with ABHD10: view

No data available for SIGNOR curated interactions for ABHD10 Gene

Drugs & Compounds for ABHD10 Gene

(3) Drugs for ABHD10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mycophenolic acid Approved Pharma 987
Water Approved Pharma 0
D-Glucuronic acid Experimental Pharma 0

(1) Additional Compounds for ABHD10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Mycophenolic acid O-acyl-glucuronide
genes like me logo Genes that share compounds with ABHD10: view

Transcripts for ABHD10 Gene

Unigene Clusters for ABHD10 Gene

Abhydrolase domain containing 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABHD10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for ABHD10 Gene

GeneLoc Exon Structure for
ABHD10
ECgene alternative splicing isoforms for
ABHD10

Expression for ABHD10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABHD10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABHD10 Gene

This gene is overexpressed in Salivary gland (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABHD10 Gene



Protein tissue co-expression partners for ABHD10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABHD10 Gene:

ABHD10

SOURCE GeneReport for Unigene cluster for ABHD10 Gene:

Hs.477115

Evidence on tissue expression from TISSUES for ABHD10 Gene

  • Liver(4.4)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with ABHD10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABHD10 Gene

Orthologs for ABHD10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ABHD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABHD10 33 34
  • 99.89 (n)
cow
(Bos Taurus)
Mammalia ABHD10 33 34
  • 86.6 (n)
dog
(Canis familiaris)
Mammalia ABHD10 33 34
  • 85.46 (n)
mouse
(Mus musculus)
Mammalia Abhd10 33 16 34
  • 81.67 (n)
rat
(Rattus norvegicus)
Mammalia Abhd10 33
  • 80.94 (n)
oppossum
(Monodelphis domestica)
Mammalia ABHD10 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABHD10 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABHD10 33 34
  • 67.73 (n)
lizard
(Anolis carolinensis)
Reptilia ABHD10 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia abhd10 33
  • 68.21 (n)
Str.11875 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14582 33
zebrafish
(Danio rerio)
Actinopterygii abhd10a 33 34
  • 62.21 (n)
abhd10b 34
  • 59 (a)
OneToMany
wufb10b08 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4816 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for ABHD10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABHD10 Gene

ENSEMBL:
Gene Tree for ABHD10 (if available)
TreeFam:
Gene Tree for ABHD10 (if available)

Paralogs for ABHD10 Gene

Pseudogenes.org Pseudogenes for ABHD10 Gene

genes like me logo Genes that share paralogs with ABHD10: view

No data available for Paralogs for ABHD10 Gene

Variants for ABHD10 Gene

Sequence variations from dbSNP and Humsavar for ABHD10 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000133176 -- 111,977,775(+) A/T upstream_transcript_variant
rs1000244554 -- 111,978,749(+) T/C upstream_transcript_variant
rs1000430212 -- 111,989,770(+) A/T intron_variant
rs1000515210 -- 111,988,786(+) C/T intron_variant
rs1000761831 -- 111,988,320(+) A/AA intron_variant

Variation tolerance for ABHD10 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.46; 28.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABHD10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABHD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ABHD10 Gene

Disorders for ABHD10 Gene

Additional Disease Information for ABHD10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ABHD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABHD10 Gene

Publications for ABHD10 Gene

  1. Human α/β hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver. (PMID: 22294686) Iwamura A … Yokoi T (The Journal of biological chemistry 2012) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ABHD10 Gene

Sources for ABHD10 Gene

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