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The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively ref... See more...
Aliases for ABCG2 Gene
Aliases for ABCG2 Gene
- ATP Binding Cassette Subfamily G Member 2 (Junior Blood Group) 2 3 5
- ABCP 2 3 4
- BCRP 2 3 4
- MXR 2 3 4
- ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (Junior Blood Group) 2 3
- Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 3 4
- Placenta-Specific ATP-Binding Cassette Transporter 3 4
- Mitoxantrone Resistance-Associated Protein 3 4
- Breast Cancer Resistance Protein 3 4
- Urate Exporter 3 4
- EST157481 2 3
- CDw338 3 4
- BCRP1 3 4
- CD338 2 3
- Multi Drug Resistance Efflux Transport ATP-Binding Cassette Sub-Family G (WHITE) Member 2 3
External Ids for ABCG2 Gene
- HGNC: 74
- Entrez Gene: 9429
- Ensembl: ENSG00000118777
- OMIM: 603756
- UniProtKB: Q9UNQ0
Previous GeneCards Identifiers for ABCG2 Gene
- GC04M089170
- GC04M089314
- GC04M089471
- GC04M089370
- GC04M089230
- GC04M089011
- GC04M084757
Summaries for ABCG2 Gene
-
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for ABCG2 Gene
ABCG2 (ATP Binding Cassette Subfamily G Member 2 (Junior Blood Group)) is a Protein Coding gene. Diseases associated with ABCG2 include Uric Acid Concentration, Serum, Quantitative Trait Locus 1 and Blood Group, Junior System. Among its related pathways are Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics and Abacavir transport and metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and ATPase activity. An important paralog of this gene is ABCG8.
UniProtKB/Swiss-Prot Summary for ABCG2 Gene
-
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity).
-
ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.
Additional gene information for ABCG2 Gene
- HGNC(74)
- Entrez Gene(9429)
- Ensembl(ENSG00000118777)
- OMIM(603756)
- UniProtKB(Q9UNQ0)
- Open Targets Platform(ENSG00000118777)
- Monarch Initiative
- Search for ABCG2 at DataMed
- Search for ABCG2 at HumanCyc
No data available for Rfam classification and piRNA Summary for ABCG2 Gene
Genomics for ABCG2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ABCG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ABCG2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ABCG2
- Top Transcription factor binding sites by QIAGEN in the ABCG2 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- HNF-1
- HNF-1A
- PPAR-gamma1
- PPAR-gamma2
- Sp1
Genomic Locations for ABCG2 Gene
Genomic Locations for ABCG2 Gene
- chr4:88,090,150-88,231,628
- (GRCh38/hg38)
- Size:
- 141,479 bases
- Orientation:
- Minus strand
- chr4:89,011,416-89,152,474
- (GRCh37/hg19)
- Size:
- 141,059 bases
- Orientation:
- Minus strand
Genomic View for ABCG2 Gene
Genes around ABCG2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q22.1 by HGNC
- 4q22.1 by Entrez Gene
- 4q22.1 by Ensembl
ABCG2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ABCG2 Gene
Proteins for ABCG2 Gene
-
Protein details for ABCG2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UNQ0-ABCG2_HUMAN
- Recommended name:
- Broad substrate specificity ATP-binding cassette transporter ABCG2
- Protein Accession:
- Q9UNQ0
- A0A1W3
- A8K1T5
- O95374
- Q4W5I3
- Q53ZQ1
- Q569L4
- Q5YLG4
- Q86V64
- Q8IX16
- Q96LD6
- Q96TA8
- Q9BY73
- Q9NUS0
Protein attributes for ABCG2 Gene
- Size:
- 655 amino acids
- Molecular mass:
- 72314 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked (PubMed:15001581, PubMed:17686774, PubMed:18056989, PubMed:28554189). The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers (PubMed:15001581).
- SequenceCaution:
-
- Sequence=AF093771; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AF093772; Type=Frameshift; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ABCG2 Gene
Protein Expression for ABCG2 Gene
Post-translational modifications for ABCG2 Gene
- N-glycosylated (PubMed:15807535, PubMed:23189181). Glycosylation-deficient ABCG2 is normally expressed and functional.
- Phosphorylated. Phosphorylation at Thr-362 by PIM1 is induced by drugs like mitoxantrone and is associated with cells increased drug resistance. It regulates the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter.
-
Glycosylation at Asn596
- NX_Q9UNQ0 (NX_Q9UNQ0-1)
- Modification sites at PhosphoSitePlus
Other Protein References for ABCG2 Gene
Antibody Products
- GeneTex Anti-ABCG2 antibody and Anti-ABCG2 antibody [3G8]
-
Custom Antibody ServicesOriGene Antibodies for ABCG2
- Novus Biologicals Antibodies for ABCG2
-
Abcam antibodies for ABCG2
- Invitrogen Antibodies for ABCG2 (AFLGC-ABCG2)
- antibodies-online: Show 18 available ABCG2 Antibodies ranked by validation data
-
Santa Cruz Biotechnology (SCBT) Antibodies for ABCG2
- Sino Biological Antibodies for ABCG2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ABCG2
- Origene Custom Protein Services for ABCG2
- Novus Biologicals proteins for ABCG2
-
Signalway Proteins for ABCG2
-
Abcam proteins for ABCG2
Assay Products
No data available for DME Specific Peptides for ABCG2 Gene
Domains & Families for ABCG2 Gene
Gene Families for ABCG2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ABCG2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ABCG2 Gene
- GenScript: Design optimal peptide antigens:
-
- Placenta-specific ATP-binding cassette transporter (ABCG2_HUMAN)
- Multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 (F8S0F2_HUMAN)
- Multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 (F8S0F6_HUMAN)
- Multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 (F8S0F7_HUMAN)
- Breast cancer resistance protein (Q8WZ76_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UNQ0UniProtKB/Swiss-Prot:
ABCG2_HUMAN :- The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.
- Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
- Domain:
-
- The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin.
- Family:
-
- Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Function for ABCG2 Gene
Molecular function for ABCG2 Gene
- UniProtKB/Swiss-Prot Function:
- Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:11306452, PubMed:12958161, PubMed:19506252, PubMed:20705604, PubMed:28554189, PubMed:30405239, PubMed:31003562). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:20705604, PubMed:23189181). Also mediates the efflux of sphingosine-1-P from cells (PubMed:20110355). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (PubMed:19506252, PubMed:20368174, PubMed:22132962, PubMed:31003562). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (By similarity). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (PubMed:12682043, PubMed:28554189, PubMed:30405239). Mediates the secretion of the riboflavin and biotin vitamins into milk (By similarity). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (By similarity). Plays an important role in the exclusion of xenobiotics from the brain (Probable). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:11306452, PubMed:12477054, PubMed:15670731, PubMed:18056989, PubMed:31254042). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (By similarity). May play a role in early stem cell self-renewal by blocking differentiation (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).; EC=7.6.2.2; Evidence={ECO:0000269|PubMed:11306452, ECO:0000269|PubMed:12477054, ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:31254042};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=urate(out) = urate(in); Xref=Rhea:RHEA:60368, ChEBI:CHEBI:17775; Evidence={ECO:0000269|PubMed:19506252, ECO:0000269|PubMed:20368174, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:31003562};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + indoxyl sulfate(in) = ADP + H(+) + indoxyl sulfate(out) + phosphate; Xref=Rhea:RHEA:61332, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:144643, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:Q7TMS5};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out); Xref=Rhea:RHEA:38951, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60119, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:20110355};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + estrone 3-sulfate(in) + H2O = ADP + estrone 3-sulfate(out) + H(+) + phosphate; Xref=Rhea:RHEA:61348, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60050, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:12682043, ECO:0000269|PubMed:28554189, ECO:0000269|PubMed:30405239};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O = 3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:61364, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57905, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:12682043};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:61368, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:144581, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:12682043};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:61384, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:144584, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:12682043};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:61372, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:144582, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:12682043};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:61376, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:144583, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:12682043};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:12682043};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + methotrexate(in) = ADP + H(+) + methotrexate(out) + phosphate; Xref=Rhea:RHEA:61356, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:50681, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:12682043};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + riboflavin(in) = ADP + H(+) + phosphate + riboflavin(out); Xref=Rhea:RHEA:61352, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57986, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:Q7TMS5};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + pheophorbide a(in) = ADP + H(+) + pheophorbide a(out) + phosphate; Xref=Rhea:RHEA:61360, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58687, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:Q7TMS5};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=16.6 uM for estrone 3-sulfate {ECO:0000269|PubMed:12682043}; KM=1.23 mM for ATP {ECO:0000269|PubMed:12682043}; KM=12.9 uM for 4-methylumbelliferone sulfate {ECO:0000269|PubMed:12682043}; KM=26.9 uM for 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole sulfate {ECO:0000269|PubMed:12682043}; KM=8.24 mM for urate {ECO:0000269|PubMed:22132962}; Vmax=2.34 nmol/min/mg enzyme for estrone 3-sulfate transport {ECO:0000269|PubMed:12682043}; Vmax=6.96 nmol/min/mg enzyme for urate transport {ECO:0000269|PubMed:22132962};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Specifically inhibited by the fungal toxin fumitremorgin C and Ko143.
- GENATLAS Biochemistry:
- ATP binding cassette superfamily,subfamily G (WHITE),member 2,multidrug resistance transporter,expressed in the placenta,involved in transport of specific molecules into or out the placenta,homolog to Drosophila white and yeast ADP1 gene
Enzyme Numbers (IUBMB) for ABCG2 Gene
Phenotypes From GWAS Catalog for ABCG2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 18056989 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008559 | xenobiotic transmembrane transporting ATPase activity | IDA | 9861027 |
| GO:0015143 | urate transmembrane transporter activity | IMP | 19506252 |
Phenotypes for ABCG2 Gene
- MGI mutant phenotypes for ABCG2:
-
inferred from 5 alleles
- nervous system phenotype
- immune system phenotype
- normal phenotype
- cellular phenotype
- behavior/neurological phenotype
- homeostasis/metabolism phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- integument phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for ABCG2:
Animal Models for ABCG2 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for ABCG2
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ABCG2 - Select products 50% OFF >
- * ABCG2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCG2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCG2
miRNA for ABCG2 Gene
- miRTarBase miRNAs that target ABCG2
-
- hsa-miR-328-3p (MIRT000081)
- hsa-miR-519c-3p (MIRT000998)
- hsa-miR-520h (MIRT001952)
- hsa-miR-192-5p (MIRT004129)
- hsa-miR-26b-5p (MIRT029929)
- hsa-miR-10a-5p (MIRT047731)
- hsa-miR-181a-5p (MIRT437399)
- hsa-miR-142-3p (MIRT437871)
- hsa-miR-487a-3p (MIRT438649)
- hsa-miR-374b-5p (MIRT444279)
- hsa-miR-374a-5p (MIRT444280)
- hsa-miR-889-3p (MIRT444281)
- hsa-miR-876-5p (MIRT444282)
- hsa-miR-3167 (MIRT444283)
- hsa-miR-4635 (MIRT444284)
- hsa-miR-195-3p (MIRT444285)
- hsa-miR-16-2-3p (MIRT444286)
- hsa-miR-5692b (MIRT444287)
- hsa-miR-5692c (MIRT444288)
- hsa-miR-369-3p (MIRT444289)
- hsa-miR-7158-3p (MIRT526188)
- hsa-miR-340-5p (MIRT526189)
- hsa-miR-4539 (MIRT526190)
- hsa-miR-181a-2-3p (MIRT526191)
- hsa-miR-4724-5p (MIRT526192)
- hsa-miR-497-3p (MIRT526193)
- hsa-miR-222-3p (MIRT733347)
- hsa-miR-212-3p (MIRT733390)
- hsa-miR-320a (MIRT733728)
- hsa-miR-4496 (MIRT733729)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCG2
- Browse OriGene Inhibitory RNA Products For ABCG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCG2
Clone Products
- Applied Biological Materials (abm): Clones for ABCG2 - Select products 50% OFF >
- * ABCG2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ABCG2
- Addgene plasmids for ABCG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCG2
Cell Line Products
-
Horizon Cell Lines for ABCG2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCG2 Gene
Localization for ABCG2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ABCG2 Gene
- Cell membrane. Multi-pass membrane protein. Apical cell membrane. Multi-pass membrane protein. Mitochondrion membrane. Multi-pass membrane protein. Note=Enriched in membrane lipid rafts. {ECO:0000269 PubMed:28623970}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| mitochondrion | 4 |
| extracellular | 3 |
| cytoskeleton | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
- Plasma membrane (4)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for ABCG2 Gene
Pathways by source for ABCG2 Gene
5 BioSystems pathways for ABCG2 Gene
5 Reactome pathways for ABCG2 Gene
3 KEGG pathways for ABCG2 Gene
3 R&D Systems pathways for ABCG2 Gene
1 Cell Signaling Technology pathway for ABCG2 Gene
Interacting Proteins for ABCG2 Gene
Selected Interacting proteins:
Q9UNQ0-ABCG2_HUMAN
ENSP00000237612
for ABCG2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ABCG2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006879 | cellular iron ion homeostasis | TAS | -- |
| GO:0015747 | urate transport | IEA | -- |
| GO:0015878 | biotin transport | ISS | -- |
| GO:0032218 | riboflavin transport | IDA | 17145775 |
| GO:0046415 | urate metabolic process | IMP | 18834626 |
Drugs & Compounds for ABCG2 Gene
(277) Drugs for ABCG2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Doxorubicin | Approved, Investigational | Pharma | Transporter, substrate | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 2029 | |
| Gefitinib | Approved, Investigational | Pharma | Transporter, substrate, inhibitor | EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors | 409 | |
| Irinotecan | Approved, Investigational | Pharma | Transporter, substrate | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1414 | |
| Methotrexate | Approved | Pharma | Transporter, substrate | Folate antagonist,inhibits DFHR | 1825 | |
| Mitoxantrone | Approved, Investigational | Pharma | Transporter, substrate, inhibitor | 299 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 5-Hydroxyomeprazole |
|
|||||
| Hydroxylansoprazole |
|
|||||
| N-desmethylimatinib |
|
|||||
| O-Desmethylverapamil (D-702) |
|
|
(3) Tocris Compounds for ABCG2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Fumitremorgin C | Inhibitor of BCRP-mediated multidrug resistance | 118974-02-0 |
| Ko 143 | Potent and selective BCRP inhibitor | 461054-93-3 |
| Pyrimethamine | Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor | 58-14-0 |
(6) ApexBio Compounds for ABCG2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Dofequidar fumarate | MDR reversal agent | 153653-30-6 |
| Elacridar | BCRP inhibitor | 143664-11-3 |
| Elacridar hydrochloride | BCRP and P-GP inhibitor | 143851-98-3 |
| Ko 143 | BCRP inhibitor,potent and selective | 461054-93-3 |
| Tariquidar methanesulfonate, hydrate | P-glycoprotein inhibitor, potent and selective | 625375-83-9 |
| Zosuquidar | MDR modulator | 167354-41-8 |
Transcripts for ABCG2 Gene
mRNA/cDNA for ABCG2 Gene
- 7 REFSEQ mRNAs :
- 91 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000650821 4844 nts (view in UCSC)
- ENST00000515655 4276 nts (view in UCSC)
- ENST00000237612 4206 nts (view in UCSC)
- ENST00000505480 804 nts (view in UCSC)
- ENST00000503830 475 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ABCG2 - Select products 50% OFF >
- * ABCG2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCG2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCG2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCG2
- Browse OriGene Inhibitory RNA Products For ABCG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCG2
Clone Products
- Applied Biological Materials (abm): Clones for ABCG2 - Select products 50% OFF >
- * ABCG2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ABCG2
- Addgene plasmids for ABCG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCG2
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | · | 16c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - |
Relevant External Links for ABCG2 Gene
- GeneLoc Exon Structure for
- ABCG2
Expression for ABCG2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Limbal Basal Epithelial Cells Limbus Epithelium
- Fetal Corneal Basal Epithelial Cells Corneal Epithelium
- Mature Choroid Plexus Cells Choroid Plexus
- Amniotic Epithelial Cells Amniotic Membrane
- Limbal epithelial stem cells
-
Eye (Sensory Organs)
- Limbal Basal Epithelial Cells Limbus Epithelium
- Fetal Corneal Basal Epithelial Cells Corneal Epithelium
- Fetal Limbal Epithelial Cells Limbus Epithelium
- Limbal epithelial stem cells
- Limbal corneal epithelial stem cells
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Mature Endothelial Cells Blood Brain Barrier
- Choroid Plexus Progenitor Cells Choroid Plexus
- Adult Endothelial Cells Blood Brain Barrier
- Cerebral Cortex
- Inner Cell Mass (Early Embryonic Tissues)
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Mature brain microvascular endothelial cells (Lippmann ES et. al. 2012)
-
Gonad
- Spermatid Seminiferous Tubules
- Primordial Germ Cells Primitive Gonad
- Heart (Cardiovascular System)
-
Adipose (Muscoskeletal System)
- Stromal Cells Subcutaneous White Adipose
-
Blood (Hematopoietic System)
- Erythroblasts Hematopoietic Bone Marrow
-
Testis (Reproductive System)
- Spermatid Seminiferous Tubules
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
-
Trophoblast (Extraembryonic Tissues)
- Mural Trophectoderm Cells Mural Trophectoderm
-
Amnion (Extraembryonic Tissues)
- Amniotic Epithelial Cells Amniotic Membrane
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Neural Tube (Nervous System)
- NULL (Sensory Organs)
This gene is overexpressed in Milk (66.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCG2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ABCG2
SOURCE GeneReport for Unigene cluster for ABCG2 Gene:
Hs.480218mRNA Expression by UniProt/SwissProt for ABCG2 Gene:
Q9UNQ0-ABCG2_HUMAN
Tissue specificity:
Highly expressed in placenta (PubMed:9850061). Low expression in small intestine, liver and colon (PubMed:9861027). Expressed in brain (at protein level) (PubMed:12958161).
Evidence on tissue expression from TISSUES for ABCG2 Gene
- Nervous system(4.9)
- Pancreas(4.4)
- Intestine(3.5)
- Blood(3.4)
- Liver(3.4)
- Kidney(3)
- Heart(2.8)
- Lung(2.7)
- Skin(2.6)
- Muscle(2.5)
- Bone marrow(2.4)
- Eye(2.4)
- Thyroid gland(2.3)
- Urine(2.3)
- Gall bladder(2.1)
- Stomach(2.1)
- Lymph node(2.1)
Primer Products
-
OriGene qPCR primer pairs for ABCG2
-
OriGene qPCR primer pairs and template standards for ABCG2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCG2 Gene
Orthologs for ABCG2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ABCG2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ABCG2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ABCG2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Abcg2 30 17 31 |
|
OneToMany | |
| Abcg3 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Abcg2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | ABCG2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ABCG2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ABCG2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | abcg2 30 |
|
||
| Str.8262 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | abcg2a 30 31 |
|
OneToMany | |
| abcg2d 31 |
|
OneToMany | |||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2184 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | WHITE_ANOGA 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | w 30 32 |
|
||
| E23 32 |
|
|
|||
| st 32 |
|
|
|||
| bw 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | wht-7 30 |
|
||
| C05D10.3 32 |
|
|
|||
| C10C6.5 32 |
|
|
|||
| T26A5.1 32 |
|
|
|||
| wht-1 31 |
|
ManyToMany | |||
| C16C10.12 32 |
|
|
|||
| Y47D3A.11 32 |
|
|
|||
| F02E11.1 32 |
|
|
|||
| F19B6.4 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ADP1 30 31 33 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0D04554g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER190W 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT5G06530 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0157400 30 |
|
||
| Os.8900 30 |
|
||||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU02544 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for ABCG2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ABCG2 Gene
- ENSEMBL:
- Gene Tree for ABCG2 (if available)
- TreeFam:
- Gene Tree for ABCG2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ABCG2: view image
Paralogs for ABCG2 Gene
(27) SIMAP similar genes for ABCG2 Gene using alignment to 9 proteins:
- ABCG2_HUMAN
- F8S0F2_HUMAN
- F8S0F6_HUMAN
- F8S0F7_HUMAN
- H0YAF1_HUMAN
- H0YAF3_HUMAN
- I4EPX2_HUMAN
- I7JB59_HUMAN
- Q8WZ76_HUMAN
Pseudogenes.org Pseudogenes for ABCG2 Gene
Variants for ABCG2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ABCG2 Gene
- ABCG2_HUMAN-Q9UNQ0
- Genetic variations in ABCG2 define the blood group Junior system (JR) [MIM:614490]. Individuals with Jr(a-) blood group lack the Jr(a) antigen on their red blood cells. These individuals may have anti-Jr(a) antibodies in their serum, which can cause transfusion reactions or hemolytic disease of the fetus or newborn. Although the clinical significance of the Jr(a-) blood group has been controversial, severe fatal hemolytic disease of the newborn has been reported. The Jr(a-) phenotype has a higher frequency in individuals of Asian descent, compared to those of European descent. The Jr(a-) phenotype is inherited as an autosomal recessive trait.
- ABCG2_HUMAN-Q9UNQ0
- Genetic variations in ABCG2 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 1 (UAQTL1) [MIM:138900]. Excess serum accumulation of uric acid can lead to the development of gout, a common disorder characterized by tissue deposition of monosodium urate crystals as a consequence of hyperuricemia (PubMed:18834626, PubMed:19506252, PubMed:20368174).
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ABCG2 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 782442 | Benign: not provided | 88,132,638(-) | G/A | INTRON_VARIANT | |
| 787808 | Benign: not provided | 88,131,812(-) | G/A | SYNONYMOUS_VARIANT | |
| rs140207606 | Association: Blood group, Junior system | 88,118,244(-) | G/A | NONSENSE | |
| rs1553935607 | Uncertain Significance: not provided | 88,131,172(-) | TA/T | FRAMESHIFT_VARIANT | |
| rs200190472 | Affects: Blood group, Junior system | 88,118,214(-) | G/A | NONSENSE |
Residual Variation Intolerance Score:
79.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.94;
79.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ABCG2 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for ABCG2 Gene
(41) MalaCards diseases for ABCG2 Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| uric acid concentration, serum, quantitative trait locus 1 |
|
|
| blood group, junior system |
|
|
| hyperuricemia |
|
|
| placental choriocarcinoma |
|
|
| gout |
|
|
Search ABCG2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ABCG2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ABCG2 Gene
Publications for ABCG2 Gene
- Glutathione transport is a unique function of the ATP-binding cassette protein ABCG2. (PMID: 20332504) Brechbuhl HM … Day BJ (The Journal of biological chemistry 2010) 3 4 23
- Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation. (PMID: 20103600) Lagas JS … Schinkel AH (Molecular cancer therapeutics 2010) 3 23 26
- Identification and functional characterization of breast cancer resistance protein in human bronchial epithelial cells (Calu-3). (PMID: 19782742) Paturi DK … Mitra AK (International journal of pharmaceutics 2010) 3 23 26
- ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin. (PMID: 20130569) Tomlinson B … Li EK (Clinical pharmacology and therapeutics 2010) 3 23 41
- Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. (PMID: 19506252) Woodward OM … Köttgen M (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4 41
ExternalLinks
Products for ABCG2 Gene
- Custom Antibody ServicesOriGene Antibodies for ABCG2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ABCG2
- Origene Custom Protein Services for ABCG2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCG2
- Browse OriGene Inhibitory RNA Products For ABCG2
- OriGene qPCR primer pairs for ABCG2
- OriGene qPCR primer pairs and template standards for ABCG2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ABCG2
- Sino Biological Human cDNA Clone for ABCG2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for ABCG2
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ABCG2
- Novus Biologicals proteins for ABCG2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ABCG2
- Abcam proteins for ABCG2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for ABCG2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ABCG2 (AFLGC-ABCG2)
- ApexBio compounds for ABCG2
- VectorBuilder Custom and pre-made DNA vectors for ABCG2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ABCG2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ABCG2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ABCG2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ABCG2
- Addgene plasmids for ABCG2
- antibodies-online: Show 18 available ABCG2 Antibodies ranked by validation data
- antibodies-online: Search results for available ABCG2 related products ranked by validation data
- antibodies-online: Search results for available ABCG2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for ABCG2
- Search Santa Cruz Biotechnology (SCBT) for ABCG2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ABCG2
- Horizon Cell Lines for ABCG2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCG2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCG2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ABCG2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCG2
Sources for ABCG2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB