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Aliases for ABCF2 Gene

Aliases for ABCF2 Gene

  • ATP Binding Cassette Subfamily F Member 2 2 3 5
  • ATP-Binding Cassette, Sub-Family F (GCN20), Member 2 2 3
  • Iron-Inhibited ABC Transporter 2 3 4
  • ATP-Binding Cassette Sub-Family F Member 2 3
  • ABC-Type Transport Protein 3
  • EST133090 3
  • HUSSY-18 3
  • HUSSY18 3
  • ABC28 3

External Ids for ABCF2 Gene

Previous GeneCards Identifiers for ABCF2 Gene

  • GC07M149151
  • GC07M150219
  • GC07M150296
  • GC07M150342
  • GC07M150535
  • GC07M150904
  • GC07M144715

Summaries for ABCF2 Gene

Entrez Gene Summary for ABCF2 Gene

  • This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding cassette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 7. [provided by RefSeq, May 2017]

GeneCards Summary for ABCF2 Gene

ABCF2 (ATP Binding Cassette Subfamily F Member 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity.

Gene Wiki entry for ABCF2 Gene

Additional gene information for ABCF2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCF2 Gene

Genomics for ABCF2 Gene

GeneHancer (GH) Regulatory Elements for ABCF2 Gene

Promoters and enhancers for ABCF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J151225 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 678.8 +0.0 17 2.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ABCF2 LOC105375570 ENSG00000243433 ENSG00000285480
GH07J151223 Promoter 0.5 EPDnew 650.7 +3.6 3612 0.1 ABCF2 ENSG00000285480
GH07J151218 Promoter 0.5 EPDnew 650.4 +9.2 9247 0.1 ABCF2 ENSG00000285480
GH07J151245 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 39.3 -22.0 -21983 9.1 HDGF PKNOX1 FOXA2 ARNT SIN3A ZNF2 YY1 ZNF143 KLF13 ZNF263 SMARCD3 ENSG00000243018 ENSG00000244151 NUB1 ABCF2 ASB10 GBX1 ENSG00000229591 SLC4A2 TMUB1
GH07J151231 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 27.7 -5.6 -5636 2.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 CHPF2 GC07M151231 ABCF2 NUB1 ENSG00000244151 SMARCD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ABCF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ABCF2 gene promoter:
  • MyoD
  • E2F-1
  • E2F
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Ik-2
  • SEF-1 (1)

Genomic Locations for ABCF2 Gene

Genomic Locations for ABCF2 Gene
19,545 bases
Minus strand
19,395 bases
Minus strand

Genomic View for ABCF2 Gene

Genes around ABCF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCF2 Gene

Proteins for ABCF2 Gene

  • Protein details for ABCF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-binding cassette sub-family F member 2
    Protein Accession:
    Secondary Accessions:
    • O60864
    • Q75MJ0
    • Q75MJ1
    • Q96TE8

    Protein attributes for ABCF2 Gene

    623 amino acids
    Molecular mass:
    71290 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCF2 Gene


neXtProt entry for ABCF2 Gene

Post-translational modifications for ABCF2 Gene

  • Ubiquitination at posLast=618618, posLast=602602, Lys508, posLast=436436, Lys365, Lys339, and posLast=315315
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCF2 Gene

No data available for DME Specific Peptides for ABCF2 Gene

Domains & Families for ABCF2 Gene

Gene Families for ABCF2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ABCF2 Gene

Suggested Antigen Peptide Sequences for ABCF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
  • Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
genes like me logo Genes that share domains with ABCF2: view

Function for ABCF2 Gene

Molecular function for ABCF2 Gene

GENATLAS Biochemistry:
ATP-binding cassette superfamily,subfamily F (GCN20),member 2

Phenotypes From GWAS Catalog for ABCF2 Gene

Gene Ontology (GO) - Molecular Function for ABCF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity TAS 9878413
GO:0005524 ATP binding IEA,TAS --
GO:0016887 ATPase activity IEA --
genes like me logo Genes that share ontologies with ABCF2: view

Phenotypes for ABCF2 Gene

genes like me logo Genes that share phenotypes with ABCF2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCF2

CRISPR Products

miRNA for ABCF2 Gene

miRTarBase miRNAs that target ABCF2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCF2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABCF2 Gene

Localization for ABCF2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCF2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 4
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ABCF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005740 mitochondrial envelope TAS 9878413
GO:0016020 membrane HDA 19946888
GO:0043190 ATP-binding cassette (ABC) transporter complex TAS 9878413
genes like me logo Genes that share ontologies with ABCF2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ABCF2 Gene

Pathways & Interactions for ABCF2 Gene

SuperPathways for ABCF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABCF2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ABCF2 Gene

Drugs & Compounds for ABCF2 Gene

(1) Drugs for ABCF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ABCF2: view

Transcripts for ABCF2 Gene

mRNA/cDNA for ABCF2 Gene

Unigene Clusters for ABCF2 Gene

ATP-binding cassette, sub-family F (GCN20), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCF2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCF2 Gene

No ASD Table

Relevant External Links for ABCF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABCF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCF2 Gene

Protein differential expression in normal tissues from HIPED for ABCF2 Gene

This gene is overexpressed in Lung (44.5) and Breast (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCF2 Gene

Protein tissue co-expression partners for ABCF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ABCF2 Gene:


SOURCE GeneReport for Unigene cluster for ABCF2 Gene:


Evidence on tissue expression from TISSUES for ABCF2 Gene

  • Lung(4.3)
  • Intestine(4.2)
  • Skin(2.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ABCF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCF2 Gene

Orthologs for ABCF2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABCF2 33
  • 99.74 (n)
(Canis familiaris)
Mammalia ABCF2 33
  • 94.01 (n)
(Bos Taurus)
Mammalia ABCF2 33
  • 93.15 (n)
(Mus musculus)
Mammalia Abcf2 16 33
  • 91.87 (n)
(Gallus gallus)
Aves ABCF2 33
  • 80.74 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6657 33
African clawed frog
(Xenopus laevis)
Amphibia abcf2-prov 33
(Danio rerio)
Actinopterygii abcf2a 33
  • 76.53 (n)
abcf2 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10004 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002693 33
  • 67.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9281 35 33
  • 65.39 (n)
(Caenorhabditis elegans)
Secernentea abcf-2 33
  • 61.83 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR232C 33
  • 55.12 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A01452g 33
  • 54.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARB1 36 33
  • 52.89 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons GCN1 33
  • 61.42 (n)
(Glycine max)
eudicotyledons Gma.7643 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1549 33
(Oryza sativa)
Liliopsida Os09g0572400 33
  • 64.68 (n)
(Triticum aestivum)
Liliopsida Ta.28668 33
(Zea mays)
Liliopsida Zm.2713 33
bread mold
(Neurospora crassa)
Ascomycetes NCU08920 33
  • 56.7 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.3407 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3407 33
Species where no ortholog for ABCF2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ABCF2 Gene

Gene Tree for ABCF2 (if available)
Gene Tree for ABCF2 (if available)
Evolutionary constrained regions (ECRs) for ABCF2: view image

Paralogs for ABCF2 Gene

(22) SIMAP similar genes for ABCF2 Gene using alignment to 5 proteins:

  • L0R4T3_HUMAN
  • Q75MJ1_HUMAN
genes like me logo Genes that share paralogs with ABCF2: view

No data available for Paralogs for ABCF2 Gene

Variants for ABCF2 Gene

Sequence variations from dbSNP and Humsavar for ABCF2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000038159 -- 151,217,529(-) G/A intron_variant
rs1000146707 -- 151,225,174(-) C/G intron_variant
rs1000169109 -- 151,209,356(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000307528 -- 151,209,485(-) GG/G genic_downstream_transcript_variant, intron_variant
rs1000374572 -- 151,211,129(-) C/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABCF2 Gene

Variant ID Type Subtype PubMed ID
nsv951649 CNV deletion 24416366
nsv831188 CNV loss 17160897
nsv609035 CNV loss 21841781
nsv435860 CNV deletion 17901297
nsv1151906 OTHER inversion 26484159
nsv1067934 OTHER inversion 25765185
esv2735396 CNV deletion 23290073
dgv3695n106 OTHER inversion 24896259

Variation tolerance for ABCF2 Gene

Residual Variation Intolerance Score: 4.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 52.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABCF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCF2 Gene

Disorders for ABCF2 Gene

Additional Disease Information for ABCF2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ABCF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCF2 Gene

Publications for ABCF2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F … Valle G (Yeast (Chichester, England) 2001) 3 4 58

Products for ABCF2 Gene

Sources for ABCF2 Gene

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