The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import... See more...

Aliases for ABCD4 Gene

Aliases for ABCD4 Gene

  • ATP Binding Cassette Subfamily D Member 4 2 3 5
  • PMP69 2 3 4
  • P70R 2 3 4
  • ATP-Binding Cassette, Sub-Family D (ALD), Member 4 2 3
  • ATP-Binding Cassette Sub-Family D Member 4 3 4
  • Lysosomal Cobalamin Transporter ABCD4 3 4
  • Peroxisomal Membrane Protein 69 3 4
  • PMP70-Related Protein 3 4
  • EST352188 2 3
  • PXMP1-L 3 4
  • PXMP1L 3 4
  • Peroxisomal Membrane Protein 1-Like 4
  • 69 KDa Peroxisomal ABC-Transporter 3
  • ABC41 3
  • MAHCJ 3
  • ABCD4 5
  • P79R 3

External Ids for ABCD4 Gene

Previous HGNC Symbols for ABCD4 Gene

  • PXMP1L

Previous GeneCards Identifiers for ABCD4 Gene

  • GC14M072257
  • GC14M068547
  • GC14M072742
  • GC14M073821
  • GC14M074751
  • GC14M054918

Summaries for ABCD4 Gene

Entrez Gene Summary for ABCD4 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in several protein-coding and non-protein-coding variants. [provided by RefSeq, Jul 2017]

GeneCards Summary for ABCD4 Gene

ABCD4 (ATP Binding Cassette Subfamily D Member 4) is a Protein Coding gene. Diseases associated with ABCD4 include Methylmalonic Aciduria And Homocystinuria, Cblj Type and Disorders Of Intracellular Cobalamin Metabolism. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include ATPase activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCD2.

UniProtKB/Swiss-Prot Summary for ABCD4 Gene

  • Lysosomal transporter that plays a role in the lysosomal release of vitamin B12 into the cytosol (PubMed:22922874). Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791).

Gene Wiki entry for ABCD4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABCD4 Gene

Genomics for ABCD4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ABCD4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABCD4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ABCD4

Top Transcription factor binding sites by QIAGEN in the ABCD4 gene promoter:
  • AML1a
  • c-Myb
  • Elk-1
  • FOXO3
  • FOXO3a
  • GATA-1
  • LyF-1
  • N-Myc
  • NRSF form 1
  • NRSF form 2

Genomic Locations for ABCD4 Gene

Genomic Locations for ABCD4 Gene
chr14:74,285,269-74,303,062
(GRCh38/hg38)
Size:
17,794 bases
Orientation:
Minus strand
chr14:74,751,980-74,769,767
(GRCh37/hg19)
Size:
17,788 bases
Orientation:
Minus strand

Genomic View for ABCD4 Gene

Genes around ABCD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCD4 Gene

Proteins for ABCD4 Gene

  • Protein details for ABCD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14678-ABCD4_HUMAN
    Recommended name:
    Lysosomal cobalamin transporter ABCD4
    Protein Accession:
    O14678
    Secondary Accessions:
    • A8K5L7
    • Q6IAQ0
    • Q96E75

    Protein attributes for ABCD4 Gene

    Size:
    606 amino acids
    Molecular mass:
    68597 Da
    Quaternary structure:
    • Homodimer or heterodimer (PubMed:27456980). Interacts with LMBRD1; this interaction induces the translocation of ABCD4 from the ER to the lysosome membrane (PubMed:27456980). Interacts with ABCD4 and MMACHC; this interaction ensures the transport of cobalamin from the lysosome to the cytosol (PubMed:25535791).

    Three dimensional structures from OCA and Proteopedia for ABCD4 Gene

neXtProt entry for ABCD4 Gene

Post-translational modifications for ABCD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ABCD4 Gene

Domains & Families for ABCD4 Gene

Gene Families for ABCD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ABCD4 Gene

InterPro:
Blocks:
  • ABC transporter, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for ABCD4 Gene

GenScript: Design optimal peptide antigens:
  • Peroxisomal membrane protein 69 (ABCD4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14678

UniProtKB/Swiss-Prot:

ABCD4_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
Family:
  • Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
genes like me logo Genes that share domains with ABCD4: view

Function for ABCD4 Gene

Molecular function for ABCD4 Gene

UniProtKB/Swiss-Prot Function:
Lysosomal transporter that plays a role in the lysosomal release of vitamin B12 into the cytosol (PubMed:22922874). Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane (PubMed:27456980). Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791).
GENATLAS Biochemistry:
ATP-binding cassette superfamily,subfamily D (ALD),member 4,ubiquitously expressed,peroxisomal membrane protein 1-like,transporter,putatively involved in ALDP expression

Phenotypes From GWAS Catalog for ABCD4 Gene

Gene Ontology (GO) - Molecular Function for ABCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 25535791
GO:0005524 ATP binding IEA,NAS 9266848
GO:0016887 ATPase activity IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA,TAS --
genes like me logo Genes that share ontologies with ABCD4: view
genes like me logo Genes that share phenotypes with ABCD4: view

Human Phenotype Ontology for ABCD4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ABCD4 Gene

MGI Knock Outs for ABCD4:
  • Abcd4 Abcd4<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCD4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ABCD4 Gene

Localization for ABCD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCD4 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein. Lysosome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCD4 gene
Compartment Confidence
plasma membrane 5
peroxisome 5
lysosome 4
endoplasmic reticulum 3
mitochondrion 2
golgi apparatus 2
extracellular 1
cytoskeleton 1
nucleus 1
endosome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ABCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS --
GO:0005777 NOT peroxisome IEA,IDA 19010322
GO:0005778 peroxisomal membrane IEA --
GO:0005789 endoplasmic reticulum membrane IEA,IDA 27456980
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ABCD4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABCD4 Gene

Pathways & Interactions for ABCD4 Gene

genes like me logo Genes that share pathways with ABCD4: view

Gene Ontology (GO) - Biological Process for ABCD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009235 cobalamin metabolic process TAS --
GO:0055085 transmembrane transport IEA,NAS 9266848
GO:1990830 cellular response to leukemia inhibitory factor IEA --
genes like me logo Genes that share ontologies with ABCD4: view

No data available for SIGNOR curated interactions for ABCD4 Gene

Drugs & Compounds for ABCD4 Gene

(1) Additional Compounds for ABCD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABCD4: view

Transcripts for ABCD4 Gene

mRNA/cDNA for ABCD4 Gene

24 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
28 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCD4

Alternative Splicing Database (ASD) splice patterns (SP) for ABCD4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: - -
SP9: - - - - - - -
SP10: - - - - - -
SP11: - -
SP12: - - - - - - - -
SP13: - - - -
SP14: - -
SP15:
SP16:
SP17: - - -
SP18:
SP19:
SP20: -

ExUns: 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c · 20d · 20e · 20f
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for ABCD4 Gene

GeneLoc Exon Structure for
ABCD4

Expression for ABCD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABCD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ABCD4 Gene

This gene is overexpressed in Adrenal (56.3) and Breast (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCD4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ABCD4

SOURCE GeneReport for Unigene cluster for ABCD4 Gene:

Hs.94395

mRNA Expression by UniProt/SwissProt for ABCD4 Gene:

O14678-ABCD4_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for ABCD4 Gene

  • Nervous system(4.4)
  • Muscle(4.4)
  • Skin(2.2)
  • Liver(2.2)
  • Adrenal gland(2.2)
  • Kidney(2.2)
  • Intestine(2)
  • Spleen(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCD4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • eye
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • diaphragm
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • abdominal wall
  • intestine
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with ABCD4: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ABCD4 Gene

Orthologs for ABCD4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ABCD4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ABCD4 30 31
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ABCD4 30 31
  • 90.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ABCD4 31
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Abcd4 30
  • 88.21 (n)
Mouse
(Mus musculus)
Mammalia Abcd4 30 17 31
  • 88.17 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ABCD4 31
  • 80 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ABCD4 31
  • 56 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ABCD4 30 31
  • 74.75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ABCD4 31
  • 74 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia abcd4 30
  • 62.89 (n)
Zebrafish
(Danio rerio)
Actinopterygii abcd4 30 31
  • 65.25 (n)
OneToOne
Dr.18695 30
Worm
(Caenorhabditis elegans)
Secernentea pmp-3 30 31
  • 47.27 (n)
OneToMany
C54G10.3 32
  • 41 (a)
pmp-5 31
  • 31 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PXA1 31
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToOne
Species where no ortholog for ABCD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ABCD4 Gene

ENSEMBL:
Gene Tree for ABCD4 (if available)
TreeFam:
Gene Tree for ABCD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ABCD4: view image

Paralogs for ABCD4 Gene

Paralogs for ABCD4 Gene

(2) SIMAP similar genes for ABCD4 Gene using alignment to 11 proteins:

  • ABCD4_HUMAN
  • E9PI46_HUMAN
  • E9PPB6_HUMAN
  • F8W7M4_HUMAN
  • G3V3W1_HUMAN
  • G3V4U7_HUMAN
  • H0YCY9_HUMAN
  • H0YJ78_HUMAN
  • H0YJ82_HUMAN
  • H0YJL8_HUMAN
  • H0YJX8_HUMAN
genes like me logo Genes that share paralogs with ABCD4: view

Variants for ABCD4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ABCD4 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
646672 Uncertain Significance: Methylmalonic acidemia with homocystinuria, type cblJ 74,295,957(-) T/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT
648720 Uncertain Significance: Methylmalonic acidemia with homocystinuria, type cblJ 74,296,372(-) G/A MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT
652295 Uncertain Significance: Methylmalonic acidemia with homocystinuria, type cblJ 74,287,868(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
657074 Uncertain Significance: Methylmalonic acidemia with homocystinuria, type cblJ 74,286,773(-) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
660320 Uncertain Significance: Methylmalonic acidemia with homocystinuria, type cblJ 74,290,094(-) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for ABCD4 Gene

Structural Variations from Database of Genomic Variants (DGV) for ABCD4 Gene

Variant ID Type Subtype PubMed ID
esv3551772 CNV deletion 23714750
nsv565182 CNV loss 21841781
nsv565183 CNV loss 21841781

Variation tolerance for ABCD4 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.59; 97.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABCD4 Gene

Human Gene Mutation Database (HGMD)
ABCD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCD4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCD4 Gene

Disorders for ABCD4 Gene

MalaCards: The human disease database

(14) MalaCards diseases for ABCD4 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ABCD4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ABCD4_HUMAN
  • Methylmalonic aciduria and homocystinuria type cblJ (MAHCJ) [MIM:614857]: A disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl). Clinical features include feeding difficulties, poor growth, hypotonia, lethargy, anemia, and developmental delay. {ECO:0000269 PubMed:22922874}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ABCD4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ABCD4: view

No data available for Genatlas for ABCD4 Gene

Publications for ABCD4 Gene

  1. Primary structure of human PMP69, a putative peroxisomal ABC-transporter. (PMID: 9266848) Holzinger A … Roscher AA (Biochemical and biophysical research communications 1997) 2 3 4 23
  2. Genomic organization and chromosomal localization of the human peroxisomal membrane protein-1-like protein (PXMP1-L) gene encoding a peroxisomal ABC transporter. (PMID: 9599016) Holzinger A … Kammerer S (FEBS letters 1998) 3 4 23
  3. Identification of a fourth half ABC transporter in the human peroxisomal membrane. (PMID: 9302272) Shani N … Valle D (Human molecular genetics 1997) 2 3 4
  4. Translocation of the ABC transporter ABCD4 from the endoplasmic reticulum to lysosomes requires the escort protein LMBD1. (PMID: 27456980) Kawaguchi K … Imanaka T (Scientific reports 2016) 3 4
  5. Purification and interaction analyses of two human lysosomal vitamin B12 transporters: LMBD1 and ABCD4. (PMID: 25535791) Deme JC … Coulton JW (Molecular membrane biology 2014) 3 4

Products for ABCD4 Gene

Sources for ABCD4 Gene