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Aliases for ABCC5 Gene

Aliases for ABCC5 Gene

  • ATP Binding Cassette Subfamily C Member 5 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 2 3
  • Multi-Specific Organic Anion Transporter C 3 4
  • MOAT-C 3 4
  • PABC11 3 4
  • MRP5 3 4
  • SMRP 3 4
  • Canalicular Multispecific Organic Anion Transporter C 3
  • ATP-Binding Cassette Sub-Family C Member 5 4
  • Multidrug Resistance-Associated Protein 5 3
  • EST277145 3
  • ABC33 3
  • MOATC 3

External Ids for ABCC5 Gene

Previous GeneCards Identifiers for ABCC5 Gene

  • GC03M180375
  • GC03M184632
  • GC03M185039
  • GC03M184958
  • GC03M185120
  • GC03M183637
  • GC03M181047

Summaries for ABCC5 Gene

Entrez Gene Summary for ABCC5 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for ABCC5 Gene

ABCC5 (ATP Binding Cassette Subfamily C Member 5) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include ATPase activity and organic anion transmembrane transporter activity. An important paralog of this gene is ABCC12.

UniProtKB/Swiss-Prot for ABCC5 Gene

  • Acts as a multispecific organic anion pump which can transport nucleotide analogs.

Gene Wiki entry for ABCC5 Gene

Additional gene information for ABCC5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC5 Gene

Genomics for ABCC5 Gene

GeneHancer (GH) Regulatory Elements for ABCC5 Gene

Promoters and enhancers for ABCC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J184015 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 664.3 +1.0 1013 3.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ABCC5 YEATS2 HTR3D ENSG00000271682 RPS3P3 HTR3C EIF2B5 AP2M1 ALG3 CAMK2N2
GH03J184133 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 -117.2 -117223 3.1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 ZNF610 GLIS1 EIF2B5 ENSG00000273181 LOC105374249 ENSG00000272721 DVL3 VWA5B2 RPS3P3 POLR2H AP2M1 ABCC5-AS1
GH03J183975 Enhancer 1 ENCODE 21.6 +40.9 40887 2.7 HDGF PKNOX1 ATF1 ARNT ZNF121 ZNF766 ATF7 CAVIN1 NCOA1 ZNF592 ABCC5 HTR3C PARL RPSAP31 HTR3E-AS1 EIF2B5 EIF4G1 FAM131A VWA5B2 CAMK2N2
GH03J183913 Enhancer 0.7 ENCODE 22.7 +103.7 103748 2.8 SOX13 PKNOX1 FOXA2 SAP130 BATF IRF4 RARA CBX5 ATF7 NR2F6 ABCC5 PARL RPSAP31 EIF2B5 VWA5B2 HTR3C CAMK2N2 MAP6D1 CYP2AB1P PIR62380
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABCC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ABCC5 gene promoter:
  • CUTL1
  • AREB6
  • FOXL1
  • SRF (504 AA)
  • SRF
  • NF-1
  • E47
  • Tal-1beta
  • POU6F1 (c2)

Genomic Locations for ABCC5 Gene

Genomic Locations for ABCC5 Gene
98,082 bases
Minus strand
98,082 bases
Minus strand

Genomic View for ABCC5 Gene

Genes around ABCC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC5 Gene

Proteins for ABCC5 Gene

  • Protein details for ABCC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multidrug resistance-associated protein 5
    Protein Accession:
    Secondary Accessions:
    • B9EIQ2
    • O14517
    • Q29ZA9
    • Q29ZB1
    • Q86UX3
    • Q86W30
    • Q9UN85
    • Q9UNP5
    • Q9UQC3

    Protein attributes for ABCC5 Gene

    1437 amino acids
    Molecular mass:
    160660 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCC5 Gene


neXtProt entry for ABCC5 Gene

Post-translational modifications for ABCC5 Gene

  • Glycosylation at posLast=14171417, Asn1329, posLast=10441044, posLast=897897, Asn890, Asn684, Asn636, and Asn494
  • Ubiquitination at Lys383
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABCC5 Gene

Domains & Families for ABCC5 Gene

Gene Families for ABCC5 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for ABCC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC5: view

Function for ABCC5 Gene

Molecular function for ABCC5 Gene

UniProtKB/Swiss-Prot Function:
Acts as a multispecific organic anion pump which can transport nucleotide analogs.
GENATLAS Biochemistry:
ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 5

Phenotypes From GWAS Catalog for ABCC5 Gene

Gene Ontology (GO) - Molecular Function for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA,TAS --
GO:0008514 organic anion transmembrane transporter activity TAS --
GO:0016887 ATPase activity IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA --
GO:0043225 ATPase-coupled anion transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with ABCC5: view
genes like me logo Genes that share phenotypes with ABCC5: view

Animal Models for ABCC5 Gene

MGI Knock Outs for ABCC5:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC5

miRNA for ABCC5 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC5 Gene

Localization for ABCC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCC5 gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cell Junctions (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9827529
GO:0016020 membrane IDA 15297306
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABCC5: view

Pathways & Interactions for ABCC5 Gene

genes like me logo Genes that share pathways with ABCC5: view

Gene Ontology (GO) - Biological Process for ABCC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015711 organic anion transport IEA --
GO:0030213 hyaluronan biosynthetic process TAS --
GO:0055085 transmembrane transport TAS --
GO:0099133 ATP hydrolysis coupled anion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ABCC5: view

No data available for SIGNOR curated interactions for ABCC5 Gene

Drugs & Compounds for ABCC5 Gene

(29) Drugs for ABCC5 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Transporter, inducer Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2906
Probenecid Approved, Investigational Pharma Inhibition, Inhibitor, Activator, Transporter, inhibitor 35
Fluorouracil Approved Pharma Transporter, substrate RNA processing inhibitor and thymidylate synthase inhibitor 1970
Adefovir Dipivoxil Approved, Investigational Pharma Transporter, substrate 138
Dipyridamole Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor Adenosine transport inhibitor 84

(7) Additional Compounds for ABCC5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABCC5: view

Transcripts for ABCC5 Gene

Unigene Clusters for ABCC5 Gene

ATP-binding cassette, sub-family C (CFTR/MRP), member 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - - - - -
SP3: -
SP4: - -
SP5: -
SP6: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b
SP2: -

Relevant External Links for ABCC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ABCC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC5 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for ABCC5 Gene

This gene is overexpressed in Lung (59.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCC5 Gene

Protein tissue co-expression partners for ABCC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABCC5 Gene:


SOURCE GeneReport for Unigene cluster for ABCC5 Gene:


mRNA Expression by UniProt/SwissProt for ABCC5 Gene:

Tissue specificity: All isoforms are equally expressed in retina.

Evidence on tissue expression from TISSUES for ABCC5 Gene

  • Nervous system(4.8)
  • Pancreas(4.5)
  • Muscle(4.4)
  • Eye(4.3)
  • Bone marrow(4.2)
  • Intestine(2.2)
  • Kidney(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with ABCC5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC5 Gene

Orthologs for ABCC5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ABCC5 34
  • 96 (a)
(Canis familiaris)
Mammalia ABCC5 34 33
  • 92.6 (n)
(Ornithorhynchus anatinus)
Mammalia ABCC5 34
  • 91 (a)
(Monodelphis domestica)
Mammalia ABCC5 34
  • 89 (a)
(Mus musculus)
Mammalia Abcc5 16 34 33
  • 88.83 (n)
(Rattus norvegicus)
Mammalia Abcc5 33
  • 88.23 (n)
(Gallus gallus)
Aves ABCC5 33
  • 79.75 (n)
(Anolis carolinensis)
Reptilia ABCC5 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732220 33
  • 73.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68608 33
(Danio rerio)
Actinopterygii abcc5 34 33
  • 68.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7806 35
  • 29 (a)
Sur 34 35
  • 18 (a)
(Caenorhabditis elegans)
Secernentea mrp-5 33
  • 48.41 (n)
(Oryza sativa)
Liliopsida Os02g0288400 33
  • 45.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
Species where no ortholog for ABCC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ABCC5 Gene

Gene Tree for ABCC5 (if available)
Gene Tree for ABCC5 (if available)
Evolutionary constrained regions (ECRs) for ABCC5: view image

Paralogs for ABCC5 Gene

Paralogs for ABCC5 Gene

(21) SIMAP similar genes for ABCC5 Gene using alignment to 8 proteins:

  • H7C271_HUMAN
  • Q86UX3_HUMAN
genes like me logo Genes that share paralogs with ABCC5: view

Variants for ABCC5 Gene

Sequence variations from dbSNP and Humsavar for ABCC5 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs386352272 uncertain-significance, not provided 183,965,410(-) T/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000004346 -- 183,986,259(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000034633 -- 183,939,591(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000064311 -- 183,945,707(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000087614 -- 183,942,066(-) G/A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC5 Gene

Variant ID Type Subtype PubMed ID
esv1002813 CNV loss 20482838
esv25219 CNV loss 19812545
esv2678542 CNV deletion 23128226
esv2726293 CNV deletion 23290073
esv2726294 CNV deletion 23290073
esv3563008 CNV deletion 23714750
esv3598934 CNV gain 21293372
esv3598935 CNV gain 21293372
esv3598936 CNV gain 21293372
esv3893835 CNV loss 25118596
nsv1073270 CNV deletion 25765185
nsv1077428 CNV duplication 25765185
nsv520094 CNV loss 19592680
nsv592656 CNV gain 21841781
nsv955573 CNV deletion 24416366

Variation tolerance for ABCC5 Gene

Residual Variation Intolerance Score: 0.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABCC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC5 Gene

Disorders for ABCC5 Gene

Additional Disease Information for ABCC5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ABCC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCC5 Gene

Publications for ABCC5 Gene

  1. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. (PMID: 10840050) Wijnholds J … Borst P (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 22 25 58
  2. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky MG … Kruh GD (Journal of the National Cancer Institute 1998) 2 3 4 22 58
  3. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. (PMID: 12695538) Reid G … Borst P (Molecular pharmacology 2003) 3 22 25 58
  4. Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts. (PMID: 10721709) Suzuki T … Nishio K (Gene 2000) 3 4 22 58
  5. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. (PMID: 10893247) Jedlitschky G … Keppler D (The Journal of biological chemistry 2000) 3 22 25 58

Products for ABCC5 Gene

Sources for ABCC5 Gene

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