Aliases for ABCC4 Gene
- ATP Binding Cassette Subfamily C Member 4 2 3 5
- Multidrug Resistance-Associated Protein 4 2 3 4
- MOAT-B 2 3 4
- MRP4 2 3 4
- Canalicular Multispecific Organic Anion Transporter (ABC Superfamily) 2 3
- BA464I2.1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) 2 3
- Multi-Specific Organic Anion Transporter B 3 4
External Ids for ABCC4 Gene
Previous GeneCards Identifiers for ABCC4 Gene
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
GeneCards Summary for ABCC4 Gene
ABCC4 (ATP Binding Cassette Subfamily C Member 4) is a Protein Coding gene. Diseases associated with ABCC4 include Dubin-Johnson Syndrome and Biliary Tract Disease. Among its related pathways are Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include ATPase activity and 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. An important paralog of this gene is ABCC1.
UniProtKB/Swiss-Prot Summary for ABCC4 Gene
May be an organic anion pump relevant to cellular detoxification.