The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistan... See more...

Aliases for ABCC4 Gene

Aliases for ABCC4 Gene

  • ATP Binding Cassette Subfamily C Member 4 2 3 5
  • Multidrug Resistance-Associated Protein 4 2 3 4
  • MOAT-B 2 3 4
  • MRP4 2 3 4
  • Canalicular Multispecific Organic Anion Transporter (ABC Superfamily) 2 3
  • BA464I2.1 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) 2 3
  • Multi-Specific Organic Anion Transporter B 3 4
  • MRP/CMOAT-Related ABC Transporter 3 4
  • MOATB 2 3
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 2
  • ATP-Binding Cassette Sub-Family C Member 4 4
  • Multispecific Organic Anion Transporter B 2
  • EST170205 2
  • ABCC4 5

External Ids for ABCC4 Gene

Previous GeneCards Identifiers for ABCC4 Gene

  • GC13M094033
  • GC13M090059
  • GC13M094508
  • GC13M093370
  • GC13M094470
  • GC13M095672
  • GC13M076269

Summaries for ABCC4 Gene

Entrez Gene Summary for ABCC4 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for ABCC4 Gene

ABCC4 (ATP Binding Cassette Subfamily C Member 4) is a Protein Coding gene. Diseases associated with ABCC4 include Dubin-Johnson Syndrome and Biliary Tract Disease. Among its related pathways are Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include ATPase activity and 15-hydroxyprostaglandin dehydrogenase (NAD+) activity. An important paralog of this gene is ABCC1.

UniProtKB/Swiss-Prot Summary for ABCC4 Gene

  • May be an organic anion pump relevant to cellular detoxification.

Gene Wiki entry for ABCC4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABCC4 Gene

Genomics for ABCC4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ABCC4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J095297 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 262.6 +1.6 1560 5.6 BCLAF1 MYC IKZF1 ZNF600 ZNF592 CEBPA ZNF223 POLR2A NFIC ZIC2 ABCC4 HSALNG0098706 LOC102724149 lnc-CLDN10-8 lnc-ABCC4-1 lnc-CLDN10-9 SOX21
GH13J095324 Promoter/Enhancer 0.8 EPDnew Ensembl 271.6 -22.9 -22926 0.8 FEZF1 ZNF316 PRDM6 MAFK GATA2 CHD2 EMSY ABCC4 HSALNG0098710 HSALNG0098709 CLDN10
GH13J095265 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 21.8 +30.0 30025 11.7 MYC NCOR1 ZNF600 IKZF1 JUND ZNF592 CEBPA NFIC ZIC2 CEBPB piR-61945-127 ABCC4 lnc-CLDN10-9 RF00017-1334 SOX21
GH13J095285 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.3 +14.2 14174 5 NCOR1 IKZF1 ZNF600 ZNF580 ZNF592 ATF2 NFIC HES1 BHLHE40 FEZF1 ABCC4 DNAJC3-DT lnc-CLDN10-9 LOC102724149 SOX21
GH13J095241 Enhancer 1 Ensembl ENCODE 23.9 +56.7 56674 7.2 MYC IKZF1 NCOR1 ZNF592 NFIC BHLHE40 MBD2 TAF9B TAL1 ZNF316 ABCC4 RF00017-1334 piR-61945-127 SOX21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABCC4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ABCC4

Top Transcription factor binding sites by QIAGEN in the ABCC4 gene promoter:
  • ATF-2
  • c-Ets-1
  • C/EBPalpha
  • CUTL1
  • E4BP4
  • GR
  • GR-alpha
  • GR-beta
  • N-Myc
  • Sp1

Genomic Locations for ABCC4 Gene

Latest Assembly
281,641 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
281,617 bases
Minus strand

(GRCh37/hg19 by Ensembl)
281,605 bases
Minus strand

Genomic View for ABCC4 Gene

Genes around ABCC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC4 Gene

Proteins for ABCC4 Gene

  • Protein details for ABCC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Multidrug resistance-associated protein 4
    Protein Accession:
    Secondary Accessions:
    • A9Z1Z7
    • B7Z3Q7
    • Q8IVZ4
    • Q8IZN6
    • Q8NEW8
    • Q9Y6J2

    Protein attributes for ABCC4 Gene

    1325 amino acids
    Molecular mass:
    149527 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain).

    Alternative splice isoforms for ABCC4 Gene


neXtProt entry for ABCC4 Gene

Post-translational modifications for ABCC4 Gene

  • Glycosylation at Asn651, Asn690, Asn746, Asn754, Asn792, Asn1176, and Asn1309
  • Ubiquitination at Lys702, Lys1265, Lys1271, and Lys1289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABCC4 Gene

Domains & Families for ABCC4 Gene

Gene Families for ABCC4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for ABCC4 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52311, highly similar to Multidrug resistance-associated protein 4 (B7Z3Q7_HUMAN)
  • Multi-specific organic anion transporter B (MRP4_HUMAN)
  • ABC transporter MOAT-B isoform (O75555_HUMAN)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 4, isoform CRA_d (Q8IWU1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC4: view

Function for ABCC4 Gene

Molecular function for ABCC4 Gene

UniProtKB/Swiss-Prot Function:
May be an organic anion pump relevant to cellular detoxification.
GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 4

Phenotypes From GWAS Catalog for ABCC4 Gene

Gene Ontology (GO) - Molecular Function for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 29146910
GO:0005524 ATP binding IEA --
GO:0015216 purine nucleotide transmembrane transporter activity IMP 25986174
GO:0015431 glutathione S-conjugate-exporting ATPase activity IDA 17959747
genes like me logo Genes that share ontologies with ABCC4: view
genes like me logo Genes that share phenotypes with ABCC4: view

Animal Models for ABCC4 Gene

MGI Knock Outs for ABCC4:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC4

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC4 Gene

Localization for ABCC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC4 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCC4 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 3
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,IDA 15297306
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane ISS 18619525
GO:0016324 apical plasma membrane IDA 11856762
genes like me logo Genes that share ontologies with ABCC4: view

Pathways & Interactions for ABCC4 Gene

genes like me logo Genes that share pathways with ABCC4: view

Interacting Proteins for ABCC4 Gene

Gene Ontology (GO) - Biological Process for ABCC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0010033 response to organic substance IEA --
GO:0010243 response to organonitrogen compound IEA --
GO:0014070 response to organic cyclic compound IEA --
GO:0032310 prostaglandin secretion IDA 25173977
genes like me logo Genes that share ontologies with ABCC4: view

No data available for SIGNOR curated interactions for ABCC4 Gene

Drugs & Compounds for ABCC4 Gene

(80) Drugs for ABCC4 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR 1884
Mercaptopurine Approved Pharma Transporter, substrate 237
Zidovudine Approved Pharma Transporter, substrate 506
Dipyridamole Approved Pharma Transporter, inhibitor Adenosine transport inhibitor 97
Probenecid Approved, Investigational Pharma Transporter, inhibitor 45

(16) Additional Compounds for ABCC4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetate
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
  • 4'-Hydroxycelecoxib
  • 4’-Hydroxycelecoxib
  • Hydroxycelecoxib
O-Desmethylverapamil (D-702)

(1) ApexBio Compounds for ABCC4 Gene

Compound Action Cas Number
PTC124 (Ataluren) CFTR-G542X nonsense allele inhibitor 775304-57-9
genes like me logo Genes that share compounds with ABCC4: view

Drug products for research

Transcripts for ABCC4 Gene

mRNA/cDNA for ABCC4 Gene

23 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC4

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
SP1: - - - -
SP2: - - - - -
SP3: - -
SP5: -
SP6: -

ExUns: 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b
SP1: -
SP2: -
SP7: - - -

Relevant External Links for ABCC4 Gene

GeneLoc Exon Structure for

Expression for ABCC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABCC4 Gene

mRNA differential expression in normal tissues according to GTEx for ABCC4 Gene

This gene is overexpressed in Bladder (x5.2).

Protein differential expression in normal tissues from HIPED for ABCC4 Gene

This gene is overexpressed in Nasal epithelium (55.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCC4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ABCC4

SOURCE GeneReport for Unigene cluster for ABCC4 Gene:


mRNA Expression by UniProt/SwissProt for ABCC4 Gene:

Tissue specificity: Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Evidence on tissue expression from TISSUES for ABCC4 Gene

  • Kidney(4.6)
  • Nervous system(4.5)
  • Blood(3.2)
  • Stomach(3.1)
  • Liver(2.9)
  • Intestine(2.6)
  • Gall bladder(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with ABCC4: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC4 Gene

Orthologs for ABCC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ABCC4 29 30
  • 99.4 (n)
(Bos Taurus)
Mammalia ABCC4 30
  • 90 (a)
(Canis familiaris)
Mammalia ABCC4 29 30
  • 86.94 (n)
(Ornithorhynchus anatinus)
Mammalia ABCC4 30
  • 82 (a)
(Rattus norvegicus)
Mammalia Abcc4 29
  • 81.74 (n)
(Mus musculus)
Mammalia Abcc4 29 16 30
  • 81.61 (n)
(Monodelphis domestica)
Mammalia ABCC4 30
  • 81 (a)
(Gallus gallus)
Aves ABCC4 29 30
  • 74.9 (n)
(Anolis carolinensis)
Reptilia -- 30
  • 32 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia abcc4 29
  • 70.63 (n)
(Danio rerio)
Actinopterygii abcc4 29 30
  • 65.9 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG4562 29 31
  • 51.88 (n)
CG9270 31
  • 46 (a)
Sur 31
  • 43 (a)
CG7627 30 31
  • 42 (a)
Mrp4 30
  • 42 (a)
BEST:CK01227 31
  • 42 (a)
CG5789 31
  • 42 (a)
CG31792 30
  • 41 (a)
CG10505 31
  • 39 (a)
CG11897 31
  • 39 (a)
CG11898 31
  • 35 (a)
CG7806 31
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006427 29
  • 51.2 (n)
(Caenorhabditis elegans)
Secernentea mrp-6 29 31
  • 49.22 (n)
mrp-2 30
  • 30 (a)
mrp-4 30
  • 30 (a)
mrp-7 30
  • 29 (a)
C18C4.2 31
  • 24 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 30
  • 32 (a)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons MRP3 29
  • 45.62 (n)
(Oryza sativa)
Liliopsida Os01g0173900 29
  • 44.54 (n)
Os.33212 29
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 32 (a)
Species where no ortholog for ABCC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ABCC4 Gene

Gene Tree for ABCC4 (if available)
Gene Tree for ABCC4 (if available)
Evolutionary constrained regions (ECRs) for ABCC4: view image
Alliance of Genome Resources:
Additional Orthologs for ABCC4

Paralogs for ABCC4 Gene

Paralogs for ABCC4 Gene

(22) SIMAP similar genes for ABCC4 Gene using alignment to 4 proteins:

  • B7Z3Q7_HUMAN
genes like me logo Genes that share paralogs with ABCC4: view

Variants for ABCC4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ABCC4 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs11568644 Benign: not provided 95,053,126(-) G/Ap.Thr1142Met
NM_005845.4(ABCC4):c.3425C>T (p.Thr1142Met)
rs11568652 Benign: not provided 95,062,815(-) G/T
NM_005845.4(ABCC4):c.3255C>A (p.Ile1085=)
rs11568664 Likely Benign: not provided 95,170,619(-) A/G
NM_005845.4(ABCC4):c.1737T>C (p.Cys579=)
rs11568666 Benign: not provided 95,164,453(-) G/A
NM_005845.4(ABCC4):c.2100C>T (p.Ala700=)
rs11568669 Benign: not provided 95,186,754(-) T/Cp.Lys498Glu
NM_005845.4(ABCC4):c.1492A>G (p.Lys498Glu)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ABCC4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ABCC4 Gene

Variant ID Type Subtype PubMed ID
dgv1731n100 CNV gain 25217958
dgv3327n54 CNV gain 21841781
dgv575e212 CNV gain 25503493
esv1580429 CNV insertion 17803354
esv2393854 CNV deletion 18987734
esv2530045 CNV insertion 19546169
esv2666266 CNV deletion 23128226
esv2666461 CNV deletion 23128226
esv2672928 CNV deletion 23128226
esv2747844 CNV deletion 23290073
esv2903 CNV loss 18987735
esv3336662 CNV insertion 20981092
esv3427279 CNV duplication 20981092
esv3432022 CNV duplication 20981092
esv3550918 CNV deletion 23714750
esv3633238 CNV loss 21293372
esv3633239 CNV loss 21293372
esv3633240 CNV loss 21293372
esv3633241 CNV loss 21293372
esv3633242 CNV loss 21293372
nsv1043019 CNV gain 25217958
nsv1121498 CNV deletion 24896259
nsv1125576 CNV tandem duplication 24896259
nsv1129374 OTHER inversion 24896259
nsv1138253 CNV deletion 24896259
nsv1145689 CNV deletion 24896259
nsv1152339 CNV deletion 26484159
nsv456078 CNV gain 19166990
nsv456080 CNV gain 19166990
nsv471169 CNV gain 18288195
nsv517610 CNV gain+loss 19592680
nsv522179 CNV loss 19592680
nsv525194 CNV loss 19592680
nsv562767 CNV loss 21841781
nsv562768 CNV loss 21841781
nsv562769 CNV loss 21841781
nsv562770 CNV gain 21841781
nsv7246 OTHER inversion 18451855
nsv832688 CNV gain 17160897
nsv832689 CNV loss 17160897
nsv957466 CNV insertion 24416366

Variation tolerance for ABCC4 Gene

Residual Variation Intolerance Score: 33.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.48; 82.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABCC4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC4 Gene

Disorders for ABCC4 Gene

MalaCards: The human disease database

(16) MalaCards diseases for ABCC4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
dubin-johnson syndrome
  • djs
biliary tract disease
  • biliary tract abnormality
  • bile occlusion
fanconi-like syndrome
  • fanconi like syndrome
thiopurines, poor metabolism of, 1
  • thpm1
- elite association - COSMIC cancer census association via MalaCards
Search ABCC4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ABCC4

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ABCC4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC4 Gene

Publications for ABCC4 Gene

  1. Human skeletal muscle drug transporters determine local exposure and toxicity of statins. (PMID: 19940267) Knauer MJ … Tirona RG (Circulation research 2010) 3 22 25
  2. Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy. (PMID: 17083032) Izzedine H … Deray AG (The Journal of infectious diseases 2006) 3 22 40
  3. Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. (PMID: 14643890) Bai J … Tan TM (The international journal of biochemistry & cell biology 2004) 3 22 25
  4. The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. (PMID: 12835412) Reid G … Borst P (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 22 25
  5. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. (PMID: 12883481) Rius M … Keppler D (Hepatology (Baltimore, Md.) 2003) 3 22 25

Products for ABCC4 Gene

Sources for ABCC4 Gene