The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistan... See more...

Aliases for ABCC3 Gene

Aliases for ABCC3 Gene

  • ATP Binding Cassette Subfamily C Member 3 2 3 5
  • Canalicular Multispecific Organic Anion Transporter 2 2 3 4
  • MOAT-D 2 3 4
  • CMOAT2 2 3 4
  • MLP2 2 3 4
  • MRP3 2 3 4
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3 2 3
  • ATP-Binding Cassette Sub-Family C Member 3 3 4
  • Multi-Specific Organic Anion Transporter D 3 4
  • Multidrug Resistance-Associated Protein 3 3 4
  • EST90757 2 3
  • Canicular Multispecific Organic Anion Transporter 3
  • Multidrug Resistance Associated Protein 3
  • EC 3.6.3.44 50
  • EC 6.3.2.4 50
  • EC 7.6.2.- 4
  • EC 7.6.2.2 4
  • EC 7.6.2.3 4
  • EC 3.6.3 50
  • ABC31 3
  • ABCC3 5

External Ids for ABCC3 Gene

Previous GeneCards Identifiers for ABCC3 Gene

  • GC17P048425
  • GC17P051193
  • GC17P049054
  • GC17P049186
  • GC17P046067
  • GC17P048712
  • GC17P044080

Summaries for ABCC3 Gene

Entrez Gene Summary for ABCC3 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

CIViC Summary for ABCC3 Gene

GeneCards Summary for ABCC3 Gene

ABCC3 (ATP Binding Cassette Subfamily C Member 3) is a Protein Coding gene. Diseases associated with ABCC3 include Dubin-Johnson Syndrome and Extrahepatic Cholestasis. Among its related pathways are Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC1.

UniProtKB/Swiss-Prot Summary for ABCC3 Gene

  • ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813).

Gene Wiki entry for ABCC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABCC3 Gene

Genomics for ABCC3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ABCC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABCC3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ABCC3

Top Transcription factor binding sites by QIAGEN in the ABCC3 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • GR
  • GR-alpha
  • GR-beta
  • HNF-4alpha1
  • HNF-4alpha2
  • p53
  • Sp1

Genomic Locations for ABCC3 Gene

Latest Assembly
chr17:50,634,777-50,692,253
(GRCh38/hg38)
Size:
57,477 bases
Orientation:
Plus strand

Previous Assembly
chr17:48,712,242-48,769,614
(GRCh37/hg19 by Entrez Gene)
Size:
57,373 bases
Orientation:
Plus strand

chr17:48,712,138-48,769,613
(GRCh37/hg19 by Ensembl)
Size:
57,476 bases
Orientation:
Plus strand

Genomic View for ABCC3 Gene

Genes around ABCC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC3 Gene

Proteins for ABCC3 Gene

  • Protein details for ABCC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15438-MRP3_HUMAN
    Recommended name:
    ATP-binding cassette sub-family C member 3
    Protein Accession:
    O15438
    Secondary Accessions:
    • B2RPA9
    • D3DTX9
    • O60265
    • O60922
    • O75621
    • O95078
    • O95289
    • O95290
    • Q86X85
    • Q9UN52

    Protein attributes for ABCC3 Gene

    Size:
    1527 amino acids
    Molecular mass:
    169343 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB71756.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAD01430.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAD38185.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
    • [Isoform 4]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Alternative splice isoforms for ABCC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC3 Gene

Selected DME Specific Peptides for ABCC3 Gene

O15438:
  • SVGQRQL
  • GEIRIDG
  • LSGGQRQRV
  • ASTVGEI

Post-translational modifications for ABCC3 Gene

  • Glycosylation at Asn18, Asn1006, and Asn1007
  • Modification sites at PhosphoSitePlus

Domains & Families for ABCC3 Gene

Gene Families for ABCC3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for ABCC3 Gene

GenScript: Design optimal peptide antigens:
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 3, isoform CRA_b (D3DTY0_HUMAN)
  • Multidrug resistance-associated protein 3 (MRP3_HUMAN)
  • ABCC3 protein (Q2M3C9_HUMAN)
  • ABCC3 protein (Q86VN9_HUMAN)
  • Multidrug resistance associated protein (Q96QA9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15438

UniProtKB/Swiss-Prot:

MRP3_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC3: view

Function for ABCC3 Gene

Molecular function for ABCC3 Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out); Xref=Rhea:RHEA:50052, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:36257, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:O88563};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate; Xref=Rhea:RHEA:50056, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29746, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:O88563};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O + taurolithocholate sulfate(in) = ADP + H(+) + phosphate + taurolithocholate sulfate(out); Xref=Rhea:RHEA:50084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58301, ChEBI:CHEBI:456216; Evidence={ECO:0000250|UniProtKB:O88563};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90779, ChEBI:CHEBI:456216; EC=7.6.2.3; Evidence={ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066, ECO:0000269|PubMed:9827529};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).; EC=7.6.2.2; Evidence={ECO:0000269|PubMed:10359813, ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:9827529};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3beta-sulfooxy-androst-5-en-17-one(in) + ATP + H2O = 3beta-sulfooxy-androst-5-en-17-one(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:61364, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57905, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:15083066};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:11581266, ECO:0000269|PubMed:15083066};.
UniProtKB/Swiss-Prot Induction:
Strongly up-regulated under conditions of MRP2 deficiency.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=17.7 uM for oestradiol-17-(beta-D-glucuronide) {ECO:0000269|PubMed:11581266}; KM=24.2 uM for oestradiol-17-(beta-D-glucuronide) {ECO:0000269|PubMed:15083066}; KM=46.3 uM for dehydroepiandrosterone- 3-sulfate {ECO:0000269|PubMed:15083066}; Vmax=281 pmol/min/mg enzyme for dehydroepiandrosterone- 3-sulfate transport {ECO:0000269|PubMed:15083066}; Vmax=474 pmol/min/mg enzyme for oestradiol-17-(beta-D-glucuronide) transport {ECO:0000269|PubMed:11581266}; Vmax=71.5 pmol/min/mg enzyme for oestradiol-17-(beta-D-glucuronide) transport {ECO:0000269|PubMed:15083066};
GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 3,expressed in liver,colon,small intestine and prostate,involved in the adrenal glands,biliary and intestinal excretion of organic anions

Enzyme Numbers (IUBMB) for ABCC3 Gene

Phenotypes From GWAS Catalog for ABCC3 Gene

Gene Ontology (GO) - Molecular Function for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding IEA --
GO:0008514 organic anion transmembrane transporter activity IEA --
GO:0008559 xenobiotic transmembrane transporting ATPase activity IMP 18245269
GO:0015164 glucuronoside transmembrane transporter activity IDA 18698235
genes like me logo Genes that share ontologies with ABCC3: view
genes like me logo Genes that share phenotypes with ABCC3: view

Animal Models for ABCC3 Gene

MGI Knock Outs for ABCC3:

Animal Models for research

  • Taconic Biosciences Mouse Models for ABCC3

miRNA for ABCC3 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC3 Gene

Localization for ABCC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC3 Gene

Basolateral cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCC3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA,IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABCC3: view

Pathways & Interactions for ABCC3 Gene

genes like me logo Genes that share pathways with ABCC3: view

SIGNOR curated interactions for ABCC3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ABCC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006855 drug transmembrane transport IMP 11581266
GO:0015721 bile acid and bile salt transport TAS --
GO:0015722 canalicular bile acid transport ISS --
GO:0015779 glucuronoside transport IEA --
GO:0042908 xenobiotic transport IDA 18698235
genes like me logo Genes that share ontologies with ABCC3: view

Drugs & Compounds for ABCC3 Gene

(54) Drugs for ABCC3 Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Transporter, inducer Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum 3624
Doxorubicin Approved, Investigational Pharma Transporter, inhibitor Topo II inhibitor,immunosuppresive antineoplastic antibiotic 2106
Methotrexate Approved Pharma Transporter, substrate, inhibitor Folate antagonist,inhibits DFHR 1884
Vincristine Approved, Investigational Pharma Transporter, inhibitor Microtubule disrupter,antitumor agent 1112
Etoposide Approved Pharma Transporter, substrate, inhibitor Topo II inhibitor, Topoisomerase 2 Inhibitors 1532

(97) Additional Compounds for ABCC3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid
  • (3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-glucopyranosiduronate
  • Chenodeoxycholic acid 3-glucuronide
  • Chenodeoxycholic acid-3-b-D-glucuronide
  • Chenodeoxycholic acid-3-beta-delta-glucuronide
58814-71-4
1,3,12-Trihydroxycholan-24-oic acid
  • 1,3,12-Trihydroxycholan-24-Oate
  • 1,3,12-Trihydroxy-5b-cholanoate
  • 1,3,12-Trihydroxy-5b-cholanoic acid
  • 1,3,12-Trihydroxy-cholan-24-Oate
  • 1,3,12-Trihydroxy-cholan-24-Oic acid
63266-91-1
1,3,7,12-Tetrahydroxycholan-24-oic acid
  • 1,3,7,12-Tetrahydroxycholan-24-Oate
  • 1,3,7,12-Tetrahydroxy-cholan-24-Oate
  • 1,3,7,12-Tetrahydroxy-cholan-24-Oic acid
  • 1,3,7,12-Tetrahydroxycholanoate
  • 1,3,7,12-Tetrahydroxycholanoic acid
63266-89-7
12a-Hydroxy-3-oxocholadienic acid
  • 12a-Hydroxy-3-oxocholadienate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-Oate
  • 12a-Hydroxy-3-oxo-4,6-choladien-24-Oic acid
  • 12a-Hydroxy-3-oxo-chola-4,6-dienate
  • 12a-Hydroxy-3-oxo-chola-4,6-dienic acid
13535-96-1
12b-Hydroxy-5b-cholanoic acid
  • 12b-Hydroxy-5b-cholanoate
  • 12-Hydroxy-(5b,12b)-cholan-24-Oate
  • 12-Hydroxy-(5b,12b)-cholan-24-Oic acid
  • 12b-Hydroxy-5b-cholan-24-Oate
  • 12b-Hydroxy-5b-cholan-24-Oic acid
15173-23-6
genes like me logo Genes that share compounds with ABCC3: view

Transcripts for ABCC3 Gene

mRNA/cDNA for ABCC3 Gene

4 REFSEQ mRNAs :
22 NCBI additional mRNA sequence :
18 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC3

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a ·
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

ExUns: 20b ^ 21 ^ 22 ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ^ 25 ^ 26a · 26b · 26c ^ 27 ^ 28a · 28b ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33a · 33b ^
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4:
SP5: -
SP6: - -
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12: - -
SP13:
SP14:
SP15:
SP16:

ExUns: 34 ^ 35a · 35b · 35c ^ 36 ^ 37a · 37b · 37c · 37d
SP1: - - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6: - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -
SP16:

Relevant External Links for ABCC3 Gene

GeneLoc Exon Structure for
ABCC3

Expression for ABCC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABCC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC3 Gene

This gene is overexpressed in Adrenal Gland (x9.2), Liver (x7.7), Colon - Transverse (x5.6), and Pancreas (x4.2).

Protein differential expression in normal tissues from HIPED for ABCC3 Gene

This gene is overexpressed in Islet of Langerhans (27.8), Pancreas (10.9), and Adrenal (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCC3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ABCC3

SOURCE GeneReport for Unigene cluster for ABCC3 Gene:

Hs.463421

mRNA Expression by UniProt/SwissProt for ABCC3 Gene:

O15438-MRP3_HUMAN
Tissue specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney.

Evidence on tissue expression from TISSUES for ABCC3 Gene

  • Liver(4.7)
  • Blood(4.6)
  • Intestine(3.6)
  • Gall bladder(2.9)
  • Adrenal gland(2.5)
  • Stomach(2.5)
  • Kidney(2.5)
  • Skin(2.4)
  • Nervous system(2.4)
  • Lung(2.2)
  • Pancreas(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with ABCC3: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC3 Gene

Orthologs for ABCC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ABCC3 29 30
  • 94.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ABCC3 29 30
  • 86.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ABCC3 29 30
  • 85.92 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Abcc3 29 16 30
  • 82.45 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Abcc3 29
  • 81.65 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 77 (a)
OneToMany
-- 30
  • 70 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia ABCC3 30
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ABCC3 29 30
  • 67.8 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ABCC3 30
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia abcc3 29
  • 64.87 (n)
Zebrafish
(Danio rerio)
Actinopterygii ABCC3 30
  • 62 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta MRP 29
  • 57.2 (n)
CG6214 31
  • 47 (a)
Sur 31
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009835 29
  • 53.5 (n)
Worm
(Caenorhabditis elegans)
Secernentea mrp-7 29 31
  • 49.48 (n)
mrp-2 31
  • 45 (a)
mrp-8 31
  • 42 (a)
cft-1 30
  • 24 (a)
ManyToMany
C18C4.2 31
  • 23 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AGR047W 29
  • 48.26 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20075g 29
  • 47.8 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCF1 29 30
  • 46.78 (n)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons MRP10 29
  • 45.58 (n)
Rice
(Oryza sativa)
Liliopsida Os04g0209200 29
  • 48.35 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU09012 29
  • 51.85 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes abc2 29
  • 46.4 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 34 (a)
OneToMany
Species where no ortholog for ABCC3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ABCC3 Gene

ENSEMBL:
Gene Tree for ABCC3 (if available)
TreeFam:
Gene Tree for ABCC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ABCC3: view image
Alliance of Genome Resources:
Additional Orthologs for ABCC3

Paralogs for ABCC3 Gene

Paralogs for ABCC3 Gene

(20) SIMAP similar genes for ABCC3 Gene using alignment to 9 proteins:

  • MRP3_HUMAN
  • D3DTY0_HUMAN
  • D6RAB7_HUMAN
  • D6RJE5_HUMAN
  • H0Y8Q6_HUMAN
  • H0Y8T5_HUMAN
  • H0Y9T4_HUMAN
  • Q2M3C9_HUMAN
  • Q86VN9_HUMAN
genes like me logo Genes that share paralogs with ABCC3: view

Variants for ABCC3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ABCC3 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs114877000 Likely Benign: not provided 50,684,048(+) C/T
NM_003786.4(ABCC3):c.4054C>T (p.Leu1352Phe)
MISSENSE
rs11568582 Likely Benign: not provided 50,678,156(+) C/T
NM_003786.4(ABCC3):c.3642C>T (p.Ala1214=)
SYNONYMOUS
rs11568583 Benign: not provided 50,678,089(+) A/G
NM_003786.4(ABCC3):c.3579-4A>G
INTRON
rs11568589 Benign: not provided 50,684,002(+) G/A
NM_003786.4(ABCC3):c.4008G>A (p.Leu1336=)
SYNONYMOUS
rs149910028 Likely Benign: not provided 50,673,111(+) C/T
NM_003786.4(ABCC3):c.2382C>T (p.Ile794=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ABCC3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ABCC3 Gene

Variant ID Type Subtype PubMed ID
dgv42n68 CNV loss 17160897
esv2716038 CNV deletion 23290073
nsv2083 CNV insertion 18451855
nsv833477 CNV loss 17160897

Variation tolerance for ABCC3 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.81; 73.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABCC3 Gene

Human Gene Mutation Database (HGMD)
ABCC3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCC3
Leiden Open Variation Database (LOVD)
ABCC3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC3 Gene

Disorders for ABCC3 Gene

MalaCards: The human disease database

(22) MalaCards diseases for ABCC3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
dubin-johnson syndrome
  • djs
extrahepatic cholestasis
  • extrahepatic biliary stasis
cholestasis
  • bile occlusion
cholangiolocellular carcinoma
intrahepatic cholestasis of pregnancy
  • gravidic intrahepatic cholestasis
- elite association - COSMIC cancer census association via MalaCards
Search ABCC3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ABCC3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ABCC3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC3 Gene

Publications for ABCC3 Gene

  1. Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). (PMID: 11581266) Zelcer N … Borst P (The Journal of biological chemistry 2001) 3 4 22 25
  2. Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. (PMID: 9827529) Belinsky MG … Kruh GD (Journal of the National Cancer Institute 1998) 2 3 4 22
  3. Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients. (PMID: 19107936) Müller PJ … Risch A (International journal of cancer 2009) 3 22 40
  4. Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. (PMID: 19334674) Zehnpfennig B … Galla HJ (Biochemistry 2009) 3 22 25
  5. Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. (PMID: 17495421) Fukushima-Uesaka H … Sawada J (Drug metabolism and pharmacokinetics 2007) 3 22 40

Products for ABCC3 Gene

Sources for ABCC3 Gene