Aliases for ABCC2 Gene
External Ids for ABCC2 Gene
Previous HGNC Symbols for ABCC2 Gene
Previous GeneCards Identifiers for ABCC2 Gene
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCC2 Gene
ABCC2 (ATP Binding Cassette Subfamily C Member 2) is a Protein Coding gene. Diseases associated with ABCC2 include Dubin-Johnson Syndrome and Pseudoxanthoma Elasticum. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include transporter activity and protein domain specific binding. An important paralog of this gene is ABCC1.
UniProtKB/Swiss-Prot Summary for ABCC2 Gene
Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Also transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). May function as a cellular cisplatin transporter.