Aliases for ABCC2 Gene
External Ids for ABCC2 Gene
Previous HGNC Symbols for ABCC2 Gene
Previous GeneCards Identifiers for ABCC2 Gene
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCC2 Gene
ABCC2 (ATP Binding Cassette Subfamily C Member 2) is a Protein Coding gene. Diseases associated with ABCC2 include Dubin-Johnson Syndrome and Bilirubin Metabolic Disorder. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. Gene Ontology (GO) annotations related to this gene include transporter activity and protein domain specific binding. An important paralog of this gene is ABCC1.
UniProtKB/Swiss-Prot Summary for ABCC2 Gene
Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Also transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). May function as a cellular cisplatin transporter.