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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistan... See more...
Aliases for ABCC2 Gene
Aliases for ABCC2 Gene
External Ids for ABCC2 Gene
- HGNC: 53
- Entrez Gene: 1244
- Ensembl: ENSG00000023839
- OMIM: 601107
- UniProtKB: Q92887
Previous HGNC Symbols for ABCC2 Gene
- CMOAT
Previous GeneCards Identifiers for ABCC2 Gene
- GC10P100435
- GC10P100776
- GC10P101673
- GC10P101207
- GC10P101532
- GC10P095169
Summaries for ABCC2 Gene
-
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCC2 Gene
ABCC2 (ATP Binding Cassette Subfamily C Member 2) is a Protein Coding gene. Diseases associated with ABCC2 include Dubin-Johnson Syndrome and Bilirubin Metabolic Disorder. Among its related pathways are Statin Pathway - Generalized, Pharmacokinetics and Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. Gene Ontology (GO) annotations related to this gene include transporter activity and protein domain specific binding. An important paralog of this gene is ABCC1.
UniProtKB/Swiss-Prot Summary for ABCC2 Gene
-
Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Also transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). May function as a cellular cisplatin transporter.
Additional gene information for ABCC2 Gene
- HGNC(53)
- Entrez Gene(1244)
- Ensembl(ENSG00000023839)
- OMIM(601107)
- UniProtKB(Q92887)
- Open Targets Platform(ENSG00000023839)
- Monarch Initiative
- Search for ABCC2 at DataMed
- Search for ABCC2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABCC2 Gene
Genomics for ABCC2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ABCC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ABCC2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ABCC2
- Top Transcription factor binding sites by QIAGEN in the ABCC2 gene promoter:
-
- FOXC1
- FOXD3
- FOXI1
- FOXJ2
- FOXJ2 (long isoform)
- FOXL1
- GATA-2
- GATA-3
- HFH-3
- Sox5
Genomic Locations for ABCC2 Gene
Genomic Locations for ABCC2 Gene
- chr10:99,782,602-99,853,741
- (GRCh38/hg38)
- Size:
- 71,140 bases
- Orientation:
- Plus strand
- chr10:101,542,463-101,611,949
- (GRCh37/hg19)
- Size:
- 69,487 bases
- Orientation:
- Plus strand
Genomic View for ABCC2 Gene
Genes around ABCC2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.2 by HGNC
- 10q24.2 by Entrez Gene
- 10q24.2 by Ensembl
ABCC2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ABCC2 Gene
Proteins for ABCC2 Gene
-
Protein details for ABCC2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92887-MRP2_HUMAN
- Recommended name:
- Canalicular multispecific organic anion transporter 1
- Protein Accession:
- Q92887
- B2RMT8
- Q14022
- Q5T2B1
- Q92500
- Q92798
- Q99663
- Q9UMS2
Protein attributes for ABCC2 Gene
- Size:
- 1545 amino acids
- Molecular mass:
- 174207 Da
- Quaternary structure:
- No Data Available
Protein Expression for ABCC2 Gene
Post-translational modifications for ABCC2 Gene
Other Protein References for ABCC2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ABCC2 / MRP2 Antibody
- G Biosciences Immunotag™ ABCC2 Antibody
- NSJ Bioreagents MRP2 Antibody / ABCC2
- Creative Diagnostics Anti-ABCC2 monoclonal antibody, clone FQS21009
-
Creative Biolabs
- Recombinant Anti-human ABCC2 Antibody
- Recombinant Anti-human ABCC2 Antibody scFv Fragment
- Mouse Anti-ABCC2 (AA 215-310) Recombinant Antibody (CBFYM-0820)
- Hi-Affi™ Recombinant Rabbit Anti-ABCC2 Monoclonal Antibody (DS12AB)
- Mouse Anti-ABCC2 Recombinant Antibody (M2III-5)
- Mouse Anti-ABCC2 Recombinant Antibody (2H6)
- GeneTex Anti-MRP2 antibody [M2III-6] and Anti-MRP2 antibody
-
Custom Antibody ServicesOriGene Antibodies for ABCC2
- Novus Biologicals Antibodies for ABCC2
-
Abcam antibodies for ABCC2
- Invitrogen Antibodies for ABCC2 (AFLGC-ABCC2)
-
Biorbyt antibodies for ABCC2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ABCC2
- Sino Biological Antibodies for ABCC2
Protein Products
- Creative Biomart Recombinant Human ABCC2
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ABCC2
- Origene Custom Protein Services for ABCC2
- Novus Biologicals proteins for ABCC2
-
Abcam proteins for ABCC2
Assay Products
- antibodies-online: Show 6 available ABCC2 Elisa Kits ranked by validation data
- Compare Top ABCC2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ABCC2 Gene
Domains & Families for ABCC2 Gene
Gene Families for ABCC2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- FDA approved drug targets
- Plasma proteins
- Predicted membrane proteins
- Transporters
Protein Domains for ABCC2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ABCC2 Gene
- GenScript: Design optimal peptide antigens:
-
- Multidrug resistance-associated protein 2 (MRP2_HUMAN)
- Canalicular multispecific organic anion transporter (Q9UN90_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q92887UniProtKB/Swiss-Prot:
MRP2_HUMAN :- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
- Family:
-
- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Function for ABCC2 Gene
Molecular function for ABCC2 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:11500505). Also transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). May function as a cellular cisplatin transporter.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + taurolithocholate sulfate(in) = ADP + H(+) + phosphate + taurolithocholate sulfate(out); Xref=Rhea:RHEA:50084, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58301, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:16332456};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).; EC=7.6.2.2; Evidence={ECO:0000269|PubMed:11500505};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:11500505};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:11500505};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=8.2 uM for taurolithocholate sulfate {ECO:0000269|PubMed:16332456}; Vmax=1530 pmol/min/mg enzyme for taurolithocholate sulfate transport {ECO:0000269|PubMed:16332456};
- GENATLAS Biochemistry:
- ATP binding cassette superfamily,subfamily C (CFTR/MRP),member 2,mainly expressed in canilicular membranes of hepatocytes,also present in other apical domains of prolonged cells,such as the epithelial cells of proximal tubule of kidney
Enzyme Numbers (IUBMB) for ABCC2 Gene
Phenotypes From GWAS Catalog for ABCC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 17825285 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008514 | organic anion transmembrane transporter activity | IEA,TAS | 7559771 |
| GO:0008559 | xenobiotic transmembrane transporting ATPase activity | IEA | -- |
Phenotypes for ABCC2 Gene
- MGI mutant phenotypes for ABCC2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ABCC2:
Animal Models for ABCC2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ABCC2 - Select products 50% OFF >
- * ABCC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ABCC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCC2
miRNA for ABCC2 Gene
- miRTarBase miRNAs that target ABCC2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCC2
- Browse OriGene Inhibitory RNA Products For ABCC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC2
Clone Products
- Applied Biological Materials (abm): Clones for ABCC2 - Select products 50% OFF >
- * ABCC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ABCC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCC2
Cell Line Products
-
Horizon Cell Lines for ABCC2
No data available for Transcription Factor Targets and HOMER Transcription for ABCC2 Gene
Localization for ABCC2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ABCC2 Gene
- Apical cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IDA | 17825285 |
| GO:0016020 | membrane | IEA,IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABCC2 Gene
Pathways & Interactions for ABCC2 Gene
Pathways by source for ABCC2 Gene
7 BioSystems pathways for ABCC2 Gene
2 Reactome pathways for ABCC2 Gene
25 PharmGKB pathways for ABCC2 Gene
4 KEGG pathways for ABCC2 Gene
2 R&D Systems pathways for ABCC2 Gene
1 Qiagen pathway for ABCC2 Gene
- Hepatic ABC Transporters
1 Cell Signaling Technology pathway for ABCC2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006979 | response to oxidative stress | IEA | -- |
| GO:0007565 | female pregnancy | IEA | -- |
| GO:0009408 | response to heat | IEA | -- |
| GO:0010629 | negative regulation of gene expression | IEA,ISS | -- |
| GO:0015694 | mercury ion transport | IEA | -- |
Drugs & Compounds for ABCC2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cisplatin | Approved | Pharma | Transporter, inducer | Inhibits DNA synthesis,chemotherapy drug, Potent pro-apoptotic anticancer agent; activates caspase-3, Platinum | 3412 | |
| Methotrexate | Approved | Pharma | Transporter, substrate, inhibitor | Folate antagonist,inhibits DFHR | 1825 | |
| Pravastatin | Approved | Pharma | Inhibitor, Competitive, Transporter, substrate | 167 | ||
| Ritonavir | Approved, Investigational | Pharma | Transporter, substrate | HIV protease inhibitor | 1023 | |
| Sulfinpyrazone | Approved | Pharma | Target, Transporter, inhibitor, substrate, modulator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 3',4'-Dihydrodiol |
|
|
||||
| O-Desmethylverapamil (D-702) |
|
|
(4) ApexBio Compounds for ABCC2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CP 100356 hydrochloride | 142715-48-8 | |
| Fumitremorgin C | 118974-02-0 | |
| KS 176 | 1253452-78-6 | |
| Vinblastine sulfate | Anti-mitotic agent | 143-67-9 |
Transcripts for ABCC2 Gene
mRNA/cDNA for ABCC2 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000648689 1130 nts (view in UCSC)
- ENST00000647836 1021 nts (view in UCSC)
- ENST00000647814 5806 nts (view in UCSC)
- ENST00000648324 1503 nts (view in UCSC)
- ENST00000649932 1131 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ABCC2 - Select products 50% OFF >
- * ABCC2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ABCC2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCC2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCC2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCC2
- Browse OriGene Inhibitory RNA Products For ABCC2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC2
Clone Products
- Applied Biological Materials (abm): Clones for ABCC2 - Select products 50% OFF >
- * ABCC2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ABCC2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCC2
Relevant External Links for ABCC2 Gene
- GeneLoc Exon Structure for
- ABCC2
Expression for ABCC2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Liver (Hepatobiliary System)
- Brain (Nervous System)
- Endothelium (Cardiovascular System)
- Epithelial Cells (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for ABCC2 Gene
This gene is overexpressed in Liver (x33.3) and Kidney - Cortex (x4.4).
This gene is overexpressed in Oral epithelium (25.5), Liver (17.0), and Plasma (14.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCC2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ABCC2
SOURCE GeneReport for Unigene cluster for ABCC2 Gene:
Hs.368243mRNA Expression by UniProt/SwissProt for ABCC2 Gene:
Q92887-MRP2_HUMAN
Tissue specificity:
Expressed by polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Evidence on tissue expression from TISSUES for ABCC2 Gene
- Liver(4.8)
- Intestine(3.3)
- Kidney(3.2)
- Gall bladder(2.9)
- Blood(2.6)
- Stomach(2.5)
- Nervous system(2.4)
- Urine(2.4)
- Thyroid gland(2.2)
- Lung(2.2)
- Pancreas(2.1)
- Skin(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- urinary
Regions:
Head and neck:
- eye
- head
- mouth
Abdomen:
- biliary tract
- gallbladder
- kidney
- liver
- pancreas
- stomach
General:
- skin
Primer Products
-
OriGene qPCR primer pairs for ABCC2
Gene Expression Assay Products
Orthologs for ABCC2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | ABCC2 30 |
|
||
| MRP2 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | ABCC2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Abcc2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Abcc2 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ABCC2 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ABCC2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ABCC2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ABCC2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | abcc2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | abcc2 30 31 |
|
OneToOne | |
| zgc66072 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Sur 32 |
|
|
|
| MRP 31 |
|
ManyToMany | |||
| CG6214 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | mrp-2 32 |
|
|
|
| mrp-8 32 |
|
|
|||
| mrp-3 31 |
|
ManyToMany | |||
| mrp-7 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YCF1 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MRP1 30 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.9148 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany |
- Species where no ortholog for ABCC2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for ABCC2 Gene
- ENSEMBL:
- Gene Tree for ABCC2 (if available)
- TreeFam:
- Gene Tree for ABCC2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ABCC2: view image
Paralogs for ABCC2 Gene
Paralogs for ABCC2 Gene
(20) SIMAP similar genes for ABCC2 Gene using alignment to 2 proteins:
- MRP2_HUMAN
- Q5TCZ5_HUMAN
Pseudogenes.org Pseudogenes for ABCC2 Gene
Variants for ABCC2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ABCC2 Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 680397 | Likely Benign: not provided | 99,817,465(+) | T/G | MISSENSE_VARIANT | |
| 692030 | Pathogenic: Dubin-Johnson syndrome | 99,844,329(+) | G/A | NONSENSE | |
| 707868 | Conflicting Interpretations: Dubin-Johnson syndrome; not provided | 99,813,059(+) | T/C | MISSENSE_VARIANT | |
| 708493 | Conflicting Interpretations: Dubin-Johnson syndrome; not provided | 99,784,600(+) | G/A | INTRON_VARIANT | |
| 710646 | Likely Benign: not provided | 99,793,996(+) | A/G | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv506n106 | CNV | deletion | 24896259 |
| esv3423829 | CNV | duplication | 20981092 |
| nsv1046030 | CNV | loss | 25217958 |
| nsv1137953 | CNV | deletion | 24896259 |
| nsv825539 | CNV | loss | 20364138 |
| nsv825540 | CNV | gain | 20364138 |
| nsv831960 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.72;
78.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ABCC2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC2 Gene
Disorders for ABCC2 Gene
(34) MalaCards diseases for ABCC2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dubin-johnson syndrome |
|
|
| bilirubin metabolic disorder |
|
|
| pseudoxanthoma elasticum |
|
|
| cholestasis |
|
|
| intrahepatic cholestasis of pregnancy |
|
|
Search ABCC2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MRP2_HUMAN- Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. {ECO:0000269 PubMed:10053008, ECO:0000269 PubMed:10464142, ECO:0000269 PubMed:11093739, ECO:0000269 PubMed:11266082, ECO:0000269 PubMed:11477083, ECO:0000269 PubMed:22290738, ECO:0000269 PubMed:25336012, ECO:0000269 PubMed:9425227}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ABCC2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for ABCC2 Gene
Publications for ABCC2 Gene
- Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. (PMID: 11500505) Ito K … Cole SP (The Journal of biological chemistry 2001) 3 4 23 26
- A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. (PMID: 8797578) Taniguchi K … Kuwano M (Cancer research 1996) 2 3 4 23
- A nonsynonymous variation in MRP2/ABCC2 is associated with neurological adverse drug reactions of carbamazepine in patients with epilepsy. (PMID: 20216337) Kim WJ … Lee MG (Pharmacogenetics and genomics 2010) 3 23 41
- Multidrug resistance-related protein 2 genotype of the donor affects kidney graft function. (PMID: 19214140) Grisk O … Rettig R (Pharmacogenetics and genomics 2009) 3 23 41
- Telmisartan pharmacokinetics in Japanese renal transplant recipients. (PMID: 18838068) Miura M … Suzuki T (Clinica chimica acta; international journal of clinical chemistry 2009) 3 23 41
ExternalLinks
Products for ABCC2 Gene
- Custom Antibody ServicesOriGene Antibodies for ABCC2
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- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ABCC2
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Invitrogen Antibodies for ABCC2 (AFLGC-ABCC2)
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- VectorBuilder Custom and pre-made DNA vectors for ABCC2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ABCC2 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for ABCC2
- antibodies-online: Show 27 available ABCC2 Antibodies ranked by validation data
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- antibodies-online: Show 10 available ABCC2 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for ABCC2
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- Santa Cruz Biotechnology (SCBT) CRISPR for ABCC2
- Horizon Cell Lines for ABCC2
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCC2
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- Biorbyt antibodies for ABCC2
Sources for ABCC2 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (67) Reactome
- (68) GeneGo (Thomson Reuters)
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- (75) Invitrogen
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