This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistanc... See more...

Aliases for ABCC13 Gene

Aliases for ABCC13 Gene

  • ATP Binding Cassette Subfamily C Member 13 (Pseudogene) 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 13, Pseudogene 3
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 13 2
  • ATP-Binding Cassette Transporter C13 3
  • ATP-Binding Cassette Protein C13 3
  • C21orf73 3
  • ABCC13P 3
  • PRED6 3

External Ids for ABCC13 Gene

Previous GeneCards Identifiers for ABCC13 Gene

  • GC21P012310
  • GC21P014567
  • GC21P015647
  • GC21P001016

Summaries for ABCC13 Gene

Entrez Gene Summary for ABCC13 Gene

  • This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCC13 Gene

ABCC13 (ATP Binding Cassette Subfamily C Member 13 (Pseudogene)) is a Pseudogene. Gene Ontology (GO) annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.

Gene Wiki entry for ABCC13 Gene

Additional gene information for ABCC13 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABCC13 Gene

Genomics for ABCC13 Gene

GeneHancer (GH) Regulatory Elements for ABCC13 Gene

Promoters and enhancers for ABCC13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J014236 Enhancer 0.2 Ensembl 750.6 +0.1 95 0.2 ABCC13 lnc-RBM11-5 RBM11 LIPI piR-46662-412
GH21J014273 Promoter/Enhancer 0.9 Ensembl ENCODE 32.4 +37.7 37701 1 SP1 SCRT2 GATA3 NRF1 HNF4A MAX SIN3A ZBTB33 CBFA2T3 ABCC13 RBM11 piR-46662-412 lnc-RBM11-5
GH21J014266 Enhancer 0.3 Ensembl ENCODE 28.2 +30.9 30939 1.3 ABCC13 RBM11 piR-46662-412 lnc-RBM11-5
GH21J014874 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.3 +641.8 641795 8.8 GATA3 LCORL FOXA1 MLX NR2F1 NR2F6 ZNF217 MIXL1 ETV6 RELA ENSG00000235277 NRIP1 ABCC13 SAMSN1 piR-52079-126 lnc-RBM11-15 NONHSAG032404.2 LINC02246 ENSG00000235609
GH21J014259 Enhancer 0.5 ENCODE 7.4 +24.2 24192 2.5 CTCF RAD21 REST SMC3 GATA3 NFE2 IKZF1 RBM11 ABCC13 piR-46662-412 lnc-RBM11-5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABCC13 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ABCC13 gene promoter:
  • Brachyury
  • E4BP4
  • GATA-1
  • HNF-1
  • HNF-1A
  • Pax-4a
  • POU2F1
  • POU2F1a
  • Sox9
  • STAT1

Genomic Locations for ABCC13 Gene

Genomic Locations for ABCC13 Gene
chr21:14,236,206-14,362,754
(GRCh38/hg38)
Size:
126,549 bases
Orientation:
Plus strand
chr21:15,608,527-15,735,075
(GRCh37/hg19)
Size:
126,549 bases
Orientation:
Plus strand

Genomic View for ABCC13 Gene

Genes around ABCC13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC13 Gene

Proteins for ABCC13 Gene

Post-translational modifications for ABCC13 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ABCC13 Gene

Domains & Families for ABCC13 Gene

Gene Families for ABCC13 Gene

Suggested Antigen Peptide Sequences for ABCC13 Gene

GenScript: Design optimal peptide antigens:
  • Putative ATP-binding cassette sub-family C member 13 (ABCCD_HUMAN)
genes like me logo Genes that share domains with ABCC13: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ABCC13 Gene

Function for ABCC13 Gene

Phenotypes From GWAS Catalog for ABCC13 Gene

genes like me logo Genes that share phenotypes with ABCC13: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ABCC13 Gene

Localization for ABCC13 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ABCC13 Gene

Pathways & Interactions for ABCC13 Gene

PathCards logo

SuperPathways for ABCC13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ABCC13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ABCC13 Gene

Drugs & Compounds for ABCC13 Gene

No Compound Related Data Available

Transcripts for ABCC13 Gene

mRNA/cDNA for ABCC13 Gene

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC13 Gene

No ASD Table

Relevant External Links for ABCC13 Gene

GeneLoc Exon Structure for
ABCC13
ECgene alternative splicing isoforms for
ABCC13

Expression for ABCC13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCC13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ABCC13 Gene

This gene is overexpressed in Whole Blood (x18.8), Colon - Transverse (x13.4), and Small Intestine - Terminal Ileum (x11.7).

Protein differential expression in normal tissues from HIPED for ABCC13 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for ABCC13 Gene



Protein tissue co-expression partners for ABCC13 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABCC13 Gene:

ABCC13

SOURCE GeneReport for Unigene cluster for ABCC13 Gene:

Hs.366575
genes like me logo Genes that share expression patterns with ABCC13: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC13 Gene

Orthologs for ABCC13 Gene

Evolution for ABCC13 Gene

ENSEMBL:
Gene Tree for ABCC13 (if available)
TreeFam:
Gene Tree for ABCC13 (if available)

No data available for Orthologs for ABCC13 Gene

Paralogs for ABCC13 Gene

(4) SIMAP similar genes for ABCC13 Gene using alignment to 1 proteins:

  • ABCCD_HUMAN
genes like me logo Genes that share paralogs with ABCC13: view

No data available for Paralogs for ABCC13 Gene

Variants for ABCC13 Gene

Sequence variations from dbSNP and Humsavar for ABCC13 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000017349 -- 14,274,488(+) C/T intron_variant
rs1000023434 -- 14,296,003(+) T/A genic_downstream_transcript_variant, intron_variant
rs1000049924 -- 14,274,229(+) T/A intron_variant
rs1000261466 -- 14,279,761(+) G/A intron_variant
rs1000267566 -- 14,289,732(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC13 Gene

Variant ID Type Subtype PubMed ID
dgv1260e212 CNV loss 25503493
dgv4389n100 CNV gain 25217958
esv2446530 CNV insertion 19546169
esv3305555 CNV mobile element insertion 20981092
esv3307980 CNV mobile element insertion 20981092
esv3339161 CNV insertion 20981092
esv3365195 CNV insertion 20981092
esv3373510 CNV insertion 20981092
esv3646422 CNV gain 21293372
esv3646425 CNV gain 21293372
esv3893371 CNV gain 25118596
nsv459095 CNV gain 19166990
nsv470878 CNV gain 18288195
nsv520538 CNV gain 19592680
nsv587044 CNV gain 21841781

Additional Variant Information for ABCC13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ABCC13 Gene

Disorders for ABCC13 Gene

Additional Disease Information for ABCC13

No disorders were found for ABCC13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCC13 Gene

Publications for ABCC13 Gene

  1. Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages. (PMID: 15203202) Annilo T … Dean M (Genomics 2004) 2 3 56
  2. ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver. (PMID: 12445816) Yabuuchi H … Ishikawa T (Biochemical and biophysical research communications 2002) 2 3 56
  3. A genome-wide association study for reading and language abilities in two population cohorts. (PMID: 23738518) Luciano M … Bates TC (Genes, brain, and behavior 2013) 3 56
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 56

Products for ABCC13 Gene

Sources for ABCC13 Gene