Aliases for ABCC12 Gene
External Ids for ABCC12 Gene
Previous GeneCards Identifiers for ABCC12 Gene
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for ABCC12 Gene
ABCC12 (ATP Binding Cassette Subfamily C Member 12) is a Protein Coding gene. Diseases associated with ABCC12 include Dubin-Johnson Syndrome. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include ATPase activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC11.
UniProtKB/Swiss-Prot for ABCC12 Gene