The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in mu... See more...

Aliases for ABCC10 Gene

Aliases for ABCC10 Gene

  • ATP Binding Cassette Subfamily C Member 10 2 3 5
  • ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 10 2 3
  • ATP-Binding Cassette Sub-Family C Member 10 3 4
  • Multidrug Resistance-Associated Protein 7 3 4
  • SIMRP7 3 4
  • MRP7 3 4
  • EST182763 3

External Ids for ABCC10 Gene

Previous GeneCards Identifiers for ABCC10 Gene

  • GC06U990186
  • GC06P043391
  • GC06P043442
  • GC06P043503
  • GC06P043117
  • GC06P043396

Summaries for ABCC10 Gene

Entrez Gene Summary for ABCC10 Gene

  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

CIViC Summary for ABCC10 Gene

GeneCards Summary for ABCC10 Gene

ABCC10 (ATP Binding Cassette Subfamily C Member 10) is a Protein Coding gene. Among its related pathways are Tenofovir/Adefovir Pathway, Pharmacokinetics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include ATPase activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC3.

UniProtKB/Swiss-Prot Summary for ABCC10 Gene

  • ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.

Gene Wiki entry for ABCC10 Gene

Additional gene information for ABCC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABCC10 Gene

Genomics for ABCC10 Gene

GeneHancer (GH) Regulatory Elements for ABCC10 Gene

Promoters and enhancers for ABCC10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABCC10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ABCC10 gene promoter:
  • AREB6
  • C/EBPalpha
  • E47
  • Hand1
  • HEN1
  • HFH-1
  • LCR-F1
  • NF-1/L
  • Sp1
  • Spz1

Genomic Locations for ABCC10 Gene

Genomic Locations for ABCC10 Gene
chr6:43,427,366-43,451,980
(GRCh38/hg38)
Size:
24,615 bases
Orientation:
Plus strand
chr6:43,395,104-43,418,168
(GRCh37/hg19)
Size:
23,065 bases
Orientation:
Plus strand

Genomic View for ABCC10 Gene

Genes around ABCC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCC10 Gene

Proteins for ABCC10 Gene

  • Protein details for ABCC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T3U5-MRP7_HUMAN
    Recommended name:
    Multidrug resistance-associated protein 7
    Protein Accession:
    Q5T3U5
    Secondary Accessions:
    • Q8NHX7
    • Q9H7N2
    • Q9NXY3
    • Q9UF48

    Protein attributes for ABCC10 Gene

    Size:
    1492 amino acids
    Molecular mass:
    161629 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92227.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15736.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for ABCC10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCC10 Gene

Post-translational modifications for ABCC10 Gene

  • Ubiquitination at Lys460, Lys664, and Lys688
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ABCC10 Gene

Domains & Families for ABCC10 Gene

Gene Families for ABCC10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ABCC10 Gene

Suggested Antigen Peptide Sequences for ABCC10 Gene

GenScript: Design optimal peptide antigens:
  • ATP-binding cassette sub-family C member 10 (MRP7_HUMAN)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (Q5T3T7_HUMAN)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (Q5T3U2_HUMAN)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (Q5T3U3_HUMAN)
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (Q5T3U4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T3U5

UniProtKB/Swiss-Prot:

MRP7_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Family:
  • Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
genes like me logo Genes that share domains with ABCC10: view

Function for ABCC10 Gene

Molecular function for ABCC10 Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=57.8 uM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius) {ECO:0000269 PubMed:12527806}; Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees Celsius) {ECO:0000269 PubMed:12527806};
GENATLAS Biochemistry:
ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 10

Phenotypes From GWAS Catalog for ABCC10 Gene

Gene Ontology (GO) - Molecular Function for ABCC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA,IBA 21873635
genes like me logo Genes that share ontologies with ABCC10: view
genes like me logo Genes that share phenotypes with ABCC10: view

Animal Models for ABCC10 Gene

MGI Knock Outs for ABCC10:

Animal Model Products

  • Taconic Biosciences Mouse Models for ABCC10

CRISPR Products

miRNA for ABCC10 Gene

miRTarBase miRNAs that target ABCC10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC10 Gene

Localization for ABCC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCC10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCC10 gene
Compartment Confidence
plasma membrane 5
mitochondrion 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for ABCC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane HDA 17897319
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ABCC10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABCC10 Gene

Pathways & Interactions for ABCC10 Gene

genes like me logo Genes that share pathways with ABCC10: view

Gene Ontology (GO) - Biological Process for ABCC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034220 ion transmembrane transport IEA --
GO:0055085 transmembrane transport IEA,TAS --
GO:0099131 ATP hydrolysis coupled ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with ABCC10: view

No data available for SIGNOR curated interactions for ABCC10 Gene

Drugs & Compounds for ABCC10 Gene

(22) Drugs for ABCC10 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved, Investigational Pharma Transporter, substrate Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 2231
Paclitaxel Approved, Vet_approved Pharma Transporter, substrate, inhibitor Tubulin and Bcl2 inhibitor, Taxanes 3454
Vincristine Approved, Investigational Pharma Transporter, substrate, inhibitor Microtubule disrupter,antitumor agent 1046
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor, Transporter, inhibitor Immunosuppressive agent, Calcineurin inhibitor 0
Cytarabine Approved, Experimental, Investigational Pharma Transporter, substrate 1294

(1) Additional Compounds for ABCC10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ABCC10: view

Transcripts for ABCC10 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCC10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18a ·
SP1: - -
SP2: -
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9: -
SP10:
SP11: - - - -
SP12:

ExUns: 18b · 18c ^ 19a · 19b · 19c ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ABCC10 Gene

GeneLoc Exon Structure for
ABCC10
ECgene alternative splicing isoforms for
ABCC10

Expression for ABCC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCC10 Gene

Protein differential expression in normal tissues from HIPED for ABCC10 Gene

This gene is overexpressed in Monocytes (25.2), Tlymphocyte (19.3), Liver (9.5), and Ovary (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCC10 Gene



Protein tissue co-expression partners for ABCC10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABCC10 Gene:

ABCC10

SOURCE GeneReport for Unigene cluster for ABCC10 Gene:

Hs.55879

mRNA Expression by UniProt/SwissProt for ABCC10 Gene:

Q5T3U5-MRP7_HUMAN
Tissue specificity: Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.

Evidence on tissue expression from TISSUES for ABCC10 Gene

  • Intestine(4.3)
  • Spleen(4.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ABCC10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC10 Gene

Orthologs for ABCC10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCC10 33 32
  • 99.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ABCC10 33 32
  • 88.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ABCC10 33 32
  • 88.53 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Abcc10 32
  • 85.35 (n)
mouse
(Mus musculus)
Mammalia Abcc10 17 33 32
  • 85.18 (n)
oppossum
(Monodelphis domestica)
Mammalia ABCC10 33
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ABCC10 33
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ABCC10 33 32
  • 64.27 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ABCC10 33
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216149 32
  • 59.55 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC556709 32
  • 60.06 (n)
Dr.16618 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6670 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007917 32
  • 49.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7806 33 32
  • 48.51 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BPT1 33
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons MRP11 32
  • 46.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10668 33
  • 42 (a)
OneToOne
Species where no ortholog for ABCC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ABCC10 Gene

ENSEMBL:
Gene Tree for ABCC10 (if available)
TreeFam:
Gene Tree for ABCC10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ABCC10: view image

Paralogs for ABCC10 Gene

Paralogs for ABCC10 Gene

(24) SIMAP similar genes for ABCC10 Gene using alignment to 3 proteins:

  • MRP7_HUMAN
  • D6R9B3_HUMAN
  • H0Y904_HUMAN
genes like me logo Genes that share paralogs with ABCC10: view

Variants for ABCC10 Gene

Sequence variations from dbSNP and Humsavar for ABCC10 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000144165 -- 43,443,353(+) T/C intron_variant
rs1000429626 -- 43,437,011(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000434065 -- 43,430,759(+) G/C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000534219 -- 43,441,629(+) A/G intron_variant
rs1000885104 -- 43,436,746(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ABCC10 Gene

Variant ID Type Subtype PubMed ID
esv3416007 CNV duplication 20981092
nsv603000 CNV loss 21841781
nsv950172 CNV deletion 24416366

Variation tolerance for ABCC10 Gene

Residual Variation Intolerance Score: 21.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.54; 86.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABCC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC10 Gene

Disorders for ABCC10 Gene

Additional Disease Information for ABCC10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ABCC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCC10 Gene

Publications for ABCC10 Gene

  1. Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel. (PMID: 15256465) Hopper-Borge E … Kruh GD (Cancer research 2004) 3 4 23 56
  2. Genomic structure, gene expression, and promoter analysis of human multidrug resistance-associated protein 7. (PMID: 12566991) Kao HH … Huang JD (Journal of biomedical science 2003) 3 4 23 56
  3. Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. (PMID: 19720054) Kuang YH … Chen ZS (Biochemical pharmacology 2010) 3 23 56
  4. Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. (PMID: 19118001) Hopper-Borge E … Kruh GD (Cancer research 2009) 3 23 56
  5. Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance. (PMID: 19150344) Zhou Y … Chen ZS (Biochemical pharmacology 2009) 3 23 56

Products for ABCC10 Gene

Sources for ABCC10 Gene