Aliases for ABCC1 Gene
- ATP Binding Cassette Subfamily C Member 1 2 3 5
- ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 2 3
- Multidrug Resistance-Associated Protein 1 3 4
- Leukotriene C(4) Transporter 3 4
- LTC4 Transporter 3 4
- MRP1 3 4
- MRP 3 4
- ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&14 3
- ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25&26 3
- ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13 3
External Ids for ABCC1 Gene
Previous HGNC Symbols for ABCC1 Gene
Previous GeneCards Identifiers for ABCC1 Gene
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
GeneCards Summary for ABCC1 Gene
ABCC1 (ATP Binding Cassette Subfamily C Member 1) is a Protein Coding gene. Diseases associated with ABCC1 include Dubin-Johnson Syndrome and Pseudoxanthoma Elasticum. Among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Methotrexate Pathway, Pharmacokinetics. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC3.
UniProtKB/Swiss-Prot for ABCC1 Gene
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.