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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
ABCC1 (ATP Binding Cassette Subfamily C Member 1) is a Protein Coding gene. Diseases associated with ABCC1 include Dubin-Johnson Syndrome and Pseudoxanthoma Elasticum. Among its related pathways are Arachidonic acid metabolism and Sphingolipid signaling pathway. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC3.
ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0005524 | ATP binding | IEA | -- |
GO:0008514 | organic anion transmembrane transporter activity | IBA | -- |
GO:0008559 | xenobiotic transmembrane transporting ATPase activity | IBA | 21873635 |
GO:0015420 | cobalamin-transporting ATPase activity | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | IDA,TAS | -- |
GO:0005887 | integral component of plasma membrane | IEA | -- |
GO:0009925 | basal plasma membrane | IDA | 18619525 |
GO:0016020 | membrane | IEA,IBA | 21873635 |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006691 | leukotriene metabolic process | TAS | -- |
GO:0009235 | cobalamin metabolic process | TAS | -- |
GO:0015889 | cobalamin transport | IEA | -- |
GO:0034775 | glutathione transmembrane transport | IBA | 21873635 |
GO:0042493 | response to drug | IEA,ISS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Doxorubicin | Approved, Investigational | Pharma | Transporter, substrate, inhibitor | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 2029 | |
Irinotecan | Approved, Investigational | Pharma | Transporter, substrate | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1414 | |
Methotrexate | Approved | Pharma | Transporter, substrate, inhibitor | Folate antagonist,inhibits DFHR | 1825 | |
Ritonavir | Approved, Investigational | Pharma | Transporter, inhibitor, inducer | HIV protease inhibitor | 1023 | |
Sulfinpyrazone | Approved | Pharma | Target, Transporter, inhibitor, modulator | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
4'-Hydroxydiclofenac |
|
64118-84-9 | ||||
O-Desmethylverapamil (D-702) |
|
|
Compound | Action | Cas Number |
---|---|---|
Fumitremorgin C | Inhibitor of BCRP-mediated multidrug resistance | 118974-02-0 |
Ko 143 | Potent and selective BCRP inhibitor | 461054-93-3 |
Pyrimethamine | Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor | 58-14-0 |
Compound | Action | Cas Number |
---|---|---|
CP 100356 hydrochloride | 142715-48-8 | |
Dofequidar fumarate | MDR reversal agent | 153653-30-6 |
Fumitremorgin C | 118974-02-0 | |
KS 176 | 1253452-78-6 | |
Reversan | 313397-13-6 | |
Tariquidar methanesulfonate, hydrate | P-glycoprotein inhibitor, potent and selective | 625375-83-9 |
Vinblastine sulfate | Anti-mitotic agent | 143-67-9 |
Zosuquidar | MDR modulator | 167354-41-8 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: |
ExUns: | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||
SP2: | |||||||||||||||||||||||
SP3: | |||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ABCC1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MRP1 31 |
|
OneToOne | |
ABCC1 30 |
|
||||
Cow (Bos Taurus) |
Mammalia | ABCC1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ABCC1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ABCC1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Abcc1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Abcc1 30 |
|
||
Chicken (Gallus gallus) |
Aves | ABCC1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ABCC1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.3748 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ABCC1 31 |
|
OneToOne | |
abcc1 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG6214 32 |
|
|
|
Sur 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | mrp-2 30 32 |
|
||
mrp-7 32 |
|
|
|||
mrp-8 31 32 |
|
ManyToMany | |||
C18C4.2 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YCF1 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MRP5 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3011 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os03g0142800 30 |
|
||
Os.5631 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.4445 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.28932 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.6283 30 |
|
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711596 | Likely Benign: not provided | 16,124,784(+) | C/T | INTRON_VARIANT | |
714075 | Benign: not provided | 16,115,084(+) | G/A | INTRON_VARIANT | |
714692 | Benign: not provided | 16,122,020(+) | G/A | MISSENSE_VARIANT | |
715982 | Benign: not provided | 16,083,536(+) | C/T | SYNONYMOUS_VARIANT | |
736797 | Likely Benign: not provided | 16,125,818(+) | G/A | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
dubin-johnson syndrome |
|
|
pseudoxanthoma elasticum |
|
|
colchicine resistance |
|
|
lung cancer |
|
|
colon adenocarcinoma |
|