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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug ... See more...
Aliases for ABCC1 Gene
Aliases for ABCC1 Gene
- ATP Binding Cassette Subfamily C Member 1 2 3 5
- ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 2 3
- Glutathione-S-Conjugate-Translocating ATPase ABCC1 3 4
- Multidrug Resistance-Associated Protein 1 3 4
- Leukotriene C(4) Transporter 3 4
- LTC4 Transporter 3 4
- GS-X 2 3
- MRP1 3 4
- MRP 3 4
- ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&14 3
- ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25&26 3
External Ids for ABCC1 Gene
- HGNC: 51
- NCBI Entrez Gene: 4363
- Ensembl: ENSG00000103222
- OMIM®: 158343
- UniProtKB/Swiss-Prot: P33527
Previous HGNC Symbols for ABCC1 Gene
- MRP
- MRP1
Previous GeneCards Identifiers for ABCC1 Gene
- GC16P015870
- GC16P015325
- GC16P016009
- GC16P015950
- GC16P016043
- GC16P015437
Summaries for ABCC1 Gene
-
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
GeneCards Summary for ABCC1 Gene
ABCC1 (ATP Binding Cassette Subfamily C Member 1) is a Protein Coding gene. Diseases associated with ABCC1 include Deafness, Autosomal Dominant 77 and Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna. Among its related pathways are Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC3.
UniProtKB/Swiss-Prot Summary for ABCC1 Gene
-
Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).
-
ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.
Additional gene information for ABCC1 Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ABCC1 Gene
Genomics for ABCC1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ABCC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ABCC1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ABCC1
- Top Transcription factor binding sites by QIAGEN in the ABCC1 gene promoter:
-
- AP-1
- c-Fos
Genomic Locations for ABCC1 Gene
Latest Assembly
- chr16:15,949,138-16,143,257
- (GRCh38/hg38)
- Size:
- 194,120 bases
- Orientation:
- Plus strand
Previous Assembly
- chr16:16,043,473-16,236,910
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 193,438 bases
- Orientation:
- Plus strand
Alternative Locations (GRCh38/hg38)
- chr16(ALT_REF_LOCI_1):1,607,598-1,800,945 (+)
Genomic View for ABCC1 Gene
Genes around ABCC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.11 by HGNC
- 16p13.11 by Entrez Gene
- 16p13.11 by Ensembl
ABCC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ABCC1 Gene
Proteins for ABCC1 Gene
-
Protein details for ABCC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33527-MRP1_HUMAN
- Recommended name:
- Multidrug resistance-associated protein 1
- Protein Accession:
- P33527
- A3RJX2
- C9JPJ4
- O14819
- O43333
- P78419
- Q59GI9
- Q9UQ97
- Q9UQ99
- Q9UQA0
Protein attributes for ABCC1 Gene
- Size:
- 1531 amino acids
- Molecular mass:
- 171591 Da
- Quaternary structure:
- No Data Available
Protein Expression for ABCC1 Gene
Selected DME Specific Peptides for ABCC1 Gene
- P33527:
-
- LSGGQKQRV
- SVGQRQL
Post-translational modifications for ABCC1 Gene
Other Protein References for ABCC1 Gene
Antibodies for research
- G Biosciences Immunotag™ ABCC1 Antibody
- GeneTex Anti-MRP1 antibody [N1N2], N-term and Anti-MRP1 antibody
- NSJ Bioreagents MRP1 Antibody
-
BioLegend
- Anti-MRP1 (ABCC1)
- MRP1 (ABCC1) Antibody (370202)
- MRP1 (ABCC1) Antibody (370204)
- MRP1 (ABCC1) Antibody (370302)
- MRP1 (ABCC1) Antibody (370403)
- MRP1 (ABCC1) Antibody (370303)
- MRP1 (ABCC1) Antibody (370304)
- MRP1 (ABCC1) Antibody (370404)
- MRP1 (ABCC1) Antibody (370203)
- MRP1 (ABCC1) Antibody (370402)
- MRP1 (ABCC1) Antibody (370102)
- MRP1 (ABCC1) Antibody (370103)
- MRP1 (ABCC1) Antibody (370104)
- MRP1 (ABCC1) Antibody (370306)
- MRP1 (ABCC1) Antibody (370305)
- MRP1 (ABCC1) Antibody (370308)
- MRP1 (ABCC1) Antibody (370106)
-
Custom Antibody ServicesOriGene Antibodies for ABCC1
- Novus Biologicals Antibodies for ABCC1
-
Abcam antibodies for ABCC1
- Invitrogen Antibodies for ABCC1 (AFLGC-ABCC1)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ABCC1
Protein products for research
-
OriGene Purified Proteins for ABCC1
- Search Origene for MassSpec and Protein Over-expression Lysates for ABCC1
- Origene Custom Protein Services for ABCC1
- Novus Biologicals proteins for ABCC1
- antibodies-online: Show 13 available ABCC1 Proteins ranked by validation data
- Compare Top ABCC1 Proteins
-
Quality Products:
-
Abcam proteins for ABCC1
Assay products for research
Domains & Families for ABCC1 Gene
Gene Families for ABCC1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Plasma proteins
- Predicted membrane proteins
- Transporters
Protein Domains for ABCC1 Gene
Suggested Antigen Peptide Sequences for ABCC1 Gene
- GenScript: Design optimal peptide antigens:
-
- Leukotriene C(4) transporter (MRP1_HUMAN)
- Multidrug resistance protein (Q9UQ98_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P33527UniProtKB/Swiss-Prot:
MRP1_HUMAN :- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
- Family:
-
- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Function for ABCC1 Gene
Molecular function for ABCC1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).; EC=7.6.2.2; Evidence={ECO:0000269|PubMed:9281595};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate; Xref=Rhea:RHEA:19121, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:90779, ChEBI:CHEBI:456216; EC=7.6.2.3; Evidence={ECO:0000250|UniProtKB:O35379};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + sphing-4-enine 1-phosphate(in) = ADP + H(+) + phosphate + sphing-4-enine 1-phosphate(out); Xref=Rhea:RHEA:38951, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60119, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:17050692};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate; Xref=Rhea:RHEA:38963, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57973, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:7961706, ECO:0000269|PubMed:9281595};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:60128, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:82961, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:9281595};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + daunorubicin(in) + H2O = ADP + daunorubicin(out) + H(+) + phosphate; Xref=Rhea:RHEA:33147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64677, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:9281595};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + H2O + vincristine(in) = ADP + H(+) + phosphate + vincristine(out); Xref=Rhea:RHEA:60160, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143658, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:9281595};.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=97 nM for leukotriene C4 {ECO:0000269|PubMed:7961706}; KM=19 uM for ATP {ECO:0000269|PubMed:7961706}; KM=98 nM for leukotriene C4 {ECO:0000269|PubMed:9281595}; KM=4.8 uM for 17beta-estradiol 17-glucosiduronic acid {ECO:0000269|PubMed:9281595}; Vmax=100 pmol/min/mg enzyme for leukotriene C4 transport {ECO:0000269|PubMed:7961706}; Vmax=920 pmol/min/mg enzyme for leukotriene C4 transport {ECO:0000269|PubMed:9281595}; Vmax=1.4 nmol/min/mg enzyme for 17beta-estradiol 17-glucosiduronic acid transport {ECO:0000269|PubMed:9281595};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- MK 571 inhibits sphingosine 1-phosphate and leukotriene C4 export.
- GENATLAS Biochemistry:
- ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with several alternatively spliced forms,also containing a CGG repeat in 5'utr
Enzyme Numbers (IUBMB) for ABCC1 Gene
Phenotypes From GWAS Catalog for ABCC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008559 | xenobiotic transmembrane transporting ATPase activity | IBA | 21873635 |
| GO:0015420 | cobalamin-transporting ATPase activity | TAS | -- |
| GO:0015431 | glutathione S-conjugate-exporting ATPase activity | ISS | -- |
Phenotypes for ABCC1 Gene
- MGI mutant phenotypes for ABCC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ABCC1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Dynamic nuclei (hole, folded or small irregular)
- Increased S DNA content
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased shRNA abundance
- Increased Nanog expression
- Increased HPV16-GFP infection
- Decreased Salmonella enterica Typhimurium invasion
Animal Models for research
-
Taconic Biosciences Mouse Models for ABCC1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ABCC1 - Starting at $85 >
- * ABCC1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ABCC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCC1
miRNA for ABCC1 Gene
- miRTarBase miRNAs that target ABCC1
-
- hsa-miR-345-5p (MIRT003198)
- hsa-miR-7-5p (MIRT003199)
- hsa-miR-134-5p (MIRT004494)
- hsa-miR-9-5p (MIRT021440)
- hsa-miR-1-3p (MIRT024051)
- hsa-miR-98-5p (MIRT027818)
- hsa-let-7b-5p (MIRT032483)
- hsa-miR-615-3p (MIRT040354)
- hsa-miR-339-5p (MIRT042744)
- hsa-miR-125b-5p (MIRT046005)
- hsa-miR-23b-3p (MIRT046316)
- hsa-miR-16-5p (MIRT051224)
- hsa-miR-1291 (MIRT053213)
- hsa-miR-3180-5p (MIRT706001)
- hsa-miR-524-5p (MIRT706002)
- hsa-miR-520d-5p (MIRT706003)
- hsa-miR-361-3p (MIRT706004)
- hsa-miR-1825 (MIRT706005)
- hsa-miR-548o-3p (MIRT706006)
- hsa-miR-1323 (MIRT706007)
- hsa-miR-5195-3p (MIRT706008)
- hsa-miR-5582-3p (MIRT706009)
- hsa-miR-145-5p (MIRT706010)
- hsa-miR-199a-5p (MIRT706011)
- hsa-miR-199b-5p (MIRT706012)
- hsa-miR-224-5p (MIRT706013)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCC1
- Browse OriGene Inhibitory RNA Products For ABCC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC1
Clone products for research
- Applied Biological Materials (abm): Clones for ABCC1 - Starting at $45 >
- * ABCC1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ABCC1
- Addgene plasmids for ABCC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCC1
Cell Lines for research
-
Horizon Cell Lines for ABCC1
No data available for Transcription Factor Targets and HOMER Transcription for ABCC1 Gene
Localization for ABCC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ABCC1 Gene
- Cell membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| golgi apparatus | 1 |
- Cell Junctions (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 1360704 |
| GO:0009925 | basal plasma membrane | IDA | 18619525 |
| GO:0016020 | membrane | TAS,IBA | 21873635 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ABCC1 Gene
Pathways by source for ABCC1 Gene
3 BioSystems pathways for ABCC1 Gene
9 Reactome pathways for ABCC1 Gene
5 KEGG pathways for ABCC1 Gene
2 R&D Systems pathways for ABCC1 Gene
1 Cell Signaling Technology pathway for ABCC1 Gene
Interacting Proteins for ABCC1 Gene
GPS-Prot Interaction Network for ABCC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006691 | leukotriene metabolic process | TAS | -- |
| GO:0009235 | cobalamin metabolic process | TAS | -- |
| GO:0015889 | cobalamin transport | IEA | -- |
| GO:0034775 | glutathione transmembrane transport | IBA | 21873635 |
| GO:0042493 | response to drug | ISS | -- |
Drugs & Compounds for ABCC1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Doxorubicin | Approved, Investigational | Pharma | Transporter, substrate, inhibitor | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 2106 | |
| Irinotecan | Approved, Investigational | Pharma | Transporter, substrate | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1504 | |
| Methotrexate | Approved | Pharma | Transporter, substrate, inhibitor | Folate antagonist,inhibits DFHR | 1884 | |
| Ritonavir | Approved, Investigational | Pharma | Transporter, inhibitor, inducer | HIV protease inhibitor | 1042 | |
| Sulfinpyrazone | Approved | Pharma | Target, Transporter, inhibitor, modulator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4'-Hydroxydiclofenac |
|
64118-84-9 | ||||
| O-Desmethylverapamil (D-702) |
|
(3) Tocris Compounds for ABCC1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Fumitremorgin C | Inhibitor of BCRP-mediated multidrug resistance | 118974-02-0 |
| Ko 143 | Potent and selective BCRP inhibitor | 461054-93-3 |
| Pyrimethamine | Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor | 58-14-0 |
(8) ApexBio Compounds for ABCC1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| CP 100356 hydrochloride | 142715-48-8 | |
| Dofequidar fumarate | MDR reversal agent | 153653-30-6 |
| Fumitremorgin C | 118974-02-0 | |
| KS 176 | 1253452-78-6 | |
| Reversan | 313397-13-6 | |
| Tariquidar methanesulfonate, hydrate | P-glycoprotein inhibitor, potent and selective | 625375-83-9 |
| Vinblastine sulfate | Anti-mitotic agent | 143-67-9 |
| Zosuquidar | MDR modulator | 167354-41-8 |
Transcripts for ABCC1 Gene
mRNA/cDNA for ABCC1 Gene
- 7 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000399408 6594 nts (view in UCSC)
- ENST00000399410 6504 nts (view in UCSC)
- ENST00000572882 6387 nts (view in UCSC)
- ENST00000574224 2616 nts (view in UCSC)
- ENST00000574761 996 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for ABCC1 - Starting at $85 >
- * ABCC1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for ABCC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCC1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCC1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCC1
- Browse OriGene Inhibitory RNA Products For ABCC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC1
Clone products for research
- Applied Biological Materials (abm): Clones for ABCC1 - Starting at $45 >
- * ABCC1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for ABCC1
- Addgene plasmids for ABCC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCC1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
| ExUns: | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: |
Relevant External Links for ABCC1 Gene
- GeneLoc Exon Structure for
- ABCC1
Expression for ABCC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Endothelial Cells Blood Brain Barrier
- Mature brain microvascular endothelial cells (Lippmann ES et. al. 2012)
- Endothelium (Cardiovascular System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
- Bone (Muscoskeletal System)
This gene is overexpressed in Breast (29.1) and Nasal epithelium (28.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCC1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ABCC1
SOURCE GeneReport for Unigene cluster for ABCC1 Gene:
Hs.391464mRNA Expression by UniProt/SwissProt for ABCC1 Gene:
P33527-MRP1_HUMAN
Tissue specificity:
Lung, testis and peripheral blood mononuclear cells.
Evidence on tissue expression from TISSUES for ABCC1 Gene
- Nervous system(4.5)
- Liver(4.5)
- Blood(2.9)
- Intestine(2.8)
- Lung(2.7)
- Kidney(2.5)
- Skin(2.4)
- Heart(2.4)
- Muscle(2.3)
- Lymph node(2.3)
- Stomach(2.2)
- Bone marrow(2.2)
- Spleen(2.2)
- Pancreas(2.1)
- Thyroid gland(2.1)
Primer products for research
-
OriGene qPCR primer pairs for ABCC1
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC1 Gene
Orthologs for ABCC1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ABCC1 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MRP1 30 |
|
OneToOne | |
| ABCC1 29 |
|
||||
| Cow (Bos Taurus) |
Mammalia | ABCC1 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ABCC1 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ABCC1 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Abcc1 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Abcc1 29 |
|
||
| Chicken (Gallus gallus) |
Aves | ABCC1 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ABCC1 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.3748 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ABCC1 30 |
|
OneToOne | |
| abcc1 29 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6214 31 |
|
|
|
| Sur 31 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | mrp-2 29 31 |
|
||
| mrp-7 31 |
|
|
|||
| mrp-8 30 31 |
|
ManyToMany | |||
| C18C4.2 31 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YCF1 30 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | MRP5 29 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3011 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os03g0142800 29 |
|
||
| Os.5631 29 |
|
||||
| Barley (Hordeum vulgare) |
Liliopsida | Hv.4445 29 |
|
||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.28932 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 30 |
|
ManyToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.6283 29 |
|
- Species where no ortholog for ABCC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for ABCC1 Gene
- ENSEMBL:
- Gene Tree for ABCC1 (if available)
- TreeFam:
- Gene Tree for ABCC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ABCC1: view image
- Alliance of Genome Resources:
- Additional Orthologs for ABCC1
Paralogs for ABCC1 Gene
Paralogs for ABCC1 Gene
(22) SIMAP similar genes for ABCC1 Gene using alignment to 7 proteins:
- MRP1_HUMAN
- G0ZCM3_HUMAN
- G0ZCM4_HUMAN
- G0ZCM5_HUMAN
- G0ZCM6_HUMAN
- I3L2H9_HUMAN
- I3L4X2_HUMAN
Variants for ABCC1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ABCC1 Gene
| SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 929256 | Pathogenic: Deafness, autosomal dominant 77 | 16,068,247(+) |
A/G NM_004996.4(ABCC1):c.1769A>G (p.Asn590Ser) |
MISSENSE | |
| rs11075295 | Uncertain Significance: Familial cancer of breast | 16,083,830(+) |
G/A NM_004996.4(ABCC1):c.2292+288G>A |
INTRON | |
| rs11866794 | Uncertain Significance: Familial cancer of breast | 16,075,717(+) |
G/A NM_004996.4(ABCC1):c.1913-609G>A |
INTRON | |
| rs143595490 | Benign: not provided | 16,125,881(+) |
G/A NM_004996.4(ABCC1):c.3789G>A (p.Arg1263=) |
SYNONYMOUS | |
| rs149296075 | Benign: not provided | 16,115,084(+) |
G/A NM_004996.4(ABCC1):c.3390+8G>A |
INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
2.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.96;
59.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ABCC1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC1 Gene
Disorders for ABCC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal dominant 77 |
|
|
| autosomal dominant non-syndromic sensorineural deafness type dfna |
|
|
| dubin-johnson syndrome |
|
|
| pseudoxanthoma elasticum |
|
|
| uterine sarcoma |
|
|
Search ABCC1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MRP1_HUMAN- Deafness, autosomal dominant, 77 (DFNA77) [MIM:618915]: A form of non-syndromic deafness characterized by adult onset of bilateral, postlingual, mild-to-severe sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:31273342}. Note=The gene represented in this entry is involved in disease pathogenesis.
Additional Disease Information for ABCC1
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for ABCC1 Gene
Publications for ABCC1 Gene
- Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. (PMID: 9281595) Stride BD … Deeley RG (Molecular pharmacology 1997) 3 4 22 25
- Extrusion pump ABCC1 was first linked with nonsyndromic hearing loss in humans by stepwise genetic analysis. (PMID: 31273342) Li M … Feng Y (Genetics in medicine : official journal of the American College of Medical Genetics 2019) 3 4 72
- Human skeletal muscle drug transporters determine local exposure and toxicity of statins. (PMID: 19940267) Knauer MJ … Tirona RG (Circulation research 2010) 3 22 25
- 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. (PMID: 19214143) Tantisira KG … Weiss ST (Pharmacogenetics and genomics 2009) 3 22 40
- ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment. (PMID: 18851956) Rebecchi IM … Hirata RD (Biochemical pharmacology 2009) 3 22 40
ExternalLinks
Products for ABCC1 Gene
- Custom Antibody ServicesOriGene Antibodies for ABCC1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ABCC1
- Search Origene for MassSpec and Protein Over-expression Lysates for ABCC1
- Origene Custom Protein Services for ABCC1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCC1
- Browse OriGene Inhibitory RNA Products For ABCC1
- OriGene qPCR primer pairs for ABCC1
- OriGene CRISPR knockouts for ABCC1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ABCC1
- Sino Biological Human cDNA Clone for ABCC1
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for ABCC1
- Novus Biologicals proteins for ABCC1
- Browse Antibodies
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- Taconic Biosciences Mouse Models for ABCC1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ABCC1 (AFLGC-ABCC1)
- ApexBio compounds for ABCC1
- VectorBuilder Custom and pre-made DNA vectors for ABCC1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ABCC1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ABCC1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ABCC1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ABCC1
- Addgene plasmids for ABCC1
- antibodies-online: Show 12 available ABCC1 Antibodies ranked by validation data
- Compare Top ABCC1 Antibodies
- antibodies-online: Show 37 available ABCC1 Elisa Kits ranked by validation data
- Compare Top ABCC1 Elisa Kits
- antibodies-online: Show 13 available ABCC1 Proteins ranked by validation data
- Compare Top ABCC1 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for ABCC1
- Search Santa Cruz Biotechnology (SCBT) for ABCC1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ABCC1
- Horizon Cell Lines for ABCC1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCC1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ABCC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC1
Sources for ABCC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
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- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources