Aliases for ABCC1 Gene
Aliases for ABCC1 Gene
- ATP Binding Cassette Subfamily C Member 1 2 3 5
- ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 2 3
- Leukotriene C(4) Transporter 3 4
- LTC4 Transporter 3 4
- MRP1 3 4
- MRP 3 4
- ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13&14 3
- ATP-Binding Cassette Transporter Variant ABCC1delta-Ex25&26 3
- ATP-Binding Cassette Transporter Variant ABCC1delta-Ex13 3
External Ids for ABCC1 Gene
- HGNC: 51
- Entrez Gene: 4363
- Ensembl: ENSG00000103222
- OMIM: 158343
- UniProtKB: P33527
Previous HGNC Symbols for ABCC1 Gene
- MRP
- MRP1
Previous GeneCards Identifiers for ABCC1 Gene
- GC16P015870
- GC16P015325
- GC16P016009
- GC16P015950
- GC16P016043
- GC16P015437
Summaries for ABCC1 Gene
-
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
GeneCards Summary for ABCC1 Gene
ABCC1 (ATP Binding Cassette Subfamily C Member 1) is a Protein Coding gene. Diseases associated with ABCC1 include Dubin-Johnson Syndrome and Pseudoxanthoma Elasticum. Among its related pathways are Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics and MicroRNAs in cancer. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCC3.
UniProtKB/Swiss-Prot for ABCC1 Gene
-
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
-
ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.
Additional gene information for ABCC1 Gene
- Monarch Initiative
- Search for ABCC1 at DataMed
- Search for ABCC1 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCC1 Gene
Genomics for ABCC1 Gene
GeneHancer (GH) Regulatory Elements for ABCC1 Gene
Promoters and enhancers for ABCC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ABCC1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ABCC1 gene promoter:
-
- AP-1
- c-Fos
Regulatory Element Products
Genomic Locations for ABCC1 Gene
Genomic Locations for ABCC1 Gene
- chr16:15,949,577-16,143,074
- (GRCh38/hg38)
- Size:
- 193,498 bases
- Orientation:
- Plus strand
- chr16:16,043,434-16,236,931
- (GRCh37/hg19)
- Size:
- 193,498 bases
- Orientation:
- Plus strand
Genomic View for ABCC1 Gene
Genes around ABCC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.11 by Entrez Gene
- 16p13.11 by HGNC
- 16p13.11 by Ensembl
ABCC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ABCC1 Gene
Proteins for ABCC1 Gene
-
Protein details for ABCC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33527-MRP1_HUMAN
- Recommended name:
- Multidrug resistance-associated protein 1
- Protein Accession:
- P33527
- A3RJX2
- C9JPJ4
- O14819
- O43333
- P78419
- Q59GI9
- Q9UQ97
- Q9UQ99
- Q9UQA0
Protein attributes for ABCC1 Gene
- Size:
- 1531 amino acids
- Molecular mass:
- 171591 Da
- Quaternary structure:
- No Data Available
Protein Expression for ABCC1 Gene
Post-translational modifications for ABCC1 Gene
- Glycosylation at posLast=10061006, posLast=2323, and posLast=1919
- Ubiquitination at Lys1502, posLast=13691369, Lys1360, posLast=13331333, Lys1322, posLast=908908, Lys891, Lys814, Lys773, Lys636, Lys513, posLast=503503, posLast=488488, Lys315, Lys307, and posLast=303303
- Modification sites at PhosphoSitePlus
Other Protein References for ABCC1 Gene
Antibody Products
- R&D Systems Antibodies for ABCC1 (MRP1)
-
Custom Antibody ServicesOriGene Antibodies for ABCC1
- Novus Biologicals Antibodies for ABCC1
-
Abcam antibodies for ABCC1
- Invitrogen Antibodies for ABCC1 (AFLGC-ABCC1)
- GeneTex ABCC1 Antibody for ABCC1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ABCC1
Protein Products
-
OriGene Purified Proteins for ABCC1
- Search Origene for MassSpec and Protein Over-expression Lysates for ABCC1
- Origene Custom Protein Services for ABCC1
- Novus Biologicals proteins for ABCC1
- antibodies-online: Search results for 11 available ABCC1 Proteins ranked by validation data
- Compare Top ABCC1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ABCC1
-
Abcam proteins for ABCC1
Assay Products
No data available for DME Specific Peptides for ABCC1 Gene
Domains & Families for ABCC1 Gene
Gene Families for ABCC1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- FDA approved drug targets
- Plasma proteins
- Predicted membrane proteins
- Transporters
Protein Domains for ABCC1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ABCC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P33527UniProtKB/Swiss-Prot:
MRP1_HUMAN :- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
- Family:
-
- Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Function for ABCC1 Gene
Molecular function for ABCC1 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
- GENATLAS Biochemistry:
- ATP binding cassettte superfamily,subfamily C (CFTR/MRP),member 1,ubiquitously expressed,with several alternatively spliced forms,also containing a CGG repeat in 5utr
Phenotypes From GWAS Catalog for ABCC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004012 | phospholipid-translocating ATPase activity | IMP | 17050692 |
| GO:0005215 | transporter activity | TAS | 1360704 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008514 | organic anion transmembrane transporter activity | IBA | -- |
| GO:0008559 | xenobiotic transmembrane transporting ATPase activity | IBA | -- |
Phenotypes for ABCC1 Gene
- MGI mutant phenotypes for ABCC1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ABCC1:
-
- Decreased HPV16-GFP infection
- Increased G1 DNA content
- Dynamic nuclei (hole, folded or small irregular)
- Increased Nanog expression
- Decreased Salmonella enterica Typhimurium invasion
- Decreased viability
- no effect
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance
Animal Model Products
-
Taconic Biosciences Mouse Models for ABCC1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ABCC1
-
CRISPR Products
-
OriGene CRISPR knockouts for ABCC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCC1
- genomics-online: gRNA clones - Search results for 67 available ABCC1 gene related products
- Overview of 67 available ABCC1 gene related products
- Applied Biological Materials CRISPR for ABCC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCC1
- GenScript: Design CRISPR guide RNA sequences for ABCC1
miRNA for ABCC1 Gene
- miRTarBase miRNAs that target ABCC1
-
- hsa-mir-345-5p (MIRT003198)
- hsa-mir-7-5p (MIRT003199)
- hsa-mir-134-5p (MIRT004494)
- hsa-mir-9-5p (MIRT021440)
- hsa-mir-1-3p (MIRT024051)
- hsa-mir-98-5p (MIRT027818)
- hsa-let-7b-5p (MIRT032483)
- hsa-mir-615-3p (MIRT040354)
- hsa-mir-339-5p (MIRT042744)
- hsa-mir-125b-5p (MIRT046005)
- hsa-mir-23b-3p (MIRT046316)
- hsa-mir-16-5p (MIRT051224)
- hsa-mir-1291 (MIRT053213)
- hsa-mir-3180-5p (MIRT706001)
- hsa-mir-524-5p (MIRT706002)
- hsa-mir-520d-5p (MIRT706003)
- hsa-mir-361-3p (MIRT706004)
- hsa-mir-1825 (MIRT706005)
- hsa-mir-548o-3p (MIRT706006)
- hsa-mir-1323 (MIRT706007)
- hsa-mir-5195-3p (MIRT706008)
- hsa-mir-5582-3p (MIRT706009)
- hsa-mir-145-5p (MIRT706010)
- hsa-mir-199a-5p (MIRT706011)
- hsa-mir-199b-5p (MIRT706012)
- hsa-mir-224-5p (MIRT706013)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCC1
- Browse OriGene Inhibitory RNA Products For ABCC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC1
- genomics-online: shRNA clones - Search results for 67 available ABCC1 gene related products
- Overview of 67 available ABCC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ABCC1
- Addgene plasmids for ABCC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCC1
- Applied Biological Materials Clones for ABCC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ABCC1 (MRP1)
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ABCC1 Gene
Localization for ABCC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ABCC1 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005774 | vacuolar membrane | IBA | -- |
| GO:0005886 | plasma membrane | IDA,TAS | -- |
| GO:0005887 | integral component of plasma membrane | IBA,IEA | -- |
| GO:0016020 | membrane | IBA,IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for ABCC1 Gene
Pathways by source for ABCC1 Gene
3 BioSystems pathways for ABCC1 Gene
9 Reactome pathways for ABCC1 Gene
5 KEGG pathways for ABCC1 Gene
2 R&D Systems pathways for ABCC1 Gene
1 Cell Signaling Technology pathway for ABCC1 Gene
Interacting Proteins for ABCC1 Gene
GPS-Prot Interaction Network for ABCC1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006691 | leukotriene metabolic process | TAS | -- |
| GO:0006855 | drug transmembrane transport | IBA | -- |
| GO:0009235 | cobalamin metabolic process | TAS | -- |
| GO:0015889 | cobalamin transport | IEA | -- |
| GO:0034775 | glutathione transmembrane transport | IBA | -- |
Drugs & Compounds for ABCC1 Gene
(144) Drugs for ABCC1 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Doxorubicin | Approved, Investigational | Pharma | Transporter, substrate, inhibitor | Topo II inhibitor,immunosuppresive antineoplastic antibiotic | 1828 | |
| Irinotecan | Approved, Investigational | Pharma | Transporter, substrate | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1181 | |
| Methotrexate | Approved | Pharma | Transporter, substrate, inhibitor | Folate antagonist,inhibits DFHR | 1603 | |
| Ritonavir | Approved, Investigational | Pharma | Transporter, inhibitor, inducer | HIV protease inhibitor | 897 | |
| Sulfinpyrazone | Approved | Pharma | modulator, Target, Transporter, inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4'-Hydroxydiclofenac |
|
64118-84-9 | ||||
| O-Desmethylverapamil (D-702) |
|
|
(3) Tocris Compounds for ABCC1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Fumitremorgin C | Inhibitor of BCRP-mediated multidrug resistance | 118974-02-0 |
| Ko 143 | Potent and selective BCRP inhibitor | 461054-93-3 |
| Pyrimethamine | Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor | 58-14-0 |
Drug Products
Transcripts for ABCC1 Gene
mRNA/cDNA for ABCC1 Gene
- (16) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (200) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000399408 6594 bps (uc002del.5)
- ENST00000574761 996 bps (uc059rgk.1)
- ENST00000572053 744 bps (uc059rgj.1)
- ENST00000576557 542 bps (uc059rgi.1)
- ENST00000575422 1198 bps (uc059rgh.1)
Unigene Clusters for ABCC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ABCC1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ABCC1
- genomics-online: gRNA clones - Search results for 67 available ABCC1 gene related products
- Overview of 67 available ABCC1 gene related products
- Applied Biological Materials CRISPR for ABCC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ABCC1
- GenScript: Design CRISPR guide RNA sequences for ABCC1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ABCC1
- Browse OriGene Inhibitory RNA Products For ABCC1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCC1
- genomics-online: shRNA clones - Search results for 67 available ABCC1 gene related products
- Overview of 67 available ABCC1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ABCC1
- Addgene plasmids for ABCC1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ABCC1
- Applied Biological Materials Clones for ABCC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ABCC1 (MRP1)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
| ExUns: | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: |
Expression for ABCC1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Choroid Plexus Cells Choroid Plexus
- Endothelial Cells Blood Brain Barrier
- Mature brain microvascular endothelial cells(Lippmann ES et. al. 2012)
- Endothelium (Cardiovascular System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
-
Epithelial Cells
- Mature Choroid Plexus Cells Choroid Plexus
- Bone (Muscoskeletal System)
This gene is overexpressed in Breast (29.1) and Nasal epithelium (28.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCC1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ABCC1 Gene:
ABCC1SOURCE GeneReport for Unigene cluster for ABCC1 Gene:
Hs.391464mRNA Expression by UniProt/SwissProt for ABCC1 Gene:
P33527-MRP1_HUMAN
Tissue specificity:
Lung, testis and peripheral blood mononuclear cells.
Evidence on tissue expression from TISSUES for ABCC1 Gene
- Liver(4.5)
- Nervous system(4.5)
- Blood(2.6)
- Lung(2.6)
- Intestine(2.4)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for ABCC1
- genomics-online: primer clones - Search results for 67 available ABCC1 gene related products
- Overview of 67 available ABCC1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCC1 Gene
Orthologs for ABCC1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ABCC1 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MRP1 34 |
|
OneToOne | |
| ABCC1 33 |
|
||||
| cow (Bos Taurus) |
Mammalia | ABCC1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ABCC1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ABCC1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Abcc1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Abcc1 33 |
|
||
| chicken (Gallus gallus) |
Aves | ABCC1 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ABCC1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.3748 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ABCC1 34 |
|
OneToOne | |
| abcc1 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6214 35 |
|
|
|
| Sur 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | mrp-2 35 33 |
|
||
| mrp-7 35 |
|
|
|||
| mrp-8 34 35 |
|
ManyToMany | |||
| C18C4.2 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YCF1 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | MRP5 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.3011 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0142800 33 |
|
||
| Os.5631 33 |
|
||||
| barley (Hordeum vulgare) |
Liliopsida | Hv.4445 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.28932 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| Cin.6283 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.6283 33 |
|
- Species where no ortholog for ABCC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for ABCC1 Gene
- ENSEMBL:
- Gene Tree for ABCC1 (if available)
- TreeFam:
- Gene Tree for ABCC1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ABCC1: view image
Paralogs for ABCC1 Gene
(22) SIMAP similar genes for ABCC1 Gene using alignment to 7 proteins:
- MRP1_HUMAN
- G0ZCM3_HUMAN
- G0ZCM4_HUMAN
- G0ZCM5_HUMAN
- G0ZCM6_HUMAN
- I3L2H9_HUMAN
- I3L4X2_HUMAN
Variants for ABCC1 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs11075295 | uncertain-significance, Familial cancer of breast | 16,083,830(+) | G/A | intron_variant | |
| rs11866794 | uncertain-significance, Familial cancer of breast | 16,075,717(+) | G/A/C | intron_variant | |
| rs35623 | uncertain-significance, Familial cancer of breast | 16,075,608(+) | G/T | intron_variant | |
| rs35625 | uncertain-significance, Familial cancer of breast | 16,075,709(+) | C/T | intron_variant | |
| rs35626 | uncertain-significance, Familial cancer of breast | 16,076,758(+) | G/T | intron_variant |
Residual Variation Intolerance Score:
2.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.96;
59.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ABCC1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCC1 Gene
Disorders for ABCC1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dubin-johnson syndrome |
|
|
| pseudoxanthoma elasticum |
|
|
| colchicine resistance |
|
|
| microsporidiosis |
|
|
| uterine sarcoma |
|
|
Search ABCC1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ABCC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ABCC1 Gene
Publications for ABCC1 Gene
- 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. (PMID: 19214143) Tantisira KG … Weiss ST (Pharmacogenetics and genomics 2009) 3 22 44 58
- Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis. (PMID: 18381794) Ranganathan P … McLeod HL (The Journal of rheumatology 2008) 3 22 44 58
- Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer. (PMID: 17925548) Marsh S … Brown R (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007) 3 22 44 58
- Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. (PMID: 16041239) Colombo S … Swiss HIV Cohort Study (Pharmacogenetics and genomics 2005) 3 22 44 58
- NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. (PMID: 16330681) Wojnowski L … Hasenfuss G (Circulation 2005) 3 22 44 58
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Sources for ABCC1 Gene
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