ABCB1 Gene (Protein Coding)

ATP Binding Cassette Subfamily B Member 1

GC07M087504
GIFtS:
52
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the ... See more...

Aliases for ABCB1 Gene

Aliases for ABCB1 Gene

  • ATP Binding Cassette Subfamily B Member 1 2 3 5
  • Multidrug Resistance Protein 1 2 3 4
  • ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 2 3
  • ATP-Dependent Translocase ABCB1 3 4
  • Phospholipid Transporter ABCB1 3 4
  • Colchicin Sensitivity 2 3
  • P-Glycoprotein 1 3 4
  • ABC20 2 3
  • CD243 2 3
  • GP170 2 3
  • P-170 2 3
  • MDR1 3 4
  • PGY1 3 4
  • ATP-Binding Cassette Sub-Family B Member 1 4
  • Doxorubicin Resistance 3
  • CD243 Antigen 4
  • EC 3.6.3.44 50
  • EC 7.6.2.2 4
  • EC 7.6.2.1 4
  • EC 3.6.3 50
  • ABCB1 5
  • CLCS 3
  • P-GP 3
  • P-Gp 2

External Ids for ABCB1 Gene

Previous HGNC Symbols for ABCB1 Gene

  • PGY1
  • MDR1
  • CLCS

Previous GeneCards Identifiers for ABCB1 Gene

  • GC07M085668
  • GC07M086731
  • GC07M086745
  • GC07M086744
  • GC07M086777
  • GC07M086970
  • GC07M087132
  • GC07M081743

Summaries for ABCB1 Gene

Entrez Gene Summary for ABCB1 Gene

  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]

CIViC Summary for ABCB1 Gene

GeneCards Summary for ABCB1 Gene

ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. Diseases associated with ABCB1 include Colchicine Resistance and Inflammatory Bowel Disease 13. Among its related pathways are Lamotrigine Pathway, Pharmacokinetics and Pharmacodynamics and Blood-Brain Barrier and Immune Cell Transmigration: Pathways Overview. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCB4.

UniProtKB/Swiss-Prot Summary for ABCB1 Gene

  • Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).

Tocris Summary for ABCB1 Gene

  • ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.

Gene Wiki entry for ABCB1 Gene

PharmGKB "VIP" Summary for ABCB1 Gene

Additional gene information for ABCB1 Gene

No data available for Rfam classification and piRNA Summary for ABCB1 Gene

Genomics for ABCB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ABCB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J087598 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 250.1 +113.4 113424 3.2 ZNF600 CEBPA YY1 MXD4 BCL11A FOXA1 TRIM22 HES1 BHLHE40 FEZF1 HSALNG0059391 ABCB1 RUNDC3B SLC25A40 piR-37663-055 lnc-ABCB1-2 ABCB4
GH07J087712 Promoter/Enhancer 0.5 EPDnew Ensembl 250.7 +0.5 522 2 ABCB1 lnc-ABCB1-2 SLC25A40 piR-33614-255 MK280607-095 RUNDC3B
GH07J087933 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.6 -221.3 -221278 2.4 BCLAF1 ZNF207 ZNF600 POLR2A ZIC2 MXD4 SIN3A TARDBP ETS1 ZNF341 ADAM22 HSALNG0059403 ABCB4 ABCB1 hsa-miR-5095-464 SRI MK280607-095
GH07J087589 Enhancer 0.4 Ensembl ENCODE 7.2 +122.1 122135 3.2 ZNF189 RUNDC3B ABCB1 HSALNG0059391 piR-37663-055 ABCB4
GH07J087627 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +84.7 84722 2.4 SP1 ZNF600 ZNF580 ZMYM3 MXD4 SIN3A FEZF1 ZNF341 FOXA2 CTBP1 RUNDC3B DMTF1 SLC25A40 MK280607-095 lnc-ABCB1-2 ABCB1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ABCB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ABCB1

Top Transcription factor binding sites by QIAGEN in the ABCB1 gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun

Genomic Locations for ABCB1 Gene

Latest Assembly
chr7:87,503,017-87,713,323
(GRCh38/hg38)
Size:
210,307 bases
Orientation:
Minus strand

Previous Assembly
chr7:87,132,333-87,342,611
(GRCh37/hg19 by Entrez Gene)
Size:
210,279 bases
Orientation:
Minus strand

chr7:87,133,175-87,342,611
(GRCh37/hg19 by Ensembl)
Size:
209,437 bases
Orientation:
Minus strand

Genomic View for ABCB1 Gene

Genes around ABCB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ABCB1 Gene

Proteins for ABCB1 Gene

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  • Protein details for ABCB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08183-MDR1_HUMAN
    Recommended name:
    ATP-dependent translocase ABCB1
    Protein Accession:
    P08183
    Secondary Accessions:
    • A8K294
    • B5AK60
    • Q12755
    • Q14812

    Protein attributes for ABCB1 Gene

    Size:
    1280 amino acids
    Molecular mass:
    141479 Da
    Quaternary structure:
    • Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
    SequenceCaution:
    • Sequence=AAM49149.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ABCB1 Gene

    Alternative splice isoforms for ABCB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCB1 Gene

Protein Expression for ABCB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ABCB1 Gene

P08183:
  • GWKLTLV
  • YGWQLTLLL
  • VQEALDKAR
  • ENIRYGR
  • TGALTTRLA
  • GTHQQLL
  • ILKGLNLKV
  • SGGQKQRIAIARALVRQP
  • LVGSSGCGKSTVVQLLERFY
  • MTRYAYYYSG
  • EVKKGQTL
  • NLFSLLFL
  • QLSGGQKQR
  • DGQDIRTINVR
  • LGIVSQEP
  • QRIAIARA
  • ALDKAREGRT
  • QLSGGQKQRIAIARALVR
  • IAHRLSTVR
  • GQTVALVG
  • RLYDPTEG
  • RNADVIAGF
  • LFDCSIAENI
  • AIRTVIAFGGQ
  • EWPYFVVG
  • VIAHRLST
  • RTVVSLT
  • TFFLQGFTFGKAGEILT
  • KILLLDE
  • GKIATEAIEN
  • KGQTLAL
  • LVRNPKIL
  • SGCGKSTTVQL
  • AFLLIYASYALAFWYG
  • LNVQWLRA
  • ELNTRLTDD
  • LDEATSALDTESE
  • LIGAFSVGQA
  • VIAHRLSTIQNAD
  • LLLDEATSALD
  • LSGQALKDKK
  • AYIQVSFW
  • QEIGWFD
  • SSFAPDYAKA
  • VSQEPVLF
  • FGITFSFTQAMMYFSYA
  • KAVKEANAY
  • AHRLSTI
  • AYAKAGAVAEE
  • ANLGTGII

Post-translational modifications for ABCB1 Gene

  • Glycosylation at Asn91, Asn94, and Asn99
  • Ubiquitination at Lys279, Lys367, Lys515, Lys519, Lys915, Lys1093, and Lys1164
  • Modification sites at PhosphoSitePlus

Other Protein References for ABCB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for ABCB1 Gene

Gene Families for ABCB1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ABCB1 Gene

InterPro:

Suggested Antigen Peptide Sequences for ABCB1 Gene

GenScript: Design optimal peptide antigens:
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (A1L471_HUMAN)
  • Multidrug resistance protein 1 (A4D1D2_HUMAN)
  • Multidrug resistance protein 1 (B5U2G4_HUMAN)
  • Multidrug resistance protein 1 (F4ZUQ5_HUMAN)
  • Multidrug resistance protein 1 (F4ZUT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08183

UniProtKB/Swiss-Prot:

MDR1_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Family:
  • Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
genes like me logo Genes that share domains with ABCB1: view

Function for ABCB1 Gene

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  6. Cell Lines for research

Molecular function for ABCB1 Gene

UniProtKB/Swiss-Prot Function:
Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).; EC=7.6.2.2; Evidence={ECO:0000269|PubMed:9038218};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).; EC=7.6.2.1; Evidence={ECO:0000269|PubMed:8898203};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:36439, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:64612, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8898203};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38583, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57643, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8898203};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38943, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:22801, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8898203};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a sphingomyelin(in) + ATP + H2O = a sphingomyelin(out) + ADP + H(+) + phosphate; Xref=Rhea:RHEA:38903, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; Evidence={ECO:0000269|PubMed:8898203};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Translocase activity is inhibited by verapamil and is sensitive to energy depletion.
GENATLAS Biochemistry:
ATP binding cassette superfamily,subfamily B (MDR/TAP),member 1,putatively activated by random chromosomal rearrangements,and overexpressed in acute myeloid leukemia and cancer cell lines,by hypomethylation of the promoter and altered chromatin structure,up-regulated by P/CAF : NFY heterodimer

Enzyme Numbers (IUBMB) for ABCB1 Gene

Phenotypes From GWAS Catalog for ABCB1 Gene

Gene Ontology (GO) - Molecular Function for ABCB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 17088979
GO:0005524 ATP binding IDA 28757552
GO:0008559 xenobiotic transmembrane transporting ATPase activity IDA 28757552
GO:0015562 efflux transmembrane transporter activity IMP 25986174
genes like me logo Genes that share ontologies with ABCB1: view
genes like me logo Genes that share phenotypes with ABCB1: view

Human Phenotype Ontology for ABCB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ABCB1 Gene

MGI Knock Outs for ABCB1:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCB1

No data available for Transcription Factor Targets and HOMER Transcription for ABCB1 Gene

Localization for ABCB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCB1 Gene

Cell membrane. Multi-pass membrane protein. Apical cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCB1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 4
cytoskeleton 3
cytosol 3
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ABCB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 19384922
GO:0016020 membrane IDA 26006083
GO:0016021 integral component of membrane TAS,IBA 21873635
genes like me logo Genes that share ontologies with ABCB1: view

Pathways & Interactions for ABCB1 Gene

PathCards logo

SuperPathways for ABCB1 Gene

SuperPathway Contained pathways
1 Imipramine/Desipramine Pathway, Pharmacokinetics
Paroxetine Pathway, Pharmacokinetics
.57
Verapamil Pathway, Pharmacokinetics
.56
Amitriptyline and Nortriptyline Pathway, Pharmacokinetics
.50
Olanzapine Pathway, Pharmacokinetics
.50
Pimozide Pathway, Pharmacokinetics
.50
Venlafaxine Pathway, Pharmacokinetics
.44
Ivacaftor pathway, pharmacokinetics/pharmacodynamics
.43
Warfarin Pathway, Pharmacokinetics
.40
Clozapine Pathway, Pharmacokinetics
.38
Candesartan Pathway, Pharmacokinetics
.01
Citalopram Pathway, Pharmacokinetics
.01
Proton Pump Inhibitor Pathway, Pharmacokinetics
.01
Tacrolimus/Cyclosporine Pathway, Pharmacokinetics
.01
2 Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics
Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics
.54
Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics
.54
Imatinib Pathway, Pharmacokinetics/Pharmacodynamics
.47
Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics
.44
Taxane Pathway, Pharmacokinetics
.31
3 Codeine and Morphine Metabolism
Carvedilol Pathway, Pharmacokinetics
.46
Codeine and Morphine Metabolism
.46
Codeine and Morphine Pathway, Pharmacokinetics
.41
Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics
.40
Clopidogrel Pathway, Pharmacokinetics
.31
4 Statin Pathway - Generalized, Pharmacokinetics
Statin Pathway - Generalized, Pharmacokinetics
.42
Atorvastatin/Lovastatin/Simvastatin Pathway, Pharmacokinetics
.01
Pravastatin Pathway, Pharmacokinetics
.01
5 Erlotinib Pathway, Pharmacokinetics
Dasatinib Pathway, Pharmacokinetics
.54
Erlotinib Pathway, Pharmacokinetics
.54
Gefitinib Pathway, Pharmacokinetics
.54
genes like me logo Genes that share pathways with ABCB1: view

SIGNOR curated interactions for ABCB1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ABCB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 19384922
GO:0042493 response to drug TAS 3022150
GO:0042969 lactone transport IMP --
GO:0045332 phospholipid translocation IDA 8898203
GO:0046865 terpenoid transport ISS --
genes like me logo Genes that share ontologies with ABCB1: view

Drugs & Compounds for ABCB1 Gene

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  1. Drug products for research

(655) Drugs for ABCB1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Colchicine Approved Pharma Transporter, substrate, inducer, binder Tubulin Inhibitor 180
Tacrolimus Approved, Investigational Pharma Transporter, substrate, inhibitor, inducer 1328
Atazanavir Approved, Investigational Pharma Transporter, substrate, inhibitor, inducer HIV protease inhibitor,highly potent 0
Daunorubicin Approved Pharma Transporter, substrate, inhibitor, inducer DNA topoisomerase II inhibitor 399
Dexamethasone Approved, Investigational, Vet_approved Pharma Transporter, substrate, inhibitor, inducer Anti-inflammatory glucocorticoid 3149

(57) Additional Compounds for ABCB1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Hydroxychlorpropamide
  • N-(4-Chloro-2-hydroxybenzenesulfonyl)propane-1-carbamimidate
  • N-(4-Chloro-2-hydroxybenzenesulphonyl)propane-1-carbamimidate
  • N-(4-Chloro-2-hydroxybenzenesulphonyl)propane-1-carbamimidic acid
 36892-36-1
2-Hydroxynevirapine
  • Monodesmethylcitalopram monohydrochloride
  • Monodesmethylcitalopram
  • Monodesmethylcitalopram oxalate
3',4'-Dihydrodiol
4-Hydroxycyclophosphamide
  • Tetrahydro-2-(bis(2-chloroethyl)amino)-2H-1,3,2-oxazaphosphorin-4-ol 2-oxide
  • 4-Hydroxycyclophosphamide, (cis)-isomer
  • 4-Hydroxycyclophosphamide, (trans)-isomer
 40277-05-2
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetate
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
 64118-84-9

(3) Tocris Compounds for ABCB1 Gene

Compound Action Cas Number
Fumitremorgin C Inhibitor of BCRP-mediated multidrug resistance 118974-02-0
Ko 143 Potent and selective BCRP inhibitor 461054-93-3
Pyrimethamine Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor 58-14-0

(15) ApexBio Compounds for ABCB1 Gene

Compound Action Cas Number
Colchicine Tubulin Inhibitor 64-86-8
CP 100356 hydrochloride 142715-48-8
Dofequidar fumarate MDR reversal agent 153653-30-6
Elacridar BCRP inhibitor 143664-11-3
Elacridar hydrochloride BCRP and P-GP inhibitor 143851-98-3
Fumitremorgin C 118974-02-0
KS 176 1253452-78-6
LY335979 (Zosuquidar 3HCL) Pgp (P-glycoprotein) inhibitor 167465-36-3
Posaconazole Sterol C14ɑ demethylase inhibitor 171228-49-2
Reversan 313397-13-6
Tariquidar P-glycoprotein inhibitor,potent and non-competitive 206873-63-4
Tariquidar methanesulfonate, hydrate P-glycoprotein inhibitor, potent and selective 625375-83-9
Valspodar P-glycoprotein inhibitor 121584-18-7
Vinblastine sulfate Anti-mitotic agent 143-67-9
Zosuquidar MDR modulator 167354-41-8
genes like me logo Genes that share compounds with ABCB1: view

Drug products for research

Transcripts for ABCB1 Gene

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mRNA/cDNA for ABCB1 Gene

4 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ABCB1

Alternative Splicing Database (ASD) splice patterns (SP) for ABCB1 Gene

No ASD Table

Relevant External Links for ABCB1 Gene

GeneLoc Exon Structure for
ABCB1

Expression for ABCB1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ABCB1 Gene

mRNA expression in normal human tissues for ABCB1 Gene
mRNA expression by GTEx for ABCB1 GenemRNA expression by BioGPS for ABCB1 Gene

mRNA differential expression in normal tissues according to GTEx for ABCB1 Gene

This gene is overexpressed in Adrenal Gland (x18.3).

Protein differential expression in normal tissues from HIPED for ABCB1 Gene

This gene is overexpressed in Amniocyte (52.1) and Urine (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ABCB1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ABCB1

SOURCE GeneReport for Unigene cluster for ABCB1 Gene:

Hs.489033

mRNA Expression by UniProt/SwissProt for ABCB1 Gene:

P08183-MDR1_HUMAN
Tissue specificity: Expressed in liver, kidney, small intestine and brain.

Evidence on tissue expression from TISSUES for ABCB1 Gene

  • Nervous system(4.8)
  • Kidney(3.3)
  • Liver(3.3)
  • Adrenal gland(3.3)
  • Intestine(3.1)
  • Blood(3)
  • Skin(2.5)
  • Lung(2.5)
  • Heart(2.4)
  • Gall bladder(2.3)
  • Bone marrow(2.2)
  • Pancreas(2.1)
  • Spleen(2.1)
  • Lymph node(2.1)
  • Urine(2.1)
  • Stomach(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCB1 Gene

Germ Layers:
  • endoderm
Systems:
  • digestive
Regions:
Abdomen:
  • intestine
  • large intestine
genes like me logo Genes that share expression patterns with ABCB1: view

Primer products for research

No data available for Protein tissue co-expression partners for ABCB1 Gene

Orthologs for ABCB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ABCB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ABCB1 29 30
  • 99.56 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MDR1 30
  • 91 (a)
 OneToOne
ABCB1 29
  • 90.06 (n)
Mouse
(Mus musculus)
 Mammalia Abcb1a 29 16 30
  • 86.07 (n)
 OneToMany
Abcb1b 30
  • 81 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia ABCB1 29 30
  • 85.86 (n)
 OneToMany
-- 30
  • 66 (a)
 OneToMany
Rat
(Rattus norvegicus)
 Mammalia Abcb1a 29
  • 85.73 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 81 (a)
 OneToMany
-- 30
  • 73 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 30
  • 74 (a)
 OneToMany
-- 30
  • 68 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves -- 30
  • 65 (a)
 ManyToMany
ABCB1LB 30
  • 64 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 70 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia abcb1 29
  • 67.99 (n)
MGC76216 29
Zebrafish
(Danio rerio)
 Actinopterygii abcb4 30
  • 64 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta Mdr50 29 30 31
  • 51.39 (n)
 ManyToMany
Mdr49 30 31
  • 42 (a)
 ManyToMany
Mdr65 30 31
  • 41 (a)
 ManyToMany
CG10226 30 31
  • 39 (a)
 ManyToMany
Worm
(Caenorhabditis elegans)
 Secernentea pgp-9 29
  • 52.1 (n)
pgp-2 31
  • 45 (a)
pgp-1 30 31
  • 43 (a)
 ManyToMany
pgp-4 31
  • 40 (a)
pgp-12 31
  • 38 (a)
pgp-14 31
  • 38 (a)
pgp-15 31
  • 37 (a)
pgp-5 31
  • 36 (a)
pgp-6 31
  • 36 (a)
pgp-7 31
  • 36 (a)
pgp-13 31
  • 36 (a)
pgp-11 31
  • 33 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes STE6 30 32
  • 26 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons ABCB4 29
  • 51.91 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.1243 29
Rice
(Oryza sativa)
 Liliopsida Os01g0695700 29
  • 51.8 (n)
Os.20120 29
Corn
(Zea mays)
 Liliopsida Zm.4341 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.7248 30
  • 52 (a)
 ManyToMany
Bread mold
(Neurospora crassa)
 Ascomycetes NCU07546 29
  • 49.85 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes pmd1 29
  • 48.59 (n)
Species where no ortholog for ABCB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ABCB1 Gene

ENSEMBL:
Gene Tree for ABCB1 (if available)
TreeFam:
Gene Tree for ABCB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ABCB1: view image
Alliance of Genome Resources:
Additional Orthologs for ABCB1

Paralogs for ABCB1 Gene

Paralogs for ABCB1 Gene

(17) SIMAP similar genes for ABCB1 Gene using alignment to 15 proteins:

  • MDR1_HUMAN
  • A1L471_HUMAN
  • A4D1D2_HUMAN
  • A8E2S6_HUMAN
  • B5AK60_HUMAN
  • B5U2G4_HUMAN
  • E7EWT8_HUMAN
  • F4ZUQ5_HUMAN
  • F4ZUT2_HUMAN
  • F4ZUV0_HUMAN
  • F4ZUV4_HUMAN
  • F4ZUX9_HUMAN
  • F4ZUY5_HUMAN
  • F4ZV79_HUMAN
  • Q6TBL4_HUMAN
genes like me logo Genes that share paralogs with ABCB1: view

Variants for ABCB1 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Polymorphic Variants from UniProtKB/Swiss-Prot for ABCB1 Gene

MDR1_HUMAN-P08183
Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ABCB1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
1032492 Uncertain Significance: Inflammatory bowel disease 13 87,566,845(-) C/T
NM_001348946.2(ABCB1):c.470G>A (p.Arg157Gln) 		MISSENSE
1033150 Uncertain Significance: Inflammatory bowel disease 13 87,566,835(-) T/C
NM_001348946.2(ABCB1):c.480A>G (p.Ile160Met) 		MISSENSE
rs1007307351 Drug Response: Tramadol response 87,570,069(-) G/A
NM_001348946.2(ABCB1):c.338+103C>T 		INTRON
rs1008523470 Drug Response: Tramadol response 87,549,724(-) G/A
NM_001348946.2(ABCB1):c.1554+127C>T 		INTRON
rs1016793 Drug Response: Tramadol response 87,569,866(-) G/A
NM_001348946.2(ABCB1):c.338+306C>T 		INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ABCB1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ABCB1 Gene

Variant ID Type Subtype PubMed ID
dgv11489n54 CNV loss 21841781
esv2666273 CNV deletion 23128226
esv2734775 CNV deletion 23290073
esv2734776 CNV deletion 23290073
esv28195 CNV loss 19812545
esv3542043 CNV deletion 23714750
esv3571956 CNV loss 25503493
esv3614037 CNV loss 21293372
esv7655 CNV loss 19470904
nsv1076930 CNV deletion 25765185
nsv1078845 CNV insertion 25765185
nsv464622 CNV gain 19166990
nsv464623 CNV gain 19166990
nsv607725 CNV gain 21841781
nsv607726 CNV gain 21841781
nsv607728 CNV loss 21841781
nsv981545 CNV duplication 23825009

Variation tolerance for ABCB1 Gene

Residual Variation Intolerance Score: 22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABCB1 Gene

Human Gene Mutation Database (HGMD)
ABCB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCB1
Leiden Open Variation Database (LOVD)
ABCB1

SNP Genotyping and Copy Number Assays for research

Disorders for ABCB1 Gene

MalaCards: The human disease database

(104) MalaCards diseases for ABCB1 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
colchicine resistance
  • colchicine sensitivity; clcs
inflammatory bowel disease 13
  • ibd13
uterine sarcoma
  • sarcoma of the uterus
ulcerative colitis
  • left-sided ulcerative colitis
toxic encephalopathy
  • neurotoxicity
- elite association - COSMIC cancer census association via MalaCards
Search ABCB1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MDR1_HUMAN
  • Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for ABCB1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ABCB1: view

No data available for Genatlas for ABCB1 Gene

Publications for ABCB1 Gene

  1. MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. (PMID: 14610718) Brant SR … Cho JH (American journal of human genetics 2003) 3 4 40 72
  2. Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide. (PMID: 20179710) Bray J … Boddy AV (British journal of cancer 2010) 3 25 40
  3. Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation. (PMID: 20103600) Lagas JS … Schinkel AH (Molecular cancer therapeutics 2010) 3 22 25
  4. Explaining variability in ciclosporin exposure in adult kidney transplant recipients. (PMID: 20354687) Press RR … Guchelaar HJ (European journal of clinical pharmacology 2010) 3 22 40
  5. Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans. (PMID: 20357698) Mukonzo JK … Aklillu E (Therapeutic drug monitoring 2010) 3 22 40

ExternalLinks

View latest publications for ABCB1 gene in Mastermind

Products for ABCB1 Gene

  • Addgene plasmids for ABCB1