Aliases for ABCB1 Gene
- ATP Binding Cassette Subfamily B Member 1 2 3 5
- Multidrug Resistance Protein 1 2 3 4
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 2 3
- ATP-Dependent Translocase ABCB1 3 4
- Phospholipid Transporter ABCB1 3 4
- Colchicin Sensitivity 2 3
- P-Glycoprotein 1 3 4
- MDR1 3 4
- PGY1 3 4
- ATP-Binding Cassette Sub-Family B Member 1 4
- Doxorubicin Resistance 3
External Ids for ABCB1 Gene
Previous HGNC Symbols for ABCB1 Gene
Previous GeneCards Identifiers for ABCB1 Gene
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
GeneCards Summary for ABCB1 Gene
ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. Diseases associated with ABCB1 include Colchicine Resistance and Inflammatory Bowel Disease 13. Among its related pathways are Gastric cancer and Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include transporter activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCB4.
UniProtKB/Swiss-Prot Summary for ABCB1 Gene
Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).
ATP-binding cassette (ABC) transporters form one of the largest groups of paralogous protein families that have a wide diversity of functions and substrates. Specificity has been shown for small and large molecules, highly charged molecules and highly hydrophobic systems.