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Aliases for ABCA10 Gene

Aliases for ABCA10 Gene

  • ATP Binding Cassette Subfamily A Member 10 2 3 5
  • ATP-Binding Cassette, Sub-Family A (ABC1), Member 10 2 3
  • ATP-Binding Cassette Sub-Family A Member 10 3
  • ATP-Binding Cassette A10 3
  • EC 3.6.3.41 56
  • EST698739 3
  • EC 3.6.3 56

External Ids for ABCA10 Gene

Previous GeneCards Identifiers for ABCA10 Gene

  • GC17M066943
  • GC17M070104
  • GC17M067601
  • GC17M067741
  • GC17M064650
  • GC17M067144
  • GC17M062529

Summaries for ABCA10 Gene

Entrez Gene Summary for ABCA10 Gene

  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ABCA10 Gene

ABCA10 (ATP Binding Cassette Subfamily A Member 10) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include ATPase activity and ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is ABCA9.

UniProtKB/Swiss-Prot for ABCA10 Gene

  • Probable transporter which may play a role in macrophage lipid homeostasis.

Additional gene information for ABCA10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ABCA10 Gene

Genomics for ABCA10 Gene

GeneHancer (GH) Regulatory Elements for ABCA10 Gene

Promoters and enhancers for ABCA10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I069227 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 550.4 +16.6 16624 1.2 PKNOX1 RUNX3 ABCA10 PRO1804 GC17M069207
GH17I068508 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +732.5 732494 6.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF548 SP3 PRKAR1A NOL11 BPTF ABCA9 ABCA10 SNRPGP4 ENSG00000267731 WIPI1 SLC16A6 GC17P068532
GH17I068287 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +954.5 954489 6.2 HDGF PKNOX1 CLOCK ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 SLC16A6 ARSG NOL11 AMZ2 BPTF ABCA10 PRKAR1A GC17P068267
GH17I068454 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +788.4 788441 4.6 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A WIPI1 NOL11 PRKAR1A ABCA10 LINC01482 SLC16A6 MIR635 ENSG00000267009
GH17I068773 Enhancer 1.4 Ensembl ENCODE dbSUPER 16.9 +468.4 468425 5 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS ABCA10 ABCA8 BPTF ABCA9 ABCA6 WIPI1 LINC01482 GC17P068795 LOC105371877
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ABCA10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ABCA10 gene promoter:

Genomic Locations for ABCA10 Gene

Genomic Locations for ABCA10 Gene
chr17:69,147,214-69,244,846
(GRCh38/hg38)
Size:
97,633 bases
Orientation:
Minus strand
chr17:67,143,355-67,240,987
(GRCh37/hg19)

Genomic View for ABCA10 Gene

Genes around ABCA10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ABCA10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ABCA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ABCA10 Gene

Proteins for ABCA10 Gene

  • Protein details for ABCA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWZ4-ABCAA_HUMAN
    Recommended name:
    ATP-binding cassette sub-family A member 10
    Protein Accession:
    Q8WWZ4
    Secondary Accessions:
    • C9JZH2
    • C9K035
    • Q6PIQ6
    • Q7Z2I9
    • Q7Z7P7
    • Q86TD2

    Protein attributes for ABCA10 Gene

    Size:
    1543 amino acids
    Molecular mass:
    175790 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ABCA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ABCA10 Gene

Selected DME Specific Peptides for ABCA10 Gene

Q8WWZ4:
  • DEPTAGLD
  • NGAGKST
  • LDEPTAG
  • VLLLDEP
  • DEPTAGLDP

Post-translational modifications for ABCA10 Gene

No Post-translational modifications

Domains & Families for ABCA10 Gene

Gene Families for ABCA10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for ABCA10 Gene

Suggested Antigen Peptide Sequences for ABCA10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWZ4

UniProtKB/Swiss-Prot:

ABCAA_HUMAN :
  • Belongs to the ABC transporter superfamily. ABCA family.
Family:
  • Belongs to the ABC transporter superfamily. ABCA family.
genes like me logo Genes that share domains with ABCA10: view

Function for ABCA10 Gene

Molecular function for ABCA10 Gene

UniProtKB/Swiss-Prot Function:
Probable transporter which may play a role in macrophage lipid homeostasis.
UniProtKB/Swiss-Prot Induction:
Down-regulated by cholesterol loading of macrophages.

Enzyme Numbers (IUBMB) for ABCA10 Gene

Phenotypes From GWAS Catalog for ABCA10 Gene

Gene Ontology (GO) - Molecular Function for ABCA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity IEA --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA,IEA --
genes like me logo Genes that share ontologies with ABCA10: view
genes like me logo Genes that share phenotypes with ABCA10: view

Animal Model Products

CRISPR Products

miRNA for ABCA10 Gene

miRTarBase miRNAs that target ABCA10

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ABCA10 Gene

Localization for ABCA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ABCA10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ABCA10 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ABCA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IBA --
genes like me logo Genes that share ontologies with ABCA10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ABCA10 Gene

Pathways & Interactions for ABCA10 Gene

genes like me logo Genes that share pathways with ABCA10: view

Pathways by source for ABCA10 Gene

Interacting Proteins for ABCA10 Gene

Gene Ontology (GO) - Biological Process for ABCA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006869 lipid transport IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with ABCA10: view

No data available for SIGNOR curated interactions for ABCA10 Gene

Drugs & Compounds for ABCA10 Gene

No Compound Related Data Available

Transcripts for ABCA10 Gene

Unigene Clusters for ABCA10 Gene

ATP-binding cassette, sub-family A (ABC1), member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ABCA10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d
SP1: - -
SP2:
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for ABCA10 Gene

GeneLoc Exon Structure for
ABCA10
ECgene alternative splicing isoforms for
ABCA10

Expression for ABCA10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ABCA10 Gene

mRNA differential expression in normal tissues according to GTEx for ABCA10 Gene

This gene is overexpressed in Nerve - Tibial (x5.8) and Ovary (x5.3).

Protein differential expression in normal tissues from HIPED for ABCA10 Gene

This gene is overexpressed in Blymphocyte (32.4), Neutrophil (18.1), Monocytes (9.3), and Tlymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ABCA10 Gene



Protein tissue co-expression partners for ABCA10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ABCA10 Gene:

ABCA10

SOURCE GeneReport for Unigene cluster for ABCA10 Gene:

Hs.25377

mRNA Expression by UniProt/SwissProt for ABCA10 Gene:

Q8WWZ4-ABCAA_HUMAN
Tissue specificity: Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.

Evidence on tissue expression from TISSUES for ABCA10 Gene

  • Liver(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ABCA10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ABCA10 Gene

Orthologs for ABCA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ABCA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ABCA10 33
  • 99.05 (n)
cow
(Bos Taurus)
Mammalia ABCA10 33 34
  • 77.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
ManyToMany
-- 34
  • 57 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Abca8a 34
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 51 (a)
ManyToMany
-- 34
  • 45 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii abch1 34
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42816 34
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea abt-5 34
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToMany
Species where no ortholog for ABCA10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ABCA10 Gene

ENSEMBL:
Gene Tree for ABCA10 (if available)
TreeFam:
Gene Tree for ABCA10 (if available)

Paralogs for ABCA10 Gene

Paralogs for ABCA10 Gene

Pseudogenes.org Pseudogenes for ABCA10 Gene

genes like me logo Genes that share paralogs with ABCA10: view

Variants for ABCA10 Gene

Sequence variations from dbSNP and Humsavar for ABCA10 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs3842375 benign, not specified 69,149,050(-) GAGAGAG/GAGAG coding_sequence_variant, frameshift
rs1000030091 -- 69,154,394(-) T/C intron_variant
rs1000041945 -- 69,224,487(-) A/G intron_variant
rs1000064407 -- 69,230,787(-) T/C intron_variant
rs1000081898 -- 69,154,151(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ABCA10 Gene

Variant ID Type Subtype PubMed ID
nsv833527 CNV gain+loss 17160897
nsv575934 CNV loss 21841781
nsv575932 CNV loss 21841781
nsv575930 CNV loss 21841781
nsv516799 CNV loss 19592680
nsv470598 CNV loss 18288195
nsv457888 CNV loss 19166990
nsv2129 CNV insertion 18451855
nsv2128 CNV insertion 18451855
nsv1055156 CNV loss 25217958
dgv5757n54 CNV loss 21841781

Variation tolerance for ABCA10 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.10; 95.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ABCA10 Gene

Human Gene Mutation Database (HGMD)
ABCA10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ABCA10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ABCA10 Gene

Disorders for ABCA10 Gene

Additional Disease Information for ABCA10

No disorders were found for ABCA10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ABCA10 Gene

Publications for ABCA10 Gene

  1. ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter. (PMID: 12821155) Wenzel JJ … Schmitz G (Biochemical and biophysical research communications 2003) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The human ATP-binding cassette (ABC) transporter superfamily. (PMID: 11435397) Dean M … Allikmets R (Genome research 2001) 2 3 58
  4. A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival. (PMID: 25294155) Baecklund F … Smedby KE (BMC medical genetics 2014) 3 58
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58

Products for ABCA10 Gene

Sources for ABCA10 Gene

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