The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neur... See more...

Aliases for AATK Gene

Aliases for AATK Gene

  • Apoptosis Associated Tyrosine Kinase 2 3 5
  • Lemur Tyrosine Kinase 1 2 3 4
  • AATYK 2 3 4
  • LMTK1 2 3 4
  • LMR1 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 77 2 3
  • Brain Apoptosis-Associated Tyrosine Kinase 3 4
  • Serine/Threonine-Protein Kinase LMTK1 3 4
  • CDK5-Binding Protein 3 4
  • P35-Binding Protein 3 4
  • EC 4 50
  • KIAA0641 2 4
  • PPP1R77 2 3
  • AATYK1 2 3
  • P35BP 3 4
  • Apoptosis-Associated Tyrosine Kinase 4
  • EC 2.7.11 50
  • AATK 5

External Ids for AATK Gene

Previous GeneCards Identifiers for AATK Gene

  • GC17U990147
  • GC17M082453
  • GC17M079653
  • GC17M079791
  • GC17M076707
  • GC17M079091

Summaries for AATK Gene

Entrez Gene Summary for AATK Gene

  • The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for AATK Gene

AATK (Apoptosis Associated Tyrosine Kinase) is a Protein Coding gene. Diseases associated with AATK include Neuroblastoma. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LMTK3.

UniProtKB/Swiss-Prot Summary for AATK Gene

Gene Wiki entry for AATK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AATK Gene

Genomics for AATK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AATK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AATK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AATK

Top Transcription factor binding sites by QIAGEN in the AATK gene promoter:
  • AREB6
  • ATF
  • LCR-F1
  • NCX
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • SRF
  • YY1

Genomic Locations for AATK Gene

Latest Assembly
55,735 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
48,927 bases
Minus strand

(GRCh37/hg19 by Ensembl)
48,783 bases
Minus strand

Genomic View for AATK Gene

Genes around AATK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AATK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AATK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AATK Gene

Proteins for AATK Gene

  • Protein details for AATK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase LMTK1
    Protein Accession:
    Secondary Accessions:
    • O75136
    • Q6ZN31
    • Q86X28

    Protein attributes for AATK Gene

    1374 amino acids
    Molecular mass:
    144569 Da
    Quaternary structure:
    • Interacts with CDK5.

    Alternative splice isoforms for AATK Gene


neXtProt entry for AATK Gene

Selected DME Specific Peptides for AATK Gene


Post-translational modifications for AATK Gene

Domains & Families for AATK Gene

Gene Families for AATK Gene

Protein Domains for AATK Gene

Suggested Antigen Peptide Sequences for AATK Gene

GenScript: Design optimal peptide antigens:
  • p35-binding protein (LMTK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with AATK: view

Function for AATK Gene

Molecular function for AATK Gene

UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=;.
UniProtKB/Swiss-Prot Induction:
Up-regulated during apoptosis.
GENATLAS Biochemistry:
apoptosis associated tyrosine-kinase (AATYK),murine homolog

Enzyme Numbers (IUBMB) for AATK Gene

Phenotypes From GWAS Catalog for AATK Gene

Gene Ontology (GO) - Molecular Function for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,IBA 21873635
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IBA 21873635
GO:0005515 protein binding IPI 22321011
genes like me logo Genes that share ontologies with AATK: view
genes like me logo Genes that share phenotypes with AATK: view

Animal Models for AATK Gene

MGI Knock Outs for AATK:
  • Aatk Aatk<tm1Shhi>

Animal Models for research

  • Taconic Biosciences Mouse Models for AATK

miRNA for AATK Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AATK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AATK Gene

Localization for AATK Gene

Subcellular locations from UniProtKB/Swiss-Prot for AATK Gene

Membrane. Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AATK gene
Compartment Confidence
plasma membrane 3
mitochondrion 3
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with AATK: view

Pathways & Interactions for AATK Gene

PathCards logo

SuperPathways for AATK Gene

No Data Available

SIGNOR curated interactions for AATK Gene


Gene Ontology (GO) - Biological Process for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IBA 21873635
GO:0007420 brain development IBA 21873635
GO:0008150 biological_process ND --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with AATK: view

No data available for Pathways by source for AATK Gene

Drugs & Compounds for AATK Gene

No Compound Related Data Available

Transcripts for AATK Gene

mRNA/cDNA for AATK Gene

7 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AATK

Alternative Splicing Database (ASD) splice patterns (SP) for AATK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP2: -
SP3: -
SP4: -

Relevant External Links for AATK Gene

GeneLoc Exon Structure for

Expression for AATK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AATK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AATK Gene

This gene is overexpressed in Nerve - Tibial (x8.4) and Brain - Spinal cord (cervical c-1) (x5.0).

Protein differential expression in normal tissues from HIPED for AATK Gene

This gene is overexpressed in Ovary (35.1), Adipocyte (23.6), and NK cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AATK Gene

Protein tissue co-expression partners for AATK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AATK

SOURCE GeneReport for Unigene cluster for AATK Gene:


mRNA Expression by UniProt/SwissProt for AATK Gene:

Tissue specificity: Expressed in brain.

Evidence on tissue expression from TISSUES for AATK Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with AATK: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AATK Gene

Orthologs for AATK Gene

This gene was present in the common ancestor of chordates.

Orthologs for AATK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AATK 29 30
  • 95.69 (n)
(Canis familiaris)
Mammalia AATK 29 30
  • 83.36 (n)
(Bos Taurus)
Mammalia AATK 29 30
  • 81.47 (n)
(Rattus norvegicus)
Mammalia Aatk 29
  • 78.05 (n)
(Mus musculus)
Mammalia Aatk 29 16 30
  • 77.8 (n)
(Monodelphis domestica)
Mammalia AATK 30
  • 54 (a)
(Gallus gallus)
Aves AATK 29 30
  • 68.58 (n)
(Anolis carolinensis)
Reptilia AATK 30
  • 50 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia aatk 29
  • 56.87 (n)
(Danio rerio)
Actinopterygii aatkb 29 30
  • 60.55 (n)
aatka 30
  • 37 (a)
Species where no ortholog for AATK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AATK Gene

Gene Tree for AATK (if available)
Gene Tree for AATK (if available)
Evolutionary constrained regions (ECRs) for AATK: view image
Alliance of Genome Resources:
Additional Orthologs for AATK

Paralogs for AATK Gene

Paralogs for AATK Gene

(4) SIMAP similar genes for AATK Gene using alignment to 4 proteins:

  • H7C175_HUMAN
  • I3L360_HUMAN
  • I3L461_HUMAN
genes like me logo Genes that share paralogs with AATK: view

Variants for AATK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AATK Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs133704004 An ovarian mucinous carcinoma sample p.Met104Val
VAR_032679 An ovarian mucinous carcinoma sample p.Ser81Phe
VAR_032680 A lung adenocarcinoma sample p.Leu97Val
rs36000545 -- p.Phe1266Ser
rs55713566 -- p.Ala1332Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for AATK Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for AATK Gene

Variant ID Type Subtype PubMed ID
dgv191e215 CNV deletion 23714750
dgv3292n100 CNV gain 25217958
dgv46n68 CNV loss 17160897
esv1011110 CNV insertion 20482838
esv1314431 CNV deletion 17803354
esv2148507 CNV deletion 18987734
esv2278259 CNV deletion 18987734
esv26223 CNV gain+loss 19812545
esv2668695 CNV deletion 23128226
esv2716425 CNV deletion 23290073
esv2716426 CNV deletion 23290073
esv2716427 CNV deletion 23290073
esv2716428 CNV deletion 23290073
esv2716430 CNV deletion 23290073
esv2716431 CNV deletion 23290073
esv2716432 CNV deletion 23290073
esv2716433 CNV deletion 23290073
esv2716434 CNV deletion 23290073
esv2758707 CNV gain 17122850
esv3307516 CNV mobile element insertion 20981092
esv3414086 CNV duplication 20981092
esv3426009 CNV insertion 20981092
esv3554872 CNV deletion 23714750
esv3582923 CNV loss 25503493
esv3641392 CNV gain 21293372
nsv1057306 CNV loss 25217958
nsv1065052 CNV gain 25217958
nsv1066947 CNV loss 25217958
nsv1116243 CNV deletion 24896259
nsv1127604 CNV deletion 24896259
nsv1131341 CNV deletion 24896259
nsv1131342 CNV deletion 24896259
nsv1140228 CNV deletion 24896259
nsv1141310 CNV duplication 24896259
nsv1149351 CNV deletion 26484159
nsv428351 CNV gain 18775914
nsv470619 CNV loss 18288195
nsv523417 CNV gain 19592680
nsv828128 CNV loss 20364138
nsv833564 CNV loss 17160897
nsv952388 CNV deletion 24416366
nsv952389 CNV deletion 24416366

Variation tolerance for AATK Gene

Gene Damage Index Score: 9.14; 87.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AATK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AATK Gene

Disorders for AATK Gene

MalaCards: The human disease database

(1) MalaCards diseases for AATK Gene - From: COP and GCD

Disorder Aliases PubMed IDs
  • nb
- elite association - COSMIC cancer census association via MalaCards
Search AATK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AATK

genes like me logo Genes that share disorders with AATK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AATK Gene

Publications for AATK Gene

  1. Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (PMID: 14521924) Honma N … Hisanaga S (Biochemical and biophysical research communications 2003) 3 4 22
  2. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. (PMID: 10837911) Raghunath M … Damodar Reddy C (Brain research. Molecular brain research 2000) 3 4 22
  3. Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization. (PMID: 10083745) Seki N … Saito T (Journal of human genetics 1999) 2 3 22
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  5. LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. (PMID: 22573681) Takano T … Hisanaga S (The Journal of neuroscience : the official journal of the Society for Neuroscience 2012) 2 3

Products for AATK Gene

Sources for AATK Gene