The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neur... See more...

Aliases for AATK Gene

Aliases for AATK Gene

  • Apoptosis Associated Tyrosine Kinase 2 3 5
  • Lemur Tyrosine Kinase 1 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 77 2 3
  • Brain Apoptosis-Associated Tyrosine Kinase 3 4
  • Serine/Threonine-Protein Kinase LMTK1 3 4
  • CDK5-Binding Protein 3 4
  • P35-Binding Protein 3 4
  • EC 2.7.11.1 4 54
  • AATYK 3 4
  • LMTK1 3 4
  • P35BP 3 4
  • LMR1 3 4
  • Apoptosis-Associated Tyrosine Kinase 4
  • EC 2.7.11 54
  • KIAA0641 4
  • PPP1R77 3
  • AATYK1 3

External Ids for AATK Gene

Previous GeneCards Identifiers for AATK Gene

  • GC17U990147
  • GC17M082453
  • GC17M079653
  • GC17M079791
  • GC17M076707
  • GC17M079091

Summaries for AATK Gene

Entrez Gene Summary for AATK Gene

  • The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for AATK Gene

AATK (Apoptosis Associated Tyrosine Kinase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is LMTK3.

UniProtKB/Swiss-Prot Summary for AATK Gene

Gene Wiki entry for AATK Gene

Additional gene information for AATK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AATK Gene

Genomics for AATK Gene

GeneHancer (GH) Regulatory Elements for AATK Gene

Promoters and enhancers for AATK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AATK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AATK gene promoter:
  • AREB6
  • ATF
  • LCR-F1
  • NCX
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • SRF
  • YY1

Genomic Locations for AATK Gene

Genomic Locations for AATK Gene
chr17:81,117,295-81,166,221
(GRCh38/hg38)
Size:
48,927 bases
Orientation:
Minus strand
chr17:79,091,095-79,139,877
(GRCh37/hg19)
Size:
48,783 bases
Orientation:
Minus strand

Genomic View for AATK Gene

Genes around AATK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AATK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AATK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AATK Gene

Proteins for AATK Gene

  • Protein details for AATK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMQ8-LMTK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase LMTK1
    Protein Accession:
    Q6ZMQ8
    Secondary Accessions:
    • O75136
    • Q6ZN31
    • Q86X28

    Protein attributes for AATK Gene

    Size:
    1374 amino acids
    Molecular mass:
    144569 Da
    Quaternary structure:
    • Interacts with CDK5.

    Alternative splice isoforms for AATK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AATK Gene

Selected DME Specific Peptides for AATK Gene

Q6ZMQ8:
  • HSDLALRNC
  • CGVLHLH

Post-translational modifications for AATK Gene

Domains & Families for AATK Gene

Gene Families for AATK Gene

Suggested Antigen Peptide Sequences for AATK Gene

GenScript: Design optimal peptide antigens:
  • p35-binding protein (LMTK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZMQ8

UniProtKB/Swiss-Prot:

LMTK1_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with AATK: view

Function for AATK Gene

Molecular function for AATK Gene

UniProtKB/Swiss-Prot Function:
May be involved in neuronal differentiation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;.
UniProtKB/Swiss-Prot Induction:
Up-regulated during apoptosis.
GENATLAS Biochemistry:
apoptosis associated tyrosine-kinase (AATYK),murine homolog

Enzyme Numbers (IUBMB) for AATK Gene

Phenotypes From GWAS Catalog for AATK Gene

Gene Ontology (GO) - Molecular Function for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with AATK: view
genes like me logo Genes that share phenotypes with AATK: view

Animal Models for AATK Gene

MGI Knock Outs for AATK:
  • Aatk Aatk<tm1Shhi>

Animal Model Products

  • Taconic Biosciences Mouse Models for AATK

CRISPR Products

miRNA for AATK Gene

miRTarBase miRNAs that target AATK

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AATK Gene

Localization for AATK Gene

Subcellular locations from UniProtKB/Swiss-Prot for AATK Gene

Membrane; Single-pass type I membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Note=Predominantly perinuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AATK gene
Compartment Confidence
plasma membrane 2
mitochondrion 2
extracellular 1
endosome 1
cytosol 1
cytoskeleton 0
peroxisome 0
nucleus 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with AATK: view

Pathways & Interactions for AATK Gene

PathCards logo

SuperPathways for AATK Gene

No Data Available

SIGNOR curated interactions for AATK Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for AATK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0008150 biological_process ND --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with AATK: view

No data available for Pathways by source for AATK Gene

Drugs & Compounds for AATK Gene

No Compound Related Data Available

Transcripts for AATK Gene

mRNA/cDNA for AATK Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AATK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b
SP1:
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:

Relevant External Links for AATK Gene

GeneLoc Exon Structure for
AATK
ECgene alternative splicing isoforms for
AATK

Expression for AATK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AATK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AATK Gene

This gene is overexpressed in Nerve - Tibial (x8.4) and Brain - Spinal cord (cervical c-1) (x5.0).

Protein differential expression in normal tissues from HIPED for AATK Gene

This gene is overexpressed in Ovary (35.1), Adipocyte (23.6), and NK cells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AATK Gene



Protein tissue co-expression partners for AATK Gene

NURSA nuclear receptor signaling pathways regulating expression of AATK Gene:

AATK

SOURCE GeneReport for Unigene cluster for AATK Gene:

Hs.514575

mRNA Expression by UniProt/SwissProt for AATK Gene:

Q6ZMQ8-LMTK1_HUMAN
Tissue specificity: Expressed in brain.

Evidence on tissue expression from TISSUES for AATK Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with AATK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for AATK Gene

Orthologs for AATK Gene

This gene was present in the common ancestor of chordates.

Orthologs for AATK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AATK 33 32
  • 95.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AATK 33 32
  • 83.36 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AATK 33 32
  • 81.47 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aatk 32
  • 78.05 (n)
mouse
(Mus musculus)
Mammalia Aatk 17 33 32
  • 77.8 (n)
oppossum
(Monodelphis domestica)
Mammalia AATK 33
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves AATK 33 32
  • 68.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AATK 33
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aatk 32
  • 56.87 (n)
zebrafish
(Danio rerio)
Actinopterygii aatkb 33 32
  • 60.55 (n)
OneToMany
aatka 33
  • 37 (a)
OneToMany
Species where no ortholog for AATK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AATK Gene

ENSEMBL:
Gene Tree for AATK (if available)
TreeFam:
Gene Tree for AATK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AATK: view image

Paralogs for AATK Gene

Paralogs for AATK Gene

(4) SIMAP similar genes for AATK Gene using alignment to 4 proteins:

  • LMTK1_HUMAN
  • H7C175_HUMAN
  • I3L360_HUMAN
  • I3L461_HUMAN
genes like me logo Genes that share paralogs with AATK: view

Variants for AATK Gene

Sequence variations from dbSNP and Humsavar for AATK Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1337040042 An ovarian mucinous carcinoma sample 81,131,085(-) T/C coding_sequence_variant, initiator_codon_variant, missense_variant
VAR_032679 An ovarian mucinous carcinoma sample p.Ser81Phe
VAR_032680 A lung adenocarcinoma sample p.Leu97Val
rs1000075806 -- 81,167,786(-) G/A upstream_transcript_variant
rs1000099430 -- 81,159,413(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AATK Gene

Variant ID Type Subtype PubMed ID
dgv191e215 CNV deletion 23714750
dgv3292n100 CNV gain 25217958
dgv46n68 CNV loss 17160897
esv1011110 CNV insertion 20482838
esv1314431 CNV deletion 17803354
esv2148507 CNV deletion 18987734
esv2278259 CNV deletion 18987734
esv26223 CNV gain+loss 19812545
esv2668695 CNV deletion 23128226
esv2716425 CNV deletion 23290073
esv2716426 CNV deletion 23290073
esv2716427 CNV deletion 23290073
esv2716428 CNV deletion 23290073
esv2716430 CNV deletion 23290073
esv2716431 CNV deletion 23290073
esv2716432 CNV deletion 23290073
esv2716433 CNV deletion 23290073
esv2716434 CNV deletion 23290073
esv2758707 CNV gain 17122850
esv3307516 CNV mobile element insertion 20981092
esv3414086 CNV duplication 20981092
esv3426009 CNV insertion 20981092
esv3554872 CNV deletion 23714750
esv3582923 CNV loss 25503493
esv3641392 CNV gain 21293372
nsv1057306 CNV loss 25217958
nsv1065052 CNV gain 25217958
nsv1066947 CNV loss 25217958
nsv1116243 CNV deletion 24896259
nsv1127604 CNV deletion 24896259
nsv1131341 CNV deletion 24896259
nsv1131342 CNV deletion 24896259
nsv1140228 CNV deletion 24896259
nsv1141310 CNV duplication 24896259
nsv1149351 CNV deletion 26484159
nsv428351 CNV gain 18775914
nsv470619 CNV loss 18288195
nsv523417 CNV gain 19592680
nsv828128 CNV loss 20364138
nsv833564 CNV loss 17160897
nsv952388 CNV deletion 24416366
nsv952389 CNV deletion 24416366

Variation tolerance for AATK Gene

Gene Damage Index Score: 9.14; 87.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AATK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AATK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AATK Gene

Disorders for AATK Gene

Additional Disease Information for AATK

No disorders were found for AATK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AATK Gene

Publications for AATK Gene

  1. Apoptosis-associated tyrosine kinase is a Cdk5 activator p35 binding protein. (PMID: 14521924) Honma N … Hisanaga S (Biochemical and biophysical research communications 2003) 3 4 23 56
  2. A novel kinase, AATYK induces and promotes neuronal differentiation in a human neuroblastoma (SH-SY5Y) cell line. (PMID: 10837911) Raghunath M … Damodar Reddy C (Brain research. Molecular brain research 2000) 3 4 23 56
  3. Chromosomal assignment of a human apoptosis-associated tyrosine kinase gene on chromosome 17q25.3 by somatic hybrid analysis and fluorescence in situ hybridization. (PMID: 10083745) Seki N … Saito T (Journal of human genetics 1999) 2 3 23 56
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 56
  5. LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. (PMID: 22573681) Takano T … Hisanaga S (The Journal of neuroscience : the official journal of the Society for Neuroscience 2012) 2 3 56

Products for AATK Gene

Sources for AATK Gene