Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
AATF (Apoptosis Antagonizing Transcription Factor) is a Protein Coding gene. Diseases associated with AATF include Lacrimal Apparatus Disease and Chromosome 17Q12 Deletion Syndrome. Among its related pathways are RET signaling and Regulation of retinoblastoma protein. Gene Ontology (GO) annotations related to this gene include protein domain specific binding.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH17J036947 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 756.8 | +0.6 | 561 | 3.5 | SIN3A SP1 ZBTB40 CTCF MLX RBPJ POLR2A CTBP1 USF2 ATF1 | AATF ENSG00000277911 | |
GH17J036972 | Enhancer | 1.3 | VISTA UCNEbase Ensembl | 22.5 | +25.9 | 25926 | 6.4 | ZNF362 MAFK PRDM1 ATF7 ZNF316 ZNF10 ZBTB17 ZNF18 CEBPG ZNF366 | AATF ENSG00000277911 | |
GH17J036978 | Enhancer | 1.4 | VISTA UCNEbase Ensembl ENCODE | 10.8 | +31.0 | 31026 | 3 | ZNF362 PRDM1 ZNF680 PKNOX1 ZNF512 ZEB2 ZXDB OSR2 PRDM4 KLF8 | ENSG00000277911 AATF LHX1 | |
GH17J037044 | Enhancer | 1.2 | Ensembl ENCODE dbSUPER | 11.9 | +100.8 | 100826 | 9.8 | CTCF RAD21 SREBF1 SP1 MLLT1 SP7 ZSCAN21 SMARCA4 DPF2 PKNOX1 | AATF ENSG00000278638 LOC105371753 RF00017-2358 | |
GH17J037017 | Enhancer | 0.9 | UCNEbase Ensembl | 10.7 | +69.8 | 69825 | 4.2 | SP1 ZNF585B JUND OSR2 FOXA2 POLR2A RCOR1 HNF4A PRDM6 | AATF RF00017-2357 ENSG00000277589 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 10783144 |
GO:0019901 | protein kinase binding | IEA | -- |
GO:0043522 | leucine zipper domain binding | IEA,IPI | 10580117 |
GO:0048156 | tau protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 10580117 |
GO:0005730 | nucleolus | IBA | 21873635 |
GO:0005737 | cytoplasm | IDA,IEA | 14627703 |
GO:0005794 | Golgi apparatus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | p75 NTR receptor-mediated signalling | ||
2 | Signaling by GPCR | ||
3 | RET signaling | ||
4 | Regulation of retinoblastoma protein |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006974 | cellular response to DNA damage stimulus | IEP | 18049476 |
GO:0007155 | cell adhesion | IEA | -- |
GO:0007346 | regulation of mitotic cell cycle | IEA | -- |
GO:0032929 | negative regulation of superoxide anion generation | IDA | 15207272 |
GO:0040016 | embryonic cleavage | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | AATF 32 |
|
||
dog (Canis familiaris) |
Mammalia | AATF 32 |
|
||
cow (Bos Taurus) |
Mammalia | AATF 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Aatf 32 |
|
||
mouse (Mus musculus) |
Mammalia | Aatf 17 32 |
|
||
chicken (Gallus gallus) |
Aves | AATF 32 |
|
||
tropical clawed frog (Silurana tropicalis) |
Amphibia | aatf 32 |
|
||
Str.10137 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.7093 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | aatf 32 |
|
||
sbcb109 32 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.13361 32 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007394 32 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | Y73E7A.2 32 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT5G61330 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os01g0526200 32 |
|
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000008224 | -- | 37,050,092(+) | G/T | intron_variant | |
rs1000070395 | -- | 37,019,802(+) | TATTAT/TAT | intron_variant | |
rs1000077055 | -- | 36,959,272(+) | C/T | intron_variant | |
rs1000101975 | -- | 37,005,825(+) | T/C | intron_variant | |
rs1000171472 | -- | 36,995,364(+) | A/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1366836 | CNV | deletion | 17803354 |
esv2315584 | CNV | deletion | 18987734 |
esv2457233 | CNV | deletion | 19546169 |
esv2715886 | CNV | deletion | 23290073 |
esv3554381 | CNV | deletion | 23714750 |
esv3640480 | CNV | gain | 21293372 |
nsv112350 | CNV | insertion | 16902084 |
nsv112468 | CNV | insertion | 16902084 |
nsv1142216 | CNV | tandem duplication | 24896259 |
nsv833430 | CNV | gain+loss | 17160897 |
nsv960597 | CNV | deletion | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lacrimal apparatus disease |
|
|
chromosome 17q12 deletion syndrome |
|
|
alzheimer disease |
|
|