Aliases for AATF Gene
External Ids for AATF Gene
Previous GeneCards Identifiers for AATF Gene
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for AATF Gene
AATF (Apoptosis Antagonizing Transcription Factor) is a Protein Coding gene. Diseases associated with AATF include Lacrimal Apparatus Disease and Chromosome 17Q12 Deletion Syndrome. Among its related pathways are RET signaling and Regulation of retinoblastoma protein. Gene Ontology (GO) annotations related to this gene include protein domain specific binding.
UniProtKB/Swiss-Prot Summary for AATF Gene
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.