Aliases for AARS1 Gene
External Ids for AARS1 Gene
Previous HGNC Symbols for AARS1 Gene
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
GeneCards Summary for AARS1 Gene
AARS1 (Alanyl-TRNA Synthetase 1) is a Protein Coding gene. Diseases associated with AARS1 include Charcot-Marie-Tooth Disease, Axonal, Type 2N and Epileptic Encephalopathy, Early Infantile, 29. Among its related pathways are Gene Expression and tRNA Aminoacylation. An important paralog of this gene is AARS2.
UniProtKB/Swiss-Prot Summary for AARS1 Gene
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438).