Aliases for AARD Gene

Aliases for AARD Gene

  • Alanine And Arginine Rich Domain Containing Protein 2 3 5
  • Alanine And Arginine-Rich Domain-Containing Protein 2 3 4
  • C8orf85 3 4
  • Chromosome 8 Open Reading Frame 85 2
  • LOC441376 2
  • AARD 5

External Ids for AARD Gene

Previous HGNC Symbols for AARD Gene

  • C8orf85

Previous GeneCards Identifiers for AARD Gene

  • GC08P117951

Summaries for AARD Gene

GeneCards Summary for AARD Gene

AARD (Alanine And Arginine Rich Domain Containing Protein) is a Protein Coding gene. Diseases associated with AARD include Facial Hemiatrophy. An important paralog of this gene is FAM167A.

Additional gene information for AARD Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AARD Gene

Genomics for AARD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AARD Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J116937 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 626.7 +0.2 194 1.6 CREB1 ZNF692 PATZ1 EZH2 HES1 KLF9 RAD21 CTCF EGR1 CTBP1 AARD lnc-RAD21-1 SLC30A8
GH08J116880 Promoter/Enhancer 0.8 EPDnew dbSUPER 600.2 -57.9 -57949 0.1 RUNX3 BCL11A NFATC1 IKZF1 piR-60073 AARD RAD21 piR-32023-247
GH08J116889 Enhancer 0.9 Ensembl ENCODE 11.3 -47.6 -47643 2.1 CREB1 GATAD2A GABPA CEBPA SOX13 TCF7 ZNF766 HMBOX1 CEBPB BRCA1 RAD21 AARD SLC30A8 piR-32023-247 piR-60073
GH08J116900 Enhancer 0.9 Ensembl ENCODE 10.9 -36.7 -36737 1.9 IKZF2 RELA YY1 EED DPF2 RELB RUNX3 BRCA1 CEBPB FOS RAD21 RAD21-AS1 AARD SLC30A8 piR-32023-247 piR-52008-021
GH08J116802 Enhancer 0.8 Ensembl ENCODE 11.2 -137.4 -137361 1.1 CEBPG CREB1 TARDBP FOXA1 RFX1 ATF7 SCRT2 CTBP1 PKNOX1 ZNF217 AARD RAD21 RAD21-AS1 EIF3H piR-38351-470 HSALNG0067943 UTP23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AARD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AARD

Genomic Locations for AARD Gene

Genomic Locations for AARD Gene
6,281 bases
Plus strand
6,289 bases
Plus strand

Genomic View for AARD Gene

Genes around AARD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AARD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AARD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AARD Gene

Proteins for AARD Gene

  • Protein details for AARD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alanine and arginine-rich domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A5PKU8

    Protein attributes for AARD Gene

    155 amino acids
    Molecular mass:
    17575 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AARD Gene

Post-translational modifications for AARD Gene

No Post-translational modifications

Other Protein References for AARD Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AARD Gene

Domains & Families for AARD Gene

Gene Families for AARD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AARD Gene


Suggested Antigen Peptide Sequences for AARD Gene

GenScript: Design optimal peptide antigens:
  • Alanine and arginine-rich domain-containing protein (AARD_HUMAN)
  • Chromosome 8 open reading frame 85 (B2RU19_HUMAN)
genes like me logo Genes that share domains with AARD: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AARD Gene

Function for AARD Gene

Phenotypes From GWAS Catalog for AARD Gene

Phenotypes for AARD Gene

genes like me logo Genes that share phenotypes with AARD: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AARD

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AARD Gene

Localization for AARD Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AARD gene
Compartment Confidence
nucleus 2
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for AARD Gene

Pathways & Interactions for AARD Gene

PathCards logo

SuperPathways for AARD Gene

No Data Available

Gene Ontology (GO) - Biological Process for AARD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030324 lung development IEA --
genes like me logo Genes that share ontologies with AARD: view

No data available for Pathways by source and SIGNOR curated interactions for AARD Gene

Drugs & Compounds for AARD Gene

No Compound Related Data Available

Transcripts for AARD Gene

mRNA/cDNA for AARD Gene

3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AARD

Alternative Splicing Database (ASD) splice patterns (SP) for AARD Gene

No ASD Table

Relevant External Links for AARD Gene

GeneLoc Exon Structure for

Expression for AARD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AARD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AARD Gene

This gene is overexpressed in Esophagus - Muscularis (x9.6), Testis (x9.1), Esophagus - Gastroesophageal Junction (x7.2), Colon - Sigmoid (x4.5), and Bladder (x4.5).

Protein differential expression in normal tissues from HIPED for AARD Gene

This gene is overexpressed in Adipocyte (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AARD Gene

Protein tissue co-expression partners for AARD Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AARD

SOURCE GeneReport for Unigene cluster for AARD Gene:

genes like me logo Genes that share expression patterns with AARD: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AARD Gene

Orthologs for AARD Gene

This gene was present in the common ancestor of mammals.

Orthologs for AARD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AARD 30 31
  • 98.7 (n)
(Canis familiaris)
Mammalia AARD 31
  • 77 (a)
(Bos Taurus)
Mammalia AARD 30 31
  • 75 (n)
(Mus musculus)
Mammalia Aard 30 17 31
  • 71.02 (n)
(Rattus norvegicus)
Mammalia Aard 30
  • 70.97 (n)
Species where no ortholog for AARD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for AARD Gene

Gene Tree for AARD (if available)
Gene Tree for AARD (if available)
Evolutionary constrained regions (ECRs) for AARD: view image

Paralogs for AARD Gene

Paralogs for AARD Gene

(1) SIMAP similar genes for AARD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AARD: view

Variants for AARD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AARD Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
768256 Benign: not provided 116,938,453(+) G/A SYNONYMOUS_VARIANT
rs16889283 - p.Gly96Arg

Additional dbSNP identifiers (rs#s) for AARD Gene

Structural Variations from Database of Genomic Variants (DGV) for AARD Gene

Variant ID Type Subtype PubMed ID
nsv831434 CNV gain 17160897

Variation tolerance for AARD Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.89; 83.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AARD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AARD Gene

Disorders for AARD Gene

MalaCards: The human disease database

(1) MalaCards diseases for AARD Gene - From: DISEASES

Disorder Aliases PubMed IDs
facial hemiatrophy
  • parry-romberg syndrome
- elite association - COSMIC cancer census association via MalaCards
Search AARD in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with AARD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AARD Gene

Publications for AARD Gene

  1. Alanine and arginine rich domain containing protein, Aard, is directly regulated by androgen receptor in mouse Sertoli cells. (PMID: 27959439) Geng Q … Guo J (Molecular medicine reports 2017) 2 3
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for AARD Gene

Sources for AARD Gene