Aliases for AANAT Gene
External Ids for AANAT Gene
Previous GeneCards Identifiers for AANAT Gene
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for AANAT Gene
AANAT (Aralkylamine N-Acetyltransferase) is a Protein Coding gene. Diseases associated with AANAT include Pineocytoma and Alexia. Among its related pathways are Amine-derived hormones and Tryptophan metabolism. Gene Ontology (GO) annotations related to this gene include N-acetyltransferase activity and arylamine N-acetyltransferase activity.
UniProtKB/Swiss-Prot Summary for AANAT Gene
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.