The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq... See more...

Aliases for AAMP Gene

Aliases for AAMP Gene

  • Angio Associated Migratory Cell Protein 2 3 5
  • Angio-Associated Migratory Cell Protein 3 4

External Ids for AAMP Gene

Previous GeneCards Identifiers for AAMP Gene

  • GC02M217144
  • GC02M217850
  • GC02M219092
  • GC02M219331
  • GC02M218954
  • GC02M218837
  • GC02M210981

Summaries for AAMP Gene

Entrez Gene Summary for AAMP Gene

  • The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]

GeneCards Summary for AAMP Gene

AAMP (Angio Associated Migratory Cell Protein) is a Protein Coding gene. Diseases associated with AAMP include Paroxysmal Nonkinesigenic Dyskinesia 1 and Paroxysmal Dyskinesia. Among its related pathways are Nucleotide-binding Oligomerization Domain (NOD) pathway. Gene Ontology (GO) annotations related to this gene include heparin binding. An important paralog of this gene is NWD2.

UniProtKB/Swiss-Prot Summary for AAMP Gene

  • Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.

Gene Wiki entry for AAMP Gene

Additional gene information for AAMP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AAMP Gene

Genomics for AAMP Gene

GeneHancer (GH) Regulatory Elements for AAMP Gene

Promoters and enhancers for AAMP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AAMP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AAMP gene promoter:
  • c-Myb
  • C/EBPbeta
  • Elk-1
  • GCNF
  • GCNF-1
  • GCNF-2
  • MyoD
  • NF-1
  • NF-1/L
  • Nkx2-5

Genomic Locations for AAMP Gene

Genomic Locations for AAMP Gene
chr2:218,264,123-218,270,257
(GRCh38/hg38)
Size:
6,135 bases
Orientation:
Minus strand
chr2:219,128,850-219,134,980
(GRCh37/hg19)
Size:
6,131 bases
Orientation:
Minus strand

Genomic View for AAMP Gene

Genes around AAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AAMP Gene

Proteins for AAMP Gene

  • Protein details for AAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13685-AAMP_HUMAN
    Recommended name:
    Angio-associated migratory cell protein
    Protein Accession:
    Q13685
    Secondary Accessions:
    • Q8WUJ9
    • Q96H92

    Protein attributes for AAMP Gene

    Size:
    434 amino acids
    Molecular mass:
    46751 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA68889.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG33036.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for AAMP Gene

Post-translational modifications for AAMP Gene

  • Ubiquitination at Lys245
  • Modification sites at PhosphoSitePlus

Other Protein References for AAMP Gene

No data available for DME Specific Peptides for AAMP Gene

Domains & Families for AAMP Gene

Gene Families for AAMP Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for AAMP Gene

GenScript: Design optimal peptide antigens:
  • Angio-associated migratory cell protein (AAMP_HUMAN)
genes like me logo Genes that share domains with AAMP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for AAMP Gene

Function for AAMP Gene

Molecular function for AAMP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.

Phenotypes From GWAS Catalog for AAMP Gene

Gene Ontology (GO) - Molecular Function for AAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008201 heparin binding IDA 7743515
GO:0051082 unfolded protein binding IBA 21873635
genes like me logo Genes that share ontologies with AAMP: view
genes like me logo Genes that share phenotypes with AAMP: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AAMP Gene

Localization for AAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AAMP Gene

Cell membrane. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AAMP gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 4
cytosol 4
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Microtubules (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 10329261
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with AAMP: view

Pathways & Interactions for AAMP Gene

genes like me logo Genes that share pathways with AAMP: view

Pathways by source for AAMP Gene

1 BioSystems pathway for AAMP Gene

Gene Ontology (GO) - Biological Process for AAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 10329261
GO:0007275 multicellular organism development IEA --
GO:0010595 positive regulation of endothelial cell migration ISS --
GO:0014909 smooth muscle cell migration IEP 18634987
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with AAMP: view

No data available for SIGNOR curated interactions for AAMP Gene

Drugs & Compounds for AAMP Gene

No Compound Related Data Available

Transcripts for AAMP Gene

mRNA/cDNA for AAMP Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AAMP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7: - -
SP8: - -
SP9: -
SP10: -
SP11: -
SP12:

Relevant External Links for AAMP Gene

GeneLoc Exon Structure for
AAMP
ECgene alternative splicing isoforms for
AAMP

Expression for AAMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AAMP Gene

Protein differential expression in normal tissues from HIPED for AAMP Gene

This gene is overexpressed in Lung (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AAMP Gene



Protein tissue co-expression partners for AAMP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of AAMP Gene:

AAMP

SOURCE GeneReport for Unigene cluster for AAMP Gene:

Hs.83347

mRNA Expression by UniProt/SwissProt for AAMP Gene:

Q13685-AAMP_HUMAN
Tissue specificity: Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.

Evidence on tissue expression from TISSUES for AAMP Gene

  • Nervous system(4.9)
  • Skin(4.7)
  • Liver(4.3)
  • Intestine(2.3)
  • Lung(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with AAMP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AAMP Gene

Orthologs for AAMP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AAMP 33 32
  • 99.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AAMP 33 32
  • 92.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AAMP 33 32
  • 91.09 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aamp 32
  • 89.94 (n)
mouse
(Mus musculus)
Mammalia Aamp 17 33 32
  • 89.78 (n)
oppossum
(Monodelphis domestica)
Mammalia AAMP 33
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves AAMP 33 32
  • 75.04 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 79 (a)
OneToMany
-- 33
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aamp 32
  • 68.79 (n)
Str.15278 32
zebrafish
(Danio rerio)
Actinopterygii aamp 33 32
  • 66.42 (n)
OneToOne
Dr.11399 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011387 32
  • 53.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5114 33 34 32
  • 45.76 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y111B2A.12 32
  • 43.69 (n)
Y111B2A.12 33
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD3 33
  • 15 (a)
OneToMany
SQT1 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G71840 32
  • 47.27 (n)
rice
(Oryza sativa)
Liliopsida Os03g0685600 32
  • 45.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 47 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC25H1.08c 32
  • 44.48 (n)
Species where no ortholog for AAMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AAMP Gene

ENSEMBL:
Gene Tree for AAMP (if available)
TreeFam:
Gene Tree for AAMP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AAMP: view image

Paralogs for AAMP Gene

Paralogs for AAMP Gene

genes like me logo Genes that share paralogs with AAMP: view

Variants for AAMP Gene

Sequence variations from dbSNP and Humsavar for AAMP Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1023163176 uncertain-significance, Paroxysmal nonkinesigenic dyskinesia 1 218,270,551(-) G/A/T upstream_transcript_variant
rs1201792156 uncertain-significance, Paroxysmal nonkinesigenic dyskinesia 1 218,271,546(-) C/T upstream_transcript_variant
rs121434511 pathogenic, Paroxysmal nonkinesigenic dyskinesia 1, Episodic hemiplegia, Paroxysmal dyskinesia, Paroxysmal dystonia 218,270,561(-) C/T upstream_transcript_variant
rs121434512 conflicting-interpretations-of-pathogenicity, Paroxysmal nonkinesigenic dyskinesia 1 218,270,555(-) C/T upstream_transcript_variant
rs121434513 benign, Paroxysmal nonkinesigenic dyskinesia 1 218,271,410(-) G/C/T upstream_transcript_variant

Variation tolerance for AAMP Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AAMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AAMP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AAMP Gene

Disorders for AAMP Gene

MalaCards: The human disease database

(3) MalaCards diseases for AAMP Gene - From: GeneCards

Disorder Aliases PubMed IDs
paroxysmal nonkinesigenic dyskinesia 1
  • pnkd1
paroxysmal dyskinesia
  • paroxysmal dystonic choreoathetosis
paroxysmal dystonia
- elite association - COSMIC cancer census association via MalaCards
Search AAMP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AAMP

genes like me logo Genes that share disorders with AAMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AAMP Gene

Publications for AAMP Gene

  1. Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. (PMID: 7743515) Beckner ME … Liotta LA (Cancer research 1995) 2 3 4 23 56
  2. A function for AAMP in Nod2-mediated NF-kappaB activation. (PMID: 19535145) Bielig H … Kufer TA (Molecular immunology 2009) 3 23 56
  3. Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis. (PMID: 18634987) Vogt F … Blindt R (Journal of the American College of Cardiology 2008) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Extracellular angio-associated migratory cell protein plays a positive role in angiogenesis and is regulated by astrocytes in coculture. (PMID: 11969303) Beckner ME … Peterson VA (Microvascular research 2002) 3 23 56

Products for AAMP Gene

Sources for AAMP Gene