Aliases for AAMP Gene
Aliases for AAMP Gene
External Ids for AAMP Gene
- HGNC: 18
- Entrez Gene: 14
- Ensembl: ENSG00000127837
- OMIM: 603488
- UniProtKB: Q13685
Previous GeneCards Identifiers for AAMP Gene
- GC02M217144
- GC02M217850
- GC02M219092
- GC02M219331
- GC02M218954
- GC02M218837
- GC02M210981
Summaries for AAMP Gene
-
The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]
GeneCards Summary for AAMP Gene
AAMP (Angio Associated Migratory Cell Protein) is a Protein Coding gene. Diseases associated with AAMP include Paroxysmal Choreoathetosis. Among its related pathways are Nucleotide-binding Oligomerization Domain (NOD) pathway. Gene Ontology (GO) annotations related to this gene include heparin binding.
UniProtKB/Swiss-Prot for AAMP Gene
-
Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.
Additional gene information for AAMP Gene
- Monarch Initiative
- Search for AAMP at DataMed
- Search for AAMP at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AAMP Gene
Genomics for AAMP Gene
GeneHancer (GH) Regulatory Elements for AAMP Gene
Promoters and enhancers for AAMP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around AAMP on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AAMP gene promoter:
-
- MyoD
- Nkx2-5
- Elk-1
- c-Myb
- GCNF
- GCNF-1
- GCNF-2
- C/EBPbeta
- NF-1/L
- NF-1
Regulatory Element Products
Genomic Locations for AAMP Gene
Genomic Locations for AAMP Gene
- chr2:218,264,123-218,270,257
- (GRCh38/hg38)
- Size:
- 6,135 bases
- Orientation:
- Minus strand
- chr2:219,128,850-219,134,980
- (GRCh37/hg19)
- Size:
- 6,131 bases
- Orientation:
- Minus strand
Genomic View for AAMP Gene
Genes around AAMP on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q35 by Entrez Gene
- 2q35 by HGNC
- 2q35 by Ensembl
AAMP Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AAMP Gene
Proteins for AAMP Gene
-
Protein details for AAMP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13685-AAMP_HUMAN
- Recommended name:
- Angio-associated migratory cell protein
- Protein Accession:
- Q13685
- Q8WUJ9
- Q96H92
Protein attributes for AAMP Gene
- Size:
- 434 amino acids
- Molecular mass:
- 46751 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAA68889.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAG33036.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for AAMP Gene
Post-translational modifications for AAMP Gene
Other Protein References for AAMP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for AAMP
- Invitrogen Antibodies for AAMP
- antibodies-online: Search results for 48 available AAMP Antibodies ranked by validation data
- Compare Top AAMP Antibodies
-
Recommended
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-
Boster Bio Antibodies for AAMP
Protein Products
-
OriGene Purified Proteins for AAMP
- Search Origene for MassSpec and Protein Over-expression Lysates for AAMP
- Origene Custom Protein Services for AAMP
- Search GeneTex for Proteins for AAMP
Assay Products
No data available for DME Specific Peptides for AAMP Gene
Domains & Families for AAMP Gene
Gene Families for AAMP Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for AAMP Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for AAMP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for AAMP Gene
Function for AAMP Gene
Molecular function for AAMP Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.
Phenotypes From GWAS Catalog for AAMP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IEA | -- |
| GO:0008201 | heparin binding | IDA | 7743515 |
| GO:0051082 | unfolded protein binding | IBA | -- |
Phenotypes for AAMP Gene
Animal Model Products
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-
CRISPR Products
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OriGene CRISPR knockouts for AAMP
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- Overview of 146 available AAMP gene related products
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for AAMP
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miRNA for AAMP Gene
- miRTarBase miRNAs that target AAMP
miRNA Products
Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 146 available AAMP gene related products
- Overview of 146 available AAMP gene related products
Clone Products
- Sino Biological Human cDNA Clone for AAMP
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AAMP
- Applied Biological Materials Clones for AAMP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AAMP Gene
Localization for AAMP Gene
Subcellular locations from UniProtKB/Swiss-Prot for AAMP Gene
- Cell membrane. Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| nucleus | 2 |
- Cytosol (4)
- Microtubules (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IDA | 10329261 |
| GO:0015630 | microtubule cytoskeleton | IDA | -- |
Pathways & Interactions for AAMP Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Nucleotide-binding Oligomerization Domain (NOD) pathway | ||
Pathways by source for AAMP Gene
1 BioSystems pathway for AAMP Gene
Interacting Proteins for AAMP Gene
GPS-Prot Interaction Network for AAMP
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | NAS | 10329261 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0010595 | positive regulation of endothelial cell migration | ISS | -- |
| GO:0014909 | smooth muscle cell migration | IEP | 18634987 |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for SIGNOR curated interactions for AAMP Gene
Transcripts for AAMP Gene
mRNA/cDNA for AAMP Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (570) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000248450 1886 bps (uc002vhk.4)
- ENST00000420660 1761 bps (uc061siy.1)
- ENST00000422731 742 bps (uc061sjb.1)
- ENST00000444053 1804 bps (uc002vhl.4)
- ENST00000447885 671 bps (uc061sjd.1)
Unigene Clusters for AAMP Gene
CRISPR Products
-
OriGene CRISPR knockouts for AAMP
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AAMP
- genomics-online: gRNA clones - Search results for 146 available AAMP gene related products
- Overview of 146 available AAMP gene related products
- Applied Biological Materials CRISPR for AAMP
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AAMP
- GenScript: Design CRISPR guide RNA sequences for AAMP
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AAMP
- Browse OriGene Inhibitory RNA Products For AAMP
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AAMP
- genomics-online: shRNA clones - Search results for 146 available AAMP gene related products
- Overview of 146 available AAMP gene related products
Clone Products
- Sino Biological Human cDNA Clone for AAMP
- VectorBuilder custom plasmid, inducible vectors for AAMP
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AAMP
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AAMP
- Applied Biological Materials Clones for AAMP
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP11: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
Expression for AAMP Gene
This gene is overexpressed in Lung (9.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AAMP Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of AAMP Gene:
AAMPSOURCE GeneReport for Unigene cluster for AAMP Gene:
Hs.83347mRNA Expression by UniProt/SwissProt for AAMP Gene:
Q13685-AAMP_HUMAN
Tissue specificity:
Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.
Evidence on tissue expression from TISSUES for AAMP Gene
- Nervous system(4.9)
- Skin(4.7)
- Liver(4.3)
- Intestine(2.3)
- Lung(2.3)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for AAMP
- genomics-online: primer clones - Search results for 146 available AAMP gene related products
- Overview of 146 available AAMP gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AAMP Gene
Orthologs for AAMP Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AAMP 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | AAMP 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | AAMP 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Aamp 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Aamp 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | AAMP 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | AAMP 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | aamp 33 |
|
||
| Str.15278 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | aamp 34 33 |
|
OneToOne | |
| Dr.11399 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011387 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5114 34 35 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | CELE_Y111B2A.12 33 |
|
||
| Y111B2A.12 34 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SWD3 34 |
|
OneToMany | |
| SQT1 36 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT1G71840 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0685600 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC25H1.08c 33 |
|
- Species where no ortholog for AAMP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for AAMP Gene
- ENSEMBL:
- Gene Tree for AAMP (if available)
- TreeFam:
- Gene Tree for AAMP (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AAMP: view image
Paralogs for AAMP Gene
No data available for Paralogs for AAMP Gene
Variants for AAMP Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1031435484 | uncertain-significance, Paroxysmal choreoathetosis | 218,270,572(-) | C/T | upstream_transcript_variant | |
| rs121434511 | pathogenic, Paroxysmal choreoathetosis, Episodic hemiplegia, Paroxysmal dyskinesia, Paroxysmal dystonia | 218,270,561(-) | C/T | upstream_transcript_variant | |
| rs121434512 | pathogenic, Paroxysmal choreoathetosis | 218,270,555(-) | C/T | upstream_transcript_variant | |
| rs121434513 | pathogenic, Paroxysmal choreoathetosis | 218,271,410(-) | G/C/T | upstream_transcript_variant | |
| rs183319984 | likely-benign, Paroxysmal choreoathetosis | 218,270,431(-) | A/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.93;
59.51% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AAMP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AAMP
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for AAMP Gene
Disorders for AAMP Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| paroxysmal choreoathetosis |
|
|
Search AAMP in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AAMP
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for AAMP Gene
Publications for AAMP Gene
- Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence. (PMID: 7743515) Beckner ME … Liotta LA (Cancer research 1995) 2 3 4 22 58
- A function for AAMP in Nod2-mediated NF-kappaB activation. (PMID: 19535145) Bielig H … Kufer TA (Molecular immunology 2009) 3 22 58
- Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis. (PMID: 18634987) Vogt F … Blindt R (Journal of the American College of Cardiology 2008) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Extracellular angio-associated migratory cell protein plays a positive role in angiogenesis and is regulated by astrocytes in coculture. (PMID: 11969303) Beckner ME … Peterson VA (Microvascular research 2002) 3 22 58
Products for AAMP Gene
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- VectorBuilder custom plasmid, inducible vectors for AAMP
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 48 available AAMP Antibodies ranked by validation data
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- Recommended
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- antibodies-online: Search results for 7 available AAMP Proteins ranked by validation data
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- GeneTex AAMP Antibody for AAMP
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- genomics-online: cdna clones - Search results for 146 available AAMP gene related products
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- Overview of 146 available AAMP gene related products
- genomics-online: gRNA clones - Search results for 146 available AAMP gene related products
- Overview of 146 available AAMP gene related products
- genomics-online: primer clones - Search results for 146 available AAMP gene related products
- Overview of 146 available AAMP gene related products
- genomics-online: shRNA clones - Search results for 146 available AAMP gene related products
- Overview of 146 available AAMP gene related products
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Sources for AAMP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
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