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The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]
AAMP (Angio Associated Migratory Cell Protein) is a Protein Coding gene. Diseases associated with AAMP include Large Congenital Melanocytic Nevus. Among its related pathways are Nucleotide-binding Oligomerization Domain (NOD) pathway. Gene Ontology (GO) annotations related to this gene include heparin binding. An important paralog of this gene is NWD2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IEA,IPI | 28514442 |
GO:0008201 | heparin binding | IDA | 7743515 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
GO:0005886 | plasma membrane | IEA | -- |
GO:0009986 | cell surface | IDA | 10329261 |
GO:0015630 | microtubule cytoskeleton | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Nucleotide-binding Oligomerization Domain (NOD) pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001525 | angiogenesis | NAS | 10329261 |
GO:0007275 | multicellular organism development | IEA | -- |
GO:0010595 | positive regulation of endothelial cell migration | ISS | -- |
GO:0014909 | smooth muscle cell migration | IEP | 18634987 |
GO:0030154 | cell differentiation | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AAMP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AAMP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AAMP 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Aamp 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Aamp 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | AAMP 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Chicken (Gallus gallus) |
Aves | AAMP 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aamp 30 |
|
||
Str.15278 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | aamp 30 31 |
|
OneToOne | |
Dr.11399 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP011387 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5114 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | CELE_Y111B2A.12 30 |
|
||
Y111B2A.12 31 |
|
OneToOne | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SWD3 31 |
|
OneToMany | |
SQT1 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G71840 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os03g0685600 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC25H1.08c 30 |
|
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2305835 | - | p.Ile250Val |
Disorder | Aliases | PubMed IDs |
---|---|---|
large congenital melanocytic nevus |
|
|