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Aliases for AAED1 Gene

Aliases for AAED1 Gene

  • AhpC/TSA Antioxidant Enzyme Domain Containing 1 2 3 5
  • AhpC/TSA Antioxidant Enzyme Domain-Containing Protein 1 3 4
  • C9orf21 3 4
  • Chromosome 9 Open Reading Frame 21 2
  • Thioredoxin-Like Protein AAED1 3
  • UPF0308 Protein C9orf21 3

External Ids for AAED1 Gene

Previous HGNC Symbols for AAED1 Gene

  • C9orf21

Previous GeneCards Identifiers for AAED1 Gene

  • GC09M099404

Summaries for AAED1 Gene

GeneCards Summary for AAED1 Gene

AAED1 (AhpC/TSA Antioxidant Enzyme Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and antioxidant activity.

Additional gene information for AAED1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AAED1 Gene

Genomics for AAED1 Gene

GeneHancer (GH) Regulatory Elements for AAED1 Gene

Promoters and enhancers for AAED1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J096653 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.6 631 3 ATF1 FOXA2 ARNT SIN3A GTF3C2 ZNF766 GLIS2 ZNF207 SP3 REST AAED1 NCBP1 ERCC6L2 ZNF322P1 ZNF510 LOC441454 CDC14B LINC00476 MFSD14C CCDC180
GH09J097012 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.4 -357.9 -357877 2.4 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 POLR2B GLIS2 ZNF213 E2F8 ZNF782 MFSD14C CTSV NCBP1 ENSG00000236896 AAED1 TDRD7 YRDCP2
GH09J097524 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.6 -872.2 -872182 5.8 BATF IRF4 BRCA1 RFX5 ZNF143 RCOR1 ATF7 FOS ETV6 IKZF2 TMOD1 LOC105376168 TDRD7 ANKRD18CP ENSG00000203279 AAED1 CCDC180 PIR34153
GH09J096645 Enhancer 0.9 FANTOM5 Ensembl ENCODE 6 +8.7 8684 1.6 POLR2A MAX SPI1 ENSG00000224848 AAED1 CDC14B
GH09J096686 Promoter/Enhancer 1.2 Ensembl ENCODE 0.3 -31.6 -31563 1.2 CTCF BACH1 SIN3A CEBPG E2F1 CTBP1 ELK1 POLR2A ZNF143 ZNF444 ENSG00000224848 NUTM2G AAED1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around AAED1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for AAED1 Gene

Genomic Locations for AAED1 Gene
chr9:96,639,577-96,655,323
(GRCh38/hg38)
Size:
15,747 bases
Orientation:
Minus strand
chr9:99,401,859-99,417,599
(GRCh37/hg19)

Genomic View for AAED1 Gene

Genes around AAED1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AAED1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AAED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AAED1 Gene

Proteins for AAED1 Gene

  • Protein details for AAED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTV5-AAED1_HUMAN
    Recommended name:
    Thioredoxin-like protein AAED1
    Protein Accession:
    Q7RTV5
    Secondary Accessions:
    • B2RMW4
    • Q5JU02

    Protein attributes for AAED1 Gene

    Size:
    226 amino acids
    Molecular mass:
    24857 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AAED1 Gene

Post-translational modifications for AAED1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AAED1 Gene

No data available for DME Specific Peptides for AAED1 Gene

Domains & Families for AAED1 Gene

Gene Families for AAED1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for AAED1 Gene

Suggested Antigen Peptide Sequences for AAED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7RTV5

UniProtKB/Swiss-Prot:

AAED1_HUMAN :
  • Belongs to the AAED1 family.
Family:
  • Belongs to the AAED1 family.
genes like me logo Genes that share domains with AAED1: view

Function for AAED1 Gene

Gene Ontology (GO) - Molecular Function for AAED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016209 antioxidant activity IBA --
genes like me logo Genes that share ontologies with AAED1: view
genes like me logo Genes that share phenotypes with AAED1: view

Animal Model Products

CRISPR Products

miRNA for AAED1 Gene

miRTarBase miRNAs that target AAED1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AAED1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AAED1 Gene

Localization for AAED1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AAED1 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for AAED1 Gene

Pathways & Interactions for AAED1 Gene

SuperPathways for AAED1 Gene

No Data Available

Interacting Proteins for AAED1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364382%0d%0a9606.ENSP00000349465%0d%0a
Selected Interacting proteins: Q7RTV5-AAED1_HUMAN ENSP00000364382 for AAED1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for AAED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IBA --
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with AAED1: view

No data available for Pathways by source and SIGNOR curated interactions for AAED1 Gene

Drugs & Compounds for AAED1 Gene

No Compound Related Data Available

Transcripts for AAED1 Gene

mRNA/cDNA for AAED1 Gene

(83) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for AAED1 Gene

AhpC/TSA antioxidant enzyme domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AAED1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AAED1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - - -
SP3:

Relevant External Links for AAED1 Gene

GeneLoc Exon Structure for
AAED1
ECgene alternative splicing isoforms for
AAED1

Expression for AAED1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AAED1 Gene

Protein differential expression in normal tissues from HIPED for AAED1 Gene

This gene is overexpressed in Islet of Langerhans (53.4) and Bone (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AAED1 Gene



Protein tissue co-expression partners for AAED1 Gene

NURSA nuclear receptor signaling pathways regulating expression of AAED1 Gene:

AAED1

SOURCE GeneReport for Unigene cluster for AAED1 Gene:

Hs.44640
genes like me logo Genes that share expression patterns with AAED1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AAED1 Gene

Orthologs for AAED1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for AAED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AAED1 34 33
  • 99.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia AAED1 34 33
  • 90.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia AAED1 34 33
  • 90.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Aaed1 16 34 33
  • 86.79 (n)
chicken
(Gallus gallus)
Aves C9ORF21 33
  • 73.05 (n)
AAED1 34
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AAED1 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aaed1 33
  • 61.65 (n)
Str.4655 33
zebrafish
(Danio rerio)
Actinopterygii LOC100332791 33
  • 58.86 (n)
AAED1 34
  • 54 (a)
OneToOne
Dr.16712 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.215 33
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G37240 33
  • 45.34 (n)
rice
(Oryza sativa)
Liliopsida Os03g0284600 33
  • 42.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10381 34
  • 32 (a)
OneToOne
Species where no ortholog for AAED1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for AAED1 Gene

ENSEMBL:
Gene Tree for AAED1 (if available)
TreeFam:
Gene Tree for AAED1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AAED1: view image

Paralogs for AAED1 Gene

(1) SIMAP similar genes for AAED1 Gene using alignment to 3 proteins:

  • AAED1_HUMAN
  • H0Y5J5_HUMAN
  • H0Y7F1_HUMAN

Pseudogenes.org Pseudogenes for AAED1 Gene

genes like me logo Genes that share paralogs with AAED1: view

No data available for Paralogs for AAED1 Gene

Variants for AAED1 Gene

Sequence variations from dbSNP and Humsavar for AAED1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000010551 -- 96,649,834(-) C/G intron_variant
rs1000362731 -- 96,654,834(-) A/C intron_variant
rs1000691767 -- 96,643,505(-) C/G intron_variant
rs1000983037 -- 96,642,971(-) A/T intron_variant
rs1001021112 -- 96,648,283(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AAED1 Gene

Variant ID Type Subtype PubMed ID
nsv1147999 OTHER inversion 26484159
nsv824999 CNV gain 20364138

Variation tolerance for AAED1 Gene

Residual Variation Intolerance Score: 90.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AAED1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AAED1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AAED1 Gene

Disorders for AAED1 Gene

Additional Disease Information for AAED1

No disorders were found for AAED1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AAED1 Gene

Publications for AAED1 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  2. Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. (PMID: 12234665) Gilligan P … Venkatesh B (Gene 2002) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for AAED1 Gene

Sources for AAED1 Gene

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