Aliases for AADAT Gene
- Aminoadipate Aminotransferase 2 3 5
- Kynurenine Aminotransferase II 2 3 4
- Kynurenine/Alpha-Aminoadipate Aminotransferase, Mitochondrial 3 4
- L Kynurenine/Alpha Aminoadipate Aminotransferase 2 3
- Kynurenine--Oxoglutarate Aminotransferase II 3 4
- Kynurenine--Oxoglutarate Transaminase II 3 4
- Kynurenine--Oxoglutarate Transaminase 2 3 4
- Alpha-Aminoadipate Aminotransferase 3 4
External Ids for AADAT Gene
Previous GeneCards Identifiers for AADAT Gene
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for AADAT Gene
AADAT (Aminoadipate Aminotransferase) is a Protein Coding gene. Diseases associated with AADAT include Detrusor Sphincter Dyssynergia and Huntington Disease. Among its related pathways are Carbon metabolism and Tryptophan metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and kynurenine-oxoglutarate transaminase activity. An important paralog of this gene is KYAT1.
UniProtKB/Swiss-Prot Summary for AADAT Gene
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).