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This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine ... See more...
Aliases for AADAT Gene
Aliases for AADAT Gene
- Aminoadipate Aminotransferase 2 3 5
- Kynurenine Aminotransferase II 2 3 4
- KAT2 2 3 4
- Kynurenine/Alpha-Aminoadipate Aminotransferase, Mitochondrial 3 4
- L Kynurenine/Alpha Aminoadipate Aminotransferase 2 3
- Kynurenine--Oxoglutarate Aminotransferase II 3 4
- Kynurenine--Oxoglutarate Transaminase II 3 4
- Kynurenine--Oxoglutarate Transaminase 2 3 4
- Alpha-Aminoadipate Aminotransferase 3 4
External Ids for AADAT Gene
- HGNC: 17929
- Entrez Gene: 51166
- Ensembl: ENSG00000109576
- OMIM: 611754
- UniProtKB: Q8N5Z0
Previous GeneCards Identifiers for AADAT Gene
- GC00U991148
- GC04M171565
- GC04M171677
- GC04M171356
- GC04M171218
- GC04M170981
- GC04M166736
Summaries for AADAT Gene
-
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for AADAT Gene
AADAT (Aminoadipate Aminotransferase) is a Protein Coding gene. Diseases associated with AADAT include Detrusor Sphincter Dyssynergia and Huntington Disease. Among its related pathways are Lysine degradation and Tryptophan metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and kynurenine-oxoglutarate transaminase activity. An important paralog of this gene is KYAT3.
UniProtKB/Swiss-Prot Summary for AADAT Gene
-
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
Additional gene information for AADAT Gene
- HGNC(17929)
- Entrez Gene(51166)
- Ensembl(ENSG00000109576)
- OMIM(611754)
- UniProtKB(Q8N5Z0)
- Open Targets Platform(ENSG00000109576)
- Search for AADAT at DataMed
- Search for AADAT at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AADAT Gene
Genomics for AADAT Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for AADAT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around AADAT on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AADAT
- Top Transcription factor binding sites by QIAGEN in the AADAT gene promoter:
-
- E47
- SREBP-1a
- SREBP-1b
- SREBP-1c
- Tal-1beta
Genomic Locations for AADAT Gene
Genomic Locations for AADAT Gene
- chr4:170,060,222-170,091,699
- (GRCh38/hg38)
- Size:
- 31,478 bases
- Orientation:
- Minus strand
- chr4:170,981,373-171,012,850
- (GRCh37/hg19)
- Size:
- 31,478 bases
- Orientation:
- Minus strand
Genomic View for AADAT Gene
Genes around AADAT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q33 by HGNC
- 4q33 by Entrez Gene
- 4q33 by Ensembl
AADAT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AADAT Gene
Proteins for AADAT Gene
-
Protein details for AADAT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N5Z0-AADAT_HUMAN
- Recommended name:
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- Protein Accession:
- Q8N5Z0
- B3KP84
- Q9UL02
Protein attributes for AADAT Gene
- Size:
- 425 amino acids
- Molecular mass:
- 47352 Da
- Cofactor:
- Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
- Quaternary structure:
-
- Homodimer.
- Miscellaneous:
-
- [Isoform 1]: May be due to a competing donor splice site.
Three dimensional structures from OCA and Proteopedia for AADAT Gene
Protein Expression for AADAT Gene
Post-translational modifications for AADAT Gene
Other Protein References for AADAT Gene
Antibody Products
- LifeSpan BioSciences KATII / AADAT Antibody (LS-A9490) and KATII / AADAT Antibody (LS-A9492)
- Creative Diagnostics Anti-AADAT monoclonal antibody, clone LZOV5B7
- Creative Biolabs Mouse Anti-AADAT Recombinant Antibody (CBLNA-163)
-
Custom Antibody ServicesOriGene Antibodies for AADAT
- Novus Biologicals Antibodies for AADAT
-
Abcam antibodies for AADAT
- Invitrogen Antibodies for AADAT (AFLGC-Aadat)
-
Biorbyt antibodies for AADAT
-
Boster Bio Antibodies for AADAT
-
Santa Cruz Biotechnology (SCBT) Antibodies for AADAT
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for AADAT
- Origene Custom Protein Services for AADAT
-
ProSci Proteins for AADAT
-
Abcam proteins for AADAT
Assay Products
- antibodies-online: Show 19 available AADAT Elisa Kits ranked by validation data
- Compare Top AADAT Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for AADAT Gene
Domains & Families for AADAT Gene
Gene Families for AADAT Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for AADAT Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AADAT Gene
- GenScript: Design optimal peptide antigens:
-
- Kynurenine--oxoglutarate transaminase II (AADAT_HUMAN)
- cDNA, FLJ95590, Homo sapiens L-kynurenine/alpha-aminoadipate aminotransferase (KATII), mRNA (Q4W5N8_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8N5Z0UniProtKB/Swiss-Prot:
AADAT_HUMAN :- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
- Family:
-
- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Function for AADAT Gene
Molecular function for AADAT Gene
- UniProtKB/Swiss-Prot Function:
- Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate; Xref=Rhea:RHEA:20964, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959, ChEBI:CHEBI:58147; EC=2.6.1.7;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate; Xref=Rhea:RHEA:12601, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57499, ChEBI:CHEBI:58672; EC=2.6.1.39;.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.9 mM for aminoadipate {ECO:0000269|PubMed:18620547}; KM=4.7 mM for kynurenine {ECO:0000269|PubMed:18620547}; KM=1.7 mM for methionine {ECO:0000269|PubMed:18620547}; KM=1.6 mM for glutamate {ECO:0000269|PubMed:18620547}; KM=1.8 mM for tyrosine {ECO:0000269|PubMed:18620547}; KM=1.2 mM for 2-oxoglutarate {ECO:0000269|PubMed:18620547}; KM=1.5 mM for 2-oxocaproic acid {ECO:0000269|PubMed:18620547}; KM=1.8 mM for phenylpyruvate {ECO:0000269|PubMed:18620547}; KM=1.4 mM for ino-3-pyruvate {ECO:0000269|PubMed:18620547}; pH dependence: Optimum pH is 7-9. {ECO:0000269|PubMed:18620547}; Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269|PubMed:18620547};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Kynurenine transaminase activity is competitively inhibited by aminoadipate, asparagine, glutamate, histidine, cysteine, lysine, 3-hydroxy-kynurenine and phenylalanine.
Enzyme Numbers (IUBMB) for AADAT Gene
Phenotypes From GWAS Catalog for AADAT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0008483 | transaminase activity | IBA | 21873635 |
| GO:0016212 | kynurenine-oxoglutarate transaminase activity | IBA,IDA | 18620547 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0030170 | pyridoxal phosphate binding | IEA | -- |
Phenotypes for AADAT Gene
- MGI mutant phenotypes for AADAT:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for AADAT:
-
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Strongly decreased CFP-tsO45G cell surface transport
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Decreased shRNA abundance (Z-score < -2)
- Two nuclei (binuclear)
- Synthetic lethal with c-Myc after tamoxifen stimulation
Animal Models for AADAT Gene
- MGI Knock Outs for AADAT:
-
- Aadat Aadat<tm1Tag>
Animal Model Products
-
Taconic Biosciences Mouse Models for AADAT
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for AADAT - Select products 50% OFF >
- * AADAT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for AADAT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AADAT
-
Santa Cruz Biotechnology (SCBT) CRISPR for AADAT
miRNA for AADAT Gene
- miRTarBase miRNAs that target AADAT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AADAT
- Browse OriGene Inhibitory RNA Products For AADAT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADAT
Clone Products
- Applied Biological Materials (abm): Clones for AADAT - Select products 50% OFF >
- * AADAT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206782
- MR206782
- MR206782L1
- MR206782L2
- MR206782L3
- MR206782L4
- RC222252
- RC222252L3
- RC222252L4
- RC223277
- RC223277L1
- RC223277L2
- RC223277L3
- RC223277L4
- RC238149
- RC238181
- RG222252
- RG223277
- RR213490
- RR213490L3
- RR213490L4
- MR206782L1V
- MR206782L2V
- MR206782L3V
- MR206782L4V
- RC222252L3V
- RC222252L4V
- RC223277L1V
- RC223277L2V
- RC223277L3V
- RC223277L4V
- RR213490L3V
- RR213490L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AADAT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AADAT
Cell Line Products
-
Horizon Cell Lines for AADAT
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AADAT Gene
Localization for AADAT Gene
Subcellular locations from UniProtKB/Swiss-Prot for AADAT Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| plasma membrane | 3 |
| extracellular | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005759 | mitochondrial matrix | TAS | -- |
Pathways & Interactions for AADAT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | ||
| 2 | Metabolism |
.40
|
|
| 3 | Tryptophan metabolism | ||
| 4 | Carbon metabolism | ||
| 5 | Lysine degradation | ||
Pathways by source for AADAT Gene
1 BioSystems pathway for AADAT Gene
4 KEGG pathways for AADAT Gene
UniProtKB/Swiss-Prot Q8N5Z0-AADAT_HUMAN
- Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6.
Interacting Proteins for AADAT Gene
GPS-Prot Interaction Network for AADAT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006103 | 2-oxoglutarate metabolic process | IDA | 18620547 |
| GO:0006536 | glutamate metabolic process | IDA | 18620547 |
| GO:0006554 | lysine catabolic process | TAS | -- |
| GO:0006569 | tryptophan catabolic process | TAS | -- |
| GO:0009058 | biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for AADAT Gene
Drugs & Compounds for AADAT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutamic acid | Approved | Nutra | Agonist, Full agonist, Target | 304 | ||
| Pyridoxal Phosphate | Approved, Investigational | Nutra | Target, cofactor | 16 | ||
| Famotidine | Approved | Pharma | Histamine H2-receptor antagonist | 82 | ||
| L-Kynurenine | Experimental | Pharma | Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand | 0 | ||
| Oxogluric acid | Experimental, Investigational | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid |
|
|
||||
| 4-(2-Aminophenyl)-2,4-dioxobutanoic acid |
|
|
||||
| Aminoadipic acid |
|
542-32-5 |
|
|||
| Hydroxykynurenine |
|
484-78-6 |
|
|||
| L-3-Hydroxykynurenine |
|
606-14-4 |
|
Transcripts for AADAT Gene
mRNA/cDNA for AADAT Gene
- 4 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000337664 2250 nts (view in UCSC)
- ENST00000509167 2113 nts (view in UCSC)
- ENST00000515480 2193 nts (view in UCSC)
- ENST00000353187 2101 nts (view in UCSC)
- ENST00000505906 629 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for AADAT - Select products 50% OFF >
- * AADAT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for AADAT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AADAT
-
Santa Cruz Biotechnology (SCBT) CRISPR for AADAT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AADAT
- Browse OriGene Inhibitory RNA Products For AADAT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADAT
Clone Products
- Applied Biological Materials (abm): Clones for AADAT - Select products 50% OFF >
- * AADAT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206782
- MR206782
- MR206782L1
- MR206782L2
- MR206782L3
- MR206782L4
- RC222252
- RC222252L3
- RC222252L4
- RC223277
- RC223277L1
- RC223277L2
- RC223277L3
- RC223277L4
- RC238149
- RC238181
- RG222252
- RG223277
- RR213490
- RR213490L3
- RR213490L4
- MR206782L1V
- MR206782L2V
- MR206782L3V
- MR206782L4V
- RC222252L3V
- RC222252L4V
- RC223277L1V
- RC223277L2V
- RC223277L3V
- RC223277L4V
- RR213490L3V
- RR213490L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for AADAT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AADAT
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: |
Relevant External Links for AADAT Gene
- GeneLoc Exon Structure for
- AADAT
Expression for AADAT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
- Proximal Tubule Cells Proximal Tubule
- Proximal Tubule
- Epithelial Tubule
- Metanephros
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
- Proximal Tubule Cells Proximal Tubule
-
Liver (Hepatobiliary System)
This gene is overexpressed in Gallbladder (58.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AADAT Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AADAT
SOURCE GeneReport for Unigene cluster for AADAT Gene:
Hs.529735mRNA Expression by UniProt/SwissProt for AADAT Gene:
Q8N5Z0-AADAT_HUMAN
Tissue specificity:
Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.
Evidence on tissue expression from TISSUES for AADAT Gene
- Nervous system(4.6)
- Liver(4.6)
- Kidney(2.2)
- Intestine(2.2)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for AADAT
-
OriGene qPCR primer pairs and template standards for AADAT
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AADAT Gene
Orthologs for AADAT Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | AADAT 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | AADAT 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | AADAT 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Aadat 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Aadat 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | AADAT 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Chicken (Gallus gallus) |
Aves | AADAT 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aadat 30 |
|
||
| Str.16644 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68542 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC557979 30 |
|
||
| AADAT 31 |
|
OneToOne | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARO8 31 33 |
|
OneToMany | |
| ARO9 31 |
|
OneToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4740 31 |
|
OneToOne |
- Species where no ortholog for AADAT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for AADAT Gene
- ENSEMBL:
- Gene Tree for AADAT (if available)
- TreeFam:
- Gene Tree for AADAT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AADAT: view image
Paralogs for AADAT Gene
Variants for AADAT Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AADAT Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs56350236 | - | p.Val243Ile |
Residual Variation Intolerance Score:
21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.28;
6.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AADAT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AADAT
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADAT Gene
Disorders for AADAT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| detrusor sphincter dyssynergia |
|
|
| huntington disease |
|
Search AADAT in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for AADAT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for AADAT Gene
Publications for AADAT Gene
- Crystal structure of human kynurenine aminotransferase II. (PMID: 18056995) Han Q … Li J (The Journal of biological chemistry 2008) 2 3 4 23
- Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. (PMID: 18620547) Han Q … Li J (Bioscience reports 2008) 3 4 23
- Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia. (PMID: 18056996) Rossi F … Rizzi M (The Journal of biological chemistry 2008) 3 4 23
- Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). (PMID: 12126930) Goh DL … Geraghty MT (Molecular genetics and metabolism 2002) 2 3 4
- Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. (PMID: 10441733) Yu P … Tagle DA (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 23
ExternalLinks
Products for AADAT Gene
- View all 2 R&D Systems AADAT (alpha-Aminoadipate Aminotransferase) Products
- View all R&D Systems AADAT (alpha-Aminoadipate Aminotransferase) Proteins and Enzymes
- View all R&D Systems AADAT (alpha-Aminoadipate Aminotransferase) Primary Antibodies
- Learn more about R&D Systems custom AADAT antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for AADAT
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for AADAT
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for AADAT
- Browse OriGene Inhibitory RNA Products For AADAT
- OriGene qPCR primer pairs for AADAT
- OriGene qPCR primer pairs and template standards for AADAT
- OriGene CRISPR knockouts for AADAT
- MG206782
- MR206782
- MR206782L1
- MR206782L2
- MR206782L3
- MR206782L4
- RC222252
- RC222252L3
- RC222252L4
- RC223277
- RC223277L1
- RC223277L2
- RC223277L3
- RC223277L4
- RC238149
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- RG222252
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- RR213490
- RR213490L3
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- MR206782L1V
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- MR206782L3V
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- RC222252L3V
- RC222252L4V
- RC223277L1V
- RC223277L2V
- RC223277L3V
- RC223277L4V
- RR213490L3V
- RR213490L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for AADAT
- Browse Sino Biological Recombinant Proteins
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for AADAT
- Novus Biologicals proteins and lysates for AADAT
- Browse Antibodies
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- Abcam proteins for AADAT
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- Taconic Biosciences Mouse Models for AADAT
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for AADAT (AFLGC-Aadat)
- VectorBuilder Custom and pre-made DNA vectors for AADAT (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for AADAT (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for AADAT (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for AADAT CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for AADAT
- antibodies-online: Show 28 available AADAT Antibodies ranked by validation data
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- antibodies-online: Show 19 available AADAT Elisa Kits ranked by validation data
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- antibodies-online: Show 14 available AADAT Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for AADAT
- Search Santa Cruz Biotechnology (SCBT) for AADAT siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AADAT
- Search for AADAT Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for AADAT
- Horizon Cell Lines for AADAT
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AADAT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AADAT
- Search GeneCopoeia for miRNA 3'UTR Target clone products for AADAT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADAT
- Boster Bio Antibodies for AADAT
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for AADAT
Sources for AADAT Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB