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This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
AADAT (Aminoadipate Aminotransferase) is a Protein Coding gene. Diseases associated with AADAT include Detrusor Sphincter Dyssynergia and Huntington Disease. Among its related pathways are Lysine degradation and Tryptophan metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and kynurenine-oxoglutarate transaminase activity. An important paralog of this gene is KYAT3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0008483 | transaminase activity | IBA | 21873635 |
GO:0016212 | kynurenine-oxoglutarate transaminase activity | IBA,IDA | 18620547 |
GO:0016740 | transferase activity | IEA | -- |
GO:0030170 | pyridoxal phosphate binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IEA | -- |
GO:0005759 | mitochondrial matrix | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | ||
2 | Metabolism |
.40
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3 | Tryptophan metabolism | ||
4 | Carbon metabolism | ||
5 | Lysine degradation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006103 | 2-oxoglutarate metabolic process | IDA | 18620547 |
GO:0006536 | glutamate metabolic process | IDA | 18620547 |
GO:0006554 | lysine catabolic process | TAS | -- |
GO:0006569 | tryptophan catabolic process | TAS | -- |
GO:0009058 | biosynthetic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Glutamic acid | Approved | Nutra | Agonist, Full agonist, Target | 304 | ||
Pyridoxal Phosphate | Approved, Investigational | Nutra | Target, cofactor | 16 | ||
Famotidine | Approved | Pharma | Histamine H2-receptor antagonist | 82 | ||
L-Kynurenine | Experimental | Pharma | Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand | 0 | ||
Oxogluric acid | Experimental, Investigational | Nutra | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid |
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4-(2-Aminophenyl)-2,4-dioxobutanoic acid |
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Aminoadipic acid |
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542-32-5 |
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Hydroxykynurenine |
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484-78-6 |
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L-3-Hydroxykynurenine |
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606-14-4 |
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ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP8: |
ExUns: | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | |||||||||
SP7: | |||||||||
SP8: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AADAT 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AADAT 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AADAT 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Aadat 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Aadat 30 |
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Platypus (Ornithorhynchus anatinus) |
Mammalia | AADAT 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Chicken (Gallus gallus) |
Aves | AADAT 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aadat 30 |
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Str.16644 30 |
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African clawed frog (Xenopus laevis) |
Amphibia | MGC68542 30 |
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Zebrafish (Danio rerio) |
Actinopterygii | LOC557979 30 |
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AADAT 31 |
|
OneToOne | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARO8 31 33 |
|
OneToMany | |
ARO9 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4740 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs56350236 | - | p.Val243Ile |
Disorder | Aliases | PubMed IDs |
---|---|---|
detrusor sphincter dyssynergia |
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huntington disease |
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