Aliases for AADAT Gene
Aliases for AADAT Gene
- Aminoadipate Aminotransferase 2 3 5
- Kynurenine Aminotransferase II 2 3 4
- L Kynurenine/Alpha Aminoadipate Aminotransferase 2 3
- Kynurenine--Oxoglutarate Aminotransferase II 3 4
- Kynurenine--Oxoglutarate Transaminase II 3 4
- Kynurenine--Oxoglutarate Transaminase 2 3 4
- Alpha-Aminoadipate Aminotransferase 3 4
- 2-Aminoadipate Aminotransferase 3 4
- 2-Aminoadipate Transaminase 3 4
External Ids for AADAT Gene
- HGNC: 17929
- Entrez Gene: 51166
- Ensembl: ENSG00000109576
- OMIM: 611754
- UniProtKB: Q8N5Z0
Previous GeneCards Identifiers for AADAT Gene
- GC00U991148
- GC04M171565
- GC04M171677
- GC04M171356
- GC04M171218
- GC04M170981
- GC04M166736
Summaries for AADAT Gene
-
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
GeneCards Summary for AADAT Gene
AADAT (Aminoadipate Aminotransferase) is a Protein Coding gene. Among its related pathways are Metabolism and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and kynurenine-oxoglutarate transaminase activity.
UniProtKB/Swiss-Prot for AADAT Gene
-
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AADAT Gene
Genomics for AADAT Gene
GeneHancer (GH) Regulatory Elements for AADAT Gene
Promoters and enhancers for AADAT Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J170088 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 671.1 | +1.7 | 1738 | 2.2 | ZFP64 ARID4B SIN3A YY1 ETS1 GLIS2 ELK1 ZNF143 RXRA MXD4 | AADAT MFAP3L | |
| GH04J170091 | Promoter | 0.5 | EPDnew | 650.7 | 0.0 | -16 | 0.1 | AADAT APOBEC3AP1 | ||
| GH04J170025 | Promoter/Enhancer | 2.2 | EPDnew Ensembl ENCODE dbSUPER | 16.4 | +65.0 | 64961 | 2.3 | ARNT ARID4B NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF207 ZNF143 KLF13 | MFAP3L AADAT ENSG00000251200 GC04M169997 | |
| GH04J170101 | Enhancer | 0.8 | ENCODE | 22.1 | -10.8 | -10799 | 1.2 | FOXA2 RAD21 YY1 ZNF614 EGR1 ATF7 RXRA CEBPB ZBTB25 REST | AADAT APOBEC3AP1 PIR59480 | |
| GH04J170109 | Enhancer | 0.6 | Ensembl ENCODE | 25 | -18.2 | -18189 | 1.1 | USF1 POLR2A | AADAT APOBEC3AP1 PIR59480 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around AADAT on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the AADAT gene promoter:
-
- SREBP-1c
- SREBP-1b
- SREBP-1a
- E47
- Tal-1beta
Regulatory Element Products
Genomic Locations for AADAT Gene
Genomic Locations for AADAT Gene
- chr4:170,060,222-170,091,699
- (GRCh38/hg38)
- Size:
- 31,478 bases
- Orientation:
- Minus strand
- chr4:170,981,373-171,012,850
- (GRCh37/hg19)
- Size:
- 31,478 bases
- Orientation:
- Minus strand
Genomic View for AADAT Gene
Genes around AADAT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q33 by Entrez Gene
- 4q33 by HGNC
- 4q33 by Ensembl
AADAT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for AADAT Gene
Proteins for AADAT Gene
-
Protein details for AADAT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N5Z0-AADAT_HUMAN
- Recommended name:
- Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
- Protein Accession:
- Q8N5Z0
- B3KP84
- Q9UL02
Protein attributes for AADAT Gene
- Size:
- 425 amino acids
- Molecular mass:
- 47352 Da
- Cofactor:
- Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
- Quaternary structure:
-
- Homodimer.
Three dimensional structures from OCA and Proteopedia for AADAT Gene
Protein Expression for AADAT Gene
Post-translational modifications for AADAT Gene
Other Protein References for AADAT Gene
Antibody Products
- R&D Systems Antibodies for AADAT (alpha-Aminoadipate Aminotransferase)
-
Custom Antibody ServicesOriGene Antibodies for AADAT
- Novus Biologicals Antibodies for AADAT
-
Abcam antibodies for AADAT
- Invitrogen Antibodies for AADAT
- GeneTex AADAT Antibody for AADAT
-
Boster Bio Antibodies for AADAT
-
Santa Cruz Biotechnology (SCBT) Antibodies for AADAT
Protein Products
- R&D Systems Proteins and Enzymes for AADAT (alpha-Aminoadipate Aminotransferase)
- Search Origene for MassSpec and Protein Over-expression Lysates for AADAT
- Origene Custom Protein Services for AADAT
- Search GeneTex for Proteins for AADAT
-
ProSci Proteins for AADAT
-
Abcam proteins for AADAT
Assay Products
- antibodies-online: Search results for 17 available AADAT Elisa Kits ranked by validation data
- Compare Top AADAT Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for AADAT Gene
Domains & Families for AADAT Gene
Gene Families for AADAT Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for AADAT Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for AADAT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8N5Z0UniProtKB/Swiss-Prot:
AADAT_HUMAN :- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
- Family:
-
- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Function for AADAT Gene
Molecular function for AADAT Gene
- UniProtKB/Swiss-Prot Function:
- Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Kynurenine transaminase activity is competitively inhibited by aminoadipate, asparagine, glutamate, histidine, cysteine, lysine, 3-hydroxy-kynurenine and phenylalanine.
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.9 mM for aminoadipate {ECO:0000269 PubMed:18620547}; KM=4.7 mM for kynurenine {ECO:0000269 PubMed:18620547}; KM=1.7 mM for methionine {ECO:0000269 PubMed:18620547}; KM=1.6 mM for glutamate {ECO:0000269 PubMed:18620547}; KM=1.8 mM for tyrosine {ECO:0000269 PubMed:18620547}; KM=1.2 mM for 2-oxoglutarate {ECO:0000269 PubMed:18620547}; KM=1.5 mM for 2-oxocaproic acid {ECO:0000269 PubMed:18620547}; KM=1.8 mM for phenylpyruvate {ECO:0000269 PubMed:18620547}; KM=1.4 mM for ino-3-pyruvate {ECO:0000269 PubMed:18620547}; pH dependence: Optimum pH is 7-9. {ECO:0000269 PubMed:18620547}; Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269 PubMed:18620547};
Enzyme Numbers (IUBMB) for AADAT Gene
Phenotypes From GWAS Catalog for AADAT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008483 | transaminase activity | IEA | -- |
| GO:0016212 | kynurenine-oxoglutarate transaminase activity | TAS | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0030170 | pyridoxal phosphate binding | IEA | -- |
| GO:0042803 | protein homodimerization activity | IPI | 18620547 |
Phenotypes for AADAT Gene
- MGI mutant phenotypes for AADAT:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for AADAT:
-
- Dynamic nuclei (hole, folded or small irregular)
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
- shRNA abundance <= 50%
Animal Models for AADAT Gene
- MGI Knock Outs for AADAT:
-
- Aadat Aadat<tm1Tag>
Animal Model Products
-
Taconic Biosciences Mouse Models for AADAT
- Cyagen custom Knockout/knockin (KOKI) mouse models for AADAT
-
CRISPR Products
-
OriGene CRISPR knockouts for AADAT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AADAT
- genomics-online: gRNA clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
- Applied Biological Materials CRISPR for AADAT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AADAT
- GenScript: Design CRISPR guide RNA sequences for AADAT
miRNA for AADAT Gene
- miRTarBase miRNAs that target AADAT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AADAT
- Browse OriGene Inhibitory RNA Products For AADAT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADAT
- genomics-online: shRNA clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
Clone Products
- Sino Biological Human cDNA Clone for AADAT
- VectorBuilder custom plasmid, inducible vectors for AADAT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AADAT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AADAT
- Applied Biological Materials Clones for AADAT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for AADAT
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AADAT Gene
Localization for AADAT Gene
Subcellular locations from UniProtKB/Swiss-Prot for AADAT Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| plasma membrane | 3 |
| extracellular | 1 |
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005759 | mitochondrial matrix | TAS | -- |
Pathways & Interactions for AADAT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | superpathway of tryptophan utilization | ||
| 4 | Carbon metabolism | ||
| 5 | Lysine degradation | ||
Pathways by source for AADAT Gene
1 BioSystems pathway for AADAT Gene
4 KEGG pathways for AADAT Gene
UniProtKB/Swiss-Prot Q8N5Z0-AADAT_HUMAN
- Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6.
Interacting Proteins for AADAT Gene
GPS-Prot Interaction Network for AADAT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006103 | 2-oxoglutarate metabolic process | IDA | 18620547 |
| GO:0006536 | glutamate metabolic process | IDA | 18620547 |
| GO:0006554 | lysine catabolic process | TAS | -- |
| GO:0006569 | tryptophan catabolic process | TAS | -- |
| GO:0009058 | biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for AADAT Gene
Drugs & Compounds for AADAT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Glutamic Acid | Approved | Nutra | Full agonist, Agonist, Target | 251 | ||
| Pyridoxal Phosphate | Approved, Investigational | Nutra | Target, cofactor | 17 | ||
| Famotidine | Approved | Pharma | Histamine H2-receptor antagonist | 64 | ||
| Oxogluric acid | Experimental, Investigational | Nutra | 0 | |||
| L-Kynurenine | Pharma | Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid |
|
|
||||
| 4-(2-Aminophenyl)-2,4-dioxobutanoic acid |
|
|
||||
| Aminoadipic acid |
|
542-32-5 |
|
|||
| Hydroxykynurenine |
|
484-78-6 |
|
|||
| L-3-Hydroxykynurenine |
|
606-14-4 |
|
Transcripts for AADAT Gene
mRNA/cDNA for AADAT Gene
- (7) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (80) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000337664 2261 bps (uc003isr.4)
- ENST00000509167 2113 bps (uc003ist.4)
- ENST00000515480 2193 bps (uc032udw.1)
- ENST00000353187 2101 bps (uc003iss.4)
- ENST00000505906 629 bps (uc063ayd.1)
Unigene Clusters for AADAT Gene
CRISPR Products
-
OriGene CRISPR knockouts for AADAT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AADAT
- genomics-online: gRNA clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
- Applied Biological Materials CRISPR for AADAT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for AADAT
- GenScript: Design CRISPR guide RNA sequences for AADAT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AADAT
- Browse OriGene Inhibitory RNA Products For AADAT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADAT
- genomics-online: shRNA clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
Clone Products
- Sino Biological Human cDNA Clone for AADAT
- VectorBuilder custom plasmid, inducible vectors for AADAT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AADAT
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AADAT
- Applied Biological Materials Clones for AADAT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: |
Expression for AADAT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
- Proximal Tubule Cells Proximal Tubule
- Proximal Tubule
- Epithelial Tubule
- Metanephros
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
- Proximal Tubule Cells Proximal Tubule
-
Liver (Hepatobiliary System)
This gene is overexpressed in Gallbladder (58.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AADAT Gene
NURSA nuclear receptor signaling pathways regulating expression of AADAT Gene:
AADATSOURCE GeneReport for Unigene cluster for AADAT Gene:
Hs.529735mRNA Expression by UniProt/SwissProt for AADAT Gene:
Q8N5Z0-AADAT_HUMAN
Tissue specificity:
Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.
Evidence on tissue expression from TISSUES for AADAT Gene
- Nervous system(4.6)
- Liver(4.5)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for AADAT
-
OriGene qPCR primer pairs for AADAT
- genomics-online: primer clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AADAT Gene
Orthologs for AADAT Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | AADAT 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | AADAT 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | AADAT 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Aadat 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Aadat 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | AADAT 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | AADAT 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | aadat 33 |
|
||
| Str.16644 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68542 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC557979 33 |
|
||
| AADAT 34 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARO8 36 34 |
|
||
| ARO9 34 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4740 34 |
|
OneToOne |
- Species where no ortholog for AADAT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for AADAT Gene
- ENSEMBL:
- Gene Tree for AADAT (if available)
- TreeFam:
- Gene Tree for AADAT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for AADAT: view image
Paralogs for AADAT Gene
No data available for Paralogs for AADAT Gene
Variants for AADAT Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000015012 | -- | 170,068,394(-) | T/G | intron_variant | |
| rs1000052607 | -- | 170,066,623(-) | T/C | intron_variant | |
| rs1000330744 | -- | 170,086,108(-) | A/G | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000416079 | -- | 170,092,761(-) | T/A | upstream_transcript_variant | |
| rs1000700408 | -- | 170,076,878(-) | A/C | intron_variant |
Residual Variation Intolerance Score:
21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.28;
6.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for AADAT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- AADAT
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADAT Gene
Disorders for AADAT Gene
Additional Disease Information for AADAT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for AADAT Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AADAT Gene
Publications for AADAT Gene
- Crystal structure of human kynurenine aminotransferase II. (PMID: 18056995) Han Q … Li J (The Journal of biological chemistry 2008) 2 3 4 22 58
- Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia. (PMID: 18056996) Rossi F … Rizzi M (The Journal of biological chemistry 2008) 3 4 22 58
- Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. (PMID: 18620547) Han Q … Li J (Bioscience reports 2008) 3 4 22 58
- Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). (PMID: 12126930) Goh DL … Geraghty MT (Molecular genetics and metabolism 2002) 2 3 4 58
- Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. (PMID: 10441733) Yu P … Tagle DA (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 22 58
Products for AADAT Gene
- R&D Systems Antibodies for AADAT (alpha-Aminoadipate Aminotransferase)
- R&D Systems Proteins and Enzymes for AADAT (alpha-Aminoadipate Aminotransferase)
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for AADAT
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for AADAT
- Origene Custom Protein Services for AADAT
- Origene shrna, sirna, and RNAi products in human, mouse, rat for AADAT
- Browse OriGene Inhibitory RNA Products For AADAT
- OriGene qPCR primer pairs and template standards for AADAT
- OriGene qPCR primer pairs for AADAT
- OriGene CRISPR knockouts for AADAT
- OriGene ORF clones in human for AADAT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For AADAT
- GenScript: Next-day shipping of latest version cDNA ORF clones for AADAT in any vector
- GenScript Custom Purified and Recombinant Proteins Services for AADAT
- GenScript Custom Assay Services for AADAT
- GenScript Custom overexpressing Cell Line Services for AADAT
- GenScript: Design CRISPR guide RNA sequences for AADAT
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for AADAT
- Sino Biological Human cDNA Clone for AADAT
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for AADAT
- Novus Biologicals proteins and lysates for AADAT
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for AADAT
- Abcam proteins for AADAT
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for AADAT
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for AADAT
- Cyagen custom Knockout/knockin (KOKI) mouse models for AADAT
- VectorBuilder custom plasmid, inducible vectors for AADAT
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for AADAT
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 90 available AADAT Antibodies ranked by validation data
- Compare Top AADAT Antibodies
- Quality Products:
- antibodies-online: Search results for 17 available AADAT Elisa Kits ranked by validation data
- Compare Top AADAT Elisa Kits
- Quality Products:
- antibodies-online: Search results for 15 available AADAT Proteins ranked by validation data
- Compare Top AADAT Proteins
- GeneTex AADAT Antibody for AADAT
- Search GeneTex for Proteins for AADAT
- Santa Cruz Biotechnology (SCBT) Antibodies for AADAT
- Search Santa Cruz Biotechnology (SCBT) for AADAT siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for AADAT
- Search for AADAT Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for AADAT
- Horizon Cell Lines for AADAT
- genomics-online: cdna clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
- orf clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
- genomics-online: gRNA clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
- genomics-online: primer clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
- genomics-online: shRNA clones - Search results for 140 available AADAT gene related products
- Overview of 140 available AADAT gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for AADAT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for AADAT
- GeneCopoeia miRNA 3'UTR Target clone products for AADAT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADAT
- Boster Bio Antibodies for AADAT
- Browse Boster Bio ELISA Kits
Sources for AADAT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt