This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine ... See more...

Aliases for AADAT Gene

Aliases for AADAT Gene

  • Aminoadipate Aminotransferase 2 3 5
  • Kynurenine Aminotransferase II 2 3 4
  • KAT2 2 3 4
  • Kynurenine/Alpha-Aminoadipate Aminotransferase, Mitochondrial 3 4
  • L Kynurenine/Alpha Aminoadipate Aminotransferase 2 3
  • Kynurenine--Oxoglutarate Aminotransferase II 3 4
  • Kynurenine--Oxoglutarate Transaminase II 3 4
  • Kynurenine--Oxoglutarate Transaminase 2 3 4
  • Alpha-Aminoadipate Aminotransferase 3 4
  • 2-Aminoadipate Aminotransferase 3 4
  • 2-Aminoadipate Transaminase 3 4
  • KAT/AadAT 3 4
  • KATII 2 3
  • KYAT2 2 3
  • EC 2.6.1.39 4
  • EC 2.6.1.7 4
  • AADAT 5
  • AadAT 4

External Ids for AADAT Gene

Previous GeneCards Identifiers for AADAT Gene

  • GC00U991148
  • GC04M171565
  • GC04M171677
  • GC04M171356
  • GC04M171218
  • GC04M170981
  • GC04M166736

Summaries for AADAT Gene

Entrez Gene Summary for AADAT Gene

  • This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

GeneCards Summary for AADAT Gene

AADAT (Aminoadipate Aminotransferase) is a Protein Coding gene. Diseases associated with AADAT include Detrusor Sphincter Dyssynergia and Huntington Disease. Among its related pathways are Lysine degradation and Tryptophan metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and kynurenine-oxoglutarate transaminase activity. An important paralog of this gene is KYAT3.

UniProtKB/Swiss-Prot Summary for AADAT Gene

  • Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).

Additional gene information for AADAT Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AADAT Gene

Genomics for AADAT Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AADAT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J170088 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 625.1 +0.7 699 4.8 GATAD2A CTCF PRDM10 ZNF692 ZIC2 RBFOX2 POLR2A RXRB PATZ1 RAD21 AADAT piR-39098-187 MFAP3L RF00017-4455
GH04J170025 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 26.7 +65.3 65298 3.2 SP1 HNRNPL CREB1 PRDM10 ZNF629 TFE3 NFKBIZ KDM1A ZNF692 LARP7 MFAP3L lnc-CLCN3-12 AADAT ENSG00000251200 RF00017-4453 HPF1 MG828730-051
GH04J170003 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 18.2 +87.8 87798 0.6 ZNF316 MAFK MAFG BACH1 SPI1 EMSY MFAP3L AADAT ENSG00000249955 LINC02275 ENSG00000251200 RF00017-4453 HPF1 MG828730-051
GH04J170101 Enhancer 0.8 ENCODE 22.2 -10.8 -10799 1.2 GATAD2A ATF7 REST RXRB SP1 CEBPA SOX13 FOXA2 ATF3 YY1 AADAT APOBEC3AP1 piR-38051-212
GH04J169791 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas 10.5 +299.9 299898 0.8 CTCF PRDM10 ZNF512 ZNF692 EZH2 ZNF341 ZBTB44 KLF9 RAD21 ZNF316 PTGES3P3 lnc-HPF1-2 MFAP3L ENSG00000251200 AADAT HPF1 MG828730-051
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AADAT on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AADAT

Top Transcription factor binding sites by QIAGEN in the AADAT gene promoter:
  • E47
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Tal-1beta

Genomic Locations for AADAT Gene

Genomic Locations for AADAT Gene
chr4:170,060,222-170,091,699
(GRCh38/hg38)
Size:
31,478 bases
Orientation:
Minus strand
chr4:170,981,373-171,012,850
(GRCh37/hg19)
Size:
31,478 bases
Orientation:
Minus strand

Genomic View for AADAT Gene

Genes around AADAT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AADAT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AADAT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADAT Gene

Proteins for AADAT Gene

  • Protein details for AADAT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5Z0-AADAT_HUMAN
    Recommended name:
    Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
    Protein Accession:
    Q8N5Z0
    Secondary Accessions:
    • B3KP84
    • Q9UL02

    Protein attributes for AADAT Gene

    Size:
    425 amino acids
    Molecular mass:
    47352 Da
    Cofactor:
    Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    Miscellaneous:
    • [Isoform 1]: May be due to a competing donor splice site.

    Three dimensional structures from OCA and Proteopedia for AADAT Gene

    Alternative splice isoforms for AADAT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AADAT Gene

Post-translational modifications for AADAT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AADAT Gene

Domains & Families for AADAT Gene

Gene Families for AADAT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for AADAT Gene

Suggested Antigen Peptide Sequences for AADAT Gene

GenScript: Design optimal peptide antigens:
  • Kynurenine--oxoglutarate transaminase II (AADAT_HUMAN)
  • cDNA, FLJ95590, Homo sapiens L-kynurenine/alpha-aminoadipate aminotransferase (KATII), mRNA (Q4W5N8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N5Z0

UniProtKB/Swiss-Prot:

AADAT_HUMAN :
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with AADAT: view

Function for AADAT Gene

Molecular function for AADAT Gene

UniProtKB/Swiss-Prot Function:
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate; Xref=Rhea:RHEA:20964, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57959, ChEBI:CHEBI:58147; EC=2.6.1.7;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-oxoglutarate + L-2-aminoadipate = 2-oxoadipate + L-glutamate; Xref=Rhea:RHEA:12601, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57499, ChEBI:CHEBI:58672; EC=2.6.1.39;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.9 mM for aminoadipate {ECO:0000269|PubMed:18620547}; KM=4.7 mM for kynurenine {ECO:0000269|PubMed:18620547}; KM=1.7 mM for methionine {ECO:0000269|PubMed:18620547}; KM=1.6 mM for glutamate {ECO:0000269|PubMed:18620547}; KM=1.8 mM for tyrosine {ECO:0000269|PubMed:18620547}; KM=1.2 mM for 2-oxoglutarate {ECO:0000269|PubMed:18620547}; KM=1.5 mM for 2-oxocaproic acid {ECO:0000269|PubMed:18620547}; KM=1.8 mM for phenylpyruvate {ECO:0000269|PubMed:18620547}; KM=1.4 mM for ino-3-pyruvate {ECO:0000269|PubMed:18620547}; pH dependence: Optimum pH is 7-9. {ECO:0000269|PubMed:18620547}; Temperature dependence: Optimum temperature is 50 degrees Celsius. {ECO:0000269|PubMed:18620547};
UniProtKB/Swiss-Prot EnzymeRegulation:
Kynurenine transaminase activity is competitively inhibited by aminoadipate, asparagine, glutamate, histidine, cysteine, lysine, 3-hydroxy-kynurenine and phenylalanine.

Enzyme Numbers (IUBMB) for AADAT Gene

Phenotypes From GWAS Catalog for AADAT Gene

Gene Ontology (GO) - Molecular Function for AADAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0008483 transaminase activity IBA 21873635
GO:0016212 kynurenine-oxoglutarate transaminase activity IBA,IDA 18620547
GO:0016740 transferase activity IEA --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with AADAT: view
genes like me logo Genes that share phenotypes with AADAT: view

Animal Models for AADAT Gene

MGI Knock Outs for AADAT:

Animal Model Products

CRISPR Products

miRNA for AADAT Gene

miRTarBase miRNAs that target AADAT

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADAT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for AADAT Gene

Localization for AADAT Gene

Subcellular locations from UniProtKB/Swiss-Prot for AADAT Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AADAT gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
extracellular 2
cytoskeleton 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for AADAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with AADAT: view

Pathways & Interactions for AADAT Gene

genes like me logo Genes that share pathways with AADAT: view

UniProtKB/Swiss-Prot Q8N5Z0-AADAT_HUMAN

  • Pathway: Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6.

Gene Ontology (GO) - Biological Process for AADAT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006103 2-oxoglutarate metabolic process IDA 18620547
GO:0006536 glutamate metabolic process IDA 18620547
GO:0006554 lysine catabolic process TAS --
GO:0006569 tryptophan catabolic process TAS --
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with AADAT: view

No data available for SIGNOR curated interactions for AADAT Gene

Drugs & Compounds for AADAT Gene

(6) Drugs for AADAT Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutamic acid Approved Nutra Agonist, Full agonist, Target 304
Pyridoxal Phosphate Approved, Investigational Nutra Target, cofactor 16
Famotidine Approved Pharma Histamine H2-receptor antagonist 82
L-Kynurenine Experimental Pharma Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand 0
Oxogluric acid Experimental, Investigational Nutra 0

(7) Additional Compounds for AADAT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
  • 4-(2-amino-3-Hydroxyphenyl)-2,4-dioxobutanoate
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxobutanoate
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoate
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoic acid
Aminoadipic acid
  • (+/-)-2-aminoadipic acid
  • Aad
  • alpha-Aminoadipic acid
  • DL-2-Aminoadipic acid
  • DL-2-Aminohexanedioic acid
542-32-5
Hydroxykynurenine
  • 2-amino-4-(2-amino-3-Hydroxyphenyl)-4-oxobutanoic acid
  • 3-(3-Hydroxyanthraniloyl)alanine
  • 3-Hydroxy-DL-kynurenine
  • 2-amino-4-(2-amino-3-Hydroxyphenyl)-4-oxobutanoate
  • 3-(3-Hydroxyanthraniloyl)-alanine
484-78-6
L-3-Hydroxykynurenine
  • (2S)-2-amino-4-(2-amino-3-Hydroxyphenyl)-4-oxobutanoic acid
  • 3-(3-Hydroxyanthraniloyl)-L-alanine
  • (2S)-2-amino-4-(2-amino-3-Hydroxyphenyl)-4-oxobutanoate
  • 3-(2-amino-3-Hydroxybenzoyl)-L-alanine
  • 3-Hydroxy-L-kynurenine
606-14-4
genes like me logo Genes that share compounds with AADAT: view

Transcripts for AADAT Gene

mRNA/cDNA for AADAT Gene

4 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADAT

Alternative Splicing Database (ASD) splice patterns (SP) for AADAT Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - -
SP6:
SP7: - - - - - -
SP8:

ExUns: 16 ^ 17 ^ 18a · 18b · 18c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for AADAT Gene

GeneLoc Exon Structure for
AADAT

Expression for AADAT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AADAT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for AADAT Gene

This gene is overexpressed in Gallbladder (58.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for AADAT Gene



Protein tissue co-expression partners for AADAT Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AADAT

SOURCE GeneReport for Unigene cluster for AADAT Gene:

Hs.529735

mRNA Expression by UniProt/SwissProt for AADAT Gene:

Q8N5Z0-AADAT_HUMAN
Tissue specificity: Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.

Evidence on tissue expression from TISSUES for AADAT Gene

  • Nervous system(4.6)
  • Liver(4.6)
  • Kidney(2.2)
  • Intestine(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with AADAT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for AADAT Gene

Orthologs for AADAT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for AADAT Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia AADAT 30 31
  • 99.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia AADAT 30 31
  • 87.06 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia AADAT 30 31
  • 85.25 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Aadat 30 17 31
  • 79.14 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Aadat 30
  • 77.23 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia AADAT 31
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 70 (a)
OneToMany
-- 31
  • 44 (a)
OneToMany
Chicken
(Gallus gallus)
Aves AADAT 30 31
  • 70.98 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 68 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia aadat 30
  • 66.12 (n)
Str.16644 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68542 30
Zebrafish
(Danio rerio)
Actinopterygii LOC557979 30
  • 62.68 (n)
AADAT 31
  • 62 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARO8 31 33
  • 27 (a)
OneToMany
ARO9 31
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4740 31
  • 54 (a)
OneToOne
Species where no ortholog for AADAT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for AADAT Gene

ENSEMBL:
Gene Tree for AADAT (if available)
TreeFam:
Gene Tree for AADAT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for AADAT: view image

Paralogs for AADAT Gene

Paralogs for AADAT Gene

genes like me logo Genes that share paralogs with AADAT: view

Variants for AADAT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AADAT Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs56350236 - p.Val243Ile

Additional dbSNP identifiers (rs#s) for AADAT Gene

Structural Variations from Database of Genomic Variants (DGV) for AADAT Gene

Variant ID Type Subtype PubMed ID
nsv4601 CNV deletion 18451855
nsv830150 CNV gain 17160897

Variation tolerance for AADAT Gene

Residual Variation Intolerance Score: 21.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AADAT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
AADAT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADAT Gene

Disorders for AADAT Gene

MalaCards: The human disease database

(2) MalaCards diseases for AADAT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
detrusor sphincter dyssynergia
  • detrusor and sphincter dyssynergia
huntington disease
  • hd
- elite association - COSMIC cancer census association via MalaCards
Search AADAT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for AADAT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with AADAT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AADAT Gene

Publications for AADAT Gene

  1. Crystal structure of human kynurenine aminotransferase II. (PMID: 18056995) Han Q … Li J (The Journal of biological chemistry 2008) 2 3 4 23
  2. Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II. (PMID: 18620547) Han Q … Li J (Bioscience reports 2008) 3 4 23
  3. Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia. (PMID: 18056996) Rossi F … Rizzi M (The Journal of biological chemistry 2008) 3 4 23
  4. Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). (PMID: 12126930) Goh DL … Geraghty MT (Molecular genetics and metabolism 2002) 2 3 4
  5. Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. (PMID: 10441733) Yu P … Tagle DA (Mammalian genome : official journal of the International Mammalian Genome Society 1999) 2 3 23

Products for AADAT Gene

Sources for AADAT Gene