Aliases for AADACL4 Gene

Aliases for AADACL4 Gene

  • Arylacetamide Deacetylase Like 4 2 3 5
  • Arylacetamide Deacetylase-Like 4 3 4
  • EC 3.1.1.- 4

External Ids for AADACL4 Gene

Previous GeneCards Identifiers for AADACL4 Gene

  • GC01P012627
  • GC01P011857

Summaries for AADACL4 Gene

GeneCards Summary for AADACL4 Gene

AADACL4 (Arylacetamide Deacetylase Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is AADACL3.

Additional gene information for AADACL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AADACL4 Gene

Genomics for AADACL4 Gene

GeneHancer (GH) Regulatory Elements for AADACL4 Gene

Promoters and enhancers for AADACL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J012432 Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.7 -207.4 -207447 9.8 SP1 ZBTB40 FOXA1 RBPJ SMARCE1 CTBP1 CREB1 MIXL1 CC2D1A ETV6 CLCN6 PRAMEF12 LINC01784 PRAMEF30P PRAMEF11 HNRNPCL1 PRAMEF4 PRAMEF29P PRAMEF6 C1orf167-AS1
GH01J012315 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.5 -328.7 -328656 2.6 CTCF ZNF133 RAD21 ARID2 REST TRIM22 SMC3 KLF16 DHRS3 AADACL4 RNU6ATAC18P SNORA59A piR-42799-001 RF00994-002 VPS13D
GH01J012217 Enhancer 1 Ensembl 10.1 -425.9 -425946 2 SMARCE1 RUNX1 CC2D1A L3MBTL2 DACH1 TEAD4 ZC3H8 ZKSCAN8 ZNF148 GTF2F1 UBIAD1 AGTRAP MIIP MFN2 AADACL4 RPL10P17 lnc-KIAA2013-3 piR-50443-003
GH01J012422 Enhancer 0.7 Ensembl ENCODE dbSUPER 10.6 -220.6 -220646 2.2 GTF2F1 PRDM1 CAVIN1 RNU6ATAC18P DHRS3 AADACL4 SNORA59A HSALNG0000937 lnc-AADACL4-2 VPS13D
GH01J012707 Enhancer 0.6 Ensembl ENCODE 11 +67.8 67776 9.4 HLF ZNF148 ZFP64 PRDM10 POLR2A AADACL4 AADACL3 piR-61365-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AADACL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the AADACL4 gene promoter:
  • C/EBPalpha
  • Cart-1
  • Cdc5
  • CREB
  • deltaCREB
  • FOXI1
  • HFH-3
  • RREB-1
  • TBP

Genomic Locations for AADACL4 Gene

Genomic Locations for AADACL4 Gene
22,540 bases
Plus strand
22,532 bases
Plus strand

Genomic View for AADACL4 Gene

Genes around AADACL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AADACL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AADACL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADACL4 Gene

Proteins for AADACL4 Gene

  • Protein details for AADACL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylacetamide deacetylase-like 4
    Protein Accession:

    Protein attributes for AADACL4 Gene

    407 amino acids
    Molecular mass:
    46082 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AADACL4 Gene

Post-translational modifications for AADACL4 Gene

  • Glycosylation at Asn168 and Asn269
  • Modification sites at PhosphoSitePlus

Other Protein References for AADACL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AADACL4 Gene

Domains & Families for AADACL4 Gene

Gene Families for AADACL4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for AADACL4 Gene

Suggested Antigen Peptide Sequences for AADACL4 Gene

GenScript: Design optimal peptide antigens:
  • Arylacetamide deacetylase-like 4 (ADCL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 'GDXG' lipolytic enzyme family.
  • Belongs to the 'GDXG' lipolytic enzyme family.
genes like me logo Genes that share domains with AADACL4: view

Function for AADACL4 Gene

Enzyme Numbers (IUBMB) for AADACL4 Gene

Phenotypes From GWAS Catalog for AADACL4 Gene

Gene Ontology (GO) - Molecular Function for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with AADACL4: view

Phenotypes for AADACL4 Gene

genes like me logo Genes that share phenotypes with AADACL4: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AADACL4 Gene

Localization for AADACL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AADACL4 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AADACL4 gene
Compartment Confidence
plasma membrane 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AADACL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AADACL4 Gene

Pathways & Interactions for AADACL4 Gene

PathCards logo

SuperPathways for AADACL4 Gene

No Data Available

Interacting Proteins for AADACL4 Gene

Gene Ontology (GO) - Biological Process for AADACL4 Gene


No data available for Pathways by source and SIGNOR curated interactions for AADACL4 Gene

Drugs & Compounds for AADACL4 Gene

No Compound Related Data Available

Transcripts for AADACL4 Gene

mRNA/cDNA for AADACL4 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for AADACL4 Gene

No ASD Table

Relevant External Links for AADACL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for AADACL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for AADACL4 Gene

mRNA differential expression in normal tissues according to GTEx for AADACL4 Gene

This gene is overexpressed in Vagina (x8.2), Adipose - Visceral (Omentum) (x6.3), Kidney - Cortex (x4.9), and Prostate (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of AADACL4 Gene:


SOURCE GeneReport for Unigene cluster for AADACL4 Gene:

genes like me logo Genes that share expression patterns with AADACL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AADACL4 Gene

Orthologs for AADACL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for AADACL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AADACL4 33 32
  • 99.26 (n)
(Bos Taurus)
Mammalia AADACL4 32
  • 79.03 (n)
(Canis familiaris)
Mammalia AADACL4 33 32
  • 77.58 (n)
(Mus musculus)
Mammalia Gm13177 33 32
  • 71.99 (n)
Gm436 33
  • 65 (a)
Gm13178 33
  • 64 (a)
Gm438 33
  • 61 (a)
9430007A20Rik 33
  • 61 (a)
Gm13124 33
  • 59 (a)
Aadacl4 17
(Rattus norvegicus)
Mammalia Aadacl4 32
  • 71.74 (n)
(Monodelphis domestica)
Mammalia -- 33
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 41 (a)
(Gallus gallus)
Aves AADACL4 32
  • 56.73 (n)
-- 33
  • 46 (a)
-- 33
  • 44 (a)
-- 33
  • 42 (a)
-- 33
  • 40 (a)
-- 33
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 33
  • 44 (a)
-- 33
  • 42 (a)
-- 33
  • 42 (a)
-- 33
  • 42 (a)
-- 33
  • 42 (a)
-- 33
  • 42 (a)
-- 33
  • 41 (a)
-- 33
  • 41 (a)
-- 33
  • 41 (a)
-- 33
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492051 32
  • 53.78 (n)
(Danio rerio)
Actinopterygii aadacl4 33 32
  • 49.92 (n)
(Caenorhabditis elegans)
Secernentea F16F9.4 33
  • 23 (a)
Y43F8A.3 33
  • 22 (a)
T09B9.1 33
  • 21 (a)
trcs-1 33
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 24 (a)
Species where no ortholog for AADACL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AADACL4 Gene

Gene Tree for AADACL4 (if available)
Gene Tree for AADACL4 (if available)
Evolutionary constrained regions (ECRs) for AADACL4: view image

Paralogs for AADACL4 Gene

Paralogs for AADACL4 Gene

(3) SIMAP similar genes for AADACL4 Gene using alignment to 2 proteins:

  • L8E711_HUMAN Pseudogenes for AADACL4 Gene

genes like me logo Genes that share paralogs with AADACL4: view

Variants for AADACL4 Gene

Sequence variations from dbSNP and Humsavar for AADACL4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000070273 -- 12,662,374(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000108427 -- 12,643,497(+) C/T upstream_transcript_variant
rs1000129460 -- 12,665,348(+) G/A intron_variant
rs1000194867 -- 12,665,585(+) A/G intron_variant
rs1000310995 -- 12,665,803(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for AADACL4 Gene

Variant ID Type Subtype PubMed ID
esv3585236 CNV loss 21293372
nsv1011540 CNV loss 25217958
nsv515525 CNV loss 19592680

Variation tolerance for AADACL4 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AADACL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADACL4 Gene

Disorders for AADACL4 Gene

Additional Disease Information for AADACL4

No disorders were found for AADACL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for AADACL4 Gene

Publications for AADACL4 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 56
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 56

Products for AADACL4 Gene

Sources for AADACL4 Gene