Aliases for AADACL4 Gene

Aliases for AADACL4 Gene

  • Arylacetamide Deacetylase Like 4 2 3 5
  • Arylacetamide Deacetylase-Like 4 3 4
  • OTTHUMG00000001889 2
  • EC 3.1.1.- 4
  • AADACL4 5

External Ids for AADACL4 Gene

Previous GeneCards Identifiers for AADACL4 Gene

  • GC01P012627
  • GC01P011857

Summaries for AADACL4 Gene

GeneCards Summary for AADACL4 Gene

AADACL4 (Arylacetamide Deacetylase Like 4) is a Protein Coding gene. Diseases associated with AADACL4 include Agnathia-Otocephaly Complex and Hypotonia-Cystinuria Syndrome. Gene Ontology (GO) annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is AADACL3.

Additional gene information for AADACL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AADACL4 Gene

Genomics for AADACL4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AADACL4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J012432 Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.7 -207.4 -207447 9.8 ARHGAP35 SP1 HNRNPL GATAD2A PRDM10 ZNF629 REST ZNF512 LEF1 IKZF1 AADACL4 DHRS3 SNORA59A lnc-AADACL4-2 HSALNG0000937 VPS13D
GH01J012217 Enhancer 1 Ensembl 10.1 -425.9 -425946 2 LEF1 IKZF1 JUND DDX20 MTA2 PHF21A PKNOX1 ZNF24 MTA1 NR2C1 MIIP MFN2 AADACL4 UBIAD1 LOC107984917 RPL10P17 lnc-KIAA2013-3 VPS13D TNFRSF1B
GH01J012315 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.5 -328.7 -328656 2.6 CTCF REST RAD21 TRIM22 SMC3 KLF16 ZNF133 ARID2 DHRS3 AADACL4 RNU6ATAC18P SNORA59A piR-42799-001 RF00994-002 VPS13D
GH01J012422 Enhancer 0.8 Ensembl ENCODE dbSUPER 10.6 -220.6 -220646 2.2 CTCF PRDM1 TFDP1 ESRRA CAVIN1 GTF2F1 RNU6ATAC18P DHRS3 AADACL4 SNORA59A HSALNG0000937 lnc-AADACL4-2 VPS13D
GH01J012707 Enhancer 0.6 Ensembl ENCODE 11 +67.8 67776 9.4 ZFP64 PRDM10 HLF POLR2A ZNF148 AADACL4 AADACL3 piR-61365-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AADACL4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AADACL4

Top Transcription factor binding sites by QIAGEN in the AADACL4 gene promoter:
  • C/EBPalpha
  • Cart-1
  • Cdc5
  • CREB
  • deltaCREB
  • FOXI1
  • HFH-3
  • RREB-1
  • TBP

Genomic Locations for AADACL4 Gene

Genomic Locations for AADACL4 Gene
22,540 bases
Plus strand
22,532 bases
Plus strand

Genomic View for AADACL4 Gene

Genes around AADACL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AADACL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AADACL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADACL4 Gene

Proteins for AADACL4 Gene

  • Protein details for AADACL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylacetamide deacetylase-like 4
    Protein Accession:

    Protein attributes for AADACL4 Gene

    407 amino acids
    Molecular mass:
    46082 Da
    Quaternary structure:
    No Data Available

neXtProt entry for AADACL4 Gene

Post-translational modifications for AADACL4 Gene

  • Glycosylation at Asn168 and Asn269
  • Modification sites at PhosphoSitePlus

Other Protein References for AADACL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AADACL4 Gene

Domains & Families for AADACL4 Gene

Gene Families for AADACL4 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for AADACL4 Gene

  • Alpha/beta hydrolase fold-3

Suggested Antigen Peptide Sequences for AADACL4 Gene

GenScript: Design optimal peptide antigens:
  • Arylacetamide deacetylase-like 4 (ADCL4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 'GDXG' lipolytic enzyme family.
  • Belongs to the 'GDXG' lipolytic enzyme family.
genes like me logo Genes that share domains with AADACL4: view

Function for AADACL4 Gene

Enzyme Numbers (IUBMB) for AADACL4 Gene

Phenotypes From GWAS Catalog for AADACL4 Gene

Gene Ontology (GO) - Molecular Function for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IBA 21873635
GO:0034338 short-chain carboxylesterase activity IBA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with AADACL4: view

Phenotypes for AADACL4 Gene

genes like me logo Genes that share phenotypes with AADACL4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADACL4

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AADACL4 Gene

Localization for AADACL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AADACL4 Gene

Membrane. Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AADACL4 gene
Compartment Confidence
peroxisome 1
plasma membrane 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AADACL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for AADACL4 Gene

Pathways & Interactions for AADACL4 Gene

PathCards logo

SuperPathways for AADACL4 Gene

No Data Available

Interacting Proteins for AADACL4 Gene

Gene Ontology (GO) - Biological Process for AADACL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009056 catabolic process IBA --
genes like me logo Genes that share ontologies with AADACL4: view

No data available for Pathways by source and SIGNOR curated interactions for AADACL4 Gene

Drugs & Compounds for AADACL4 Gene

No Compound Related Data Available

Transcripts for AADACL4 Gene

mRNA/cDNA for AADACL4 Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADACL4

Alternative Splicing Database (ASD) splice patterns (SP) for AADACL4 Gene

No ASD Table

Relevant External Links for AADACL4 Gene

GeneLoc Exon Structure for

Expression for AADACL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AADACL4 Gene

mRNA differential expression in normal tissues according to GTEx for AADACL4 Gene

This gene is overexpressed in Vagina (x8.2), Adipose - Visceral (Omentum) (x6.3), Kidney - Cortex (x4.9), and Prostate (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AADACL4

SOURCE GeneReport for Unigene cluster for AADACL4 Gene:

genes like me logo Genes that share expression patterns with AADACL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AADACL4 Gene

Orthologs for AADACL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for AADACL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AADACL4 30 31
  • 99.26 (n)
(Bos Taurus)
Mammalia AADACL4 30
  • 79.03 (n)
(Canis familiaris)
Mammalia AADACL4 30 31
  • 77.58 (n)
(Mus musculus)
Mammalia Gm13177 30 31
  • 71.99 (n)
Gm436 31
  • 65 (a)
Gm13178 31
  • 64 (a)
Gm438 31
  • 61 (a)
9430007A20Rik 31
  • 61 (a)
Gm13124 31
  • 59 (a)
Aadacl4 17
(Rattus norvegicus)
Mammalia Aadacl4 30
  • 71.74 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 41 (a)
(Gallus gallus)
Aves AADACL4 30
  • 56.73 (n)
-- 31
  • 46 (a)
-- 31
  • 44 (a)
-- 31
  • 42 (a)
-- 31
  • 40 (a)
-- 31
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 44 (a)
-- 31
  • 42 (a)
-- 31
  • 42 (a)
-- 31
  • 42 (a)
-- 31
  • 42 (a)
-- 31
  • 42 (a)
-- 31
  • 41 (a)
-- 31
  • 41 (a)
-- 31
  • 41 (a)
-- 31
  • 40 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100492051 30
  • 53.78 (n)
(Danio rerio)
Actinopterygii aadacl4 30 31
  • 49.92 (n)
(Caenorhabditis elegans)
Secernentea F16F9.4 31
  • 23 (a)
Y43F8A.3 31
  • 22 (a)
T09B9.1 31
  • 21 (a)
trcs-1 31
  • 20 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
Species where no ortholog for AADACL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for AADACL4 Gene

Gene Tree for AADACL4 (if available)
Gene Tree for AADACL4 (if available)
Evolutionary constrained regions (ECRs) for AADACL4: view image

Paralogs for AADACL4 Gene

Paralogs for AADACL4 Gene

(3) SIMAP similar genes for AADACL4 Gene using alignment to 2 proteins:

  • L8E711_HUMAN Pseudogenes for AADACL4 Gene

genes like me logo Genes that share paralogs with AADACL4: view

Variants for AADACL4 Gene

Additional dbSNP identifiers (rs#s) for AADACL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for AADACL4 Gene

Variant ID Type Subtype PubMed ID
esv3585236 CNV loss 21293372
nsv1011540 CNV loss 25217958
nsv515525 CNV loss 19592680

Variation tolerance for AADACL4 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AADACL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AADACL4 Gene

Disorders for AADACL4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for AADACL4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
agnathia-otocephaly complex
  • agotc
hypotonia-cystinuria syndrome
  • cystinuria with mitochondrial disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for AADACL4

genes like me logo Genes that share disorders with AADACL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AADACL4 Gene

Publications for AADACL4 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for AADACL4 Gene

Sources for AADACL4 Gene