Aliases for AADACL3 Gene

Aliases for AADACL3 Gene

  • Arylacetamide Deacetylase Like 3 2 3 5
  • Arylacetamide Deacetylase-Like 3 3 4
  • OTTHUMG00000001887 2
  • EC 3.1.1.- 4
  • AADACL3 5

External Ids for AADACL3 Gene

Previous GeneCards Identifiers for AADACL3 Gene

  • GC01P012698
  • GC01P012776
  • GC01P011931

Summaries for AADACL3 Gene

GeneCards Summary for AADACL3 Gene

AADACL3 (Arylacetamide Deacetylase Like 3) is a Protein Coding gene. Diseases associated with AADACL3 include Norwegian Scabies and Mite Infestation. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is AADACL4.

Additional gene information for AADACL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for AADACL3 Gene

Genomics for AADACL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for AADACL3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J012717 Enhancer 0.4 Ensembl 600.7 +1.6 1591 0.6 NANOG HLF POU5F1 AADACL3 AADACL4 piR-31534-005 C1orf158
GH01J012757 Enhancer 0.3 Ensembl 10.9 +40.6 40591 0.2 ZIC2 AADACL3 C1orf158 PRAMEF12
GH01J012707 Enhancer 0.6 Ensembl ENCODE 0.7 -3.8 -3787 9.4 ZFP64 PRDM10 HLF POLR2A ZNF148 AADACL4 AADACL3 piR-61365-001
GH01J012658 Enhancer 1.1 Ensembl ENCODE 0.2 -57.2 -57205 1.4 ARHGAP35 CREB1 CTCF ZNF512 RFX1 IKZF1 ZNF692 JUND LARP7 DDX20 DHRS3 DRAXIN NPPA-AS1 AADACL4 piR-31534-004 AADACL3
GH01J012657 Enhancer 1 FANTOM5 0.2 -58.3 -58325 0.3 ARHGAP35 HNRNPL ZNF512 SIX5 LEF1 IKZF1 JUND DDX20 MTA2 PHF21A DHRS3 AADACL4 piR-31534-004 AADACL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around AADACL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for AADACL3

Top Transcription factor binding sites by QIAGEN in the AADACL3 gene promoter:
  • AML1a
  • ATF6
  • HOXA9
  • HOXA9B
  • LyF-1
  • Meis-1
  • Meis-1b
  • STAT1alpha
  • STAT1beta
  • STAT3

Genomic Locations for AADACL3 Gene

Genomic Locations for AADACL3 Gene
12,651 bases
Plus strand
12,609 bases
Plus strand

Genomic View for AADACL3 Gene

Genes around AADACL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AADACL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AADACL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AADACL3 Gene

Proteins for AADACL3 Gene

  • Protein details for AADACL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arylacetamide deacetylase-like 3
    Protein Accession:
    Secondary Accessions:
    • B3KXR9
    • Q5VUY1

    Protein attributes for AADACL3 Gene

    407 amino acids
    Molecular mass:
    46155 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG54581.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for AADACL3 Gene

Post-translational modifications for AADACL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for AADACL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for AADACL3 Gene

Domains & Families for AADACL3 Gene

Gene Families for AADACL3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for AADACL3 Gene

  • Alpha/beta hydrolase fold-3

Suggested Antigen Peptide Sequences for AADACL3 Gene

GenScript: Design optimal peptide antigens:
  • Arylacetamide deacetylase-like 3 (ADCL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 'GDXG' lipolytic enzyme family.
  • Belongs to the 'GDXG' lipolytic enzyme family.
genes like me logo Genes that share domains with AADACL3: view

Function for AADACL3 Gene

Enzyme Numbers (IUBMB) for AADACL3 Gene

Phenotypes From GWAS Catalog for AADACL3 Gene

Gene Ontology (GO) - Molecular Function for AADACL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IBA 21873635
GO:0034338 short-chain carboxylesterase activity IBA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with AADACL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADACL3

No data available for Molecular function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for AADACL3 Gene

Localization for AADACL3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for AADACL3 gene
Compartment Confidence
endoplasmic reticulum 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for AADACL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with AADACL3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for AADACL3 Gene

Pathways & Interactions for AADACL3 Gene

PathCards logo

SuperPathways for AADACL3 Gene

No Data Available

Interacting Proteins for AADACL3 Gene

Gene Ontology (GO) - Biological Process for AADACL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009056 catabolic process IBA --
genes like me logo Genes that share ontologies with AADACL3: view

No data available for Pathways by source and SIGNOR curated interactions for AADACL3 Gene

Drugs & Compounds for AADACL3 Gene

No Compound Related Data Available

Transcripts for AADACL3 Gene

mRNA/cDNA for AADACL3 Gene

2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for AADACL3

Alternative Splicing Database (ASD) splice patterns (SP) for AADACL3 Gene

No ASD Table

Relevant External Links for AADACL3 Gene

GeneLoc Exon Structure for

Expression for AADACL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for AADACL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AADACL3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x33.9) and Skin - Sun Exposed (Lower leg) (x14.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for AADACL3

SOURCE GeneReport for Unigene cluster for AADACL3 Gene:

genes like me logo Genes that share expression patterns with AADACL3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for AADACL3 Gene

Orthologs for AADACL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for AADACL3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia AADACL3 30 31
  • 98.57 (n)
(Bos Taurus)
Mammalia LOC530613 30
  • 76.86 (n)
  • 60 (a)
(Canis familiaris)
Mammalia AADACL3 30 31
  • 76.67 (n)
(Mus musculus)
Mammalia Aadacl3 30 17 31
  • 70.79 (n)
(Rattus norvegicus)
Mammalia Aadacl3 30
  • 70.02 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 37 (a)
(Gallus gallus)
Aves -- 31
  • 43 (a)
-- 31
  • 39 (a)
-- 31
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 40 (a)
-- 31
  • 38 (a)
-- 31
  • 38 (a)
-- 31
  • 37 (a)
-- 31
  • 37 (a)
-- 31
  • 37 (a)
-- 31
  • 34 (a)
(Danio rerio)
Actinopterygii aadacl4 31
  • 32 (a)
(Caenorhabditis elegans)
Secernentea trcs-1 31
  • 20 (a)
Y43F8A.3 31
  • 20 (a)
T09B9.1 31
  • 20 (a)
F16F9.4 31
  • 19 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 22 (a)
Species where no ortholog for AADACL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for AADACL3 Gene

Gene Tree for AADACL3 (if available)
Gene Tree for AADACL3 (if available)
Evolutionary constrained regions (ECRs) for AADACL3: view image

Paralogs for AADACL3 Gene

Paralogs for AADACL3 Gene

(4) SIMAP similar genes for AADACL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with AADACL3: view

Variants for AADACL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for AADACL3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs11121969 - p.Pro337Leu
rs17038445 - p.Arg186Trp
rs3000859 - p.Leu128Met
rs3000931 - p.Met307Ile
rs3010877 - p.Pro104Ser

Additional dbSNP identifiers (rs#s) for AADACL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for AADACL3 Gene

Variant ID Type Subtype PubMed ID
nsv1011540 CNV loss 25217958
nsv466394 CNV gain 19166990
nsv545444 CNV loss 21841781
nsv545445 CNV gain 21841781
nsv999658 CNV gain 25217958

Variation tolerance for AADACL3 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for AADACL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AADACL3 Gene

Disorders for AADACL3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for AADACL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
norwegian scabies
  • crusted scabies
mite infestation
  • mite infestations
transient hypogammaglobulinemia
  • infestation by sarcoptes scabiei
tinea corporis
  • dermatophytosis of the body
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with AADACL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AADACL3 Gene

Publications for AADACL3 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4

Products for AADACL3 Gene

Sources for AADACL3 Gene