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Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
AADAC (Arylacetamide Deacetylase) is a Protein Coding gene. Diseases associated with AADAC include Gilles De La Tourette Syndrome. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and triglyceride lipase activity. An important paralog of this gene is AADACL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | TAS | 8063807 |
GO:0004806 | triglyceride lipase activity | IBA,ISS | -- |
GO:0016298 | lipase activity | TAS | 11481320 |
GO:0016787 | hydrolase activity | IEA,IBA | 21873635 |
GO:0017171 | serine hydrolase activity | IBA,IDA | 17936933 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0031090 | organelle membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type | ||
2 | Metabolism |
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|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006805 | xenobiotic metabolic process | TAS | -- |
GO:0009056 | catabolic process | IBA | -- |
GO:0010898 | positive regulation of triglyceride catabolic process | IEA,ISS | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
3-Aminosalicylic acid |
|
570-23-0 |
|
|||
Diglycerides Group D |
|
|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | AADAC 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | AADAC 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | AADAC 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Aadac 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Aadac 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Platypus (Ornithorhynchus anatinus) |
Mammalia | AADAC 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | AADACL2 30 |
|
||
-- 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | aadac 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC100148912 30 |
|
||
aadac 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | trcs-1 31 |
|
ManyToMany | |
F16F9.4 31 |
|
ManyToMany | |||
T09B9.1 31 |
|
ManyToMany | |||
Y43F8A.3 31 |
|
ManyToMany | |||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1039.03 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1803155 | - | p.Val281Ile |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1419e212 | CNV | loss | 25503493 |
dgv4919n100 | CNV | loss | 25217958 |
dgv4920n100 | CNV | loss | 25217958 |
dgv4921n100 | CNV | loss | 25217958 |
dgv621n27 | CNV | loss | 19166990 |
dgv622n27 | CNV | loss | 19166990 |
dgv8652n54 | CNV | loss | 21841781 |
dgv8653n54 | CNV | loss | 21841781 |
dgv8654n54 | CNV | loss | 21841781 |
dgv8655n54 | CNV | loss | 21841781 |
esv25716 | CNV | loss | 19812545 |
esv2672544 | CNV | deletion | 23128226 |
esv2759189 | CNV | loss | 17122850 |
esv2763771 | CNV | loss | 21179565 |
esv3562727 | CNV | deletion | 23714750 |
esv3598188 | CNV | loss | 21293372 |
esv3893786 | CNV | loss | 25118596 |
nsv514175 | CNV | loss | 21397061 |
nsv517155 | CNV | loss | 19592680 |
nsv522472 | CNV | loss | 19592680 |
nsv592056 | CNV | loss | 21841781 |
nsv592069 | CNV | loss | 21841781 |
nsv592070 | CNV | loss | 21841781 |
nsv592072 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
gilles de la tourette syndrome |
|
|