Aliases for AADAC Gene
External Ids for AADAC Gene
Previous GeneCards Identifiers for AADAC Gene
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
GeneCards Summary for AADAC Gene
AADAC (Arylacetamide Deacetylase) is a Protein Coding gene. Diseases associated with AADAC include Schizotypal Personality Disorder and Gilles De La Tourette Syndrome. Among its related pathways are Cytochrome P450 - arranged by substrate type and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and triglyceride lipase activity. An important paralog of this gene is AADACL2.
UniProtKB/Swiss-Prot Summary for AADAC Gene
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.