External Ids for A4GNT Gene
Previous GeneCards Identifiers for A4GNT Gene
This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]
GeneCards Summary for A4GNT Gene
A4GNT (Alpha-1,4-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with A4GNT include Borna Disease and Pancreatic Intraductal Papillary-Mucinous Neoplasm. Among its related pathways are Metabolism of proteins and heparan sulfate biosynthesis. Gene Ontology (GO) annotations related to this gene include acetylglucosaminyltransferase activity. An important paralog of this gene is A4GALT.
UniProtKB/Swiss-Prot Summary for A4GNT Gene
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity).