External Ids for A4GNT Gene
Previous GeneCards Identifiers for A4GNT Gene
This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]
GeneCards Summary for A4GNT Gene
A4GNT (Alpha-1,4-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and O-linked glycosylation. Gene Ontology (GO) annotations related to this gene include acetylglucosaminyltransferase activity. An important paralog of this gene is A4GALT.
UniProtKB/Swiss-Prot Summary for A4GNT Gene
Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity).