Aliases for A4GALT Gene
- Alpha 1,4-Galactosyltransferase (P Blood Group) 2 3 5
- Lactosylceramide 4-Alpha-Galactosyltransferase 2 3 4
- Globotriaosylceramide Synthase 2 3 4
- CD77 Synthase 2 3 4
- UDP-Galactose:Beta-D-Galactosyl-Beta1-R 4-Alpha-D-Galactosyltransferase 3 4
- Alpha-1,4-N-Acetylglucosaminyltransferase 3 4
- Alpha-1,4-Galactosyltransferase 3 4
- P One Antigen (P Blood Group) 2 3
- P1/Pk Synthase 3 4
- Alpha4Gal-T1 3 4
- Gb3 Synthase 2 4
- EC 126.96.36.199 4 52
External Ids for A4GALT Gene
Previous HGNC Symbols for A4GALT Gene
Previous GeneCards Identifiers for A4GALT Gene
The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for A4GALT Gene
A4GALT (Alpha 1,4-Galactosyltransferase (P Blood Group)) is a Protein Coding gene. Diseases associated with A4GALT include Blood Group, P1pk System and Caffey Disease. Among its related pathways are Globo Sphingolipid Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. Gene Ontology (GO) annotations related to this gene include galactosyltransferase activity and lactosylceramide 4-alpha-galactosyltransferase activity. An important paralog of this gene is A4GNT.
UniProtKB/Swiss-Prot Summary for A4GALT Gene
Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10748143). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143). Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P (PubMed:10747952).
(Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins.