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A2MP1 Gene(Pseudogene)

Alpha-2-Macroglobulin Pseudogene 1

GCID:
GC12M009228
GIFtS:
16
Genes Participants
UDN Logo

Aliases for A2MP1 Gene

Aliases for A2MP1 Gene

  • Alpha-2-Macroglobulin Pseudogene 1 2 3 5
  • Pregnancy-Zone Protein Pseudogene 3
  • Alpha-2-Macroglobulin Pseudogene 2
  • A2MP 3

External Ids for A2MP1 Gene

Previous HGNC Symbols for A2MP1 Gene

  • A2MP

Previous GeneCards Identifiers for A2MP1 Gene

  • GC12M009384

Summaries for A2MP1 Gene

GeneCards Summary for A2MP1 Gene

A2MP1 (Alpha-2-Macroglobulin Pseudogene 1) is a Pseudogene.

Additional gene information for A2MP1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for A2MP1 Gene

Genomics for A2MP1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for A2MP1 Gene

Promoters and enhancers for A2MP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J009283 Enhancer 1.1 Ensembl ENCODE 26.6 -8.9 -8906 3.4 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A ZNF2 POLR2B GLIS2 ZNF207 LOC642846 A2MP1 DDX12P LINC02367 GC12M009286 GC12P009275
GH12J009333 Enhancer 0.6 ENCODE 10.7 -58.8 -58812 3.2 ZNF639 MAFG BACH1 EBF1 RAD21 ZNF395 ZNF316 POLR2A NFE2 EMSY GC12M012209 GC12M012215 GC12M012217 GC12M012219 GC12M012239 GC12M012240 GC12M012248 GC12M012250 GC12M012253 GC12M012255
GH12J009813 Enhancer 1.2 FANTOM5 Ensembl ENCODE 4.3 -538.4 -538441 1.3 CTCF PKNOX1 BACH1 SIN3A EBF1 ZIC2 ZNF2 IRF4 RAD21 HIC1 KLRF1 KLRD1 CD69 KLRB1 A2MP1 CLEC2B KLRF2 LOC100419929
GH12J009272 Enhancer 0.8 ENCODE 0.7 +2.4 2407 1.1 MZF1 FEZF1 BRCA1 RFX5 ZNF335 ZNF366 RCOR1 FOS SMARCC1 CEBPB DDX12P LOC642846 A2MP1 GC12P009275 ENSG00000256427
GH12J009240 Promoter/Enhancer 0.9 Ensembl ENCODE 0.3 +35.4 35416 0.8 RAD21 YY1 LINC00987 MIR1244-3 PTMAP4 DDX12P PZP LOC642846 A2MP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around A2MP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for A2MP1 Gene

Genomic Locations for A2MP1 Gene
chr12:9,228,533-9,275,817
(GRCh38/hg38)
Size:
47,285 bases
Orientation:
Minus strand
chr12:9,381,129-9,428,413
(GRCh37/hg19)
Size:
47,285 bases
Orientation:
Minus strand

Genomic View for A2MP1 Gene

Genes around A2MP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
A2MP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for A2MP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for A2MP1 Gene

Proteins for A2MP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for A2MP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for A2MP1 Gene

Domains & Families for A2MP1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for A2MP1 Gene

Function for A2MP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes for A2MP1 Gene

GenomeRNAi human phenotypes for A2MP1:
genes like me logo Genes that share phenotypes with A2MP1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for A2MP1 Gene

Localization for A2MP1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for A2MP1 Gene

Pathways & Interactions for A2MP1 Gene

SuperPathways for A2MP1 Gene

PathCards logo More details on SuperPathways for A2MP1
No Data Available

Interacting Proteins for A2MP1 Gene

Gene Ontology (GO) - Biological Process for A2MP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for A2MP1 Gene

Drugs & Compounds for A2MP1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for A2MP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for A2MP1 Gene

(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for A2MP1 Gene

Alpha-2-macroglobulin pseudogene 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for A2MP1 Gene

No ASD Table

Relevant External Links for A2MP1 Gene

GeneLoc Exon Structure for
A2MP1
ECgene alternative splicing isoforms for
A2MP1

Expression for A2MP1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for A2MP1 Gene

mRNA expression in normal human tissues for A2MP1 Gene
mRNA expression by GTEx for A2MP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of A2MP1 Gene:

A2MP1

SOURCE GeneReport for Unigene cluster for A2MP1 Gene:

Hs.569125
genes like me logo Genes that share expression patterns with A2MP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for A2MP1 Gene

Orthologs for A2MP1 Gene

Evolution for A2MP1 Gene

ENSEMBL:
Gene Tree for A2MP1 (if available)
TreeFam:
Gene Tree for A2MP1 (if available)

No data available for Orthologs for A2MP1 Gene

Paralogs for A2MP1 Gene

No data available for Paralogs for A2MP1 Gene

Variants for A2MP1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for A2MP1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000207543 -- 9,229,095(-) T/G intron_variant
rs1000763532 -- 9,235,822(-) T/G upstream_transcript_variant
rs1001110863 -- 9,229,523(-) C/T intron_variant
rs1001282284 -- 9,229,725(-) C/T intron_variant
rs1001314932 -- 9,229,444(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for A2MP1 Gene

Variant ID Type Subtype PubMed ID
esv2759878 CNV gain+loss 17122850
esv992832 CNV insertion 20482838
nsv1051530 CNV gain 25217958
nsv523958 CNV loss 19592680
nsv527404 CNV gain 19592680
nsv557355 CNV gain 21841781
nsv8903 CNV loss 18304495

Additional Variant Information for A2MP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
A2MP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for A2MP1 Gene

Disorders for A2MP1 Gene

Additional Disease Information for A2MP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for A2MP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for A2MP1 Gene

Publications for A2MP1 Gene

  1. An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3. (PMID: 19105203) Edwards TL … Ritchie MD (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009) 3 44 58
  2. A cluster of alpha 2-macroglobulin-related genes (alpha 2 M) on human chromosome 12p: cloning of the pregnancy-zone protein gene and an alpha 2M pseudogene. (PMID: 2478422) Devriendt K … Marynen P (Gene 1989) 2 3 58
  3. Genetic variants associated with breast size also influence breast cancer risk. (PMID: 22747683) Eriksson N … Tung JY (BMC medical genetics 2012) 3 58
  4. Recombinant soluble glypican 3 protein inhibits the growth of hepatocellular carcinoma in vitro. (PMID: 20617511) Feng M … Ho M (International journal of cancer 2011) 3 58
  5. Activator-independent transcription of Snf1-dependent genes in mutants lacking histone tails. (PMID: 21338416) Infante JJ … Young ET (Molecular microbiology 2011) 3 58

Products for A2MP1 Gene

Sources for A2MP1 Gene

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