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Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that thi... See more...
Aliases for A1CF Gene
Aliases for A1CF Gene
External Ids for A1CF Gene
- HGNC: 24086
- Entrez Gene: 29974
- Ensembl: ENSG00000148584
- OMIM: 618199
- UniProtKB: Q9NQ94
Previous GeneCards Identifiers for A1CF Gene
- GC10M052237
- GC10M052566
- GC10M046544
Summaries for A1CF Gene
-
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for A1CF Gene
A1CF (APOBEC1 Complementation Factor) is a Protein Coding gene. Diseases associated with A1CF include Anisometropia and Suppression Amblyopia. Among its related pathways are Gene Expression and mRNA Editing- C to U Conversion. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM47.
UniProtKB/Swiss-Prot Summary for A1CF Gene
-
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
Additional gene information for A1CF Gene
- HGNC(24086)
- Entrez Gene(29974)
- Ensembl(ENSG00000148584)
- OMIM(618199)
- UniProtKB(Q9NQ94)
- Open Targets Platform(ENSG00000148584)
- Search for A1CF at DataMed
- Search for A1CF at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for A1CF Gene
Genomics for A1CF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for A1CF Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J050882 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 600.7 | +1.1 | 1055 | 4.1 | GATAD2A ATF7 REST TFE3 SOX13 RCOR2 RBFOX2 RXRB IRF2 SP1 | A1CF SGMS1 ASAH2 ASAH2B piR-43939-005 | |
| GH10J050859 | Promoter | 0.3 | EPDnew | 611.7 | +25.7 | 25672 | 0.1 | A1CF piR-43939-005 ENSG00000229711 ASAH2B | ||
| GH10J050807 | Enhancer | 0.8 | Ensembl | 10.1 | +77.3 | 77284 | 0.8 | GATAD2A RFX5 FOXA1 SP1 CEBPA FOXK2 SOX13 RFX3 FOXA2 MAFF | ASAH2B A1CF lnc-SGMS1-5 ENSG00000229711 | |
| GH10J050857 | Enhancer | 0.5 | Ensembl | 11.7 | +28.0 | 27974 | 1 | PRDM10 SP1 TCF7L2 YY1 HNF4A RXRA MAX EGR1 | A1CF piR-43939-005 ENSG00000229711 ASAH2B | |
| GH10J050851 | Enhancer | 0.3 | ENCODE | 11.2 | +34.8 | 34759 | 0.2 | EZH2 | A1CF ENSG00000229711 piR-43939-005 ASAH2B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around A1CF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for A1CF
- Top Transcription factor binding sites by QIAGEN in the A1CF gene promoter:
-
- Arnt
- FOXO1
- FOXO1a
- POU2F1
- POU2F1a
- POU2F1b
- POU2F1c
- RORalpha1
- RORalpha2
- STAT3
Genomic Locations for A1CF Gene
Genomic Locations for A1CF Gene
- chr10:50,799,409-50,885,675
- (GRCh38/hg38)
- Size:
- 86,267 bases
- Orientation:
- Minus strand
- chr10:52,559,169-52,645,435
- (GRCh37/hg19)
- Size:
- 86,267 bases
- Orientation:
- Minus strand
Genomic View for A1CF Gene
Genes around A1CF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q11.23 by HGNC
- 10q11.23 by Entrez Gene
- 10q11.23 by Ensembl
A1CF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for A1CF Gene
Proteins for A1CF Gene
-
Protein details for A1CF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQ94-A1CF_HUMAN
- Recommended name:
- APOBEC1 complementation factor
- Protein Accession:
- Q9NQ94
- A1L4F2
- A8K7G7
- B7ZM14
- Q5SZQ0
- Q9NQ93
- Q9NQX8
- Q9NQX9
- Q9NXC9
- Q9NZD3
Protein attributes for A1CF Gene
- Size:
- 594 amino acids
- Molecular mass:
- 65202 Da
- Quaternary structure:
-
- Part of the apolipoprotein B mRNA editing complex with APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2 (By similarity).
- SequenceCaution:
-
- Sequence=BAA91086.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: Major isoform found in 66-78% of cDNA clones.
- [Isoform 4]: Does not exhibit APOBEC1 complementation activity.
- [Isoform 5]: Does not exhibit APOBEC1 complementation activity.
- [Isoform 6]: Minor isoform found in 2-3% of cDNA clones.
Protein Expression for A1CF Gene
Post-translational modifications for A1CF Gene
Other Protein References for A1CF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-A1CF (aa 2-51) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for A1CF
- Novus Biologicals Antibodies for A1CF
-
Abcam antibodies for A1CF
- Invitrogen Antibodies for A1CF (AFLGC-A1CF)
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for A1CF
- Origene Custom Protein Services for A1CF
- antibodies-online: Show 6 available A1CF Proteins ranked by validation data
- Compare Top A1CF Proteins
-
Quality Products:
No data available for DME Specific Peptides for A1CF Gene
Domains & Families for A1CF Gene
Gene Families for A1CF Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for A1CF Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- ProtoNet:
Suggested Antigen Peptide Sequences for A1CF Gene
- GenScript: Design optimal peptide antigens:
-
- APOBEC1-stimulating protein (A1CF_HUMAN)
- A1CF protein (Q7Z2U9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NQ94UniProtKB/Swiss-Prot:
A1CF_HUMAN :- The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity.
- Domain:
-
- The RRM domains are necessary but not sufficient for binding to APOB mRNA. Additional residues in the pre-RRM and C-terminal regions are required for RNA-binding and for complementing APOBEC1 activity.
Function for A1CF Gene
Molecular function for A1CF Gene
- UniProtKB/Swiss-Prot Function:
- Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.
Phenotypes From GWAS Catalog for A1CF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | TAS,IBA | 21873635 |
| GO:0003725 | NOT double-stranded RNA binding | IDA | 11871661 |
| GO:0003727 | single-stranded RNA binding | IDA | 11871661 |
| GO:0003729 | mRNA binding | IBA | 21873635 |
Phenotypes for A1CF Gene
- MGI mutant phenotypes for A1CF:
-
inferred from 3 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- renal/urinary system phenotype
- GenomeRNAi human phenotypes for A1CF:
Animal Models for A1CF Gene
- MGI Knock Outs for A1CF:
-
- A1cf A1cf<tm1Ddsn>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for A1CF - Select products 50% OFF >
- * A1CF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for A1CF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for A1CF
-
Santa Cruz Biotechnology (SCBT) CRISPR for A1CF
miRNA for A1CF Gene
- miRTarBase miRNAs that target A1CF
-
- hsa-miR-4480 (MIRT443253)
- hsa-miR-93-5p (MIRT443254)
- hsa-miR-526b-3p (MIRT443255)
- hsa-miR-519d-3p (MIRT443256)
- hsa-miR-20b-5p (MIRT443257)
- hsa-miR-20a-5p (MIRT443258)
- hsa-miR-17-5p (MIRT443259)
- hsa-miR-106b-5p (MIRT443260)
- hsa-miR-106a-5p (MIRT443261)
- hsa-miR-548t-5p (MIRT443262)
- hsa-miR-548az-5p (MIRT443263)
- hsa-miR-3191-5p (MIRT512840)
- hsa-miR-1252-5p (MIRT512841)
- hsa-miR-4653-5p (MIRT512842)
- hsa-miR-3921 (MIRT512843)
- hsa-miR-301b-5p (MIRT512844)
- hsa-miR-301a-5p (MIRT512845)
- hsa-miR-146a-3p (MIRT512846)
- hsa-miR-5197-3p (MIRT512847)
- hsa-miR-5571-5p (MIRT512848)
- hsa-miR-4428 (MIRT512849)
- hsa-miR-6855-5p (MIRT516016)
- hsa-miR-3170 (MIRT516018)
- hsa-miR-193b-5p (MIRT516019)
- hsa-miR-3622b-5p (MIRT516020)
- hsa-miR-6778-3p (MIRT516021)
- hsa-miR-7155-5p (MIRT516022)
- hsa-miR-150-5p (MIRT516023)
- hsa-miR-186-3p (MIRT516024)
- hsa-miR-1295b-3p (MIRT516025)
- hsa-miR-3973 (MIRT516026)
- hsa-miR-1278 (MIRT516027)
- hsa-miR-8054 (MIRT516028)
- hsa-miR-548k (MIRT516029)
- hsa-miR-548av-5p (MIRT516030)
- hsa-miR-510-3p (MIRT618841)
- hsa-miR-1238-3p (MIRT618842)
- hsa-miR-670-3p (MIRT618843)
- hsa-miR-6881-3p (MIRT618844)
- hsa-miR-6780a-3p (MIRT618845)
- hsa-miR-7111-3p (MIRT618846)
- hsa-miR-6749-3p (MIRT618847)
- hsa-miR-211-5p (MIRT618848)
- hsa-miR-204-5p (MIRT618849)
- hsa-miR-4685-3p (MIRT618850)
- hsa-miR-4287 (MIRT618851)
- hsa-miR-6734-3p (MIRT618852)
- hsa-miR-877-3p (MIRT618853)
- hsa-miR-5193 (MIRT618854)
- hsa-miR-6832-3p (MIRT618855)
- hsa-miR-5088-3p (MIRT618856)
- hsa-miR-548e-5p (MIRT618857)
- hsa-miR-6808-3p (MIRT669719)
- hsa-miR-6844 (MIRT669720)
- hsa-miR-6820-3p (MIRT669721)
- hsa-miR-3164 (MIRT669722)
- hsa-miR-3118 (MIRT669723)
- hsa-miR-134-5p (MIRT669724)
- hsa-miR-758-3p (MIRT669725)
- hsa-miR-4659b-3p (MIRT709864)
- hsa-miR-4659a-3p (MIRT709865)
- hsa-miR-4452 (MIRT709866)
- hsa-miR-183-3p (MIRT709867)
- hsa-miR-526b-5p (MIRT709868)
- hsa-miR-630 (MIRT709869)
- hsa-miR-4999-5p (MIRT709870)
- hsa-miR-4635 (MIRT709871)
- hsa-miR-4778-3p (MIRT709872)
- hsa-miR-4742-3p (MIRT709873)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for A1CF
- Browse OriGene Inhibitory RNA Products For A1CF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for A1CF
Clone Products
- Applied Biological Materials (abm): Clones for A1CF - Select products 50% OFF >
- * A1CF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG224176
- MR224176
- MR224176L1
- MR224176L2
- MR224176L3
- MR224176L4
- RC213415
- RC213415L3
- RC213415L4
- RC216861
- RC216861L3
- RC216861L4
- RC216911
- RC216911L3
- RC216911L4
- RC231331
- RC231331L3
- RC231331L4
- RC234498
- RC234515
- RG213415
- RG216861
- RG216911
- RG231331
- RG234498
- RG234515
- RR208787
- RR208787L3
- RR208787L4
- MR224176L1V
- MR224176L2V
- MR224176L3V
- MR224176L4V
- RC213415L3V
- RC213415L4V
- RC216861L3V
- RC216861L4V
- RC216911L3V
- RC216911L4V
- RC231331L3V
- RC231331L4V
- RR208787L3V
- RR208787L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for A1CF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for A1CF
Cell Line Products
-
Horizon Cell Lines for A1CF
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for A1CF Gene
Localization for A1CF Gene
Subcellular locations from UniProtKB/Swiss-Prot for A1CF Gene
- Nucleus. Endoplasmic reticulum. Cytoplasm. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| endoplasmic reticulum | 3 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 12881431 |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0030895 | apolipoprotein B mRNA editing enzyme complex | IDA | 10781591 |
Pathways & Interactions for A1CF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Editing- C to U Conversion |
.82
|
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for A1CF Gene
4 Reactome pathways for A1CF Gene
Interacting Proteins for A1CF Gene
Selected Interacting proteins:
Q9NQ94-A1CF_HUMAN
ENSP00000378868
for A1CF Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for A1CF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0007566 | embryo implantation | IEA | -- |
| GO:0010609 | mRNA localization resulting in posttranscriptional regulation of gene expression | IEA | -- |
| GO:0016554 | cytidine to uridine editing | TAS | -- |
| GO:0016556 | mRNA modification | IEA | -- |
No data available for SIGNOR curated interactions for A1CF Gene
Transcripts for A1CF Gene
mRNA/cDNA for A1CF Gene
- 8 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000374001 9221 nts (view in UCSC)
- ENST00000373993 1997 nts (view in UCSC)
- ENST00000373997 9221 nts (view in UCSC)
- ENST00000373995 2211 nts (view in UCSC)
- ENST00000493415 926 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for A1CF - Select products 50% OFF >
- * A1CF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for A1CF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for A1CF
-
Santa Cruz Biotechnology (SCBT) CRISPR for A1CF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for A1CF
- Browse OriGene Inhibitory RNA Products For A1CF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for A1CF
Clone Products
- Applied Biological Materials (abm): Clones for A1CF - Select products 50% OFF >
- * A1CF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG224176
- MR224176
- MR224176L1
- MR224176L2
- MR224176L3
- MR224176L4
- RC213415
- RC213415L3
- RC213415L4
- RC216861
- RC216861L3
- RC216861L4
- RC216911
- RC216911L3
- RC216911L4
- RC231331
- RC231331L3
- RC231331L4
- RC234498
- RC234515
- RG213415
- RG216861
- RG216911
- RG231331
- RG234498
- RG234515
- RR208787
- RR208787L3
- RR208787L4
- MR224176L1V
- MR224176L2V
- MR224176L3V
- MR224176L4V
- RC213415L3V
- RC213415L4V
- RC216861L3V
- RC216861L4V
- RC216911L3V
- RC216911L4V
- RC231331L3V
- RC231331L4V
- RR208787L3V
- RR208787L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for A1CF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for A1CF
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: | - | - |
Relevant External Links for A1CF Gene
- GeneLoc Exon Structure for
- A1CF
Expression for A1CF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for A1CF Gene
This gene is overexpressed in Liver (x36.4), Colon - Transverse (x4.6), and Pancreas (x4.3).
This gene is overexpressed in Fetal Liver (22.7), Liver (21.7), Pancreas (12.2), and Gallbladder (8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for A1CF Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for A1CF
SOURCE GeneReport for Unigene cluster for A1CF Gene:
Hs.282795mRNA Expression by UniProt/SwissProt for A1CF Gene:
Q9NQ94-A1CF_HUMAN
Tissue specificity:
Widely expressed with highest levels in brain, liver, pancreas, colon and spleen.
Evidence on tissue expression from TISSUES for A1CF Gene
- Liver(4.7)
- Intestine(4.5)
- Eye(2.3)
- Kidney(2.2)
- Nervous system(2.1)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for A1CF
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for A1CF Gene
Orthologs for A1CF Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | A1CF 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | A1CF 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | A1CF 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | A1cf 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | A1cf 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | A1CF 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | A1CF 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | A1CF 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | A1CF 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | a1cf 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | a1cf 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG17838 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | hrp-2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for A1CF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for A1CF Gene
- ENSEMBL:
- Gene Tree for A1CF (if available)
- TreeFam:
- Gene Tree for A1CF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for A1CF: view image
Paralogs for A1CF Gene
Paralogs for A1CF Gene
- RBM47 5
- RBM46 5
- DND1 5
- NCL 5
- RBM39 5
- TIAL1 5
- TIA1 5
- HNRNPA3 5
- HNRNPA2B1 5
- RBM23 5
- RBM4 5
- HNRNPA1L2 5
- MSI2 5
- HNRNPA1 5
- RBM4B 5
- MSI1 5
- RBM19 5
- HNRNPA1P48 5
- RBMX 5
- RBM14-RBM4 5
- RBMXL1 5
- HNRNPA0 5
- RBMXL2 5
- HNRNPAB 5
- HNRNPD 5
- RBMXL3 5
- RBMY1A1 5
- RBMY1B 5
- DAZAP1 5
- RBMY1D 5
- RBMY1E 5
- RBMY1F 5
- RBMY1J 5
- TRNAU1AP 5
- HNRNPDL 5
- CIRBP 5
- RBM3 5
(13) SIMAP similar genes for A1CF Gene using alignment to 4 proteins:
- A1CF_HUMAN
- F8W9F8_HUMAN
- Q5T0W7_HUMAN
- Q7Z2U9_HUMAN
Variants for A1CF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for A1CF Gene
| SNP ID | Clinical significance and condition | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 754730 | Likely Benign: not provided | 50,814,037(-) | C/T | SYNONYMOUS_VARIANT | |
| 774682 | Benign: not provided | 50,816,265(-) | G/A | SYNONYMOUS_VARIANT | |
| 779433 | Likely Benign: not provided | 50,814,012(-) | C/T | MISSENSE_VARIANT | |
| 781673 | Benign: not provided | 50,843,994(-) | A/G | SYNONYMOUS_VARIANT | |
| 786157 | Benign: not provided | 50,836,093(-) | C/T | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2658700 | CNV | deletion | 23128226 |
| esv3623216 | CNV | loss | 21293372 |
| esv3623217 | CNV | loss | 21293372 |
| nsv1035197 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.77;
58.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for A1CF Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- A1CF
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for A1CF Gene
Disorders for A1CF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| anisometropia |
|
|
| suppression amblyopia |
|
|
| amblyopia |
|
|
| epithelial-stromal tgfbi dystrophy |
|
|
| lattice corneal dystrophy |
|
|
Search A1CF in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for A1CF
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for A1CF Gene
Publications for A1CF Gene
- The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay. (PMID: 12881431) Chester A … Navaratnam N (The EMBO journal 2003) 3 4 23
- A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling. (PMID: 12896982) Blanc V … Davidson NO (The Journal of biological chemistry 2003) 3 4 23
- Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing. (PMID: 11815617) Dance GS … Smith HC (The Journal of biological chemistry 2002) 2 3 23
- Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. (PMID: 11871661) Mehta A … Driscoll DM (RNA (New York, N.Y.) 2002) 3 4 23
- Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene. (PMID: 11718896) Henderson JO … Davidson NO (Biochimica et biophysica acta 2001) 3 4 23
ExternalLinks
Products for A1CF Gene
- Custom Antibody ServicesOriGene Antibodies for A1CF
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for A1CF
- Origene Custom Protein Services for A1CF
- Origene shrna, sirna, and RNAi products in human, mouse, rat for A1CF
- Browse OriGene Inhibitory RNA Products For A1CF
- OriGene qPCR primer pairs for A1CF
- OriGene CRISPR knockouts for A1CF
- MG224176
- MR224176
- MR224176L1
- MR224176L2
- MR224176L3
- MR224176L4
- RC213415
- RC213415L3
- RC213415L4
- RC216861
- RC216861L3
- RC216861L4
- RC216911
- RC216911L3
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- RC231331
- RC231331L3
- RC231331L4
- RC234498
- RC234515
- RG213415
- RG216861
- RG216911
- RG231331
- RG234498
- RG234515
- RR208787
- RR208787L3
- RR208787L4
- MR224176L1V
- MR224176L2V
- MR224176L3V
- MR224176L4V
- RC213415L3V
- RC213415L4V
- RC216861L3V
- RC216861L4V
- RC216911L3V
- RC216911L4V
- RC231331L3V
- RC231331L4V
- RR208787L3V
- RR208787L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For A1CF
- Sino Biological Human cDNA Clone for A1CF
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for A1CF
- Novus Biologicals proteins and lysates for A1CF
- Novus Biologicals ELISA Kits for A1CF
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
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- Abcam antibodies for A1CF
- Find your target
- Browse Primary Antibodies
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for A1CF (AFLGC-A1CF)
- VectorBuilder Custom and pre-made DNA vectors for A1CF (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for A1CF (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for A1CF (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for A1CF CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for A1CF
- antibodies-online: Show 18 available A1CF Antibodies ranked by validation data
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- antibodies-online: Show 20 available A1CF Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 6 available A1CF Proteins ranked by validation data
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- Quality Products:
- Horizon Cell Lines for A1CF
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for A1CF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for A1CF
- Search GeneCopoeia for miRNA 3'UTR Target clone products for A1CF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for A1CF
Sources for A1CF Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB