Aliases for WWOX Gene
External Ids for WWOX Gene
Previous GeneCards Identifiers for WWOX Gene
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
GeneCards Summary for WWOX Gene
WWOX (WW Domain Containing Oxidoreductase) is a Protein Coding gene. Diseases associated with WWOX include Spinocerebellar Ataxia, Autosomal Recessive 12 and Epileptic Encephalopathy, Early Infantile, 28. Among its related pathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include enzyme binding and protein dimerization activity. An important paralog of this gene is RDH11.
UniProtKB/Swiss-Prot Summary for WWOX Gene
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.